scholarly journals Evaluation of Neglected Idiopathic Ctev Managed by Ligamentotaxis Using Jess: A Long-Term Followup

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Ajai Singh
Keyword(s):  
Scoring System ◽  
Clinical Results ◽  
Radiological Evaluation ◽  
Normal Range ◽  
Pirani Score ◽  
Before And After ◽  
Range Of Values

Background. This study was conducted with the aim of evaluating the role of Ligamentotaxis in the management of neglected clubfeet managed by ligamentotaxis using Joshi's External Stabilisation System (JESS).Method & Material. Total 20 subjects (28 feet) were studied, which were corrected by differential ligamentotaxis using JESS. All were evaluated clinically, radiologically, podogrammically, and by Catterall Pirani Scoring System, both before and after the correction.Results. Severity of the deformities and clinical correction was assessed by Pirani score. All patients achieved good clinical results as per Pirani score, which was statistically significant. Radiological evaluation showed that all subjects achieved the normal range of values. The pre- and postcorrection difference in FBA was statistically significant.Conclusion. Differential distraction by fixator for the correction of neglected idiopathic CTEV is an effective and patient-friendly method of management.

scholarly journals An Assessment of the Results of Controlled Fractional Distraction by Joshi's External Stabilization System in Club Foot

2015 ◽  
Vol 2 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Ashwani Sadana ◽  
Chandra Prakash Pal ◽  
Karuna Shankar Dinkar
Keyword(s):  
Club Foot ◽  
Clinical Results ◽  
Asia Pacific ◽  
Stabilization System ◽  
Congenital Deformities ◽  
Pirani Score ◽  
Before And After ◽  
External Stabilization ◽  
Range Of Values

ABSTRACT Club foot is amongst the most common of congenital deformities. Its incidence is 1 to 2 per 1000 live births. At birth, the diagnosis can be made by observing the foot for forefoot adduction, hindfoot inversion and equinus deformity. The study was conducted to evaluate the role of controlled fractional distraction in the management of neglected club feet by Joshi's external stabilization system (JESS). Total of 18 cases (22 feet) were studied, which were corrected by JESS. All cases were evaluated clinically, radiologically, podographically, and Pirani scoring system, both, before and after the correction. Severity of the deformities and clinical correction was assessed by Pirani score. All patients achieved good clinical results as per Pirani score, radiological evaluation showed that all subjects achieved the normal range of values. How to cite this article Sadana A, Pal CP, Dinkar KS. An Assessment of the Results of Controlled Fractional Distraction by Joshi's External Stabilization System in Club Foot. J Foot Ankle Surg (Asia-Pacific) 2015;2(1):13-16.

scholarly journals Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia

2021 ◽  
Vol 22 (24) ◽  
pp. 13609
Author(s):  
Lucas Wauters ◽  
Raúl Y. Tito ◽  
Matthias Ceulemans ◽  
Maarten Lambaerts ◽  
Alison Accarie ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Potential Role ◽  
Short Term ◽  
Beneficial Effects ◽  
Rrna Sequencing ◽  
Before And After

Proton pump inhibitors (PPI) may improve symptoms in functional dyspepsia (FD) through duodenal eosinophil-reducing effects. However, the contribution of the microbiome to FD symptoms and its interaction with PPI remains elusive. Aseptic duodenal brushings and biopsies were performed before and after PPI intake (4 weeks Pantoprazole 40 mg daily, FD-starters and controls) or withdrawal (2 months, FD-stoppers) for 16S-rRNA sequencing. Between- and within-group changes in genera or diversity and associations with symptoms or duodenal factors were analyzed. In total, 30 controls, 28 FD-starters and 19 FD-stoppers were followed. Mucus-associated Porphyromonas was lower in FD-starters vs. controls and correlated with symptoms in FD and duodenal eosinophils in both groups, while Streptococcus correlated with eosinophils in controls. Although clinical and eosinophil-reducing effects of PPI therapy were unrelated to microbiota changes in FD-starters, increased Streptococcus was associated with duodenal PPI effects in controls and remained higher despite withdrawal of long-term PPI therapy in FD-stoppers. Thus, duodenal microbiome analysis demonstrated differential mucus-associated genera, with a potential role of Porphyromonas in FD pathophysiology. While beneficial effects of short-term PPI therapy were not associated with microbial changes in FD-starters, increased Streptococcus and its association with PPIeffects in controls suggest a role for duodenal dysbiosis after long-term PPI therapy.

scholarly journals Impact of earthquake-triggered landslides on catchment sediment yield

