Electrochemical Influence of Collagen Piezoelectric Effect in Bone Healing

2007 ◽  
Vol 544-545 ◽  
pp. 981-984 ◽  
Author(s):  
Karem Noris-Suárez ◽  
Joaquín Lira-Olivares ◽  
Ana M. Ferreira ◽  
Armando Graterol ◽  
Jose L. Feijoo ◽  
...  
Keyword(s):  
Electric Field ◽  
Bone Healing ◽  
Bone Growth ◽  
Piezoelectric Effect ◽  
Osteoblastic Activity ◽  
Electrical Stimuli ◽  
Biomimetic Deposition

Bone healing and growth are controlled by the rate of deposition of hidroxiapatite (HA). This process have been so far accredited to the work of osteoblasts, which are attracted by the electrical dipoles produced either by piezoelectricity, due to deformation of the bone, specially the collagen in it, or due to outside electrical stimuli. The present work shows that even without osteoblasts present, the piezoelectric dipoles produced by deformed collagen, can produce the precipitation of HA by electrochemical means, without catalyzer as in biomimetic deposition. These findings could clarify the contribution of osteoblasts in bone growth as compared to the electrochemical action by itself. Further studies ascertaining the osteoblastic activity due to the electric field are being advanced.

Measurement of independent piezoelectric moduli of Ca3NbGa3Si2O14, La3Ga5.5Ta0.5O14 and La3Ga5SiO14 single crystals

2018 ◽  
Vol 51 (4) ◽  
pp. 1174-1181 ◽  
Author(s):  
D. Irzhak ◽  
D. Roshchupkin
Keyword(s):  
Electric Field ◽  
Single Crystals ◽  
External Electric Field ◽  
Piezoelectric Effect ◽  
Structural Type ◽  
X Ray

Results of measurements of independent piezoelectric moduli d 11 and d 14 in Ca3NbGa3Si2O14, La3Ga5.5Ta0.5O14 and La3Ga5SiO14, promising single crystals of the calcium gallogermanate structural type, are presented. The moduli were measured with a triple-axis X-ray diffractometer under an external electric field which causes changes in the interplanar distances due to the reverse piezoelectric effect. The results of the X-ray diffractometry measurements agree fairly well (within less than 10%) with the results obtained by different methods.

Bone Growth in Organ Culture Modified by an Electric Field

1972 ◽  
Vol 51 (5) ◽  
pp. 1492-1499 ◽  
Author(s):  
Louis A. Norton ◽  
Ronald R. Moore
Keyword(s):  
Electric Field ◽  
Organ Culture ◽  
Bone Growth

scholarly journals Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis

2014 ◽  
Vol 2014 ◽  
pp. 1-25 ◽  
Author(s):  
Vittorio Locatelli ◽  
Vittorio E. Bianchi
Keyword(s):  
Bone Metabolism ◽  
Bone Healing ◽  
Clinical Studies ◽  
Bone Growth ◽  
Bone Fractures ◽  
Human Subjects ◽  
Target Cells ◽  
Clinical Effects ◽  
Gh Treatment ◽  
Gh Secretion

Background. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth. Clinical studies reporting the use of GH and IGF-1 in osteoporosis and fracture healing are outlined.Methods. A Pubmed search revealed 39 clinical studies reporting the effects of GH and IGF-1 administration on bone metabolism in osteopenic and osteoporotic human subjects and on bone healing in operated patients with normal GH secretion. Eighteen clinical studies considered the effect with GH treatment, fourteen studies reported the clinical effects with IGF-1 administration, and seven related to the GH/IGF-1 effect on bone healing.Results. Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies. GH/IGF-1 administration in patients with hip or tibial fractures resulted in increased bone healing, rapid clinical improvements. Some conflicting results were evidenced.Conclusions. GH and IGF-1 therapy has a significant anabolic effect. GH administration for the treatment of osteoporosis and bone fractures may greatly improve clinical outcome. GH interacts with sex steroids in the anabolic process. GH resistance process is considered.

scholarly journals The Structure and Properties of Electroceramics for Bone Graft Substitution

2007 ◽  
Vol 361-363 ◽  
pp. 99-102 ◽  
Author(s):  
F.R. Baxter ◽  
I.G. Turner ◽  
Chris R. Bowen ◽  
J.P. Gittings ◽  
J.B. Chaudhuri ◽  
...  
Keyword(s):  
Grain Size ◽  
Barium Titanate ◽  
Bone Growth ◽  
Piezoelectric Properties ◽  
Piezoelectric Effect ◽  
Positive Influence ◽  
Sem Analysis ◽  
A Value ◽  
Piezoelectric Constants

