In vitro and in vivo studies on ultrafine-grained biodegradable pure Mg, Mg–Ca alloy and Mg–Sr alloy processed by high-pressure torsion

2020 ◽  
Vol 8 (18) ◽  
pp. 5071-5087
Author(s):  
Wenting Li ◽  
Xiao Liu ◽  
Yufeng Zheng ◽  
Wenhao Wang ◽  
Wei Qiao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Pressure ◽  
High Pressure Torsion ◽  
In Vivo Studies ◽  
Ultrafine Grained

High-pressure torsion processing is an effective way to significantly refine the microstructure and consequently modify the mechanical properties, biodegradable behaviors and biocompatibility of pure Mg, Mg–1Ca and Mg–2Sr alloys.

scholarly journals Microstructure and Mechanical Properties of PU/PLDL Sponges Intended for Grafting Injured Spinal Cord

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2693
Author(s):  
Anna Lis-Bartos ◽  
Dariusz Szarek ◽  
Małgorzata Krok-Borkowicz ◽  
Krzysztof Marycz ◽  
Włodzimierz Jarmundowicz ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Spinal Cord ◽  
Young Modulus ◽  
In Vivo Studies ◽  
Polymer Composition ◽  
In Vitro Toxicity ◽  
Injured Spinal Cord ◽  
Degradation Rates

Highly porous, elastic, and degradable polyurethane and polyurethane/polylactide (PU/PLDL) sponges, in various shapes and sizes, with open interconnected pores, and porosity up to 90% have been manufactured. They have been intended for gap filling in the injured spinal cord. The porosity of the sponges depended on the content of polylactide, i.e., it decreased with the increase of polylactide content. The rise of polylactide content caused an increase of Young modulus and rigidity as well as a more complex morphology of the polyurethane/polylactide blends. The mechanical properties, in vitro toxicity, and degradation in artificial cerebrospinal fluid were tested. Sponges underwent continuous degradation with varying degradation rates depending on the polymer composition. In vitro cell studies with fibroblast cultures proved the biocompatibility of the polymers. Based on the obtained results, the designed PU/PLDL sponges appeared to be promising candidates for bridging gaps within injured spinal cord in further in vitro and in vivo studies.

scholarly journals Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43

Materials ◽  
2019 ◽  
Vol 12 (21) ◽  
pp. 3627 ◽  
Author(s):  
Sergey Dobatkin ◽  
Natalia Martynenko ◽  
Natalia Anisimova ◽  
Mikhail Kiselevskiy ◽  
Dmitriy Prosvirnin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Fatigue Strength ◽  
Magnesium Alloy ◽  
Total Elongation ◽  
Relative Mass ◽  
Ultrafine Grained ◽  
Alloy We43 ◽  
Average Size

In this work, the effect of an ultrafine-grained (UFG) structure obtained by multiaxial deformation (MAD) on the mechanical properties, fatigue strength, biodegradation, and biocompatibility in vivo of the magnesium alloy WE43 was studied. The grain refinement down to 0.93 ± 0.29 µm and the formation of Mg41Nd5 phase particles with an average size of 0.34 ± 0.21 µm were shown to raise the ultimate tensile strength to 300 MPa. Besides, MAD improved the ductility of the alloy, boosting the total elongation from 9% to 17.2%. An additional positive effect of MAD was an increase in the fatigue strength of the alloy from 90 to 165 MPa. The formation of the UFG structure also reduced the biodegradation rate of the alloy under both in vitro and in vivo conditions. The relative mass loss after six weeks of experiment was 83% and 19% in vitro and 46% and 7% in vivo for the initial and the deformed alloy, respectively. Accumulation of hydrogen and the formation of necrotic masses were observed after implantation of alloy specimens in both conditions. Despite these detrimental phenomena, the desired replacement of the implant and the surrounding cavity with new connective tissue was observed in the areas of implantation.

scholarly journals Effect of Annealing Temperature on the Microstructure and Mechanical Properties of High-Pressure Torsion-Produced 316LN Stainless Steel

Materials ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 181
Author(s):  
Yuanyuan Dong ◽  
Zhe Zhang ◽  
Zhihai Yang ◽  
Ruixiao Zheng ◽  
Xu Chen
Keyword(s):  
Mechanical Properties ◽  
High Pressure ◽  
Stainless Steel ◽  
Grain Boundaries ◽  
Annealing Temperature ◽  
High Pressure Torsion ◽  
Annealing Process ◽  
Σ Phase ◽  
316Ln Stainless Steel ◽  
Ultrafine Grained

316LN stainless steel is a prospective structural material for the nuclear and medical instruments industries. Severe plastic deformation (SPD) combined with annealing possesses have been used to create materials with excellent mechanical properties. In the present work, a series of ultrafine-grained (UFG) 316LN steels were produced by high-pressure torsion (HPT) and a subsequent annealing process. The effects of annealing temperature on grain recrystallization and precipitation were investigated. Recrystallized UFG 316LN steels can be achieved after annealing at high temperature. The σ phase generates, at grain boundaries, at an annealing temperature range of 750–850 °C. The dislocations induced by recrystallized grain boundaries and strain-induced nanotwins are beneficial for enhancing ductility. Moreover, microcracks are easy to nucleate at the σ phase and the γ-austenite interface, causing unexpected rapid fractures.

