scholarly journals Paired-Pulse Inhibition in the Auditory Cortex in Parkinson's Disease and Its Dependence on Clinical Characteristics of the Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Elena Lukhanina ◽  
Natalia Berezetskaya ◽  
Irina Karaban
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Auditory Cortex ◽  
Healthy Subjects ◽  
Clinical Characteristics ◽  
Auditory Evoked Potentials ◽  
Disease Onset ◽  
Paired Pulse ◽  
Age Dependent ◽  
State Examination

We aimed to determine the value of the paired-pulse inhibition (PPI) in the auditory cortex in patients with Parkinson's disease (PD) and analyze its dependence on clinical characteristics of the patients. The central (Cz) auditory evoked potentials were recorded in 58 patients with PD and 22 age-matched healthy subjects. PPI of the N1/P2 component was significantly(P<.001)reduced for interstimulus intervals 500, 700, and 900 ms in patients with PD compared to control subjects. The value of PPI correlated negatively with the age of the PD patients(P<.05), age of disease onset(P<.05), body bradykinesia score(P<.01), and positively with the Mini Mental State Examination (MMSE) cognitive score(P<.01). Negative correlation between value of PPI and the age of the healthy subjects(P<.05)was also observed. Thus, results show that cortical inhibitory processes are deficient in PD patients and that the brain's ability to carry out the postexcitatory inhibition is age-dependent.

The prevalence of Parkinson’s disease among Vilnius inhabitants

Open Medicine ◽  
2008 ◽  
Vol 3 (2) ◽  
pp. 195-198 ◽  
Author(s):  
Vaineta Valeikiene ◽  
Jelena Ceremnych ◽  
Diana Mieliauskaite ◽  
Vidmantas Alekna
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mini Mental State Examination ◽  
Disease Onset ◽  
Time Frame ◽  
Study Group ◽  
Men And Women ◽  
The Mean ◽  
State Examination ◽  
Made In

AbstractIn a hospital-based study we investigated the prevalence of Parkinson’s disease among inhabitants of the Vilnius city, the capital of Lithuania. The study group was selected from patients who were diagnosed with Parkinson’s disease during the time frame of 1978-2005. Patients’ time of diagnosis were based on the data of dispensary cards, registration journals and/or other documentation. A questionnaire and Mini Mental State Examination provided data for analysis on the conditions of the patients. The prevalence of Parkinson’s disease in Vilnius is 1.32/1000 inhabitants and is higher in men than in women (p < 0.05). The age of Parkinson’s disease onset in men and women is the same (63.77 ± 0.70 years). The rigidity-tremor form of Parkinson’s disease is the most frequent (76.8% of all cases). The PD prevalence rate in Vilnius inhabitants are close to the mean levels observed in studies made in Finland, Austria, Germany. The prevailing form of Parkinson’s disease is rigidity-tremor.

scholarly journals Age-dependence and aging-dependence: The case of neuronal loss and lifespan in a C. elegans model of Parkinson’s disease

2017 ◽  
Author(s):  
Javier Apfeld ◽  
Walter Fontana
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Joint Distribution ◽  
Disease Onset ◽  
Joint Probability ◽  
Neuronal Loss ◽  
Joint Probability Distribution ◽  
Age Dependence ◽  
C Elegans ◽  
Age Dependent

It is often assumed, but not established, that the major neurodegenerative diseases, such as Parkinson’s disease, are not just age-dependent (their incidence changes with time) but actually aging-dependent (their incidence is coupled to the process that determines lifespan). To determine a dependence on the aging process requires the joint probability distribution of disease onset and lifespan. For human Parkinson’s disease, such a joint distribution is not available because the disease cuts lifespan short. To acquire a joint distribution, we resorted to an established C. elegans model of Parkinson’s disease in which the loss of dopaminergic neurons is not fatal. We find that lifespan is not correlated with the loss of neurons and that a lifespan-extending intervention into insulin/IGF1 signaling accelerates neuronal loss, while leaving death and neuronal loss times uncorrelated. This suggests that distinct and compartmentalized instances of the same genetically encoded insulin/IGF1 signaling machinery act independently to control neurodegeneration and lifespan in C. elegans. Although the human context might well be different, our study calls attention to maintaining a rigorous distinction between age-dependence and aging-dependence.

scholarly journals Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Velma T. E. Aho ◽  
Madelyn C. Houser ◽  
Pedro A. B. Pereira ◽  
Jianjun Chang ◽  
Knut Rudi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Fatty Acids ◽  
Parkinson's Disease ◽  
Gut Microbiota ◽  
Inflammatory Responses ◽  
Disease Onset ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Dependent Manner ◽  
Chain Fatty Acids