Hydroxyapatite (HA) and barium titanate (BT) powders were mixed and sintered to form hydroxyapatite – barium titanate (HABT) ceramics. These materials were then poled and their piezoelectric properties were measured. The microstructure of unpoled samples was examined using scanning electron microscopy (SEM).The piezoelectric constants (d33 and d31) of the ceramics were found to be dependent on the proportion of BT in the ceramic In materials containing less than 70% BT, no piezoelectric effect was found. Above this value, the piezoelectric constant increased with the addition of BT up to a value of 108pCN-1 for pure BT. Values of d33 for ceramics containing more than 80% BT are above values previously shown to have a positive influence on bone growth in vivo. SEM analysis indicated that the grain size within the materials decreased as the proportion of BT in the material was reduced. Examination of the microstructure of the ceramics indicated the presence of electrical domains in the 100% BT and 95% BT ceramics. Domains were not visible below 95% BT. The reduction in grain size may influence the reduction in piezoelectric activity within the materials but cannot be considered to be the only cause.

scholarly journals Review Article: Zirconia surface bone graft implant with Ultraviolet Stimulation works toward Accelerating Bone Healing

2019 ◽  
Vol 7 (11_suppl6) ◽  
pp. 2325967119S0046
Author(s):  
Adriel Benedict Haryono ◽  
Yoyos Dias Ismiarto
Keyword(s):  
Literature Review ◽  
Bone Healing ◽  
Bone Growth ◽  
Cell Attachment ◽  
Biomedical Application ◽  
Tetragonal Zirconia ◽  
Ceramic Materials ◽  
Bone Grafts ◽  
Bone Substitutes ◽  
Transformation Toughening

Biomedical zirconia was introduced in 1969 into medicine to solve the problem of alumina brittleness in hip replacement procedures and has since been used for various joint replacement appliances in orthopedic surgery. The most frequently-studied material is yttrium-stabilized zirconia, which is also known as tetragonal zirconia polycrystal (TZP). Y-TZP presents various interesting characteristics, such as low porosity, high density and high bending and compression strength, proving that it is suitable for biomedical application. UV-treated zirconia surfaces exhibited an enhanced osteoblast response, which was characterized by an accelerated and augmented cell attachment, accelerated cell spread and cytoskeletal development with increased proliferation. The purpose of this paper is to identify which method of treatment of zirconia material implant & ultraviolet stimulation effect for bone healing is the most effective and efficient based on literature review. Bone grafts are available in a variety of substances. These bone substitutes can be biological (natural) or synthetic. Re-absorption is also essential for bone growth. Specific cells continuously break down bones and rebuild them. Substitutes that break down too quickly are not suitable for bone grafts, as they do not allow enough time for the new bone to grow. From our literature review, Zirconia is one of the biomaterials that have a bright future because of its high mechanical strength and fracture toughness. Zirconia ceramics have several advantages over other ceramic materials due to the transformation toughening mechanisms operating in their microstructure that can be expressed in components made out of them. UV treatment substantially enhances the osteogenesis process, resulting in a greater amount of peri-implant bone, as well as an increased strength of bone-zirconia integration.

scholarly journals Stacked PZT Discs Generate Necessary Power for Bone Healing through Electrical Stimulation in a Composite Spinal Fusion Implant

2018 ◽  
Vol 5 (4) ◽  
pp. 90
Author(s):  
Eileen Cadel ◽  
Ember Krech ◽  
Paul Arnold ◽  
Elizabeth Friis
Keyword(s):  
Electrical Stimulation ◽  
Spinal Fusion ◽  
Bone Healing ◽  
Bone Growth ◽  
Fiber Composite ◽  
Piezoelectric Composite ◽  
Battery Packs ◽  
Electromechanical Performance ◽  
Piezoelectric Disc ◽  
Lumbar Spinal

Electrical stimulation devices can be used as adjunct therapy to lumbar spinal fusion to promote bone healing, but their adoption has been hindered by the large battery packs necessary to provide power. Piezoelectric composite materials within a spinal interbody cage to produce power in response to physiological lumbar loads have recently been investigated. A piezoelectric macro-fiber composite spinal interbody generated sufficient power to stimulate bone growth in a pilot ovine study, despite fabrication challenges. The objective of the present study was to electromechanically evaluate three new piezoelectric disc composites, 15-disc insert, seven-disc insert, and seven-disc Compliant Layer Adaptive Composite Stack (CLACS) insert, within a spinal interbody, and validate their use for electrical stimulation and promoting bone growth. All implants were electromechanically assessed under cyclic loads of 1000 N at 2 Hz, representing physiological lumbar loading. All three configurations produced at least as much power as the piezoelectric macro-fiber composites, validating the use of piezoelectric discs for this application. Future work is needed to characterize the electromechanical performance of commercially manufactured piezoelectric stacks under physiological lumbar loads, and mechanically assess the composite implants according to FDA guidelines for lumbar interbody fusion devices.

