scholarly journals Gastro-intestinal Mycobacterium avium complex as a cause of anaemia

2010 ◽  
Vol 11 (2) ◽  
Author(s):  
Annemarie Van de Vyver ◽  
Adele Visser
Keyword(s):  
Chronic Disease ◽  
Mycobacterium Avium Complex ◽  
Blood Count ◽  
Clinical Case ◽  
Population Group ◽  
Common Finding ◽  
Full Blood Count ◽  
Hiv Positive ◽  
Anaemia Of Chronic Disease ◽  
Hiv Negative

Anaemia is a relatively common finding in HIV-positive patients, with rates (among females) as high as 37%, compared with their HIV negative counterparts (17%). Anaemia of chronic disease plays a very important role in this population group, and is estimated to occur in 18 - 95% of cases. For this reason, it is imperative to distinguish this condition from other underlying or concurrent causes of anaemia that may warrant treatment. This clinical case illustrates the value of critically evaluating the parameters of a full blood count and haematinic screen, to so determine which patients warrant further workup.

scholarly journals Optimising laboratory monitoring of chronic conditions in primary care: a quality improvement framework

2019 ◽  
Vol 8 (1) ◽  
pp. e000349 ◽  
Author(s):  
Darunee Whiting ◽  
Richard Croker ◽  
Jessica Watson ◽  
Andy Brogan ◽  
Alex J Walker ◽  
...  
Keyword(s):  
Primary Care ◽  
Quality Improvement ◽  
Chronic Disease ◽  
Liver Function ◽  
Chronic Conditions ◽  
Blood Count ◽  
Full Blood Count ◽  
Similar Amount ◽  
Blood Tests ◽  
Ordering Systems

Monitoring of chronic conditions accounts for a significant proportion of blood testing in UK primary care; not all of this is based on evidence or guidelines. National benchmarking shows significant variation in testing rates for common blood tests. This project set out to standardise the blood tests used for monitoring of chronic conditions in primary care across North Devon, and to measure and reduce the harms of unwarranted testing. Chronic disease test groups were developed in line with current guidelines and implemented using one-click electronic test ordering systems. The main difference from previous general practitioner practice algorithms was removing the requirement for full blood count and liver function test monitoring for many conditions. Baseline harms of testing were measured and included significant costs, workload and patient anxiety. By defining the scale of the problem, we were able to leverage change across several cycles of quality improvement, using a pathology optimisation forum for peer-led improvement, and developing a framework focusing on what matters to patients. Overall primary care testing rates in North Devon fell by 14% for full blood count testing and 22% for liver function tests, but without a reduction in the number of tests showing possible significant pathology. We estimate that this has reduced testing costs by £200 000 across a population of around 180 000 people and has reduced downstream referral costs by a similar amount. Introduction of simple chronic disease test groups into primary care electronic ordering systems, when used alongside engagement with clinicians, leads to both quality improvement and reduction in system costs.

scholarly journals Homocysteine Levels in Patients with Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome in Ibadan

2020 ◽  
Vol 7 (02) ◽  
pp. 4739-4745
Author(s):  
TOLULASE OLUTOGUN ◽  
FOLUKE FASOLA ◽  
Kehinde Olufemi-Aworinde ◽  
YETUNDE AKEN'OVA
Keyword(s):  
Risk Factors ◽  
Full Blood Count ◽  
Hiv Positive ◽  
Control Group ◽  
College Hospital ◽  
Cell Counts ◽  
Increased Risk ◽  
Objective Evidence ◽  
Cd4 Cell ◽  
Hiv Negative