2015 ◽  
Vol 367 ◽  
pp. 291-296
Author(s):  
M. Vanmaercke ◽  
F. Obreja ◽  
J. Poesen
Keyword(s):  
Sediment Yield ◽  
Seismic Activity ◽  
Fold Increase ◽  
Sediment Concentration ◽  
Spatial And Temporal Variation ◽  
Strongly Correlated ◽  
Before And After ◽  
Sediment Export

Abstract. This study explores the role of seismic activity in explaining spatial and temporal variation in sediment export from the Siret basin in Romania. Based on long-term (>30 years) sediment export measurements for 38 subcatchments, we found that spatial variation in sediment yield (SY) is strongly correlated to the degree of seismic activity and catchment lithology. Combined, these factors explain 80% of the variation in SY. To investigate the role of earthquake-triggered landslides in explaining these correlations, we studied the temporal variability in sediment concentrations before and after the 7.4 Mw earthquake of 1977 for ten subcatchments. Despite the fact that this earthquake triggered many landslides, only one subcatchment showed a clear (3-fold) increase in sediment concentration per unit discharge after the earthquake. This shows that, although prolonged seismic activity strongly controls average SY, individual earthquakes do not necessarily affect sediment export at short timescales.

To Evaluate the Role of Pirani Score in Deformity Assessment and Management of Club Foot by Ponseti Method – A Hospital Based Prospective Study from Tirupati

2021 ◽  
Vol 8 (29) ◽  
pp. 2633-2638
Author(s):  
Venkat R ◽  
Suguru Rav Kumar ◽  
Penugonda Ravi Shankar ◽  
Deety Lakshmi Venkatesh
Keyword(s):  
Prospective Study ◽  
Scoring System ◽  
Club Foot ◽  
Study Groups ◽  
Ponseti Method ◽  
Classification Systems ◽  
Statistical Inferences ◽  
Pirani Score ◽  
Ethical Approval

BACKGROUND Pirani scoring system is one of the classification systems in management of club foot which is simple and easy to use. However, there is paucity of studies using Pirani system to determine the severity and monitor progress in the treatment of club foot. We therefore set out with the aim of assessing severity and monitoring the progress of treatment using the Pirani scoring system. The Pirani scoring system, together with the Ponseti method of club foot management, was assessed for its predictive value. METHODS It was a hospital-based prospective study of 57 club foot in 41 patients designed to evaluate the role of Pirani score in deformity assessment and management of club foot by Ponseti method. Consecutive patients presenting at the outpatient department at SVRRGGH, Tirupati with idiopathic club foot, and in-patients department with idiopathic club foot were recruited into the study. Informed consent was obtained from parents/guardians of the patients that were recruited in the study. This was a prerequisite for obtaining the ethical approval. Data collected from the study groups was entered into a worksheet, and analysis was performed using the statistical package for social sciences (SPSS) software for windows version 21. Significant statistical inferences were drawn at p & lt ; 0.05. RESULTS The correlation between the midfoot score, hindfoot score, Pirani score and the number of casts to achieve correction was significant (P = 0.001). Also, there was correlation between the Pirani score and the need for tenotomy (P = 0.001); between the number of casts to achieve correction and the need for tenotomy (P = 0.001). Moreover, the progress of treatment can be monitored with the Pirani score (P = 0.001). CONCLUSIONS Pirani scoring system is a simple, easy, quick and reliable system to determine severity and monitor progress in the treatment of club foot with excellent interobserver variability. KEYWORDS Pirani Score, Club Foot, Ponseti Method

scholarly journals APACHE IV system helps to determine role of cholecystostomy in elderly patients with acute cholecystitis

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110592
Author(s):  
Hua Jiang ◽  
Guo Guo ◽  
Zhimin Yao ◽  
Yuehua Wang
Keyword(s):  
High Risk ◽  
Acute Cholecystitis ◽  
Scoring System ◽  
Characteristic Curve ◽  
Chi Square ◽  
High Risk Patients ◽  
Before And After ◽  
Risk Patients ◽  
Apache Iv

Objective Cholecystostomy is a palliative treatment for patients unfit to undergo immediate cholecystectomy. Nevertheless, the role of cholecystostomy in the clinical management of such patients remains unclear. The Acute Physiology and Chronic Health Evaluation IV (APACHE IV) scoring system is useful for estimating the hospital mortality of high-risk patients. We evaluated the therapeutic effect of cholecystostomy by the APACHE IV scoring system in patients aged >65 years with acute cholecystitis. Methods In total, 597 patients aged >65 years with acute cholecystitis were retrospectively analyzed using APACHE IV scores. Results The fitness of the APACHE IV score prediction was good, with an area under the receiver operating characteristic curve of 0.894. The chi square independence test indicated that compared with conservative treatment, cholecystostomy may have different effects on mortality for patients whose estimated mortality rate was >10%. Comparison of the estimated mortality of patients before and after cholecystostomy indicated that the estimated mortality was significantly lower after than before puncture, both in the whole patient group and in the group with an estimated mortality of >10%. Conclusion The APACHE IV scoring system showed that cholecystostomy is a safe and effective treatment for elderly high-risk patients with acute cholecystitis.