Adverse effects of strenuous exercise: a densitometric and histomorphometric study in the rat

1994 ◽  
Vol 76 (5) ◽  
pp. 1999-2005 ◽  
Author(s):  
S. Bourrin ◽  
C. Genty ◽  
S. Palle ◽  
C. Gharib ◽  
C. Alexandre
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Cancellous Bone ◽  
Bone Growth ◽  
Proximal Tibia ◽  
Bone Volume ◽  
Mineral Density ◽  
Osteoblastic Activity ◽  
Tibia Length

To investigate the manner in which cancellous bone in different skeletal sites and within a bone site adapts to strenuous training, 5-wk-old male rats were subjected to intensive treadmill running [80% of maximal O2 consumption (VO2max)] for 11 wk. VO2max, tibia length, and bone mineral density were measured. Histomorphometric analysis was performed in the epiphysis, primary spongiosa (1 zero sp) and secondary spongiosa (2 zero sp) of the contralateral proximal tibia, and the 2 zero sp of thoracic and lumbar vertebrae. VO2max was increased by 39%. No changes were observed in vertebrae. Tibia length, 1 zero sp bone volume, and number of trabeculae were significantly decreased, indicating a retarded longitudinal bone growth. Bone mineral density in the proximal tibia was significantly decreased. In the epiphysis, a trabecular thinning and an increase of trabecular number were shown. In the 2 zero sp, bone volume and number of trabeculae were significantly decreased. The increased total eroded surfaces could indicate an early but transient increase in bone resorption activity. Osteoid thickness was reduced, whereas osteoclast number and osteoid surfaces were unchanged, suggesting that the observed bone loss was mostly due to an impaired osteoblastic activity. In conclusion, 1) strenuous training in young rats reduces longitudinal bone growth and induces bone loss, 2) the cancellous bone adaptation is site specific, and 3) the bone loss is mainly due to decreased osteoblastic activity rather than a global adaptation of bone remodeling.

scholarly journals Genistein acts in bone metabolism and improves peri-implant healing in rats with estrogen deficiency

2021 ◽  
Vol 10 (5) ◽  
pp. e36410515061
Author(s):  
Naara Gabriela Monteiro ◽  
Fábio Roberto De Souza Batista ◽  
Maria Isabela Lopes Gandolfo ◽  
Leonardo Perez Faverani ◽  
Letícia Pitol Palin ◽  
...  
Keyword(s):  
Bone Healing ◽  
Saline Solution ◽  
Bone Volume ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Significance Level ◽  
Osteoblastic Activity ◽  
Bilateral Ovariectomy ◽  
Ovx Rats ◽  
Genistein Treatment

The present study aimed to evaluate the peri-implantar bone healing in the presence of genistein treatment in ovariectomized rats. Thirty female rats with 4 months old were divided into 3 groups according to the experimental condition and the drug treatment: SHAM (rats submitted to the fictional surgery and gavage with 0.9% saline solution); OVX (rats submitted to bilateral ovariectomy and gavage with 0.9% saline solution); OVX GEN (rats submitted to bilateral ovariectomy and gavage with 1mg/day of genistein). 60 implants were installed, with two implants in each animal. The calcified group was subjected microcomputerized tomography and the parameters analysed was bone volume per tissue volume (BV/TV) and connective density (Cnn.Dn). The decalcified samples were evaluated through immunolabeling analysis, in order to detect the presence of RUNX2, Alkaline Phosphatase, Osteocalcin, Osteopontin and TRAP. All the quantitative data were submitted to the normality curve to determine the most adequate test. The significance level of p<0.05 was considered for all tests. The morphometric analysis of the OVX GEN group showed higher percentage of bone volume and lower connective density when compared with OVX. Immunohistochemical analysis favors expression. For the markers that positively label osteoblastic activity. This study shows that genistein therapy improves peri-implant bone healing in ovariectomized rats.

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