scholarly journals Vestibular paroxysmia in vestibular neuritis: A case report

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Michele Ori ◽  
Valeria Gambacorta ◽  
Giampietro Ricci ◽  
Mario Faralli

The term vestibular paroxysmia (VP) was introduced for the first time by Brandt and Dieterich in 1994. In 2016, the Barany Society formulated the International Classification of VP, focusing in particular on the number and duration of attacks, on the differential diagnosis and on the therapy. Ephaptic discharges in the proximal part of the eighth cranial nerve, which is covered by oligodendrocytes, are assumed to be the neural basis of VP. We report the first case in literature of an onset of symptoms and signs typical of VP in a young man following acute unilateral vestibular loss not combined with auditory symptoms. Indeed, the pathogenic mechanism affected only the vestibular nerve as confirmed by the presence of a stereotyped nystagmus pattern. The magnetic resonance imaging didn’t reveal any specific cause therefore we suggest the possible role of a neuritis triggering an ephaptic discharge as the neural mechanism of VP.

2021 ◽  
Vol 13 (3-2) ◽  
pp. 410-425
Author(s):  
Denis Ignatyev ◽  
◽  
Anastasia Nikiforova ◽  

The article is devoted to the study of the problem of alienation of culture in a modern museum and the processes of actualization of objects and phenomena of history in the space of the paramuseum. In the center of the author’s attention is the theme of creating the illusion of existential comfort. It explores the contradiction between the need for museification of culture in order for a modern person to be able to appeal to it when building one’s own identity, and the constant desire to place the culture of the past on a safe reservation. The issue of aestheticization of cultural objects in the museum space and the role of a museum in interpreting, preserving and distorting their meaning is raised. The museum, created as a repository of antiquities, a collection of masterpieces, today has become the most sensitive system that responds to changes in the life of culture and society. An axiological analysis of modern museums shows their growing popularity as an element of the entertainment industry, while their aesthetic, analytical, and intellectual role is becoming obscure. Respect for the museum as a keeper of cultural memory, for the focus of scientific life is disappearing. Instead, a simplified “attraction museum” and paramuseum is coming to the fore, creating endless games with historical objects, reconstructions, visitors and interpretations of the events of history and culture. The authors of the article are among the first to turn to the concept of “paramuseum” and give it a comprehensive assessment. For the first time, a scientific classification of paramuseums (on the example of paramuseums of northwestern Russia) is proposed. Their main features and characteristics are identified. A synergistic approach to the processes of actualization and alienation of cultural objects in the museum environment made it possible to include the viewer, the recipient, as the third, necessary component of this system. This made it possible to conclude that museum values are alienated or updated not by themselves, but only in relation to the “person watching.” Thus, modern museums and paramuseums are a form of value-based self-consciousness of society, demonstrating the total stratification of post-culture society, its fragmentation into value clusters that can represent culture as a whole only in the process of analytical consciousness, but not in the collection of subject series.


Author(s):  
Ross Purves ◽  
Alistair Edwardes ◽  
Jo Wood

Geographically referenced user generated content provides us with an opportunity to, for the first time, gather perspectives on place over large areas by exploring how very many people describe information. We present a framework for analysing large collections of user generated content. This involves classification of descriptive terms attached by users to photographs into facets of elements, qualities, and activities. We apply this framework to two contrasting photographic archives — Flickr and Geograph, representing weakly and strongly moderated content respectively. We propose a method for removing user-generated bias from such collections though the user of term profiles that can assess the effect of the most and least prolific contributors to a collection. Analysis and visualization of co–occurrence between terms suggests clear differences in the description of place between the two collections, both in terms of the facets used and their geographical footprints. This is attributed to the role of moderation/editorialising of content; to the role tags and free–text has on descriptive behaviour and on the geographic footprint of content supplied to the two collections.


Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6725
Author(s):  
Paulina Czaplewska ◽  
Aleksandra E. Bogucka ◽  
Natalia Musiał ◽  
Dmitry Tretiakow ◽  
Andrzej Skorek ◽  
...  

