scholarly journals Effects of pentagamavunon-0 (PGV-0) as alternative analgesics on orthodontic tooth movement in rats

2019 ◽  
Vol 31 (3) ◽  
pp. 152
Author(s):  
Cendrawasih Andusyana Farmasyanti ◽  
Anne Marie Kuijpers-Jagtman ◽  
Heni Susilowati ◽  
Edy Meiyanto
Keyword(s):  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Positive Control ◽  
Analgesic Drug ◽  
Movement Rate ◽  
Treatment Groups ◽  
Male Wistar Rats ◽  
Post Hoc ◽  
Tooth Movement Rate

Introduction: Some analgesic drugs may have adverse effects on bone remodelling and, thus, on orthodontic tooth movement rate (OTM). GV-0 is synthesized by reacting vanillin and cyclopentanone catalyzed in acidic condition, and it has been revealed as a selective COX-2 inhibitor. This study was aimed to investigate the effect of pentagamavunon-0 (PGV-0), one of the curcumin analogues, on OTM. Methods: This study was conducted on 50 male Wistar rats (350-450 g) which were randomly divided into five groups (n = 10 each): 1) no treatment group (NT), 2) orthodontic treatment only (ORT), 3) ORT plus 0.4% sodium carboxymethyl cellulose (Na-CMC) analgesic carrier, 4) ORT plus 200 mg/kg BW Paracetamol (PCT) as the positive control, and 5) ORT plus PGV-0 (50 mg/kg BW (PGV-0). Results: Drug and day interaction was statistically significant on two-way ANOVA. Post-hoc analyses showed that OTM increased from day 3 to 7 in all orthodontic groups over the same distance (p>0.05). Maximum OTM was found on day 6, which was significantly farther than the distance on day 4. On day 7, OTM was less than on day 6. OTM in all orthodontic groups, including in the PGV-0 group, was higher than in the NT group (p<0.05). No differences was seen in OTM between PGV-0 group and other orthodontic groups (p>0.05). Post-hoc analysis (intra days) revealed that OTM in PGV-0 and other orthodontic treatment groups increased. Conclusion: After a single orthodontic force, PGV-0 does not inhibit tooth movement in rats from day 1 to day 7. Therefore, it is possible to develop PGV-0 as an alternative analgesics during orthodontic therapy.Keywords: Analgesic drug, orthodontics, tooth movement, curcumin.

scholarly journals The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 541
Author(s):  
Adibah Maulani ◽  
Cendrawasih Andusyana Farmasyanti ◽  
Darmawan Sutantyo
Keyword(s):  
Wistar Rats ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Pressure Side ◽  
Coil Spring ◽  
Movement Rate ◽  
Normal Occlusion ◽  
Male Wistar Rats ◽  
Tooth Movement Rate ◽  
Hematoxylin Eosin

Background: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. This study aimed to determine the number of osteoblasts in the tension side and the number of osteoclasts in the pressure side of the hypofunctional teeth during orthodontic tooth movement. Method: 18 male Wistar rats were given a palatal coil spring application on the maxillary incisors. Rats were divided into two groups, the orthodontic group with normal occlusion (NO) and hypofunctional occlusion (HO). The number of osteoblasts on the tension side and osteoclasts on the pressure side on days zero (D0), five (D5), and 10 (D10) were tested with two-way ANOVA. Observations were made by hematoxylin eosin staining. Result: The results showed that the number of osteoblasts on the tension side of the HO group was the same at the NO group (p> 0.05). The number of osteoblasts on the tension side in the NO and HO groups at D5 was the same at D10 (p = 0.99), but significantly higher (p = 0.002), than D0. The number of osteoclasts on the pressure side in the HO group was significantly lower than the NO group (p <0.05). The number of osteoclasts in the NO D5 group was significantly higher than the other groups (p <0.05). Conclusions: The number of osteoblasts on the tension side was not affected by the hypofunctional state but decreased the number of osteoclasts on the pressure side during orthodontic tooth movement.

scholarly journals Applicative Characteristics of a New Zirconia Bracket with Multiple Slots

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Koutaro Maki ◽  
Katsuyoshi Futaki ◽  
Satoru Tanabe ◽  
Mariko Takahashi ◽  
Yuta Ichikawa ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Early Stage ◽  
Control Group ◽  
Dental Arch ◽  
Movement Rate ◽  
Orthodontic Bracket ◽  
Visual Analogue Pain ◽  
Before And After ◽  
Tooth Movement Rate

