Effects of relaxing music on cardiac autonomic balance and anxiety after acute myocardial infarction

1999 ◽  
Vol 8 (4) ◽  
pp. 220-230 ◽  
Author(s):  
JM White
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Rate ◽  
Respiratory Rate ◽  
Oxygen Demand ◽  
Control Group ◽  
Myocardial Oxygen Demand ◽  
Treatment As Usual ◽  
Physiological Indicators ◽  
Experimental Group

BACKGROUND: Acute myocardial infarction places additional demands on an already compromised myocardium. Relaxing music can induce a relaxation response, thereby reversing the deleterious effects of the stress response. OBJECTIVES: To compare the effects of relaxing music; quiet, uninterrupted rest; and "treatment as usual" on anxiety levels and physiological indicators of cardiac autonomic function. METHODS: A 3-group repeated measures experimental design was used. Forty-five patients, 15 per group, with acute myocardial infarction were assigned randomly to 20 minutes of (1) music in a quiet, restful environment (experimental group); (2) quiet, restful environment without music (attention); or (3) treatment as usual (control). Anxiety levels and physiological indicators were measured. RESULTS: Immediately after the intervention, reductions in heart rate, respiratory rate, and myocardial oxygen demand were significantly greater in the experimental group than in the control group. The reductions in heart rate and respiratory rate remained significantly greater 1 hour later. Changes in heart rate, respiratory rate, and myocardial oxygen demand in the attention group did not differ significantly from changes in the other 2 groups. The 3 groups did not differ with respect to systolic blood pressure. Increases in high-frequency heart rate variability were significantly greater in the experimental and attention groups than in the control group immediately after the intervention. State anxiety was reduced in the experimental group only; the reduction was significant immediately and 1 hour after the intervention. CONCLUSIONS: Patients recovering from acute myocardial infarction may benefit from music therapy in a quiet, restful environment.

REVIEW OF TREATMENT PLANS USED FOR ACUTE MYOCARDIAL INFARCTION IN ISLAMABAD, PAKISTAN

2011 ◽  
Vol 1 ◽  
pp. 10-15
Author(s):  
Ashfaq Ahmad ◽  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Rate ◽  
Chest Pain ◽  
Coronary Artery ◽  
Cardiac Muscle ◽  
Oxygen Supply ◽  
Oxygen Demand ◽  
Clinical Situation ◽  
Treatment Plans

Myocardial infarction is simply due to decreased supply of oxygen and blood to the particular tissue of heart which ultimately leads to the death of tissue. Naturally heart is quite stable in its involuntary action due to balance between oxygen supply and oxygen demand of the cardiac muscle. when this balance is disturbed by the clot formation(atherosclerosis) in coronary artery or increased demand of oxygen due to increased heart rate then clinical situation arises as tightening of chest,laboured breathing, sweating and radiating pain originating form chest and terminating to left arm and jaws as well. A male of 55 years was hospitalized in one of the most well reputed hospital of Federal area of Pakistan. The patients was nimble due to cold sweating, sever radiating left sided chest pain and was in the state of fear and apprehension.

scholarly journals From bedside to bench and back again: translational studies of mechanical unloading of the left ventricle to promote recovery after acute myocardial infarction

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1852 ◽  
Author(s):  
Navin K. Kapur ◽  
Shiva Annamalai ◽  
Lara Reyelt ◽  
Samuel J. Karmiy ◽  
Allen A. Razavi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Pilot Trial ◽  
Oxygen Demand ◽  
Myocardial Damage ◽  
Reperfusion Therapy ◽  
Circulatory Support ◽  
Myocardial Oxygen Demand ◽  
St Segment Elevation

Heart failure is a major cause of global morbidity and mortality. Acute myocardial infarction (AMI) is a primary cause of heart failure due in large part to residual myocardial damage despite timely reperfusion therapy. Since the 1970’s, multiple preclinical laboratories have tested whether reducing myocardial oxygen demand with a mechanical support pump can reduce infarct size in AMI. In the past decade, this hypothesis has been studied using contemporary circulatory support pumps. We will review the most recent series of preclinical studies in the field which led to the recently completed Door to Unload ST-segment Elevation Myocardial Infarction (DTU-STEMI) safety and feasibility pilot trial.

scholarly journals Hubungan Kualitas Tidur Dengan Status Hemodinamik Pada Pasien IMA Di Ruang ICVCU RSUD Dr. Moewardi Tahun 2016

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Syifa Mutia Desiani
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Rate ◽  
Sleep Quality ◽  
Respiratory Rate ◽  
Sleep Problems ◽  
P Value ◽  
Hemodynamic Status ◽  
Spearman Test ◽  
The Relationship