Our studies aimed to explore the protein components of the matrix of human submandibular gland sialoliths. A qualitative analysis was carried out based on the filter aided sample preparation (FASP) methodology. In the protein extraction process, we evaluated the applicability of the standard demineralization step and the use of a lysis buffer containing sodium dodecyl sulfate (SDS) and dithiothreitol (DTT). The analysis of fragmentation spectra based on the human database allowed for the identification of 254 human proteins present in the deposits. In addition, the use of multi-round search in the PEAKS Studio program against the bacterial base allowed for the identification of 393 proteins of bacterial origin present in the extract obtained from sialolith, which so far has not been carried out for this biological material. Furthermore, we successfully applied the SWATH methodology, allowing for a relative quantitative analysis of human proteins present in deposits. The obtained results correlate with the classification of sialoliths proposed by Tretiakow. The performed functional analysis allowed for the first time the selection of proteins, the levels of which differ between the tested samples, which may suggest the role of these proteins in the calcification process in different types of sialoliths. These are preliminary studies, and drawing specific conclusions requires research on a larger group, but it provides us the basis for the continuation of the work that has already begun.


2021 ◽  
Vol 12 (4) ◽  
pp. 263-277
Author(s):  
Iryna Brushnevska ◽  
Julia Ribtsun ◽  
Liudmyla Stasiuk ◽  
Nataliia Ilina ◽  
Iryna Vasylehko ◽  
...  

The article addresses psycholinguistic preconditions for development of the communicative component of speech activity in 5-year-olds with general speech retardation (GSR). The development of speech activity is analyzed through the lens of psycholinguistic motivation for the emergence of speech units. The authors for the first time identified psychological mechanisms that underlie disorders in the development of the communication component of speech activity in 5-year-olds with GSR and suggested effective interventions. The research involved a study of probability prediction within the structure of the communicative component of speech activity of 5-year-olds with GSR. The author-developed classification of non-verbal and verbal probability prediction formed the basis for a theory-based diagnostic tool to assess the communicative component of speech activity in 5-year-olds with GSR. The research demonstrated the importance of probability prediction as a dynamic process and indicator of practical realization of utterance and holistically developed coherent speech. The analysis of disorders in cognitive and speech operations and functions identified in the study points to the dominant role of weak probability prediction function at non-verbal and verbal levels. Weak probability prediction was defined as the cause of poorly developed communication component of speech activity in 5-year-olds with GSR.


2021 ◽  
Author(s):  
Junyeon Won ◽  
Daniel D. Callow ◽  
Jeremy J. Purcell ◽  
J. Carson Smith

Abstract Introduction: The relationship between gait speed and working memory is well-understood in older adults. However, it remains to be determined whether this relationship also exists in younger adults; and there is little known regarding the possible neural mechanism underlying the association between gait speed and working memory. The aims of this study are to determine if there is: 1) an association between gait speed and working memory performance; and 2) a mediating role of cerebellar subregion volume in the correlation between gait speed and working memory in healthy younger adults.Methods: 1054 younger adults (28.7±3.6 years) from the Human Connectome Project were included in the analyses. A four-meter gait test was used to assess gait speed. The N-back task was conducted to measure working memory performance [accuracy and response time(RT)]. T1-weighted structural MRI data (obtained using Siemens 3T MRI scanner) was used to assess cerebellar subregion volumes. Linear regression and mediation analysis were used to examine the relationships between the variables after controlling for age, sex, and education. Results: Faster gait speed was associated with faster working memory RT in younger adults. Greater cerebellar subregion volumes were associated with faster gait speed and better working memory performance. Faster gait speed was correlated with faster working memory RT through greater volume of cerebellar region VIIIa. Conclusions: The present study suggests faster gait speed is associated with faster RT during working memory tasks in younger individuals. The specific subregion of the cerebellum (VIIIa) may serve as an important neural basis linking gait speed and working memory.


2020 ◽  
Author(s):  
Yunzhe Liu ◽  
Marcelo G. Mattar ◽  
Timothy E J Behrens ◽  
Nathaniel D. Daw ◽  
Raymond J Dolan

AbstractTo make effective decisions we need to consider the relationship between actions and outcomes. They are, however, often separated by time and space. The biological mechanism capable of spanning those gaps remains unknown. One promising, albeit hypothetical, mechanism involves neural replay of non-local experience. Using a novel task, that segregates direct from indirect learning, combined with magnetoencephalography (MEG), we tested the role of neural replay in non-local learning in humans. Following reward receipt, we found significant backward replay of non-local experience, with a 160 msec state-to-state time lag, and this replay facilitated learning of action values. This backward replay, combined with behavioural evidence of non-local learning, was more pronounced in experiences that were of greater benefit for future behavior, as predicted by theories of prioritization. These findings establish rationally targeted non-local replay as a neural mechanism for solving complex credit assignment problems during learning.One Sentence SummaryReverse sequential replay is found, for the first time, to support non-local reinforcement learning in humans and is prioritized according to utility.


