scholarly journals Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Ida Sriyanti ◽  
Dhewa Edikresnha ◽  
Annisa Rahma ◽  
Muhammad Miftahul Munir ◽  
Heni Rachmawati ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
Intermolecular Interactions ◽  
Antioxidant Activities ◽  
High Surface ◽  
Water Soluble ◽  
Garcinia Mangostana ◽  
Sem Images ◽  
Composite Nanofiber ◽  
Nanofiber Mats

Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

Electrospun Polyvinylpyrrolidone (PVP) Nanofiber Mats Loaded by Garcinia mangostana L. Extracts

2016 ◽  
Vol 880 ◽  
pp. 11-14 ◽  
Author(s):  
Ida Sriyanti ◽  
Dhewa Edikresnha ◽  
Muhammad Miftahul Munir ◽  
Heni Rachmawati ◽  
Khairurrijal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Composite Nanofibers ◽  
Precursor Solution ◽  
Average Diameter ◽  
Delivery Systems ◽  
Garcinia Mangostana ◽  
Sem Images ◽  
Electrospinning Method ◽  
Nanofiber Mats

Composite nanofibers of polyvinylpyrrolidone (PVP) and Garcinia mangostana L. extract (GME) have been synthesized through electrospinning method for application in drug delivery systems. The precursor solution of 10 mL PVP 10% w/w and GME 2% w/w was then electrospun collected at the rotating collector at the following optimum parameters: a voltage of 15 kV, a collector-nozzle distance of 12 cm, and a flow rate of 1 mL/hour. SEM images showed that the average diameters were 476 nm and 690 nm for the PVP and PVP-GME composite nanofibers, respectively. To some degree, the addition of GME into PVP nanofibers increased the average diameter size of nanofibers. Moreover, the release studies, it was shown that 80% of the GME was released within 30 minutes. Therefore, the PVP-GME composite nanofibers can be applied as the drug delivery systems.

The Nanoporous Carbon Derived from Melamine Based Polybenzoxazine and NaCl Templating

2018 ◽  
Vol 779 ◽  
pp. 129-136
Author(s):  
Onnicha Rattanopas ◽  
Worawut Naewrittikul ◽  
Thanyalak Chaisuwan
Keyword(s):  
Surface Area ◽  
Pore Volume ◽  
High Surface ◽  
Total Pore Volume ◽  
Nanoporous Carbon ◽  
Water Soluble ◽  
Activation Process ◽  
Sem Images ◽  
Average Pore ◽  
Water Soluble Compound

Nanoporous carbon was successfully prepared by using polybenzoxazine synthesized from bisphenol-A, melamine and formaldehyde as a precursor. The varied HCl amounts have been added into the pre-polymer solution as a catalyst for the ring-opening polymerization. The reaction was traced by FTIR and DSC. In addition, the degradation behavior was studied by TGA and the textural properties were characterized by SEM and surface area analysis (AS1-MP). The nanoporous carbon obtained showed the highest char yield up to 48%. The interconnected structure from the SEM images of the nanoporous carbon exhibited significantly high surface area of 632 m2/g, high total pore volume up to 1.78 cm2/g, small average pore diameter and narrow pore size distribution detected by AS1-MP. After the activation process, the surface area has been drastically improved leading to the increasing of surface area and total pore volume up to 1119 m2/g and 1.93 cm2/g, respectively. In order to further study on the enhancement of surface area, NaCl, a water soluble compound, has been used as a template. As a result, the surface area has been improved up to 1516 m2/g.

scholarly journals Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 241
Author(s):  
Thangavel Ponrasu ◽  
Bei-Hsin Chen ◽  
Tzung-Han Chou ◽  
Jia-Jiuan Wu ◽  
Yu-Shen Cheng
Keyword(s):  
Drug Delivery ◽  
Water Vapor Permeability ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Xrd Analysis ◽  
Water Soluble ◽  
Vapor Permeability ◽  
Uv Spectrum ◽  
Sem Images ◽  
Triton X

The fast-dissolving drug delivery systems (FDDDSs) are developed as nanofibers using food-grade water-soluble hydrophilic biopolymers that can disintegrate fast in the oral cavity and deliver drugs. Jelly fig polysaccharide (JFP) and pullulan were blended to prepare fast-dissolving nanofiber by electrospinning. The continuous and uniform nanofibers were produced from the solution of 1% (w/w) JFP, 12% (w/w) pullulan, and 1 wt% Triton X-305. The SEM images confirmed that the prepared nanofibers exhibited uniform morphology with an average diameter of 144 ± 19 nm. The inclusion of JFP in pullulan was confirmed by TGA and FTIR studies. XRD analysis revealed that the increased crystallinity of JFP/pullulan nanofiber was observed due to the formation of intermolecular hydrogen bonds. The tensile strength and water vapor permeability of the JFP/pullulan nanofiber membrane were also enhanced considerably compared to pullulan nanofiber. The JFP/pullulan nanofibers loaded with hydrophobic model drugs like ampicillin and dexamethasone were rapidly dissolved in water within 60 s and release the encapsulants dispersive into the surrounding. The antibacterial activity, fast disintegration properties of the JFP/pullulan nanofiber were also confirmed by the zone of inhibition and UV spectrum studies. Hence, JFP/pullulan nanofibers could be a promising carrier to encapsulate hydrophobic drugs for fast-dissolving/disintegrating delivery applications.

