Prevalence of multi-drug resistant bacteria associated with foods and drinks in Nigeria (2015-2020): A systematic review

Foods are essential vehicles in human exposure to antibiotic resistant bacteria which serve as reservoirs for resistance genes and a rising food safety concern. Antimicrobial resistance, including multidrug resistance (MDR), is an increasing problem globally and poses a serious concern to human health. This study was designed to synthesize data regarding the prevalence of MDR bacteria associated with foods and drinks sold within Nigeria in order to contribute to the existing findings in this area. A comprehensive literature search on the prevalence of multi-drug resistant bacteria associated with foods and drinks in Nigeria from 2015 to 2020 was conducted using three databases; PubMed, Science Direct and Scopus. After screening and selection, 26 out of 82 articles were used for the qualitative data synthesis. Of the total of one thousand three hundred and twenty-six MDR bacteria reportedly isolated in all twenty-six articles, the highest prevalence (660) was observed in drinks, including water, while the lowest (20) was observed in the article which combined results for both protein and vegetable-based foods. Escherichia sp. had the most frequency of occurrence, appearing as MDR bacteria in ten out of the twenty-six articles. Salmonella sp. appeared as MDR in seven out of the twenty-six articles included in this study, in all seven articles where it was reported, it had the highest percentage (85.4%) prevalence as MDR bacteria. Public health personnel need to ensure critical control during the production and handling of foods and drinks, as well as create more awareness on proper hygienic practices to combat the spread of MDR bacteria.

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Nanoparticles Functionalized with Ampicillin Destroy Multiple-Antibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus

Applied and Environmental Microbiology ◽

10.1128/aem.06513-11 ◽

2012 ◽

Vol 78 (8) ◽

pp. 2768-2774 ◽

Cited By ~ 187

Author(s):

Ashley N. Brown ◽

Kathryn Smith ◽

Tova A. Samuels ◽

Jiangrui Lu ◽

Sherine O. Obare ◽

...

Keyword(s):

Methicillin Resistant Staphylococcus Aureus ◽

Enterobacter Aerogenes ◽

Resistance Mechanisms ◽

Resistant Bacteria ◽

Multiple Drug ◽

Drug Resistant ◽

Antibiotic Resistant ◽

Gram Positive Bacteria ◽

Drug Resistant Bacteria ◽

Multiple Drug Resistant

ABSTRACTWe show here that silver nanoparticles (AgNP) were intrinsically antibacterial, whereas gold nanoparticles (AuNP) were antimicrobial only when ampicillin was bound to their surfaces. Both AuNP and AgNP functionalized with ampicillin were effective broad-spectrum bactericides against Gram-negative and Gram-positive bacteria. Most importantly, when AuNP and AgNP were functionalized with ampicillin they became potent bactericidal agents with unique properties that subverted antibiotic resistance mechanisms of multiple-drug-resistant bacteria.

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Tea: An anti-bacterial agent against drug resistant bacteria

10.53350/pjmhs2115102506 ◽

2021 ◽

Vol 15 (10) ◽

pp. 2506-2511

Author(s):

Nayyab Sultan ◽

Sabahat Javaid Butt ◽

Wajeeha Mehak ◽

Samreen Qureshi ◽

Syed Hamza Abbas ◽

...

Keyword(s):

Bacterial Infections ◽

Salmonella Typhi ◽

Multidrug Resistant ◽

Resistant Bacteria ◽

Klebsiella Pneumonia ◽

Drug Resistant ◽

Antibiotic Resistant ◽

Bacterial Agent ◽

Drug Resistant Bacteria ◽

Scientific World

Antibiotics have played a crucial role in the treatment of bacterial infections. Past few decades are marked with advancement of multidrug resistant (MDR) pathogens, which have endangered antibiotic’s therapeutic efficacy. Scientific world is now struggling with the crisis of MDR pathogens. This supreme matter demands careful attention or otherwise it would jeopardize clinical management of infectious diseases. Implication of alternative approaches can pave a new way in the treatment of these troublesome bacteria. Tea leaves are known to pose antibacterial activity against many pathogenic microorganisms. This review has summarized the antibacterial potential of tea leave’s extracts against resistant bacterial pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, Helicobacter pylori, Escherichia coli, Klebsiella pneumonia, Salmonella typhi, Acenitobacter spp, Campylobacter spp. Consumption of natural products such as tea may very well replace, minimize or obliterate this complicated situation. Keywords: Anti-bacterial, Tea, Camellia sinensis, Drug resistant bacteria, Antibiotic resistant bacteria, Synergism, Polyphenols.

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Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01337-20 ◽

2020 ◽

Vol 64 (12) ◽

Author(s):

Jitender Yadav ◽

Sana Ismaeel ◽

Ayub Qadri

Keyword(s):

Antibacterial Activity ◽

Polymyxin B ◽

Resistant Bacteria ◽

Bacterial Membrane ◽

Gram Negative Bacteria ◽

Drug Resistant ◽

Antibiotic Resistant ◽

Gram Negative ◽

Drug Resistant Bacteria

ABSTRACT Polymyxin B, used to treat infections caused by antibiotic-resistant Gram-negative bacteria, produces nephrotoxicity at its current dosage. We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of Salmonella and at least two other Gram-negative bacteria in vitro. This combination makes bacterial membrane porous and causes degradation of DnaK, the regulator of protein folding. Polymyxin B-LPC combination may be an effective and safer regimen against drug-resistant bacteria.

