In Vitro Degradation of Ultrafine Grained Mg-Zn-Ca Alloy by High-Pressure Torsion in Simulated Body Fluid

2012 ◽  
Vol 706-709 ◽  
pp. 504-509 ◽  
Author(s):  
Shao Kang Guan ◽  
Zhen Wei Ren ◽  
Jun Heng Gao ◽  
Yu Feng Sun ◽  
Shi Jie Zhu ◽  
...  
Keyword(s):  
High Pressure ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
High Pressure Torsion ◽  
Cast Alloy ◽  
Mg Alloy ◽  
Second Phase ◽  
Ultrafine Grained ◽  
Degradation Properties

In this paper the in vitro degradation of ultrafine grained (UFG) Mg-Zn-Ca alloy produced by HPT was investigated by electrochemical measurements and immersion tests in SBF. It was found that UFG Mg alloy had better degradation properties and also higher microhardness value than as-cast Mg alloy. The corrosion current density of UFG Mg alloy decreased by about two orders of magnitude, compared with that of as-cast alloy. Through electrochemical impedance spectroscopy (EIS) test，UFG Mg alloy showed a higher charge transfer resistance value. In immersion test, UFG Mg alloy in SBF exhibited more uniform corrosion and lower degradation rate (0.0763 mm/yr) than as-cast alloy. The degradation properties were related with the microstructure evolution, namely the grain refinement and redistribution of second phase. Keywords: Mg-Zn-Ca alloy; High-pressure torsion (HPT); Degradation behavior; Simulated body fluid (SBF); Microhardness

Amorphous apatite thin film formation on a biodegradable Mg alloy for bone regeneration: strategy, characterization, biodegradation, and in vitro cell study

RSC Advances ◽  
2016 ◽  
Vol 6 (27) ◽  
pp. 22563-22574 ◽  
Author(s):  
Hamouda M. Mousa ◽  
Kamal H. Hussein ◽  
Ahmed A. Raslan ◽  
Joshua Lee ◽  
Heung M. Woo ◽  
...  
Keyword(s):  
Thin Film ◽  
Simulated Body Fluid ◽  
Bone Regeneration ◽  
Body Fluid ◽  
Film Formation ◽  
Mg Alloy ◽  
Regeneration Strategy ◽  
Thin Film Formation ◽  
Cell Study

Bioactive films with a nanoplate structure were prepared on the surface of a biodegradable AZ31B magnesium (Mg) alloy via anodization in simulated body fluid (SBF) as an electrolyte to control Mg biodegradability and improve surface bioactivity.

Homogeneous corrosion of high pressure torsion treated Mg–Zn–Ca alloy in simulated body fluid

2011 ◽  
Vol 65 (4) ◽  
pp. 691-693 ◽  
Author(s):  
J.H. Gao ◽  
S.K. Guan ◽  
Z.W. Ren ◽  
Y.F. Sun ◽  
S.J. Zhu ◽  
...  
Keyword(s):  
High Pressure ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
High Pressure Torsion

Concurrent strengthening of ultrafine-grained age-hardenable Al-Mg alloy by means of high-pressure torsion and spinodal decomposition

2017 ◽  
Vol 131 ◽  
pp. 57-64 ◽  
Author(s):  
Yongpeng Tang ◽  
Wataru Goto ◽  
Shoichi Hirosawa ◽  
Zenji Horita ◽  
Seungwon Lee ◽  
...  
Keyword(s):  
High Pressure ◽  
Spinodal Decomposition ◽  
High Pressure Torsion ◽  
Mg Alloy ◽  
Ultrafine Grained

In vitro and in vivo studies on ultrafine-grained biodegradable pure Mg, Mg–Ca alloy and Mg–Sr alloy processed by high-pressure torsion

2020 ◽  
Vol 8 (18) ◽  
pp. 5071-5087
Author(s):  
Wenting Li ◽  
Xiao Liu ◽  
Yufeng Zheng ◽  
Wenhao Wang ◽  
Wei Qiao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Pressure ◽  
High Pressure Torsion ◽  
In Vivo Studies ◽  
Ultrafine Grained

High-pressure torsion processing is an effective way to significantly refine the microstructure and consequently modify the mechanical properties, biodegradable behaviors and biocompatibility of pure Mg, Mg–1Ca and Mg–2Sr alloys.

