scholarly journals Insulin Resistance: From Mechanisms to Therapeutic Strategies

2021 ◽  
Author(s):  
Shin-Hae Lee ◽  
Shi-Young Park ◽  
Cheol Soo Choi
Keyword(s):  
Insulin Resistance ◽  
Therapeutic Strategies

scholarly journals The Adipokines in Cancer Cachexia

2020 ◽  
Vol 21 (14) ◽  
pp. 4860 ◽  
Author(s):  
Michele Mannelli ◽  
Tania Gamberi ◽  
Francesca Magherini ◽  
Tania Fiaschi
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Cancer Cachexia ◽  
Muscle Wasting ◽  
Therapeutic Strategies ◽  
Skeletal Muscle Wasting ◽  
Circulating Levels

Cachexia is a devastating pathology induced by several kinds of diseases, including cancer. The hallmark of cancer cachexia is an extended weight loss mainly due to skeletal muscle wasting and fat storage depletion from adipose tissue. The latter exerts key functions for the health of the whole organism, also through the secretion of several adipokines. These hormones induce a plethora of effects in target tissues, ranging from metabolic to differentiating ones. Conversely, the decrease of the circulating level of several adipokines positively correlates with insulin resistance, metabolic syndrome, diabetes, and cardiovascular disease. A lot of findings suggest that cancer cachexia is associated with changed secretion of adipokines by adipose tissue. In agreement, cachectic patients show often altered circulating levels of adipokines. This review reported the findings of adipokines (leptin, adiponectin, resistin, apelin, and visfatin) in cancer cachexia, highlighting that to study in-depth the involvement of these hormones in this pathology could lead to the development of new therapeutic strategies.

scholarly journals PATHOGENETIC ASPECTS OF THE PHENOTYPE OF BRONCHIAL ASTHMA ASSOCIATED WITH OBESITY

2019 ◽  
Vol 1 (71) ◽  
pp. 112-119
Author(s):  
А. Уксуменко ◽  
A. Uksumenko ◽  
Марина Антонюк ◽  
Marina Antonyuk
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Adipose Tissue ◽  
Gastroesophageal Reflux Disease ◽  
Respiratory Mechanics ◽  
Therapeutic Strategies ◽  
Obese Patients ◽  
Genetic Condition ◽  
Vitamin D Metabolism ◽  
Asthma Phenotype

Currently, in parallel with the increase in the prevalence of asthma, there is an increase in the number of obese patients. The results of numerous studies indicate that the asthma phenotype in combination with obesity has well-defined clinical features – a more severe course with frequent exacerbations and reduced control of the disease. The article considers the main pathogenetic mechanisms that determine the development of the asthma phenotype in combination with obesity. The influence of excess adipose tissue in the chest on respiratory mechanics, the correlation of gastroesophageal reflux disease and respiratory depression in sleep are described. It is shown that the phenotype of asthma with obesity is characterized by inflammation of adipose tissue, adipokine imbalance, insulin resistance, and disturbance of vitamin D metabolism. Gender peculiarities and genetic condition of asthma associated with obesity are considered. Understanding general mechanisms underlying the formation of asthma and obesity will undoubtedly contribute to the development of new therapeutic strategies.

scholarly journals Insulin Resistance Postburn: Underlying Mechanisms and Current Therapeutic Strategies

2008 ◽  
Vol 29 (5) ◽  
pp. 683-694 ◽  
Author(s):  
Gerd G. Gauglitz ◽  
David N. Herndon ◽  
Marc G. Jeschke
Keyword(s):  
Insulin Resistance ◽  
Therapeutic Strategies ◽  
Underlying Mechanisms

Effects and significance of estradiol in men

2014 ◽  
Vol 155 (23) ◽  
pp. 891-896 ◽  
Author(s):  
Judit Tőke ◽  
Gábor Czirják ◽  
Attila Bezzegh ◽  
Barna Vásárhelyi ◽  
Károly Rácz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Metabolic Disorders ◽  
Therapeutic Strategies ◽  
Cardiovascular Disorders ◽  
Androgen Deficiency ◽  
Men And Women ◽  
Estradiol Levels