Microstructure and mechanical properties of ultrafine-grained aluminum consolidated by high-pressure torsion

2017 ◽  
Vol 682 ◽  
pp. 501-508 ◽  
Author(s):  
Mohammad Khajouei-Nezhad ◽  
Mohammad Hossein Paydar ◽  
Ramin Ebrahimi ◽  
Péter Jenei ◽  
Péter Nagy ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Pressure ◽  
High Pressure Torsion ◽  
Microstructure And Mechanical Properties ◽  
Ultrafine Grained

Microstructure and Mechanical Properties of Ultrafine-Grained Mg-Zn-Ca Alloy

2017 ◽  
Vol 381 ◽  
pp. 39-43 ◽  
Author(s):  
Olya B. Kulyasova ◽  
Rinat K. Islamgaliev ◽  
Ruslan Z. Valiev
Keyword(s):  
Mechanical Properties ◽  
Grain Size ◽  
High Pressure ◽  
Chemical Composition ◽  
High Pressure Torsion ◽  
Notable Effect ◽  
Ultrafine Grained ◽  
Mean Grain Size ◽  
High Microhardness ◽  
Mean Size

This paper studies the structure and mechanical properties of the Mg-1%Zn-xCa system subjected to high-pressure torsion (HPT) treatment. It was found that the chemical composition had a notable effect on the processes of grain refinement in the alloy. As is shown, HPT of Mg-1%Zn-0.005%Ca resulted in the formation of grains with a mean size of 250 nm, while HPT of the alloy with an increased content of Са up to 0.2% led to the formation of a nanostructure with a mean grain size of 90 nm. It is demonstrated that high microhardness is typical of all HPT-processed samples. The formation of fine Mg2Ca particles was established to increase the heat resistance of the alloy.

Microstructure and Mechanical Properties of the SPD-Processed TiNi Alloys

2013 ◽  
Vol 738-739 ◽  
pp. 486-490 ◽  
Author(s):  
Dmitriy Gunderov ◽  
Alexandr Lukyanov ◽  
Egor Prokofiev ◽  
Anna Churakova ◽  
Vladimir Pushin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Plastic Deformation ◽  
High Pressure ◽  
Severe Plastic Deformation ◽  
Cold Rolling ◽  
High Pressure Torsion ◽  
Angular Pressing ◽  
Ultrafine Grained ◽  
First Results ◽  
Equal Channel Angular Pressure

The article represents results of influence of different severe plastic deformation (SPD) techniques on TiNi alloys. It is demonstrated that strength and shape memory effect (SME) of TiNi can be significantly enhanced due to formation of ultrafine-grained (UFG) and nanocrystalline (NC) structures by SPD. Influence of equal channel angular pressing (ECAP), high pressure torsion (HPT), multi-step SPD deformations (ECAP plus cold rolling) on structure, mechanical and functional properties of TiNi alloys is considered. There are represented first results of influence of equal channel angular pressure-Conform (ECAP-C) on TiNi alloys, which is a perspective technology for industrial fabrication of UFG metals and alloys.

In Vitro Degradation of Ultrafine Grained Mg-Zn-Ca Alloy by High-Pressure Torsion in Simulated Body Fluid

2012 ◽  
Vol 706-709 ◽  
pp. 504-509 ◽  
Author(s):  
Shao Kang Guan ◽  
Zhen Wei Ren ◽  
Jun Heng Gao ◽  
Yu Feng Sun ◽  
Shi Jie Zhu ◽  
...  
Keyword(s):  
High Pressure ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
High Pressure Torsion ◽  
Cast Alloy ◽  
Mg Alloy ◽  
Second Phase ◽  
Ultrafine Grained ◽  
Degradation Properties

In this paper the in vitro degradation of ultrafine grained (UFG) Mg-Zn-Ca alloy produced by HPT was investigated by electrochemical measurements and immersion tests in SBF. It was found that UFG Mg alloy had better degradation properties and also higher microhardness value than as-cast Mg alloy. The corrosion current density of UFG Mg alloy decreased by about two orders of magnitude, compared with that of as-cast alloy. Through electrochemical impedance spectroscopy (EIS) test，UFG Mg alloy showed a higher charge transfer resistance value. In immersion test, UFG Mg alloy in SBF exhibited more uniform corrosion and lower degradation rate (0.0763 mm/yr) than as-cast alloy. The degradation properties were related with the microstructure evolution, namely the grain refinement and redistribution of second phase. Keywords: Mg-Zn-Ca alloy; High-pressure torsion (HPT); Degradation behavior; Simulated body fluid (SBF); Microhardness

Microstructure and Properties of Ultrafine Grained Cu-0.73%Cr Alloy after High Pressure Torsion

2011 ◽  
Vol 391-392 ◽  
pp. 385-389 ◽  
Author(s):  
Kun Xia Wei ◽  
Wei Wei ◽  
Igor V. Alexandrov ◽  
Qing Bo Du ◽  
Jing Hu
Keyword(s):  
Mechanical Properties ◽  
Thermal Stability ◽  
Electrical Conductivity ◽  
Grain Size ◽  
High Pressure ◽  
High Pressure Torsion ◽  
Aging Treatment ◽  
High Thermal Stability ◽  
Subsequent Aging ◽  
Ultrafine Grained

Microstructure, mechanical properties and electrical conductivity in Cu-0.73%Cr alloy after HPT process and the subsequent aging treatment have been investigated. Ultrafine grained structure with the grain size ~150 nm has been achieved after the HPT and the subsequent aging treatment. Ultrafine grains with some growth twins were preserved in the overaged state, showing high thermal stability. The peak microhardness and tensile strength of Cu-0.73%Cr alloy after the HPT was found at 480 °C for 2 hours. Electrical conductivity shows an increase trend in the different aging states.

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