scholarly journals The Role of Salt in the Pathogenesis of Fructose-Induced Hypertension

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Manoocher Soleimani ◽  
Pooneh Alborzi
Keyword(s):  
Metabolic Syndrome ◽  
Caloric Intake ◽  
Visceral Obesity ◽  
The United States ◽  
Epidemiologic Studies ◽  
Western World ◽  
Induced Hypertension ◽  
Obesity Hypertension ◽  
The 1960S

Metabolic syndrome, as manifested by visceral obesity, hypertension, insulin resistance, and dyslipidemia, is reaching epidemic proportions in the Western World, specifically the United States. Epidemiologic studies suggest that the increased prevalence of metabolic syndrome directly correlates with an increase in the consumption of fructose, mainly in the form of high-fructose corn syrup. This inexpensive alternative to traditional sugar has been increasingly utilized by the food industry as a sweetener since the 1960s. While augmented caloric intake and sedentary lifestyles play important roles in the increasing prevalence of obesity, the pathogenesis of hypertension in metabolic syndrome remains controversial. One intriguing observation points to the role of salt in fructose-induced hypertension. Recent studies in rodents demonstrate that increased dietary fructose intake stimulates salt absorption in the small intestine and kidney tubules, resulting in a state of salt overload, thus setting in motion a cascade of events that will lead to hypertension. These studies point to a novel interaction between the fructose-absorbing transporter, Glut5, and the salt transporters, NHE3 and PAT1, in the intestine and kidney proximal tubule. This paper will focus on synergistic roles of fructose and salt in the pathogenesis of hypertension resulting from salt overload.

Introduction

1994 ◽  
Author(s):  
Václav Nēmec
Keyword(s):  
Ad Hoc ◽  
International Association ◽  
The United States ◽  
Ore Deposits ◽  
Western World ◽  
Mathematical Geology ◽  
25Th Anniversary ◽  
European Universities ◽  
The World

Friends and associates of Daniel F. Merriam have prepared this volume in Dan's honor to commemorate his 65th birthday and mark the 25th anniversary of the International Association for Mathematical Geology. This compendium is in the tradition of the Festschriften issued by European universities and scholarly organizations to honor an individual who has bequeathed an exceptional legacy to his students, associates, and his discipline. Certainly Dan has made such an impact on geology, and particularly mathematical geology. It is a great privilege for rne to write the introduction to this Festschrift. The editors are to be congratulated for their idea to collect and to publish so many representative scientific articles written by famous authors of several generations. Dan Merriam is the most famous mathematical geologist, in the world. This statement will probably provoke some criticism against an over-glorification of Dan. Some readers will have their own candidates (including themselves) for such a top position. I would like to bring a testimony that the statement is correct and far from an ad hoc judgment only for this solemn occasion. It may be of interest to describe how I became acquainted with Dan. In my opinion this will show how thin and delicate was the original tissue of invisible ties which helped to build up the first contacts among Western and Eastern colleagues in the completely new discipline of mathematical geology. The role of Dan Merriam in opening and increasing these contacts has been very active indeed. In the Fall 1964 I was on a family visit in the United States. This was— after the coup of Prague in 1948—my first travel to the free Western world. With some experience in computerized evaluation of ore deposits, I was curious to see the application of computers in geology and to meet colleagues who had experience with introducing statistical methods into regular estimation of ore reserves. I had very useful contacts in Colorado and in Arizona. In Tucson I visited the real birthplace of the APCOM symposia.

“It was a jet. It was a jet. It was a jet.”

2021 ◽  
pp. 3-21
Author(s):  
Jessica DuLong
Keyword(s):  
New York ◽  
The United States ◽  
Staten Island ◽  
Creative Problem ◽  
1960S And 1970S ◽  
The 1960S ◽  
Maritime Infrastructure ◽  
Maritime Community ◽  
The U.S

This chapter provides a background of the waterborne evacuation that happened after the events of 9/11. New York harbor was, and is, a busy place — the third largest container port in the United States and a vital connection between New York City and the rest of the world. Manhattan is an island, and the realities of island real estate are what ushered the port's industries off Manhattan's shores and over to Brooklyn, Staten Island, and New Jersey in the 1960s and 1970s. By late 2001, maritime infrastructure had been replaced with ornamental fencing. On September 11, 2001, as the cascade of catastrophe unfolded, people found their fates altered by the absence of that infrastructure and discovered themselves dependent upon the creative problem solving of New York harbor's maritime community — waterfront workers who had been thrust beyond their usual occupations and into the role of first responders. Long before the U.S. Coast Guard's call for “all available boats” crackled out over marine radios, scores of ferries, tugs, dinner boats, sailing yachts, and other vessels had begun converging along Manhattan's shores. Hundreds of mariners shared their skills and equipment to conduct a massive, unplanned rescue. Within hours, nearly half a million people had been delivered from Manhattan by boat.

