Correlation of skin changes with hormonal changes in polycystic ovarian syndrome: A cross-sectional study clinical study

Abstract Background Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy among young women. Insulin resistance is a key feature in the pathogenesis of PCOS; also high molecular weight adiponectin is a marker of insulin resistance. The aim of this study was to evaluate the insulin resistance, metabolic and androgenic profiles and high molecular weight adiponectin in obese and non-obese PCOS patients. Methods In this cross-sectional study in outpatient endocrinology clinics of Shiraz University of Medical Sciences, 80 women aged 17–43 years old with PCOS were enrolled. Biochemical and hormonal assay was done on fasting blood sample on the third day of follicular phase. Results The individuals had a mean age of 28.39 ± 6.56 years, mean weight of 65.41 ± 12.59 Kg, mean BMI of 25.5 ± 4.9, and mean waist circumference of 88.0 ± 13.1 cm. Of all individuals 20% had frank insulin resistance with HOMA-IR > 3.8. Although the obese PCOS patients had lower levels of high molecular weight adiponectin (P = 0.03) than the normal weight PCOS individuals, the level of insulin and insulin resistance was not different in them (P = 0.13, 0.13). Patients with classic PCOS phenotype significantly had higher levels of insulin resistance and free androgen index (P < 0.001, 0.001). We found a significant correlation between the insulin level and free androgen index (correlation coefficient: 0.266 and P = 0.018) after adjusting for BMI. Conclusion This cross-sectional study showed a high incidence of insulin resistance in PCOS patients independent of obesity, and determined BMI related lower level of high molecular weight adiponectin in obese PCOS individuals. More detailed studies are warranted for evaluation of insulin resistance and its pathophysiologic role in PCOS.

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A cross sectional study of polycystic ovarian syndrome among young women in Bhopal, Central India

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20175603 ◽

2017 ◽

Vol 5 (1) ◽

pp. 95 ◽

Cited By ~ 2

Author(s):

Mahesh Gupta ◽

Daneshwar Singh ◽

Manju Toppo ◽

Angelin Priya ◽

Soumitra Sethia ◽

...

Keyword(s):

Risk Factors ◽

Young Women ◽

Polycystic Ovarian Syndrome ◽

Cross Sectional Study ◽

Reproductive Age ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Waist Hip Ratio ◽

Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age groups. It is one of the leading causes of poor fertility. Risk factors include obesity, not enough physical exercise, and a family history. Most studies in India report prevalence of PCOS as 9.13% to 36%. Behaviour and life style modifications are important part of treatment for PCOS. A number of cases in the community due to lack of awareness and proper guidance, it remains undiagnosed. Aim of this study was to find the prevalence of PCOS among the young females of Bhopal city. Thus, risk assessment in the form of a survey would be one of the strategies to identify this syndrome early so as to encourage young women to seek timely treatment and prevent its long term complications. Methods: Non comparative cross sectional study for duration of 8 month. Results: The prevalence of PCOS in this study was 8.20%. Among all the risk factors, BMI ≥25 (P value < 0.0001) and waist hip ratio ≥0.85 (<0.0001) were strongly associated with the presence of PCOS and Lack of awareness, there were in girls (78.4%). Conclusions: Women who were having BMI ≥25 and waist hip ratio ≥0.85 should be educated about its complications and should be advised weight loss. Girls who had irregularity of menses and signs of hyperandrogenism should be investigated and must be managed accordingly. Early diagnosis of PCOS and its prompt treatment will help the girls to improve quality of life.

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Association Of Acne Vulgaris With Polycystic Ovarian Syndrome In Patients Visiting UOL Teaching Hospital

10.53350/pjmhs211561299 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1299-1301

Author(s):

A. Malik ◽

S. A H. Kazmi

Keyword(s):

Teaching Hospital ◽

Polycystic Ovarian Syndrome ◽

Acne Vulgaris ◽

Cross Sectional Study ◽

Normal Weight ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Study Population ◽

Ovarian Syndrome

Background: Polycystic syndrome (PCOS) is the most common endocrine disorder in the world affecting 8% of women. The main characters of PCOS are enlarged ovaries, chronic ovulation, menstrual cycles disturbance, androgen overdose, and insulin resistance leading to acne, hirsutism, and reproductive problems. Acne is a quite common dermatological condition in daily practice. Aim: To determine the association of acne vulgaris with polycystic ovarian syndrome in patients visiting the University of Lahore Teaching Hospital. Study design: Descriptive cross-sectional study. Place and duration of study: Dermatology Outpatient Department, University of Lahore Teaching Hospital Lahore from March 2019 to March 2020. Methodology: It was a descriptive cross-sectional study from March 2019 to March 2020 conducted at the Dermatology Out-patient Department, University of Lahore Teaching Hospital. All patients between the ages of 18 and 40, with acne vulgaris were included in the study. After obtaining informed consent, 101 women with acne vulgaris in I-IV (Indian stages), between the ages of 18-40 years, presented in the Department of Dermatology, University of Lahore Teaching Hospital, from March 2019 to March 2020, were selected for the study. Pregnant females, lactating mothers, and women on hormonal treatment (oral contraceptives or injections) were excluded from the study. A history of acne, oligomenorrhea, hirsutism, seborrhea, alopecia, acanthosis nigricans infertility, obesity and amenorrhea were taken. Weight and height were measured to calculate BMI. Data were collected in a special statistically tool and analyzed using SPSS-25. Results: A total of 101 women were examined having acne vulgaris issue. A total of 101 female were assessed and having history of acne vulgaris. Out of this, 33 were 18–23 years old, while 24 (23.4%) have ages 24–28 years. There were 18 (17.8%) patients who have 29–33 years old. while 38–40 years were 10 (9.9%) years old. Irregular menstrualcycle was reported 34.6% of the study population. As Perth WHO criteria, only 17% of the participants had BMI in normal weight range. The proportion of women, who were overweight and obese were 50.4% and 32.6% in the study population. Conclusion: Acne vulgaris has been identified as a serious skin disease found in all age groups. PCOS is more common among women with acne and obesity is a major risk factor for PCOS.

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