Background. Acute Myocardial Infraction can have unique manifestations in individual patients, such as shortness of breath, pale, headache, nausea, vomiting, and the most common presenting symptoms of myocardial infarction is chest pain. The clinical symptoms of a patient with Acute Myocardial Infarction (AMI) can cause a nursing problem and basic human problem. For example, chest pain can cause sleep problems. Sleep problems can influence the hemodynamics of a patient. The goal of this research is to find of correlation between sleep quality with a hemodynamic status of a patient with AMI. Methods. The research used descriptive analytic with the cross-sectional approach. The total sample is 30 respondents, assessing the quality of sleep using questioners sheet and to measure hemodynamic by observation sheet. Analysis of correlation data used a Spearman test. The Results. The result of research obtained 43,3% had mild sleep problems, 50% had moderate sleep problems, 6,7% had severe sleep problems. The result of analysis statistic with Spearman test shows that relationship between sleep quality with MAP obtained significance (p-value) 0,003, the relationship between sleep quality with heart rate obtained significance (p-value) 0,0001, and the relationship between sleep quality with respiratory rate obtained significance (p-value) 0,0001. Based on significance value there is a correlation between sleep quality with hemodynamic status (MAP, heart rate, respiratory rate) of patients with Acute Myocardial Infarction (AMI). Conclusion. There is a correlation between sleep quality with hemodynamic status (MAP, heart rate, and respiratory rate) of patients with Acute Myocardial Infarction (AMI) in ICVCU Dr.Moewardi Hospital.

scholarly journals Effect of Tirofiban Injection on vascular endothelial function, cardiac function and inflammatory cytokines in patients with acute myocardial infarction after emergency Percutaneous Coronary Intervention

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Shi-xin Kang ◽  
Xiao-min Meng ◽  
Jing Li
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Function ◽  
Cardiac Function ◽  
Inflammatory Cytokines ◽  
Control Group ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Significant Difference ◽  
Experimental Group

Objectives: To evaluate the effect of tirofiban injection on vascular endothelial function, cardiac function, inflammatory cytokines and other indicators in patients with acute myocardial infarction after emergency PCI and its clinical significance. Methods: Eighty patients with acute myocardial infarction admitted to Affiliated Hospital of Hebei University from March 18, 2020 to October 18, 2020 were enrolled and randomly divided into two groups: the experimental group and the control group, with 40 cases in each group. Patients in both groups underwent PCI. Patients in the control group were given oxygen inhalation, monitoring, and basic medications for myocardial infarction, such as nutritional myocardial drugs, statins, aspirin, nitrates, clopidogrel, and β-blockers. In contrast, patients in the experimental group received tirofiban 10 ug/kg intravenously over 5min immediately before PCI in addition to basic treatment, and then tirofiban 0.1 ug/(kg/min) was pumped via intravenous pump postoperatively for 48 hour. The changes of vascular endothelial function, cardiac function and adverse drug reactions (ADRs) in the two groups before treatment, one week and one month after treatment, as well as changes of inflammatory cytokines such as CRP and IL-6 in the two groups before and after treatment were compared and analyzed. Results: Compared with the control group, FMD, NO, ET-1 and other indexes in the experimental group were significantly improved one week and one month after treatment, with statistically significant differences (p<0.05). BNP, LVEDD, LVEF and additional indexes in the experimental group were significantly lower than those in the control group at one week and one month after treatment, with statistically significant differences (p=0.00). Moreover, the incidence of ST-segment fallback > 70% in the experimental group was 72.5% after treatment, which was significantly better than that of 47.5% in the control group, with a statistically significant difference (p=0.03). CRP and IL-6 in the experimental group were significantly lower than those in the control group after treatment, with a statistically significant difference (p=0.00). There was no statistical significance in the incidence of ADRs between the two groups after treatment (p=0.42). Conclusion: Tirofiban injection after emergency PCI is a beneficial treatment regime for patients with STEMI. With such a treatment regime, cardiac function and vascular endothelial function of patients can be dramatically improved, coronary blood supply will be ameliorated, inflammatory cytokines can be reduced, and no significant increase can be seen in the incidence of adverse reactions. doi: https://doi.org/10.12669/pjms.38.1.4413 How to cite this:Kang S, Meng X, Li J. Effect of Tirofiban Injection on vascular endothelial function, cardiac function and inflammatory cytokines in patients with acute myocardial infarction after emergency Percutaneous Coronary Intervention. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4413 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Clinical efficacy of cefoperazone-sulbactam in patients with acute myocardial infarction complicated with infection and effects on serum procalcitonin and serum inflammatory indicators Running tittle: Cefoperazone-sulbactam in acute myocardial infarction complicated with infection