scholarly journals Use of natural diatoms for drug delivery

Bionatura ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 1275-1279
Author(s):  
Dario Castro ◽  
Joselyn Cuasquer ◽  
Eva Chavez
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
Pore Structure ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Processing Cost ◽  
Silica Materials ◽  
Different Characteristics ◽  
Ordered Porous

Diatoms are microalgae organisms that have a cover of silica, with a fascinating ordered porous structure that varies in size, giving them some different characteristics. Because of their different size, shape, and structure, it has incredible properties, letting them be capable of been functionalized with other particles. Therefore, due to the ordered pore structure, the high surface area, biocompatibility, availability, and low processing cost, they present a growing potential for drug delivery when talking about silica materials, natural and synthetic, not to mention that is less expensive and a green alternative.

scholarly journals Evaluation of Drug Delivery and Efficacy of Ciprofloxacin-Loaded Povidone Foils and Nanofiber Mats in a Wound-Infection Model Based on Ex Vivo Human Skin

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 527 ◽  
Author(s):  
Rancan ◽  
Contardi ◽  
Jurisch ◽  
Blume-Peytavi ◽  
Vogt ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Skin ◽  
Topical Treatment ◽  
Ex Vivo ◽  
Healing Process ◽  
Delivery Systems ◽  
Water Soluble ◽  
Local Drug Delivery ◽  
Model Based ◽  
Nanofiber Mats

Topical treatment of wound infections is often a challenge due to limited drug availability at the site of infection. Topical drug delivery is an attractive option for reducing systemic side effects, provided that a more selective and sustained local drug delivery is achieved. In this study, a poorly water-soluble antibiotic, ciprofloxacin, was loaded on polyvinylpyrrolidone (PVP)-based foils and nanofiber mats using acetic acid as a solubilizer. Drug delivery kinetics, local toxicity, and antimicrobial activity were tested on an ex vivo wound model based on full-thickness human skin. Wounds of 5 mm in diameter were created on 1.5 × 1.5 cm skin blocks and treated with the investigated materials. While nanofiber mats reached the highest amount of delivered drug after 6 h, foils rapidly achieved a maximum drug concentration and maintained it over 24 h. The treatment had no effect on the overall skin metabolic activity but influenced the wound healing process, as observed using histological analysis. Both delivery systems were efficient in preventing the growth of Pseudomonas aeruginosa biofilms in ex vivo human skin. Interestingly, foils loaded with 500 µg of ciprofloxacin accomplished the complete eradication of biofilm infections with 1 × 109 bacteria/wound. We conclude that antimicrobial-loaded resorbable PVP foils and nanofiber mats are promising delivery systems for the prevention or topical treatment of infected wounds.

Synthesis and characterization of mesalamine silica nanoparticles

2021 ◽  
Vol 16 ◽  
Author(s):  
Balaji Maddiboyina ◽  
Ramya Krishna Nakkala ◽  
Prasanna Kumar Desu ◽  
Vikas Jhawat
Keyword(s):  
Particle Size ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Silica Nanoparticle ◽  
Water Soluble ◽  
Infrared Spectrometry ◽  
Burst Release ◽  
Wide Range

Background: Nanoparticles made of silica are new materials that can be used in a wide range of drug delivery methods because they are biocompatible and biodegradable. Mesalamine, a classic water-soluble medication, remains loaded into the synthesized silica nanoparticle and is considered for sustained release proficiency. Precipitation approach using high surface area and pore volume tetraethyl orthosilicate yielded mesalamine-loaded silica nanoparticles. Methods: The drug-loaded nanoparticle was created and produced using two different techniques. Fourier transform infrared spectrometry, differential scanning calorimetry, X-ray powder diffraction, Brauer Emmett teller, scanning electron microscopy, particle size measurements, and dissolution investigations have all been used to analyse the substance in some way or another. Results: Because of the high surface area, well-known results like the complete silica nanoparticle created using method-2 remained mesoporous. The onset peak of the method-2 formulation's DSC was 182.27°c, and the offset peak was 192.14°c, consistent with the DSC results. The particle size range varies from 205-225nm. The results demonstrate that the uptake of the mesalamine by burst release it for 30 minutes initial, followed by sustained maintenance of dose even after 240 minutes. The results indicate that the loading process has an effect on the extent of loading. When silica nanoparticles were impregnated with mesalamine, the amount of the drug contained was significantly higher than when they were wetted. Conclusion: In addition, the XRD results show that both the pure mesalamine and the formulation did not show any polymorphic deviation.

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