Introduction: Homocysteine is produced from the conversion of methionine to cysteine. Conditions resulting in hyper homocysteinemia leads to an increased risk of both arterial and venous thromboembolisms by about 2 fold. 20% of HIV infected patients with objective evidence of venous thromboembolism are found to be thrombophilic with higher homocysteine levels. We enquired into homocysteine levels prior to the development of a clinical evidence of a venous thrombus in both HAART naïve and those on HAART of HIV /AIDS population. We evaluated the association between homocysteine, CD4 lymphocyte count and ART use in order to identify possible risk factors for hyper homocysteinemia in HIV population. Method: Employing a cross sectional design; we compared mean plasma levels of homocysteine, full blood count parameters and CD4+ lymphocytes counts in HIV positive patients and HIV negative controls. One hundred and twenty patients with HIV infection attending the APIN clinic at the University College Hospital Ibadan and St Mary’s Catholic Hospital Eleta Ibadan and one hundred and twenty-six HIV negative healthy controls were compared in the study. Results:  Fifty-nine point one percent of the HIV positive patient had hyperhomocysteinemia i.e. homocysteine levels of >18µmol/l. The mean plasma homocysteine levels were significantly higher at 24.4µmol/l (SD=13.8) (CI -2 to -8; p=0.002) in the HIV positive group compared with 19.5µmol/L (SD=10.6) in the control group.  The use of Anti-retroviral drugs was not associated with higher homocysteine level in the seropositive group and neither were factors like age, gender or the use of combined oral contraceptive pills. There was no correlation between CD4 cell count and homocysteine levels (r= -0.01; p=0.9). Conclusion:  Homocysteine levels are elevated in HIV positive patients and hyperhomocysteinemia was found in a significant number of HIV positive patients. None of the patients investigated had features of thromboembolism or outright deep venous thrombosis. Neither CD4 cell counts nor traditional risk factors were associated with the higher homocysteine levels.

scholarly journals Malaria parasite prevalence and Haematological parameters in HIV seropositive patients attending the regional hospital Limbe, Cameroon: a hospital-based cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Sorelle Mekachie Sandie ◽  
Irene Ule Ngole Sumbele ◽  
Martin Mih Tasah ◽  
Helen Kuokuo Kimbi
Keyword(s):  
Hiv Infection ◽  
Malaria Parasite ◽  
Venous Blood ◽  
Parasite Prevalence ◽  
Mean Value ◽  
Full Blood Count ◽  
Hiv Positive ◽  
Malaria Parasites ◽  
Cross Sectional ◽  
Hiv Negative

Abstract Background Malaria and the human immunodeficiency virus (HIV) infection constitute public health problems in Cameroon including the South West Region (SWR). This study determined the prevalence of malaria parasites and haematological abnormalities in HIV positive patients in Limbe, Cameroon from April–July 2014. Methods The study was cross-sectional and involved 411 participants who were administered structured questionnaires to record socio-demographic and clinical data. Three hundred and nine (309) HIV positive patients and one hundred and two (102) HIV negative individuals were examined clinically and venous blood collected for malaria parasite detection, HIV infection diagnosis and full blood count analysis. Results Overall malaria parasite prevalence was 14.1% (58/411). This prevalence was significantly higher (P <  0.001) in the HIV negative participants (33.3%, 34/102) compared to the HIV positive patients (7.8%, 24/309). Amongst HIV positive participants, malaria parasite prevalence was significantly higher in female patients (P = 0.003), febrile patients (P <  0.001), anaemic patients (P = 0.015) and in patients who were not on antiretroviral treatment (ART) (P = 0.03) when compared with their respective counterparts. Among the HIV negative group, though not significant, malaria parasite prevalence was higher in females, febrile and anaemic patients when compared with their respective counterparts. Overall anaemia prevalence was 52.1% (214/309) and was significantly higher (P = 0.004) in HIV positive patients (56%, 173) than in HIV negative participants (40.2%, 41). Malaria/HIV co-infected patients had a significantly lower mean value of Hb (P = 0.002), RBC (P = 0.002) and Hct (P = 0.001) when compared with HIV-infected patients. Conclusion HIV negative participants had a higher prevalence of malaria parasites than their HIV positive counterparts. Anaemia prevalence was higher in HIV positive patients than in HIV negative participants. Malaria/HIV co-infected patients presented with more red blood cell abnormalities than HIV-infected patients.

scholarly journals Haemoglobin and ferritin concentrations of pregnant women at term

2011 ◽  
Vol 4 (4) ◽  
pp. 152-155 ◽  
Author(s):  
A Adediran ◽  
A Gbadegesin ◽  
T A Adeyemo ◽  
A A Akinbami ◽  
A S Akanmu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Blood Count ◽  
Full Blood Count ◽  
Second Trimester ◽  
Mean Values ◽  
Iron Stores ◽  
The Mean ◽  
Anaemia In Pregnancy ◽  
In Pregnancy ◽  
Hiv Negative