Catalonian Trademarks and the Development of Marketing Knowledge in Spain, 1850–1946

2012 ◽  
Vol 86 (2) ◽  
pp. 239-260 ◽  
Author(s):  
Patricio Sáiz ◽  
Paloma Fernández Pérez
Keyword(s):  
United States ◽  
United Kingdom ◽  
The United States ◽  
Western World ◽  
Food And Beverages ◽  
The United Kingdom ◽  
Historical Role

Trademarks have traditionally been viewed as assets that, although intangible, nevertheless contribute to the success of firms. This study, based on a compilation of national trademark data, corrects existing distortions of the historical role of brands and their—often unsuccessful—use as business tools by countries, sectors, or firms. Legislation on, and the profuse use of, trademarks in the Western world was pioneered by Spain, rather than by France, the United States, or the United Kingdom, and was initiated in unusual sectors, such as papermaking and textiles, rather than in the more usual ones of food and beverages. Analysis of the applicants of Catalan trademarks, across sectors, during almost a century, reveals that the legal possession of a brand cannot in itself guarantee a firm's success.

164 Hispanic Ethnicity and Socioeconomic Status are Independently Associated with Improved Prognosis in Glioblastoma Patients

Neurosurgery ◽  
2017 ◽  
Vol 64 (CN_suppl_1) ◽  
pp. 241-241
Author(s):  
Kevin J Moore ◽  
Angela Richardson ◽  
Tulay Koru-Sengul ◽  
Michael E Ivan
Keyword(s):  
Socioeconomic Status ◽  
Race And Ethnicity ◽  
Cox Regression ◽  
The United States ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Hispanic Ethnicity ◽  
Cancer Data ◽  
Hispanic Patients

Abstract INTRODUCTION Significant racial and social disparities have previously been identified in outcomes from glioblastoma. Although some epidemiologic studies have shown Hispanic ethnicity to be protective, other studies have not replicated this finding. As many studies do not consider race separately from ethnicity, the role of Hispanic ethnicity in glioblastoma survival is not well understood. Florida has one of the largest Hispanic populations in the United States. Using a population-based cancer database, this study examines sociodemographic and survival disparities in glioblastoma patients. METHODS Data from the Florida Cancer Data System (FCDS) and the US Census were linked for adult (>18 yrs) glioblastoma patients to determine disease burden and survival. A multivariable Cox regression model was used to model patient survival adjusting for sociodemographic, tumor, and clinical characteristics. Adjusted hazard ratios (aHR) and 95% confidence intervals (95% CI) were calculated for overall sample. All statistical analyses were completed with SAS v.9.4. RESULTS >In total, 16,180 Florida adults were diagnosed with glioblastoma between 1981 and 2013. The majority were male (56.0%) and white (93.0%), and 11.2% of glioblastoma patients identified as Hispanic with 2.4% self-identifying as Cuban. Hispanics had significantly better survival compared to non-Hispanics (aHR 0.84; 95% CI 0.78 0.90). Current smokers fared significantly worse (aHR 1.11; 95% CI 1.04 1.18). Higher socioeconomic status was also associated with increased survival (aHR 0.91, 95% CI 0.84 0.99). Younger age at diagnosis, surgical resection, chemotherapy, radiation therapy, and female sex were also associated with significantly improved outcomes. CONCLUSION This study demonstrates clear sociodemographic and survival disparities for glioblastoma patients. This analysis considers race and ethnicity as two distinct variables and shows improved survival outcomes for Hispanic patients. Additionally patients from neighborhoods with higher socioeconomic status have increased survival. Further analysis is needed to assess the role of histologic and molecular subtypes in these ethnic groups.

scholarly journals Role of endoscopy in gastroesophageal reflux disease

2015 ◽  
Vol 6 (03) ◽  
pp. 89-95
Author(s):  
Tarun Rai ◽  
Prashanth Vennalaganti ◽  
Prateek Sharma
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Indirect Costs ◽  
The United States ◽  
Epidemiological Studies ◽  
Western World ◽  
Western Countries ◽  
American Society

AbstractGastroesophageal reflux disease is a condition due to reflux of stomach content in the esophagus causing trouble symptoms or complications or both. GERD is a clinical diagnosis and typically presents with a heartburn and/or regurgitation and a positive response to antacid secretory medications. GERD is the leading outpatient diagnosis among all gastrointestinal disorders in the United States. Approximately 40% of population report occasional symptoms of GERD whereas 10-20% of patients will have symptoms at least once in a week. Recent guidelines from gastrointestinal societies such as American College of Gastroenterology, American Society for Gastrointestinal Endoscopy and American College of Physicians have laid out specific indications regarding role of esophagogastroduodenoscopy in GERD. Despite these recommendations, studies have revealed that one-fifth to two-fifth EGDs may not be clinically indicated, especially where open access endoscopy referral system is used. Traditionally, GERD has been thought to be a disease of the western world. Prevalence rates had been estimated to be lower in Asia when compared to that of the Western Countries. Few recent epidemiological studies in India showed the prevalence of reflux disease in India to be between 8-24%, which is comparable to the western world. The use of EGDs becomes more critical for developing countries such as India where prevalence of GERD and BE is comparable to the western countries but have limited resources. In addition to direct cost for an EGD, it burdens economy with indirect costs such as time off from the work, transportation and any procedural complications. Risk stratifying patients with GERD may therefore prevent unnecessary procedures, harms and costs. The aim of this paper is to review the existing evidence on the role of endoscopy in GERD.

