Electrospun Polyvinylpyrrolidone (PVP) Nanofiber Mats Loaded by Garcinia mangostana L. Extracts

Composite nanofibers of polyvinylpyrrolidone (PVP) and Garcinia mangostana L. extract (GME) have been synthesized through electrospinning method for application in drug delivery systems. The precursor solution of 10 mL PVP 10% w/w and GME 2% w/w was then electrospun collected at the rotating collector at the following optimum parameters: a voltage of 15 kV, a collector-nozzle distance of 12 cm, and a flow rate of 1 mL/hour. SEM images showed that the average diameters were 476 nm and 690 nm for the PVP and PVP-GME composite nanofibers, respectively. To some degree, the addition of GME into PVP nanofibers increased the average diameter size of nanofibers. Moreover, the release studies, it was shown that 80% of the GME was released within 30 minutes. Therefore, the PVP-GME composite nanofibers can be applied as the drug delivery systems.

Download Full-text

Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

Revista de Chimie ◽

10.37358/rc.18.7.6411 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1756-1759 ◽

Cited By ~ 1

Author(s):

Luminita Confederat ◽

Iuliana Motrescu ◽

Sandra Constantin ◽

Florentina Lupascu ◽

Lenuta Profire

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Average Diameter ◽

Delivery Systems ◽

Cross Linking ◽

Low Molecular Weight ◽

Polymeric Systems ◽

Chitosan Microparticles ◽

Degree Of Swelling

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

Download Full-text

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Journal of Nanomaterials ◽

10.1155/2017/9687896 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 23

Author(s):

Ida Sriyanti ◽

Dhewa Edikresnha ◽

Annisa Rahma ◽

Muhammad Miftahul Munir ◽

Heni Rachmawati ◽

...

Keyword(s):

Drug Delivery ◽

Surface Area ◽

Intermolecular Interactions ◽

Antioxidant Activities ◽

High Surface ◽

Water Soluble ◽

Garcinia Mangostana ◽

Sem Images ◽

Composite Nanofiber ◽

Nanofiber Mats

Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

Download Full-text

Synthesis and Electrical Property of Indium Tin Oxide Nanofibers Using Electrospinning Method

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2007.048 ◽

2007 ◽

Vol 7 (11) ◽

pp. 3910-3913 ◽

Cited By ~ 11

Author(s):

Young-In Lee ◽

Kun-Jae Lee ◽

Ki Do Kim ◽

Hee Taik Kim ◽

Young-Wook Chang ◽

...

Keyword(s):

Tin Oxide ◽

Indium Tin Oxide ◽

Composite Nanofibers ◽

Precursor Solution ◽

Average Diameter ◽

Morphological Properties ◽

Tin Chloride ◽

Transparent Conducting ◽

Electrospinning Method ◽

Indium Nitrate

In this study indium tin oxide (ITO) nanofibers were synthesized using an electrospinning method. The morphological properties of the ITO nanofibers were considered and their specific resistances were measured to determine their applicability as filler for a transparent conducting film. ITO/PVP composite nanofibers were successfully obtained by electrospinning using a precursor solution containing indium nitrate, tin chloride, and poly(vinlypyrrolidone). After the heat treatment of ITO/PVP composite nanofibers at 600 °C and 1000 °C, ITO nanofibers with an average diameter of about 168 nm and 165 nm were synthesized, respectively.

Download Full-text

Combined Curcumin and Lansoprazole-Loaded Bioactive Solid Self-Nanoemulsifying Drug Delivery Systems (Bio-SSNEDDS)

Pharmaceutics ◽

10.3390/pharmaceutics14010002 ◽

2021 ◽

Vol 14 (1) ◽

pp. 2

Author(s):

Abdulrahman Alshadidi ◽

Ahmad Abdul-Wahhab Shahba ◽

Ibrahim Sales ◽

Md Abdur Rashid ◽

Mohsin Kazi

Keyword(s):

Drug Delivery ◽

Droplet Size ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Oral Dosage ◽

Significant Enhancement ◽

In Vitro Dissolution ◽

Peptic Ulcers ◽

Scanning Calorimetry ◽

Sem Images

Background: The current study aimed to design a novel combination of lansoprazole (LNS) and curcumin (CUR) solid oral dosage form using bioactive self-nanoemulsifying drug delivery systems (Bio-SSNEDDS). Methods: Liquid SNEDDS were prepared using the lipid-excipients: Imwitor988 (cosurfactant), Kolliphor El (surfactant), the bioactive black seed (BSO) and/or zanthoxylum rhetsa seed oils (ZRO). Liquid SNEDDS were loaded with CUR and LNS, then solidified using commercially available (uncured) and processed (cured) Neusilin® US2 (NUS2) adsorbent. A novel UHPLC method was validated to simultaneously quantify CUR and LNS in lipid-based formulations. The liquid SNEDDS were characterized in terms of self-emulsification, droplet size and zeta-potential measurements. The solidified SNEDDS were characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), in vitro dissolution and stability in accelerated storage conditions. Results: Liquid SNEDDS containing BSO produced a transparent appearance and ultra-fine droplet size (14 nm) upon aqueous dilution. The solidified SNEDDS using cured and uncured NUS2 showed complete solidification with no particle agglomeration. DSC and XRD confirmed the conversion of crystalline CUR and LNS to the amorphous form in all solid SNEDDS samples. SEM images showed that CUR/LNS-SNEDDS were relatively spherical and regular in shape. The optimized solid SNEDDS showed higher percent of cumulative release as compared to the pure drugs. Curing NUS2 with 10% PVP led to significant enhancement of CUR and LNS dissolution efficiencies (up to 1.82- and 2.75-fold, respectively) compared to uncured NUS2-based solid SNEDDS. These findings could be attributed to the significant (50%) reduction in the micropore area% in cured NUS2 which reflects blocking very small pores allowing more space for the self-emulsification process to take place in the larger-size pores. Solid SNEDDS showed significant enhancement of liquid SNEDDS stability after 6 months storage in accelerated conditions. Conclusions: The developed Bio-SSNEDDS of CUR and LNS using processed NUS2 could be used as a potential combination therapy to improve the treatment of peptic ulcers.

Download Full-text

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Download Full-text