Background Anaemia in pregnancy is defined as haemoglobin (Hb) concentrations of less than 11 g/dL while low ferritin is defined as serum ferritin (SR) levels of less than 10 µg/L. Hb and ferritin concentrations of pregnant women at term were determined to establish their mean values and to determine the prevalence of anaemia in our locality. Methods Haemoglobin and ferritin levels of 170 non-smoking and HIV-negative pregnant women were determined at term. The majority 143 of 170 (84.1%) of the pregnant women recruited for the study, booked at the beginning of the second trimester and received 200 mg elemental iron in three divided doses and 5 mg folic acid daily which were commenced at booking. Five millilitres of blood were collected from each patient at term into EDTA bottles for full blood count analysis and another 5 mL into plain bottles for SR assay. Results The mean Hb and ferritin values were 10.9 ± 1.9 and 47.84 ± 98.39 µg/L, respectively. The prevalence of anaemia at term was 46.4%. Only 11.2% (19 of 170) of pregnant women at term had low SR (iron stores). A statistically significant relationship was found between women's education and SR ( P = 0.032). Booking status also correlated directly with SR and haemoglobin concentrations, while increasing age and parity did not. Conclusion About half of the patients were anaemic. Iron deficiency is not the major cause of anaemia in pregnancy in this study because the majority of the pregnant women had normal iron stores. Education and booking status are possible factors that contribute to anaemia.

Incidence of Cytological Abnormalities in Pap's Smear in HIV Positive Women

2018 ◽  
Vol 2 (S1) ◽  
pp. e000136
Author(s):  
Suhana Jotva ◽  
Hemani Desai ◽  
Hansa Goswami
Keyword(s):  
Trichomonas Vaginalis ◽  
Clinical History ◽  
Hiv Positive ◽  
Squamous Intraepithelial Lesions ◽  
Squamous Cells ◽  
Medical College ◽  
Hiv Positive Women ◽  
Cytological Abnormalities ◽  
Intraepithelial Lesions ◽  
Hiv Negative

Aims and Objectives: The aim of present study is to estimate the frequency of abnormal PAP’s smears and mainly to detect precancerous and cancerous lesions as well as inflammatory lesions in HIV infected women. Methodology: Our study was a retrospective study of total 130 cases and PAP’s smears were examined in cytology section in Department of Pathology, BJ Medical College, Ahmedabad from 1st March 2017 to 31st August 2017. Both HIV positive and HIV negative patients were included in the study. 80 patients were HIV negative and 50 patients were HIV positive. The clinical history and relevant parameters were noted. All the smears were processed by a conventional method using Papanicolaou stain.  Results: Out of 130 cases, 118 cases were reported negative for intraepithelial lesions or malignancy (NILM). Five cases were positive for squamous intraepithelial lesions (SIL) out of which four were HIV positive. Seven cases were of atypical squamous cells of undetermined significance (ASCUS) out of which 5 were HIV positive. Three cases were showing bacterial vaginosis. 1 case was showing Trichomonas Vaginalis. 19 cases were showing changes of non-specific inflammation. 6 cases were showing atrophic changes.  Conclusion: HIV infected women are at more risk to develop cervical cytological abnormalities. The study revealed a maximum number of non-specific inflammatory smears followed by smears showing atrophic changes. Smears suspicious for malignancy (ASCUS) and smears showing squamous intraepithelial lesions (SIL) were more common in HIV positive patients. Thus regular PAP’s smears screening as recommended by National AIDS Control Organization (NACO) will help in early detection of cervical abnormalities in HIV positive women. 

Bacteriological profile in CSOM (TT) - HIV positive versus HIV negative patients

2019 ◽  
Vol 9 (2) ◽  
pp. 70-72
Author(s):  
Satish Bagewadi ◽  
◽  
Umadevi Angadi ◽  
Roopali Shinde ◽  
◽  
...  
Keyword(s):  
Hiv Positive ◽  
Bacteriological Profile ◽  
Hiv Negative
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