2021 ◽  
Vol 7 (4) ◽  
pp. 730-740
Author(s):  
Shan Wang ◽  
Xiaohua Zhao ◽  
Wenbao Sun
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Therapeutic Effect ◽  
Clinical Efficacy ◽  
Predictive Value ◽  
Control Group ◽  
Bacterial Clearance ◽  
Hs Crp ◽  
Experimental Group

This study aimed to investigate clinical efficacy of cefoperazone-sulbactam in patients with acute myocardial infarction complicated by infection and effects on serum procalcitonin and serum inflammatory indicators. Prospective analysis was used in this study. A total of 109 cases of patients with acute myocardial infarction complicated with infection were collected. They were admitted to our hospital from August 2018 to September 2019 and were divided into a control group and an experimental group according to different treatment methods. Patients (53 cases) in the control group received treatment of cefoperazone, while patients (56 cases) in the experimental group received treatment of cefoperazone-sulbactam. Therapeutic effect, bacterial clearance rate and adverse reaction of the two groups were compared. Serum procalcitonin (PCT) and serum hypersensitive C-reactive protein (hs-CRP) levels were observed and compared. ROC curve was used to analyze the predictive value of PCT, hs-CRP for the treatment of acute myocardial infarction complicated by infection. Logistic regression analysis was used to analyze the risk factors for the effect of acute myocardial infarction complicated by infection. The effective rates and bacterial clearance rates of treatment in the experimental group were higher than those in the control group (P<0.05). After treatment, the PCT and hs-CRP levels of the experimental group were lower than those of the control group (P<0.05). Age, hypertension, length of hospital stay, heart failure and hs-CRP were independent risk factors affecting the effective rate of treatment for acute myocardial infarction complicated by infection. In conclusion, cefoperazone-sulbactam has good therapeutic effect on acute myocardial infarction complicated with infection. It can reduce the level of PCT and serum inflammatory indicator hs-CRP; PCT and hs-CRP have certain predictive value on the therapeutic effect, which is worthy of promotion.

scholarly journals Endothelin-1 and nitric oxide in 3-year prognosis after acute myocardial infarction

2017 ◽  
Vol 74 (9) ◽  
pp. 862-870
Author(s):  
Dragana Stanojevic ◽  
Svetlana Apostolovic ◽  
Sonja Salinger-Martinovic ◽  
Ruzica Jankovic-Tomasevic ◽  
Danijela Djordjevic-Radojkovic ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Composite Endpoint ◽  
Control Group ◽  
Endothelin 1 ◽  
Short And Long Term ◽  
St Elevation ◽  
Experimental Group

Background/Aim. Acute myocardial infarction (AMI) is an important cause of mortality/morbidity worldwide. Biomarkers improve diagnostic and prognostic accuracy in AMI. The aim of this study was to investigate an increase of markers of endothelial dysfunction in AMI, measured on the 3rd day after the initial event and to investigate their association with short- and long-term (3-year) prognosis (outcome). Methods. The prospective study included 108 patients with AMI in the experimental group and 50 apparently healthy subjects in the control group. Endothelin-1 (ET-1) and nitric oxide degradation products (NOx) were determined. Results. The average age of the participants in the experimental group was 62 ? 10 years and 59 ? 9 years in the control group; 74.1% of the patients in experimental group were males and 68.8% in the control group. In 74.1% of the patients, ST-elevation myocardial infarction (STEMI) was diagnosed, and 25.9% of the patients presented with non-ST-elevation myocardial infarction (NSTEMI). Thirteen (5.6%) patients died during 3 years and they had significantly higher ET-1 levels compared to survivors [4.02 (2.72?5.93) vs 3.06 (2.23?3.58) pg/mL; p = 0.015]. Endothelin- 1 in 46 (42.6%) patients with composite endpoint (3- year mortality and rehospitalization) was significantly increased compared to other patients [3.14 (2.54?4.41) vs 3.05 (2.18?3.56) pg/mL; p = 0.035]. Intrahospital complications were found in 41 (48%) patients. Participants with echocardiographically detected complications (ventricular dyskinesia, left ventricular thrombus and papillary muscle rupture) had higher ET-1 levels compared to other patients [4.02 (2.78?5.57) vs 3.06 (2.29?3.66) pg/mL; p = 0.012]. Endothelin- 1 concentration above the 75th percentile (> 3.77 pg/mL) was associated with the increased risk for composite endpoint [Log Rank (?2 = 13.44; p < 0.001)]. Patients who were rehospitalized had significantly lower NOx concentration [125.5 (111.4?143.6) vs 139.3 (116.79?165.2) ?mol/L; p = 0.04]. Endothelin-1 positively correlated with high sensitivity troponin I (hsTnI), brain natriuretic peptide (BNP) and a number of leukocytes. Conclusion. Endothelin- 1 and NOx were increased on the 3rd day after AMI, and they were predictors of worse short- and long-term (3- year) prognosis (outcome). Endothelin-1 positively correlated with conventional prognostic markers in AMI.

