Low body mass index in long standing rheumatoid arthritis: relation to RA disease activity and functional indices

The aim of the work was to study the relationship between the body mass index (BMI) in longstanding rheumatoid arthritis (RA) and RA disease activity and functional indices. This study included 105 RA patients. For all patients, we recorded the presence of erosions on radiographs, the presence of subcutaneous nodules (SCN), the 28-tender joint count (TJC), 28-swollen joint count (SJC) scores, the visual analogue scale (VAS), physicians’ global assessments (PhGA), the erythrocyte sedimentation rate (ESR), and the rheumatoid factor (RF). The disease activity index (DAS28) and BMI were calculated and current treatment was recorded. Patients were divided into two groups: group I: BMI 25. Group I included 32 (30.5%) patients, whereas group II included 73 (69.5%) patients. There were statistically significant differences between the two groups regarding each of the following: SJC (p=0.006), erosions (p=0.006), DAS28 (p=0.016) and PhGA (p=0.007). All were higher in group I (underweight and normal) than in group II (overweight and obese). No statistically significant differences emerged regarding age (p=0.11), smoking (p=0.69), disease duration (p=0.46), TJC (p=0.14), SCN (p=1.00), HAQ (p=0.26), VAS (p=0.16), ESR (p=0.25), RF (p=0.54) and steroid cumulative dose (p=0.08). Low BMI in longstanding RA patients may indicate more active and erosive disease and it may be considered as a poor prognostic factor.

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Study on the relationship between menopausal age, body mass index and total number of teeth

Romanian Journal of Stomatology ◽

10.37897/rjs.2021.1.5 ◽

2021 ◽

Vol 67 (1) ◽

pp. 29-34

Author(s):

Ioana Madalina Lescai ◽

◽

Laurenta Lelia Mihai ◽

Monica Mihaela Cirstoiu ◽

◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

The Body ◽

Entire Group ◽

Number Of Teeth ◽

Group I ◽

Average Body Mass ◽

Group Ii ◽

The Relationship ◽

Average Body

Objectives. The objective of this study is to assess the state of oral health, from the perspective of the number of teeth present, according to the body mass index as a representative element of health. Materials and methods. This study consists of 180 patients from a private dental practice. All 180 patient records were reviewed for an assessment of the number of teeth present and the body mass index at menopausal age. The cohort of patients was divided into two groups, a group of women aged 40 to 54.9 years and the second group, which included women aged 55 and over. The 2 groups were divided based on premenopausal (group I) and postmenopausal (group II) age. Results. The average number of present teeth (based on radiographs) for the entire population of 180 patients is 22.02 teeth. In group I, for the 109 women in the premenopausal group, the average number of teeth is 23.94. The total number of teeth for the 71 women in the postmenopausal group is 19.07. The average BMI for the entire group of patients is 27.24 kg/m2, with a lower value in group I, 26.25 kg/m2, compared to group II, 28.78 kg/m2. Discussions. The average number of teeth in the premenopausal group is higher than in the postmenopausal group. The average body mass index places the whole series of patients in the overweight category. Conclusions. This study shows that the relationship between BMI and the number of lost teeth is positive and proportional, BMI increases with increasing number of teeth lost at premenopausal age.

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Body Mass Index Impact on Disease Activity, Clinical and Sonographic Remission Rates in Patients with Rheumatoid Arthritis

Current Rheumatology Reviews ◽

10.2174/1573397115666181130143239 ◽

2019 ◽

Vol 15 (3) ◽

pp. 215-223

Author(s):