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Ultrastable radical-doped coordination compounds with antimicrobial activity against antibiotic-resistant bacteria

Chemical Communications ◽

10.1039/d0cc06379g ◽

2020 ◽

Vol 56 (92) ◽

pp. 14353-14356

Author(s):

Hua Ke ◽

Fen Hu ◽

Lingyi Meng ◽

Qi-Hua Chen ◽

Qian-Sheng Lai ◽

...

Keyword(s):

Antimicrobial Activity ◽

Broad Spectrum ◽

Coordination Compounds ◽

Lone Pair ◽

Resistant Bacteria ◽

Drug Resistant ◽

Antibiotic Resistant Bacteria ◽

Antibiotic Resistant ◽

Π Interactions ◽

Drug Resistant Bacteria

Radical-doped coordination compounds—generated as a result of lone pair–π interactions and having a long-lived charge-separated state—display photochromism and broad-spectrum antimicrobial activity, even against multi-drug-resistant bacteria.

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Wild Australian birds and drug-resistant bacteria: characterisation of antibiotic-resistant Escherichia coli and Enterococcus spp

Emu - Austral Ornithology ◽

10.1080/01584197.2019.1591162 ◽

2019 ◽

Vol 119 (4) ◽

pp. 384-390

Author(s):

Hannah G. Smith ◽

Rohan H. Clarke ◽

Jo-Ann Larkins ◽

David C. Bean ◽

Andrew R. Greenhill

Keyword(s):

Escherichia Coli ◽

Resistant Bacteria ◽

Drug Resistant ◽

Antibiotic Resistant ◽

Drug Resistant Bacteria ◽

Australian Birds ◽

Enterococcus Spp

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Exogenous Citrulline and Glutamine Contribute to Reverse the Resistance of Salmonella to Apramycin

Frontiers in Microbiology ◽

10.3389/fmicb.2021.759170 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yan Yong ◽

Yanhong Zhou ◽

Kexin Liu ◽

Guochang Liu ◽

Liqin Wu ◽

...

Keyword(s):

Bacterial Resistance ◽

Tricarboxylic Acid Cycle ◽

Animal Health ◽

Resistant Bacteria ◽

Drug Resistant ◽

Bacterial Cells ◽

Antibiotic Resistant Bacteria ◽

Antibiotic Resistant ◽

Drug Resistant Bacteria

Antibiotic resistance is an increasing concern for human and animal health worldwide. Recently, the concept of reverting bacterial resistance by changing the metabolic state of antibiotic-resistant bacteria has emerged. In this study, we investigated the reversal of Apramycin resistance in Salmonella. First, non-targeted metabonomics were used to identify key differential metabolites of drug-resistant bacteria. Then, the reversal effect of exogenous substances was verified in vivo and in vitro. Finally, the underlying mechanism was studied. The results showed that the metabolites citrulline and glutamine were significantly reduced in Apramycin-resistant Salmonella. When citrulline and glutamine were added to the culture medium of drug-resistant Salmonella, the killing effect of Apramycin was restored markedly. Mechanistic studies showed that citrulline and glutamine promoted the Tricarboxylic acid cycle, produced more NADH in the bacteria, and increased the proton-motive force, thus promoting Apramycin entry into the bacterial cells, and killing the drug-resistant bacteria. This study provides a useful method to manage infections by antibiotic-resistant bacteria.

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Antibody-Recruiting Protein-Catalyzed Capture Agents to Combat Antibiotic-Resistant Bacteria

10.1101/822346 ◽

2019 ◽

Author(s):

Matthew N. Idso ◽

Ajay Suresh Akhade ◽

Mario L. Arrieta-Ortiz ◽

Bert T. Lai ◽

Vivek Srinivas ◽

...

Keyword(s):

Rapid Development ◽

Bacterial Species ◽

Surface Protein ◽

Resistant Bacteria ◽

Synthetic Approach ◽

Drug Resistant ◽

Antibiotic Resistant ◽

Drug Resistant Bacteria ◽

New Antibiotics ◽

Drug Resistant Strains

AbstractAntibiotic resistant infections are projected to cause over 10 million deaths by 2050, yet the development of new antibiotics has slowed. This points to an urgent need for methodologies for the rapid development of antibiotics against emerging drug resistant pathogens. We report on a generalizable combined computational and synthetic approach, called antibody-recruiting protein-catalyzed capture agents (AR-PCCs), to address this challenge. We applied the combinatorial PCC technology to identify macrocyclic peptide ligands against highly conserved surface protein epitopes of carbapenem-resistant Klebsiella pneumoniae, an opportunistic gram-negative pathogen with drug resistant strains. Multi-omic data combined with bioinformatic analyses identified epitopes of the highly expressed MrkA surface protein of K. pneumoniae for targeting in PCC screens. The top-performing ligand exhibited high-affinity (EC50∼50 nM) to full-length MrkA, and selectively bound to MrkA-expressing K. pneumoniae, but not to other pathogenic bacterial species. AR-PCCs conjugated with immunogens promoted antibody recruitment to K. pneumoniae, leading to phagocytosis and phagocytic killing by macrophages. The rapid development of this highly targeted antibiotic implies that the integrated computational and synthetic toolkit described here can be used for the accelerated production of antibiotics against drug resistant bacteria.

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