Caudal cervical intervertebral disk disease in the small dog: role of distraction and stabilization in ventral slot decompression

2000 ◽  
Vol 36 (1) ◽  
pp. 68-74 ◽  
Author(s):  
RB Fitch ◽  
SC Kerwin ◽  
G Hosgood
Keyword(s):  
Motor Function ◽  
Clinical Results ◽  
Intervertebral Disk ◽  
Clinical Effects ◽  
Common Site ◽  
Intervertebral Space ◽  
Term Outcome ◽  
Long Term Outcome

The clinical outcomes in 112 dogs weighing less than 35 pounds that were presented with cervical intervertebral disk protrusions were retrospectively evaluated. Although the second to third cervical (C2 to C3) intervertebral space was the most common site (27%) of disk protrusion, 57% of disk protrusions presented were caudal to the fourth cervical (C4) vertebra. Dogs with cranial intervertebral disk protrusions, including the C2 to C3 and C3 to C4 intervertebral disk spaces, responded favorably to ventral slot decompression. By comparison, caudal intervertebral disk protrusions (within the C4 to the seventh cervical [C7] intervertebral disk spaces) responded less favorably to ventral slot decompression, demonstrating significantly more severe clinical effects in motor function, comfort, recovery, and long-term outcome following surgery. Significant improvement in clinical results was seen in caudal disk protrusions when additional surgical distraction and stabilization were provided following ventral slot decompression.

scholarly journals The Role of Fat Grafting in the Treatment of Posttraumatic Maxillofacial Deformities

2013 ◽  
Vol 6 (2) ◽  
pp. 121-125 ◽  
Author(s):  
Francesco Arcuri ◽  
Matteo Brucoli ◽  
Nicola Baragiotta ◽  
Livia Stellin ◽  
Mariangela Giarda ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Facial Asymmetry ◽  
Clinical Results ◽  
Fat Grafting ◽  
Biological Behavior ◽  
Open Approach ◽  
Fat Transplantation ◽  
Software Analysis

PurposeThe first autologous adipose tissue grafting was performed by Neuber in 1893 with an open approach. In the early 1980s, Illouz and Fournier introduced closed liposuction. In the 1990s, Coleman published a new method of atraumatic fat transplantation. Recently, immunohistochemical studies of the extracellular matrix of the lipoaspirate showed the presence of adipose-derived stem cells. The purpose of this study is to describe the role of fat grafting in the management of posttraumatic facial deformities.MethodsThe study population was composed of all patients who underwent facial fat grafting between March 2008 and November 2010 as a secondary reconstructive procedure after an initial unsatisfactory treatment of the skeletal fractures. We analyzed the postoperative morphological changes by comparing the grafted side of the face to the contralateral side with the aid of a software package.ResultsNineteen patients were surgically treated with fat transplantation for facial asymmetry due to a pathological postoperative healing of the soft tissue. Clinical examination and software analysis showed adequate postoperative facial balance without major complications.ConclusionFat grafting is a very powerful tool to correct posttraumatic maxillofacial deformities and to ensure a long-term follow-up. Although we have achieved excellent clinical results in our reconstructive clinical cases, we are convinced that more complex prospective studies, enriched by long-term radiological controls, are needed to fully understand the biological behavior of the transplanted fat in the posttraumatic face.

scholarly journals How Did Organizational Resilience Work Before and after the Financial Crisis? An Empirical Study

2018 ◽  
Vol 13 (10) ◽  
pp. 54 ◽  
Author(s):  
Pamela Palmi ◽  
Domenico Morrone ◽  
Pier Paolo Miglietta ◽  
Giulio Fusco
Keyword(s):  
Corporate Governance ◽  
Financial Crisis ◽  
Organizational Resilience ◽  
Long Term Outcomes ◽  
Before And After ◽  
Path Dependent ◽  
The 2008 Financial Crisis ◽  
The Empirical Analysis