Tanya Sapundzhieva ◽

Rositsa Karalilova ◽

Anastas Batalov

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Disease Activity ◽

Body Mass ◽

Normal Weight ◽

Clinical Disease ◽

Clinical Disease Activity ◽

Das 28 ◽

Remission Rates ◽

Activity Indices

Aim: To investigate the impact of body mass index (BMI) on clinical disease activity indices and clinical and sonographic remission rates in patients with rheumatoid arthritis (RA). Patients and Methods: Sixty-three patients with RA were categorized according to BMI score into three groups: normal (BMI<25), overweight (BMI 25-30) and obese (BMI≥30). Thirty-three of them were treated with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), and 30 with biologic DMARDs (bDMARDs). Patients underwent clinical and laboratory assessment and musculoskeletal ultrasound examination (MSUS) at baseline and at 6 months after initiation of therapy. We evaluated the rate of clinical and sonographic remission (defined as Power Doppler score (PD) = 0) and its correlation with BMI score. Results: In the csDMARDs group, 60% of the normal weight patients reached DAS28 remission; 33.3% of the overweight; and 0% of the obese patients. In the bDMARDs group, the percentage of remission was as follows: 60% in the normal weight subgroup, 33.3% in the overweight; and 15.8% in the obese. Within the csDMARDs treatment group, two significant correlations were found: BMI score–DAS 28 at 6th month, rs = .372, p = .033; BMI score–DAS 28 categories, rs = .447, p = .014. Within the bDMARDs group, three significant correlations were identified: BMI score–PDUS at sixth month, rs = .506, p =.004; BMI score–DAS 28, rs = .511, p = .004; BMI score–DAS 28 categories, rs = .592, p = .001. Sonographic remission rates at 6 months were significantly higher in the normal BMI category in both treatment groups. Conclusion: BMI influences the treatment response, clinical disease activity indices and the rates of clinical and sonographic remission in patients with RA. Obesity and overweight are associated with lower remission rates regardless of the type of treatment.

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The clinical aspect of overweight on rheumatoid arthritis and disease activity

Journal of Biotechnology Research Center ◽

10.24126/jobrc.2019.13.2.576 ◽

2019 ◽

Vol 13 (2) ◽

pp. 10-16

Author(s):

Haitham Ahmed ◽

Tagreed A. Al-Sadoon ◽

Khudhair A. Khudhair

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Body Mass ◽

Acute Phase ◽

Acute Phase Response ◽

The Body ◽

Phase Response ◽

Fat Free Mass ◽

P Value ◽

Serological Tests

Objective: To investigate the influence of obesity on disease activity in rheumatoid arthritis patients and to determine a probable connection with the acute phase response. Materials and methods: The recruited patients satisfied the criteria from the American College of Rheumatology (ACR). To evaluate the body mass index (BMI), anthropometric tests were carried out at the Rheumatology Department at Baquba Teaching Hospital, which has a consultation unit. The serum levels of anti-cyclic citrullinated peptide antibodies (anti-CCP) were measured from blood samples taken through the particle-enhanced (latex) immunonephelometry assays on the genius analyser (CO, Ltd. China) and test kits from IMTEC-CCP-Antibodies. RF screen and serological tests (latex) were carried out to determine the C-reactive protein (CRP), measure Hb and the total WBCs count, the erythrocyte sedimentation rate (ESR) was also carried out. Results: The current study findings from the sample of RA patients showed that the proportion of patients falling into the overweight classification (BMI 25-29) was 80.6% while the obese classification (BMI 30-35) was 33.33%. Among the RF and ACCP-positive cases, a marginally stronger relationship between the development of RA and the history of obesity was found. Additionally, a significant correlation between acute phase response and free mass was found in RA patients (anti-CCP p-value≤ 0.00021 ESR p≤ 0.00072 Hb p≤ 0.00054, and W.B.C p =≤ 0.000.94, CRP p≤1). Conclusion: The present study’s findings show an elevated prevalence of high body mass among the RA patients. Furthermore, a linear association existed between the fat free mass and the acute phase response.

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AB0453 Response to TOCILIZUMAB in Rheumatoid Arthritis is not Influenced by the Body Mass Index of the Patient

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.1508 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 958.1-958 ◽

Cited By ~ 1

Author(s):

Y.-M. Pers ◽

M. Godfrin-Valnet ◽

J. Lambert ◽

C. Fortunet ◽

E. Constant ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Body Mass ◽

The Body

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AB0394 The Body Mass Index Predicts the Serum and Synovial Cartilage Oligomeric Matrix Protein Level in Early and Established Rheumatoid Arthritis Patients

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.6336 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 1025.1-1025

Author(s):

T.A. Gheita ◽

A. El Defrawy ◽

H. Raslan ◽

M. El Ansary ◽

A. El Awar

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Body Mass ◽

Protein Level ◽

Cartilage Oligomeric Matrix Protein ◽

Matrix Protein ◽

The Body ◽

Established Rheumatoid Arthritis

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SAT0054 The Body Mass Index and Its Influence on the Activity of Rheumatoid Arthritis: Results from the QUEST-RA Study Morocco.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-eular.1780 ◽

2013 ◽

Vol 72 (Suppl 3) ◽

pp. A598.1-A598

Author(s):

M. Ezzahri ◽

B. Amine ◽

N. Hajjaj-Hassouni ◽

B. Benchakroun ◽

L. Benbrahim ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Body Mass Index ◽

Body Mass ◽

The Body

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Pulmonary Function Test of Forced Vital Capacity and Slow Vital Capacity Using Spirometry in Young Adults With Respect to Body Mass Index: A Normative Study

Volume 5 - 2020, Issue 9 - September - International Journal of Innovative Science and Research Technology ◽