Author(s):  
Раис Бурганов ◽  
Rais Burganov

The status of the issue: A survey of studies shows that the problems of information asymmetry in terms of the energy theory of economics have not been considered at all. Materials and methods of research are based on the use of abstraction, generalization and systematization of the data obtained. Results: The study is devoted to the consideration of theoretical and methodological aspects of the study of manifestations of asymmetric information in energy consumption in conditions of transition to the digitalization of the economy. For the first time the author has paid attention to such issues of the topic as the essence of information asymmetry in energy consumption; classification of information asymmetry in energy consumption, the problems of finding the balance of information asymmetry, the role of information asymmetry in energy productivity, energy intensity of products and energy efficiency; state participation in the regulation of information asymmetry in energy consumption. Conclusions are important to take into account the asymmetry of information in energy consumption in the transition to a digital economy.


2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Laure Buhry ◽  
Amir H. Azizi ◽  
Sen Cheng

Sequential activation of neurons that occurs during “offline” states, such as sleep or awake rest, is correlated with neural sequences recorded during preceding exploration phases. This so-calledreactivation, orreplay, has been observed in a number of different brain regions such as the striatum, prefrontal cortex, primary visual cortex and, most prominently, the hippocampus. Reactivation largely co-occurs together with hippocampal sharp-waves/ripples, brief high-frequency bursts in the local field potential. Here, we first review the mounting evidence for the hypothesis that reactivation is the neural mechanism for memory consolidation during sleep. We then discuss recent results that suggest that offline sequential activity in the waking state might not be simple repetitions of previously experienced sequences. Some offline sequential activity occurs before animals are exposed to a novel environment for the first time, and some sequences activated offline correspond to trajectories never experienced by the animal. We propose a conceptual framework for the dynamics of offline sequential activity that can parsimoniously describe a broad spectrum of experimental results. These results point to a potentially broader role of offline sequential activity in cognitive functions such as maintenance of spatial representation, learning, or planning.


2021 ◽  
Vol 17 (3) ◽  
Author(s):  
F. Espigares ◽  
D. Abad-Tortosa ◽  
S. A. M. Varela ◽  
M. G. Ferreira ◽  
R. F. Oliveira

The role of telomerase reverse transcriptase has been widely investigated in the contexts of ageing and age-related diseases. Interestingly, decreased telomerase activities (and accelerated telomere shortening) have also been reported in patients with emotion-related disorders, opening the possibility for subjective appraisal of stressful stimuli playing a key role in stress-driven telomere shortening. In fact, patients showing a pessimistic judgement bias have shorter telomeres. However, in humans the evidence for this is correlational and the causal directionality between pessimism and telomere shortening has not been established experimentally yet. We have developed and validated a judgement bias experimental paradigm to measure subjective evaluations of ambiguous stimuli in zebrafish. This behavioural assay allows classification of individuals in an optimistic–pessimistic dimension (i.e. from individuals that consistently evaluate ambiguous stimuli as negative to others that perceive them as positive). Using this behavioural paradigm we found that telomerase-deficient zebrafish ( tert − / − ) were more pessimistic in response to ambiguous stimuli than wild-type zebrafish. The fact that individuals with constitutive shorter telomeres have pessimistic behaviours demonstrates for the first time in a vertebrate model a genetic basis of judgement bias.


2019 ◽  
Vol 43 (3) ◽  
pp. 179-191
Author(s):  
Ö. Ece Demir-Lira ◽  
Macarena Suárez-Pellicioni ◽  
John V. Binzak ◽  
James R. Booth

Attitudes toward math (ATM) predict math achievement. Negative ATM are associated with avoidance of math content, while positive ATM are associated with exerting more effort on math tasks. Recent literature highlights the importance of considering interactions between ATM and math skill in examining relations to achievement. This study investigated, for the first time, the effects of the interaction between math skill and ATM on the neurocognitive basis of arithmetic processing. We examined the effect of this interaction using a single-digit multiplication task in 9- to 12-year-old children. Results showed that higher math skill was correlated with less activation in the left inferior frontal gyrus (IFG), and positive ATM were correlated with less activation in the left IFG. The relation between ATM and the neural basis of multiplication varied depending on math skill. Only among children with lower math skill, positive ATM were associated with greater activation of the left IFG. The results suggest that positive ATM in low-skill children might encourage them to more fully engage the neurocognitive systems underlying controlled effort and retrieval of multiplication facts. Our results highlight the importance of examining the role of both attitudinal and cognitive factors on the neural basis of arithmetic development.


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