The most important estrogen is estradiol in both men and women. In men elevated estradiol levels and associated metabolic disorders have been implicated in the development of common diseases including cardiovascular disorders, insulin resistance and type 2 diabetes mellitus, as increased estradiol associated with decreased testosterone levels increases the risk of these diseases. In this review the authors summarize the causes and consequences of androgen deficiency and estradiol excess, and they review recent studies on potential therapeutic strategies to correct increased estradiol levels in men. Orv. Hetil., 2014, 155(23), 891–896.

scholarly journals Insulin resistance: focus on the pathogenesis of cardiomyopathy

2020 ◽  
Vol 22 (10) ◽  
pp. 52-54
Author(s):  
Veronika N. Shishkova ◽  
◽  
Veronika N. Shishkova ◽  
Anatolii I. Martynov ◽  
◽  
...  
Keyword(s):  
Heart Failure ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Chronic Heart Failure ◽  
Developed Countries ◽  
Therapeutic Strategies ◽  
Lipid Lowering ◽  
Modern World ◽  
Unhealthy Lifestyle ◽  
Number Of Patients

Insulin resistance is the main link of pathogenesis of a lot of diseases, including cardiovascular diseases which are the leading cause of morbidity and mortality worldwide. The combination of insulin resistance – associated disorders, such as obesity, type 2 diabetes mellitus, arterial hypertension and hypertriglyceridemia, refers to metabolic syndrome. The increase in the number of patients with metabolic syndrome is due to a prevalence of unhealthy lifestyle and inappropriate di-etary pattern in the modern world, and is also partially associated with the trend of population aging in most developed countries. In this regard, it is necessary to emphasize the relevance of the link between insulin resistance and the development of a specific complication – metabolic cardiomyopathy. Given that the triggering event in pathogenesis of this cardiomyopathy is alterations in substrate balance with following accumulation of lipotoxic metabolites in cardiomyocytes, the term “lipotoxic cardiomyopathy” has been proposed. This cardiomyodystrophy is associated with myocardial hypertrophy and diastolic dysfunction, which thereafter result into chronic heart failure with a preserved ejection fraction. Although the link between the lipotoxic cardiomyodystrophy and insulin resistance–associated disorders is quite close, till now all therapeutic strategies involving only complex therapy with antidiabetic and lipid-lowering drugs have not led to a decrease in the risk for cardiomyopathy. There is a need in searching for effective therapeutic strategies to reduce the incidence of both lipotoxic cardiomyody-strophy and associated chronic heart failure.

Therapeutic Strategies for Insulin Resistance

2005 ◽  
pp. 535-560
Author(s):  
Harpal S. Randeva ◽  
Margaret Clarke ◽  
Sudhesh Kumar
Keyword(s):  
Insulin Resistance ◽  
Therapeutic Strategies

scholarly journals Metabolicheskiy sindrom kak protrombogennoei provospalitel'noe sostoyanie: vliyanieterapevticheskikh meropriyatiy

2009 ◽  
Vol 6 (4) ◽  
pp. 3-8
Author(s):  
M A Berkovskaya ◽  
S A Butrova
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Therapeutic Strategies ◽  
Review Article ◽  
Main Role ◽  
Positive Effects ◽  
Physical Exercises ◽  
Improve Insulin Resistance ◽  
Anti Inflammatory ◽  
Main Effects

The review article highlights the main effects of therapeutic strategies on proinflammatory and procoagulant abnormalities which accompany metabolic syndrome. The main role in correction of these abnormalities belongs to dietotherapy and physical exercises. Besides, sometimes it is appropriate to use drugs which improve insulin resistance - metformin and thiazolidinediones - as they display many other positive effects, such as anti-inflammatory and anticoagulant actions.

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