IN-VITRO BEHAVIOUR OF BIPHASIC CALCIUM PHOSPHATE WITH DIFFERENT RATIO OF SILICA CONTENT IN SIMULATED BODY FLUID

2015 ◽  
Vol 23 (1) ◽  
pp. 1-14
Author(s):  
Sudirman Sahid ◽  
◽  
Nor Shahida Kader Bashah ◽  
Salina Sabudin ◽  
◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Biphasic Calcium Phosphate ◽  
Silica Content

scholarly journals Tetracalcium Phosphate/Monetite/Calcium Sulfate Hemihdrate Biocement Powder Mixtures Prepared by the One-Step Synthesis for Preparation of Nanocrystalline Hydroxyapatite Biocement-Properties and In Vitro Evaluation

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2137
Author(s):  
Lubomir Medvecky ◽  
Maria Giretova ◽  
Radoslava Stulajterova ◽  
Lenka Luptakova ◽  
Tibor Sopcak
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Calcium Sulfate ◽  
Powder Mixtures ◽  
Liquid Component ◽  
Tetracalcium Phosphate ◽  
Nanocrystalline Hydroxyapatite ◽  
One Step ◽  
Calcium Sulfate Hemihydrate

A modified one-step process was used to prepare tetracalcium phosphate/monetite/calcium sulfate hemihydrate powder cement mixtures (CAS). The procedure allowed the formation of monetite and calcium sulfate hemihydrate (CSH) in the form of nanoparticles. It was hypothesized that the presence of nanoCSH in small amounts enhances the in vitro bioactivity of CAS cement in relation to osteogenic gene markers in mesenchymal stem cells (MSCs). The CAS powder mixtures with 15 and 5 wt.% CSH were prepared by milling powder tetracalcium phosphate in an ethanolic solution of both orthophosphoric and sulfuric acids. The CAS cements had short setting times (around 5 min). The fast setting of the cement samples after the addition of the liquid component (water solution of NaH2PO4) was due to the partial formation of calcium sulfate dihydrate and hydroxyapatite before soaking in SBF with a small change in the original phase composition in cement powder samples after milling. Nanocrystalline hydroxyapatite biocement was produced by soaking of cement samples after setting in simulated body fluid (SBF). The fast release of calcium ions from CAS5 cement, as well as a small rise in the pH of SBF during soaking, were demonstrated. After soaking in SBF for 7 days, the final product of the cement transformation was nanocrystalline hydroxyapatite. The compressive strength of the cement samples (up to 30 MPa) after soaking in simulated body fluid (SBF) was comparable to that of bone. Real time polymerase chain reaction (RT-PCR) analysis revealed statistically significant higher gene expressions of alkaline phosphatase (ALP), osteonectin (ON) and osteopontin (OP) in cells cultured for 14 days in CAS5 extract compared to CSH-free cement. The addition of a small amount of nanoCSH (5 wt.%) to the tetracalcium phosphate (TTCP)/monetite cement mixture significantly promoted the over expression of osteogenic markers in MSCs. The prepared CAS powder mixture with its enhanced bioactivity can be used for bone defect treatment and has good potential for bone healing.

scholarly journals Preparation and Degradation Characteristics of MAO/APS Composite Bio-Coating in Simulated Body Fluid

Coatings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 667
Author(s):  
Zexin Wang ◽  
Fei Ye ◽  
Liangyu Chen ◽  
Weigang Lv ◽  
Zhengyi Zhang ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Composite Coating ◽  
Body Fluid ◽  
Composite Coatings ◽  
Degradation Process ◽  
Ceramic Coatings ◽  
Immersion Test ◽  
Substrate Material ◽  
Atmospheric Plasma

In this work, ZK60 magnesium alloy was employed as a substrate material to produce ceramic coatings, containing Ca and P, by micro-arc oxidation (MAO). Atmospheric plasma spraying (APS) was used to prepare the hydroxyapatite layer (HA) on the MAO coating to obtain a composite coating for better biological activity. The coatings were examined by various means including an X-ray diffractometer, a scanning electron microscope and an energy spectrometer. Meanwhile, an electrochemical examination, immersion test and tensile test were used to evaluate the in vitro performance of the composite coatings. The results showed that the composite coating has a better corrosion resistance. In addition, this work proposed a degradation model of the composite coating in the simulated body fluid immersion test. This model explains the degradation process of the MAO/APS coating in SBF.

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