We have developed a new orthodontic bracket with three slots with lubricative properties on the working surfaces and proposed a new orthodontic treatment system employing 0.012−0.014-inch Ni-Ti arch wires. We recruited 54 patients, of which 27 received treatment with the new zirconia bracket with multiple slots system (M group), and the others received treatment with standard edge-wise appliances (control group [C group]). We compared the (1) tooth movement rate at the early stage of leveling; (2) changes in the dental arch morphology before and after leveling; and (3) pain caused by orthodontic treatment. Student’st-test was used in all assessments. The tooth movement rate in the maxillomandibular dentition was higher in the M group. The basal arch width, anterior length, and the intercanine width in the maxillary dentition were not significantly different in the two groups; however, the intercanine width in the mandibular dentition was higher in the C group. In assessments of treatment-related pain, the visual analogue pain score was 56.0 mm and 22.6 mm in the C and M groups, respectively. A new zirconia bracket with multiple slots system provided better outcomes with respect to tooth movement rate, treatment period, and postoperative pain, thus indicating its effectiveness over conventional orthodontic systems.

scholarly journals Vibratory stimulation in non-growing patients and its effect on the orthodontic tooth movement

2021 ◽  
Vol 8 (1) ◽  
pp. 33
Author(s):  
Tanushree Sharma ◽  
Ankita Gupta ◽  
Aseem Sharma ◽  
Pulkit Vaid ◽  
Kamlesh Singh
Keyword(s):  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Control Group ◽  
P Value ◽  
Vibratory Stimulation ◽  
Movement Rate ◽  
Canine Retraction ◽  
And Control ◽  
Tooth Movement Rate ◽  
The Impact

<p><strong>Background:</strong> Objectives of the study were to determine the impact of vibratory stimulation in non-growing patients on the orthodontic tooth movement rate and to differentiate the orthodontic tooth movement rate in both experimental and control sides.</p><p><strong>Methods:</strong> 30 non-growing patients were selected for a split-mouth study with fixed appliance therapy orthodontic treatment undergoing bilateral first premolar extractions in maxillary arch. Type 1 active tiebacks were used to perform single canine retraction in all the patients. Vibratory stimulation was provided for 15 minutes daily with the help of Oral-B battery powered toothbrushes of 125 Hz frequency. Measurement was taken with calibrated digital vernier caliper clinically and OPG were taken at regular time intervals using grid method for the tooth movement calculation.</p><p><strong>Results:</strong> P value obtained by statistical calculation shows non-significant results in both experimental and control sides in non-growing patients.</p><p><strong>Conclusions:</strong> Cyclic loading in non-growing patients with fixed orthodontic appliance shows no change in orthodontic tooth movement in experimental and control group.</p>

scholarly journals Cyclic loading; its impact on the orthodontic tooth movement in growing patients: in vivo study

2021 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Tanushree Sharma ◽  
Ankita Gupta ◽  
Aseem Sharma ◽  
Pulkit Vaid ◽  
Kamlesh Singh ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Treatment Time ◽  
Orthodontic Tooth Movement ◽  
P Value ◽  
Vibratory Stimulation ◽  
Movement Rate ◽  
Time Intervals ◽  
Tooth Movement Rate ◽  
The Impact

<p class="abstract"><strong>Background: </strong>The objective of the study was to evaluate the impact of vibratory stimulation on the orthodontic tooth movement rate in growing patients and to compare the orthodontic tooth movement rate in experimental and control sides.</p><p class="abstract"><strong>Methods: </strong>Split-mouth design study was done on 30 growing fixed appliance therapy orthodontic cases with bilateral first premolar extractions in maxillary arch. Individual canine retractions were performed in all the subjects with type-1 active tiebacks. Oral-B powered toothbrushes (125 Hz) were used to provide vibratory stimulation for 15 minutes per day (splits into 5 minutes thrice a day). The tooth movement was measured with calibrated digital vernier caliper clinically at various time intervals (T0, T1 and T2). OPG were taken at regular mentioned time intervals and grid method was used to calculate the tooth movement on OPGs.</p><p class="abstract"><strong>Results:</strong> Results were evaluated statistically and the p-value revealed significantly increased rate of tooth movement on experimental side as compared to control side.</p><p class="abstract"><strong>Conclusions: </strong>The high-frequency vibratory stimulation along with fixed orthodontic appliance can reduce treatment time expeditiously in growing patients. Powered toothbrushes can use successfully for providing vibrations to enhance the rate of tooth movement.</p>

The Comparison of Ostecyte in the Pressure area and Tension area on Tooth Movement Because of Hyperbaric Oxygen Therapy