Abstract Background Previous studies have reported that gut microbiota, permeability, short-chain fatty acids (SCFAs), and inflammation are altered in Parkinson’s disease (PD), but how these factors are linked and how they contribute to disease processes and symptoms remains uncertain. This study sought to compare and identify associations among these factors in PD patients and controls to elucidate their interrelations and links to clinical manifestations of PD. Methods Stool and plasma samples and clinical data were collected from 55 PD patients and 56 controls. Levels of stool SCFAs and stool and plasma inflammatory and permeability markers were compared between patients and controls and related to one another and to the gut microbiota. Results Calprotectin was increased and SCFAs decreased in stool in PD in a sex-dependent manner. Inflammatory markers in plasma and stool were neither intercorrelated nor strongly associated with SCFA levels. Age at PD onset was positively correlated with SCFAs and negatively correlated with CXCL8 and IL-1β in stool. Fecal zonulin correlated positively with fecal NGAL and negatively with PD motor and non-motor symptoms. Microbiota diversity and composition were linked to levels of SCFAs, inflammatory factors, and zonulin in stool. Certain relationships differed between patients and controls and by sex. Conclusions Intestinal inflammatory responses and reductions in fecal SCFAs occur in PD, are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels, highlighting candidate molecules and pathways which may contribute to PD pathogenesis and clinical presentation and which warrant further investigation.

scholarly journals Clinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: A Prospective Study

2021 ◽  
Vol 36 ◽  
pp. 153331752110213
Author(s):  
Anamaria Jurcau ◽  
Vharoon Sharma Nunkoo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Binary Logistic Regression ◽  
Binary Logistic Regression Analysis ◽  
Clinical Markers ◽  
Pearson Coefficient ◽  
Autonomic Dysfunctions ◽  
Patients At Risk ◽  
A Prospective Study ◽  
State Examination

Background: The study aims at identifying features predictive of early onset of dementia in Parkinson’s disease (PD). Methods: 103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up. Results: By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = −.621, p < 0.001) and insomnia (r = −.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017). Conclusion: Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.

THREE DAYS MONITORING OF ACTIVITIES OF DAILY LIVING AMONG YOUNG HEALTHY ADULTS AND PARKINSON’S DISEASE PATIENTS

2021 ◽  
Vol 57 (2) ◽  
pp. 177-183
Author(s):  
Seong Hyun Moon ◽  
◽  
Rahul Soangra ◽  
Christopher F. Frames ◽  
Thurmon E. Lockhart ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Healthy Subjects ◽  
Neurodegenerative Disorder ◽  
Activity Level ◽  
Measurement Unit ◽  
Great Promise ◽  
Butterworth Filters

Parkinson’s Disease (PD) is a neurodegenerative disorder affecting the substantia nigra, which leads to more than half of PD patients are considered to be at high risk of falling. Recently, Inertial Measurement Unit (IMU) sensors have shown great promise in the classification of activities of daily living (ADL) such as walking, standing, sitting, and laying down, considered to be normal movement in daily life. Measuring physical activity level from longitudinal ADL monitoring among PD patients could provide insights into their fall mechanisms. In this study, six PD patients (mean age=74.3±6.5 years) and six young healthy subjects (mean age=19.7±2.7 years) were recruited. All the subjects were asked to wear the single accelerometer, DynaPort MM+ (Motion Monitor+, McRoberts BV, The Hague, Netherlands), with a sampling frequency of 100 Hz located at the L5-S1 spinal area for 3 days. Subjects maintained a log of activities they performed and only removed the sensor while showering or performing other aquatic activities. The resultant acceleration was filtered using high and low pass Butterworth filters to determine dynamic and stationary activities. As a result, it was found that healthy young subjects performed significantly more dynamic activities (13.2%) when compared to PD subjects (7%), in contrast, PD subjects (92.9%) had significantly more stationary activities than young healthy subjects (86.8%).

Clinical characteristics of Parkinson's disease in Sudanese patients attending Daoud Charity Clinic in 2020–2021

2021 ◽  
Vol 429 ◽  
pp. 119594
Author(s):  
Radi Tofaha Alhusseini ◽  
Abbasher Hussien ◽  
Khabab Mohamed Ahmed ◽  
Hussien Abbashar ◽  
Amira Abdelgalil ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Characteristics
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