The effect of low-level light therapy on orthodontic tooth movement rate, heat shock protein 70, and matrix metallopreteinase 8 expression:  Animal study

Background: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. This study aimed to determine the number of osteoblasts in the tension side and the number of osteoclasts in the pressure side of the hypofunctional teeth during orthodontic tooth movement. Method: 18 male Wistar rats were given a palatal coil spring application on the maxillary incisors. Rats were divided into two groups, the orthodontic group with normal occlusion (NO) and hypofunctional occlusion (HO). The number of osteoblasts on the tension side and osteoclasts on the pressure side on days zero (D0), five (D5), and 10 (D10) were tested with two-way ANOVA. Observations were made by hematoxylin eosin staining. Result: The results showed that the number of osteoblasts on the tension side of the HO group was the same at the NO group (p> 0.05). The number of osteoblasts on the tension side in the NO and HO groups at D5 was the same at D10 (p = 0.99), but significantly higher (p = 0.002), than D0. The number of osteoclasts on the pressure side in the HO group was significantly lower than the NO group (p <0.05). The number of osteoclasts in the NO D5 group was significantly higher than the other groups (p <0.05). Conclusions: The number of osteoblasts on the tension side was not affected by the hypofunctional state but decreased the number of osteoclasts on the pressure side during orthodontic tooth movement.

Download Full-text

Vibratory stimulation in non-growing patients and its effect on the orthodontic tooth movement

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20214935 ◽

2021 ◽

Vol 8 (1) ◽

pp. 33

Author(s):

Tanushree Sharma ◽

Ankita Gupta ◽

Aseem Sharma ◽

Pulkit Vaid ◽

Kamlesh Singh

Keyword(s):

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Control Group ◽

P Value ◽

Vibratory Stimulation ◽

Movement Rate ◽

Canine Retraction ◽

And Control ◽

Tooth Movement Rate ◽

The Impact

Background: Objectives of the study were to determine the impact of vibratory stimulation in non-growing patients on the orthodontic tooth movement rate and to differentiate the orthodontic tooth movement rate in both experimental and control sides.Methods: 30 non-growing patients were selected for a split-mouth study with fixed appliance therapy orthodontic treatment undergoing bilateral first premolar extractions in maxillary arch. Type 1 active tiebacks were used to perform single canine retraction in all the patients. Vibratory stimulation was provided for 15 minutes daily with the help of Oral-B battery powered toothbrushes of 125 Hz frequency. Measurement was taken with calibrated digital vernier caliper clinically and OPG were taken at regular time intervals using grid method for the tooth movement calculation.Results: P value obtained by statistical calculation shows non-significant results in both experimental and control sides in non-growing patients.Conclusions: Cyclic loading in non-growing patients with fixed orthodontic appliance shows no change in orthodontic tooth movement in experimental and control group.

Download Full-text

Effects of pentagamavunon-0 (PGV-0) as alternative analgesics on orthodontic tooth movement in rats

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol31no3.20995 ◽

2019 ◽

Vol 31 (3) ◽

pp. 152

Author(s):

Cendrawasih Andusyana Farmasyanti ◽

Anne Marie Kuijpers-Jagtman ◽

Heni Susilowati ◽

Edy Meiyanto

Keyword(s):

Orthodontic Treatment ◽

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Positive Control ◽

Analgesic Drug ◽

Movement Rate ◽

Treatment Groups ◽

Male Wistar Rats ◽

Post Hoc ◽

Tooth Movement Rate

Introduction: Some analgesic drugs may have adverse effects on bone remodelling and, thus, on orthodontic tooth movement rate (OTM). GV-0 is synthesized by reacting vanillin and cyclopentanone catalyzed in acidic condition, and it has been revealed as a selective COX-2 inhibitor. This study was aimed to investigate the effect of pentagamavunon-0 (PGV-0), one of the curcumin analogues, on OTM. Methods: This study was conducted on 50 male Wistar rats (350-450 g) which were randomly divided into five groups (n = 10 each): 1) no treatment group (NT), 2) orthodontic treatment only (ORT), 3) ORT plus 0.4% sodium carboxymethyl cellulose (Na-CMC) analgesic carrier, 4) ORT plus 200 mg/kg BW Paracetamol (PCT) as the positive control, and 5) ORT plus PGV-0 (50 mg/kg BW (PGV-0). Results: Drug and day interaction was statistically significant on two-way ANOVA. Post-hoc analyses showed that OTM increased from day 3 to 7 in all orthodontic groups over the same distance (p>0.05). Maximum OTM was found on day 6, which was significantly farther than the distance on day 4. On day 7, OTM was less than on day 6. OTM in all orthodontic groups, including in the PGV-0 group, was higher than in the NT group (p<0.05). No differences was seen in OTM between PGV-0 group and other orthodontic groups (p>0.05). Post-hoc analysis (intra days) revealed that OTM in PGV-0 and other orthodontic treatment groups increased. Conclusion: After a single orthodontic force, PGV-0 does not inhibit tooth movement in rats from day 1 to day 7. Therefore, it is possible to develop PGV-0 as an alternative analgesics during orthodontic therapy.Keywords: Analgesic drug, orthodontics, tooth movement, curcumin.

Download Full-text