DENTA ◽  
2018 ◽  
Vol 12 (1) ◽  
pp. 34
Author(s):  
Arya Barahmanta ◽  
Muhammad Faizal Winaris ◽  
Pambudi Raharjo
Keyword(s):  
Hyperbaric Oxygen ◽  
Oxygen Therapy ◽  
Tooth Movement ◽  
Bone Remodelling ◽  
Orthodontic Tooth Movement ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Pressure Area

<p><strong><em>Background:</em></strong><em> Orthodontic tooth movement is a </em><em>interaction prosess</em><em> of resorption and deposition of bone remodeling. Orthodontic tooth movement by mechanical strength causes changes in alveolar bone. Osteocyte is an essential cell to respond bone remodelling. Hyperbaric Oxygen Therapy affects production of osteocyte because it can release Reactive Oxygen Species (ROS) and Nitrid Oxide (NO).  <strong>Purpose: </strong>To determine the difference number  of osteocyte in pressure and tension area during tooth movement by adjuvant of Hyperbaric Oxygen 2,4 ATA during 7 days starting on day 8 to day 14. <strong>Materials and Methods</strong>: This research used Completery Randomized Control Group Post Test Only Design. 36 cavia cobaya (male)  were divided into 3 groups randomly : the negative control groups, positive control group, and treatment group. Preparat staining used Hematoxylin Eosin (HE) and calculated on microscop 1000x with 20 field of view. Data analyses used one way ANOVA and LSD test then compared each area by using paired T test. <strong>Result:</strong> The data showed that the treatment group (P=10,67) tension area has the highest number of osteocyte than  negative control group (K-=3,67), positive control (K+=7,42). In the pressure area showed that negative control group (K-=5,00) has the highest  than positive control group (K+=3,83) and treatment (P=3,25). <strong>Conclusion: </strong>Therapy HBO 2,4 ATA 7 days starting on day 8 to day 14 is could increase osteocyte in the tissue to stimulate process of bone remodelling.</em></p><pre><strong> </strong></pre><p><strong><em>Keywords:</em></strong><em> Hyperbaric Oxygen, Tooth movement, Bone remodeling, </em><em>Osteocyte</em><em></em></p><p><em> </em></p><p><strong><em>Correspondence:</em></strong><em> </em><em>Arya Brahmanta</em><em>, Department of Orthodonty, Faculty of Dentistry, Hang Tuah University, Arif Rahman Hakim 150, Surabaya, Phone 031-5945864, Email:</em><em> </em><a href="mailto:[email protected]"><em>arya.brahmanta</em><em>@</em><em>hangtuah.ac.id</em></a></p>

scholarly journals Evaluation of IL1β and IL6 Gingival Crevicular Fluid Levels during the Early Phase of Orthodontic Tooth Movement in Adolescents and Young Adults

2021 ◽  
Vol 11 (2) ◽  
pp. 521
Author(s):  
Simina Chelărescu ◽  
Petra Șurlin ◽  
Mioara Decusară ◽  
Mădălina Oprică ◽  
Eugen Bud ◽  
...  
Keyword(s):  
Young Adults ◽  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Gingival Crevicular Fluid ◽  
Early Stage ◽  
Statistical Tests ◽  
Orthodontic Tooth Movement ◽  
Adolescents And Young Adults ◽  
Periodontal Tissues ◽  
Crevicular Fluid

Background: The crevicular fluid analysis represents a useful diagnosis tool, with the help of which noninvasive cellular metabolic activity can be analyzed. The aim of the study is to investigate comparatively IL1β and IL6 in the gingival crevicular fluid of clinically healthy adolescents and young adults during the acute phase of orthodontic treatment. Methods: Gingival crevicular fluid was collected from 20 patients (aged between 11 and 28) undergoing orthodontic treatment. Measurements were taken before (T0) and after 24 h after distalization forces were activated (T1). IL1β and IL 6 were analyzed using Elisa tests. The statistical tests used were two-sided t tests. Results: Between the two time periods there was a significant raise both in the crevicular fluid rate (0.57 µL at T0 vs. 0.95 µL at T1, p = 0.001) and in IL1β levels (15.67 pg/µL at T0 vs. 27.94 pg/µL at T1, p = 0.009). We were able to identify IL6 only in a third of the sites. There is a significantly increased level of ILβ at T1 in adolescents, more than in young adults (42.96 pg/µL vs. 17.93 pg/µL, p = 0.006). Conclusions: In the early stage of orthodontic treatment, the periodontal tissues of adolescents are more responsive to orthodontic forces than those of young adults.

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