The purpose of this paper is to assess the role of organizational resilience as an attitude, depending on the adoption of corporate governance, environmental and social practices (CESPs), in order to react to unexpected shocks, while preserving business sustainability. Organizational resilience is defined as the capacity for an enterprise to survive, to adapt and to grow in a turbulent change or unpredicted situation. Since organizational resilience is a latent path-dependent construct, it can be evaluated through long-term outcomes in an integrated perspective. The hypotheses are tested analyzing the economic performance of U.S. companies listed in Standard & Poor’s 500 index (S&P 500) and their environmental, social and governance (ESG) data has been extracted from Asset4. The period in the study covers 14 years, from 2002 to 2015, collecting the seven years before and after the 2008 financial crisis. The results of the empirical analysis highlight that economic performances of listed companies are influenced, over the 14 year period considered in the study, not only by the traditional sustainable pillars (SEPs), but also by the corporate governance ones (CESPs).

From long-term savings to instant mortgages: financial demonstration and the role of interaction in markets

Organization ◽  
2011 ◽  
Vol 18 (2) ◽  
pp. 215-235 ◽  
Author(s):  
Zsuzsanna Vargha
Keyword(s):  
Financial Advisors ◽  
Savings And Loans ◽  
Financial Products ◽  
Savings Bank ◽  
Before And After ◽  
Interactional Perspective ◽  
Retail Banks ◽  
Credit Boom

Accounts of the crisis have privileged ‘high finance’ innovations whereas retail banks constantly experimented with how they sell (new) products to consumers. I examine the case of product innovation at a home savings bank in Hungary during the pre-crisis credit boom. Turned from offering state-subsidized long-term savings-and-loans to promoting instant mortgages. Based on ethnographic observations of the bank’s Direct Selling Organization, I trace the bank’s shift from state-subsidized long-term savings-and-loans to instant mortgages, to problems with demonstrating the qualities of financial products, even ostensibly prudent ones. Drawing on concepts of scientific demonstration and proof, I compare how financial advisors explained the plan to consumers before and after it was combined with mortgages: first they drew the funds by hand, later they adopted software-generated scenarios. I suggest that as sellers perform products interactively with clients, consumers’ needs appear. Thus, when organized differently, financial demonstrations yield different consumers-with-preferences. Based on this interactional perspective, I find that consumer finance is an ‘economy of qualities’ where preferences and product properties stabilize through consultation, and where “social” embedding can enable “economic” calculations. Based on this interactional perspective, I examine US and UK proposals for consumer financial protection.

scholarly journals PDTM-44. ROLE OF ONC-206 IN REGULATING MEDULLOBLASTOMA TUMOR PROGRESSION

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi196-vi197
Author(s):  
Anshu Malhotra ◽  
Jingbo Liu ◽  
Tobey MacDonald
Keyword(s):  
Cell Lines ◽  
Small Molecule ◽  
Standard Of Care ◽  
Clinical Results ◽  
Current Standard ◽  
Survival Pathways ◽  
Cognitive Deficiencies ◽  
G Protein Coupled

Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children. Of the four different sub-groups, the Sonic Hedgehog (SHH) subgroup accounts for about 30% of human MBs. The current standard of care (resection, cranio-spinal irradiation, and chemotherapy) for MB is typically ineffective for SHH MB in non-infants and those with metastatic disease. Survivors are frequently beset with long-term side effects including cognitive deficiencies and a severely impaired quality of life. Taken together, there is a critical need for novel targeted therapies for SHH MB. Recently, promising preclinical and clinical results have been obtained in a variety of cancers treated with a small molecule antagonist, ONC-201, which acts against DRD2, a G-protein coupled receptor that is widely expressed in MBs and regulates pro-survival pathways in tumors. In the present study we report the activity of ONC-201 and another DRD2 antagonist, ONC-206, which binds DRD2 with increased affinity. We tested three different MB cell lines with varied levels of DRD2 expression against these drugs, and consistently observed increased cell death at lower doses of ONC-206 compared to ONC-201. Following literature reports about the mechanism of action of ONC-201, we also evaluated the role of ClpP gene in MB cell lines. ClpP is a mitochondrial protease that has been shown to directly bind ONC 201. We observed a decrease in the expression of this gene after treatment of MB cell lines with ONC-206. Current studies are focusing on exploring the mechanism by which ONC-206 affects MB growth and metastasis. Dissecting this mechanism will be pivotal in predicting the role of this small molecule as a pre-clinical therapeutic for MB treatment.

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