10.38124/ijisrt20aug608 ◽

2020 ◽

Vol 5 (8) ◽

pp. 1094-1111

Author(s):

Jyothy Anthraper ◽

Dr. Reeny Roy

Keyword(s):

Body Mass Index ◽

Pulmonary Function ◽

Body Mass ◽

Lung Volume ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Management Tool ◽

I 18 ◽

Group I ◽

Group Ii

Objectives: To determine the effect of Age, Gender and its correlation on pulmonary functions of Forced Vital Capacity and Slow Vital Capacity in Group I (18-24 years) and Group II (25-30 years) with respect to Body Mass Index.  Methodology: Sixty healthy adults between 18-30 years were included in the study. Participants were subdivided into Group I (18 to 24 years) and Group II (25 to 30 years) each group having 15 males and 15 females. The parameters considered were expiratory reserve volume, tidal volume, inspiratory capacity, forced vital capacity and slow vital capacity. Spirometer RMS HELIOS 401 was used. Procedures were explained to each participant; best values from 3 maneuvers were documented and were subjected to analysis.  Results: It is noticed a significant difference in various parameters of pulmonary function. As age increases there was an increase in body mass index and the lung volume also increased. Overall males had higher pulmonary function compared to females, males in Group II (25-30 years) was better compared to males in Group I (18-24 years). With an increase in body mass index, pulmonary function was increased in males compared to females. Age, gender, age, and gender interaction effect with respect to Body Mass Index was seen.  Conclusion: Values obtained can be used as reference standard for estimation of lung volume for age group 18-30 years. In future, Spirometry can be used as a clinical assessment and management tool in the field of speech language pathology, by modifying respiratory patterns to control lung volumes, phonations and the flow of speech.

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The functional state of the system of immunological protection in traumatic disease in patients with an increased body mass index

The Journal of V. N. Karazin Kharkiv National University, Series "Medicine" ◽

10.26565/2313-6693-2019-37-02 ◽

2019 ◽

Keyword(s):

Body Mass Index ◽

Multivariate Analysis ◽

Body Mass ◽

Functional State ◽

Adaptation Mechanism ◽

Group Iii ◽

Functional Relationships ◽

Group I ◽

Group Ii ◽

Immunological Protection

Introduction. An important reserve that provides adaptation processes in the immunoregulation system is the possibility of its various subsystems to redistribute structural and functional relationships between them. The approach from the perspective of systemic multivariate analysis will allow us to determine the main functional relationships that arise or are violated at different periods of traumatic disease in patients with an increased body mass index (IBMI) during polytrauma in the immune response as a whole. Aim. The aim of this study was to analyze the functional state of the immunological protection system for traumatic disease in patients with IBMI. Materials and methods The integral indicators of immunogenesis were determined using a systematic multivariate analysis on the basis of a dynamic study of 1344 complex immunograms in 224 patients with IBMI with polytrauma and a different initial value of BMI. Patients were divided into 3 groups: group I - 88 patients with BMI of up to 29.9 (26.1 ± 3.1); group II - 84 patients with BMI of up to 30.0 - 39.9 (35.2 ± 3.8 ), group III - 52 patients with BMI > 40.0 (46.2 ± 5.8). The study was conducted on the 1st, 3rd, 7th, 14th, 30th and 360th days from the moment of receiving a polytrauma. Results. In the functional state of the immune system as a whole, certain regularities were identified in patients with IBMI with polytrauma: impairment of immunoreactive processes was prolonged for 1 year or more from the time of polytrauma, regardless of BMI, their nature is regular and unidirectional, have periods of decline and increase in activity; the degree of damage, the ability of compensatory possibilities and the ability to restore them depending on BMI, since the initial deviations of the integral indicator are almost identical in all groups of patients; the immune mechanisms at all times are most determined by the state of the cell link and complement system for patients of I and III groups. Moreover, the development mechanism of secondary post-traumatic immunodeficiency, which is associated with the inclusion of extended T-suppression and a decrease in IgA concentration for more than 14 days, depends on BMI; a clear cooperation of cellular and humoral relationships, which is aimed at compensating for its consequences, was determined in patients of group II as well as active participation in the immune reactions of HLA-DR + lymphocytes as a delicate adaptation mechanism. The development of functional instability of the system occurred mainly due to the T-cell link a year after the case of polytrauma. Conclusion. Our analysis made it possible to prove objectively on mathematical models that traumatic disease is a long process. Clinical and pathogenetic aspects of immune disorders are beyond question and provide the basis for the application of the proposed treatment algorithms and changes in stereotypes regarding the treatment approach as a whole.

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