scholarly journals Analysis of the effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on Endothelial Function in patients with acute myocardial infarction

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Bosong Wang ◽  
Hong Xu ◽  
Chengqin Li ◽  
Xiaoding Wang ◽  
Weidong Sun ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Function ◽  
Human Brain ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Control Group ◽  
Endothelin 1 ◽  
Significant Difference ◽  
Experimental Group

Objective: This study aims to analyze the effect of lyophilized recombinant human brain natriuretic peptide on the endothelial function of patients with acute myocardial infarction. Methods: One hundred and thirty-six patients with acute myocardial infarction in our hospital were randomly divided into a control group and an experimental group (68 cases each). The patients in the control group were treated by conventional treatment. The patients in the experimental group were treated with lyophilized recombinant human brain natriuretic peptide besides the conventional treatment. The levels of flow-mediated dilatation (FMD), serum nitric oxide (NO), and endothelin-1 were compared between the two groups before and after treatment. Results: Before treatment, there was no significant difference between the two groups in the level of FMD (P>0.05); after treatment, the level of FMD in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05); before treatment, there was no significant difference between the two groups in the levels of serum NO and endothelin-1 (P>0.05); after treatment, the levels of serum NO and endothelin-1 in the experimental group significantly improved, which were better than those in the control group (P<0.05). Conclusion: Lyophilized recombinant human brain natriuretic peptide can improve the FMD, increase the content of NO in the blood, and effectively reduce the level of endothelin-1, which is of great significance to improve the endothelial function of patients with acute myocardial infarction and is worth clinical application. doi: https://doi.org/10.12669/pjms.37.1.2706 How to cite this:Wang B, Xu H, Li C, Wang X, Sun W, Li J. Analysis of the effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on Endothelial Function in patients with acute myocardial infarction. Pak J Med Sci. 2021;37(1):99-103. doi: https://doi.org/10.12669/pjms.37.1.2706 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Relationship of Plasminogen Activator Inhibitor-1 Levels following Thrombolytic Therapy with rt-PA as Compared to Streptokinase and Patency of Infarct Related Coronary Artery

1999 ◽  
Vol 82 (07) ◽  
pp. 104-108 ◽  
Author(s):  
Franck Paganelli ◽  
Marie Christine Alessi ◽  
Pierre Morange ◽  
Jean Michel Maixent ◽  
Samuel Lévy ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thrombolytic Therapy ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Control Group ◽  
Plasminogen Activator Inhibitor 1 ◽  
Vessel Patency ◽  
Activator Inhibitor ◽  
Pai 1

Summary Background: Type 1 plasminogen activator inhibitor (PAI-1) is considered to be risk factor for acute myocardial infarction (AMI). A rebound of circulating PAI-1 has been reported after rt-PA administration. We investigated the relationships between PAI-1 levels before and after thrombolytic therapy with streptokinase (SK) as compared to rt-PA and the patency of infarct-related arteries. Methods and Results: Fifty five consecutive patients with acute MI were randomized to strep-tokinase or rt-PA. The plasma PAI-1 levels were studied before and serially within 24 h after thrombolytic administration. Vessel patency was assessed by an angiogram at 5 ± 1days. The PAI-1 levels increased significantly with both rt-PA and SK as shown by the levels obtained from a control group of 10 patients treated with coronary angioplasty alone. However, the area under the PAI-1 curve was significantly higher with SK than with rt-PA (p <0.01) and the plasma PAI-1 levels peaked later with SK than with rt-PA (18 h versus 3 h respectively). Conversely to PAI-1 levels on admission, the PAI-1 levels after thrombolysis were related to vessel patency. Plasma PAI-1 levels 6 and 18 h after SK therapy and the area under the PAI-1 curve were significantly higher in patients with occluded arteries (p <0.002, p <0.04 and p <0.05 respectively).The same tendency was observed in the t-PA group without reaching significance. Conclusions: This study showed that the PAI-1 level increase is more pronounced after SK treatment than after t-PA treatment. There is a relationship between increased PAI-1 levels after thrombolytic therapy and poor patency. Therapeutic approaches aimed at quenching PAI-1 activity after thrombolysis might be of interest to improve the efficacy of thrombolytic therapy for acute myocardial infarction.

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