From Sufism to Universal Vision: Murat Yagan and the Teaching of Kebzeh

2014 ◽  
Vol 3 (1) ◽  
pp. 67-92
Author(s):  
Chen Bram ◽  
Meir Hatina
Keyword(s):  
Cultural Exchange ◽  
The United States ◽  
Way Of Life ◽  
The West ◽  
Art Of Living ◽  
The Caucasus ◽  
Caucasus Mountains ◽  
The 1960S ◽  
First Time

This article examines aspects of cultural exchange between the Middle East and the West in which Sufism, Christianity, the traditions of the Circassians and New Age concepts played a central role. It focuses on the teaching of Murat Yagan, of Abkhaz-Circassian origin who grew up in Turkey and immigrated to Canada in the 1960s, where he developed his philosophy, Ahmsta Kebzeh (“the knowledge of the art of living”). The Kebzeh way of life emphasizes modesty, mutual responsibility and compassion. Yagan linked these values to the ancient ethos of the Caucasus Mountains which he sought to revive as the basis of a universal vision. The nature of Kebzeh was influenced by the cosmopolitan environment in which Yagan was educated in Turkey; by his enrollment with Sufi circles in North America; and by the multicultural Canadian atmosphere. These diverse influences enabled him to devise an ecumenical model of dialogue between cultures. The article provides a first-time survey and analysis of Kebzeh ideological and communal features. It sheds new light on the role of ethnicity and cultural heritage in immigrant societies in the context of the evolution of spirituality in Canada, a relatively unexplored milieu in comparison to the United States and Europe.

Development of a Thrombus Mimic in Abdominal Aortic Aneurysms

2007 ◽  
Author(s):  
John H. Ashton ◽  
Jonathan P. Vande Geest
Keyword(s):  
United States ◽  
Cause Of Death ◽  
Growth And Development ◽  
Abdominal Aortic Aneurysms ◽  
The United States ◽  
Aortic Aneurysms ◽  
Western World ◽  
Abdominal Aortic ◽  
Significant Disease

Abdominal aortic aneurysms (AAAs) represent a significant disease in the western world as rupture of AAA is currently the 15th leading cause of death in the United States [1,2]. The rate of incidence of this disease is also thought to be increasing given the aging population. While AAA rupture is attributed to the gradual weakening of the wall, the mechanisms of aneurysm initiation, growth, and development remain relatively unclear. The role of biomechanics in the diagnosis and prevention of AAA rupture has been reported [3].

scholarly journals Review of Hyperuricemia as New Marker for Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Laura Billiet ◽  
Sarah Doaty ◽  
James D. Katz ◽  
Manuel T. Velasquez
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Lupus Erythematosus ◽  
Large Body ◽  
Epidemiologic Studies ◽  
Etiologic Factor ◽  
Systemic Diseases ◽  
Systemic Lupus ◽  
The Metabolic Syndrome

Hyperuricemia has long been established as the major etiologic factor in gout. In recent years, a large body of evidence has accumulated that suggests that hyperuricemia may play a role in the development and pathogenesis of a number of metabolic, hemodynamic, and systemic pathologic diseases, including metabolic syndrome, hypertension, stroke, and atherosclerosis. A number of epidemiologic studies have linked hyperuricemia with each of these disorders. In some studies, therapies that lower uric acid may prevent or improve certain components of the metabolic syndrome. There is an association between uric acid and the development of systemic lupus erythematosus; the connection between other rheumatic diseases such as rheumatoid arthritis and osteoarthritis is less clear. The mechanism for the role of uric acid in disorders other than gout is not well established but recent investigations point towards systemic inflammation induced by urate, as the major pathophysiological event common to systemic diseases, including atherosclerosis.

The Transplanted: International Dimensions

1988 ◽  
Vol 12 (3) ◽  
pp. 255-263
Author(s):  
Dirk Hoerder
Keyword(s):  
The United States ◽  
Community Formation ◽  
Lively Discussion ◽  
East European ◽  
New Methods ◽  
History Of ◽  
The 1960S ◽  
History Of Migration ◽  
Culture Of Origin

John Bodnar’s Study—which I consider “the standard survey on the history of migration to the United States, which for many years will remain unsurpassed” (Hoerder, 1987)—also merits a controversial and lively discussion. A synthesis of the immigrant experience has long been called for. Beginning in the 1960s, Rudolph J. Vecoli’s penetrating critique (1964) and Victor Greene’s detailed study of east European miners (1968) dismantled Oscar Handlin’s paradigm (1951). The two decades since the end of the old paradigm witnessed the introduction of new methods, new approaches, and a new sensitivity to the roots of the migrants in their old cultures. I will first place Bodnar’s study in the context of two other recent syntheses and then raise some conceptual questions; in a third section I will take up issues related to the culture of origin and to the role of female migrants in community formation.

Sign in / Sign up

Export Citation Format

Share Document