scholarly journals New bone formation by orthodontic tooth movement for implant placement

2016 ◽  
Vol 6 (2) ◽  
pp. 316
Author(s):  
Fatih Cabbar ◽  
RahimeBurcu Nur ◽  
Burcu Dikici ◽  
Ceyhun Canpolat ◽  
GoncaDuygu Capar
Keyword(s):  
Bone Formation ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
New Bone Formation ◽  
Implant Placement

scholarly journals Tooth Movement out of the Bony Wall Using Augmented Corticotomy with Nonautogenous Graft Materials for Bone Regeneration

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Kye-Bok Lee ◽  
Dong-Yeol Lee ◽  
Hyo-Won Ahn ◽  
Seong-Hun Kim ◽  
Eun-Cheol Kim ◽  
...  
Keyword(s):  
Bone Formation ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Bovine Bone ◽  
Pressure Side ◽  
New Bone Formation ◽  
Pocket Depth ◽  
Keratinized Tissue ◽  
Probing Depth ◽  
Angular Change

This prospective randomized split-mouth study was performed to compare the effects of augmented corticotomy with those of different nonautogenous bone graft materials combined with orthodontic tooth movement in dogs. Decortication was performed on the buccal bone surface of 6 male beagle dogs that were randomly assigned to receive grafts of deproteinized bovine bone mineral, irradiated cortical bone, or synthetic bone. Immediate orthodontic force was applied to the second and third premolars for buccal tipping for 6 weeks. The pocket depth and width of keratinized tissue (WKT) were measured. Histologic and histomorphometric analyses were performed. The probing depth, WKT, and ratio of the area of new bone to that of total bone on the buccal side were not significantly different between groups. All groups had considerable new bone formation on the pressure side. New bone formation on the buccal side and buccal plate formation in the coronal direction along the root surfaces were induced by the bone-derived and PDL-derived mesenchymal matrix, respectively. The angular change between groups was significantly different (P< 0.001). Augmented corticotomy using nonautogenous graft materials facilitated tooth movement without fenestrations and accelerated new bone formation on the pressure side.

Effects of sialoadenectomy and exogenous EGF on molar drift and orthodontic tooth movement in rats

1994 ◽  
Vol 266 (5) ◽  
pp. E731-E738 ◽  
Author(s):  
C. Dolce ◽  
J. Anguita ◽  
L. Brinkley ◽  
P. Karnam ◽  
M. Humphreys-Beher ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Remodeling ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Alveolar Bone Remodeling ◽  
Tooth Roots ◽  
Epidermal Growth ◽  
Tetracycline Labeling ◽  
Distal Aspect

Effects on bone remodeling have been attributed to epidermal growth factor (EGF). Sialoadenectomy (SX) removes the major source of EGF in rodents and decreases both salivary and serum EGF levels. EGF effects on rat alveolar bone remodeling manifested by molar drift (MD) and orthodontic tooth movement (OTM) were examined using the following two approaches: 1) EGF depletion by SX and replacement by orally administered EGF (50 micrograms.animal-1.day-1); 2) sham rats supplemented with matching amounts of EGF. MD and OTM were measured using cephalometric radiographs; bone formation was measured histomorphometrically using tetracycline labeling. Normal MD was not detected after SX, and alveolar bone formation was significantly reduced both around the tooth and in nondental sites. Replacement EGF given to SX rats and supplemental EGF administered to sham rats changed the direction and enhanced the rate of MD. A mesially directed orthodontic force applied to the molars of SX animals increased bone formation on the distal aspect of the tooth roots. Supplemental EGF did not significantly affect OTM. EGF affects alveolar bone remodeling, as manifested clinically by alterations in normal maxillary MD.

scholarly journals Contribution of the PDL to Osteotomy Repair and Implant Osseointegration

2017 ◽  
Vol 96 (8) ◽  
pp. 909-916 ◽  
Author(s):  
X. Pei ◽  
L. Wang ◽  
C. Chen ◽  
X. Yuan ◽  
Q. Wan ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implants ◽  
Multiple Time ◽  
New Bone Formation ◽  
Extraction Socket ◽  
Minimally Invasive Surgical ◽  
Implant Placement ◽  
Extraction Site ◽  
Immediate Implants ◽  
Immediate Implant

Our objective was to clarify the fate of the periodontal ligament (PDL) retained in the socket after tooth extraction, then determine if this tissue contributed to the osseointegration of “immediate” implants placed in these fresh extraction sockets. Mice underwent maxillary first molar extraction, the residual PDL was removed by an osteotomy, and titanium implants were placed. The osteotomy was created in such a way that the palatal surface was devoid of PDL remnants while the buccal, mesial, and distal surfaces retained PDL fibers. At multiple time points after surgery, tissues were analyzed using a battery of molecular, cellular, and histomorphometrical assays. We found that PDL remnants mineralized and directly contributed to new bone formation in the extraction site. Compared with regions of an extraction site where the PDL was removed by osteotomy, regions that retained PDL fibers had produced significantly more new bone. Around immediate implants, the retained PDL remnants directly contributed to new bone formation and osseointegration. Thus, we conclude that PDL remnants are inherently osteogenic, and if the tissue is healthy, it is reasonable to conclude that curetting out an extraction socket prior to immediate implant placement should be avoided. This recommendation aligns with contemporary trends toward minimally invasive surgical manipulations of the extraction socket prior to immediate implant placement.

scholarly journals Interleukin 1β Levels around Microscrew Implants during Orthodontic Tooth Movement

2007 ◽  
Vol 77 (6) ◽  
pp. 1073-1078 ◽  
Author(s):  
Emel Sarı ◽  
Cihan Uçar
Keyword(s):  
Treatment Group ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Gingival Crevicular Fluid ◽  
Orthodontic Tooth Movement ◽  
Experimental Period ◽  
Interleukin 1Β ◽  
Implant Placement ◽  
The Mean ◽  
Crevicular Fluid

Abstract Objective: To determine whether interleukin 1β (IL-1β) levels are elevated around microscrew implants that are used as anchorage for tooth movement. Materials and Methods: Ten young adults, aged 16.3 ± 2.5 years and with all four premolars extracted , comprised the study group. Twenty maxillary microscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for distal movement of the maxillary canines. The maxillary canines served as the treatment group, and the microscrew implants were designated as the implant group. The mandibular canines were used as controls. Peri-microscrew implant crevicular fluid (MICF) and gingival crevicular fluid (GCF) were collected at the beginning of tooth movement (2 weeks after implant placement); at 24, 48, and 168 hours later; and on days 14 and 21. An automated enzyme immunoassay was used to measure 1L-1β in the MICF and the GCF. Results: The mean 1L-1β level in the treatment group was significantly elevated at 24 hours (P = .003 &lt; .05) and 48 hours (P = .003 &lt; .05), whereas the levels in the control and implant groups did not change significantly during the experimental period. Also, the mean 1L-1β level of the treatment group was significantly higher that in both the control and implant groups at 24 and 48 hours. Conclusions: The microscrew implants did not demonstrate increased 1L-1β levels during tooth movement. This supports the concept that microscrew implants might be useful as absolute anchorage devices.

scholarly journals Biomechanics of Immediate Postextraction Implant Osseointegration

2018 ◽  
Vol 97 (9) ◽  
pp. 987-994 ◽  
Author(s):  
X. Yuan ◽  
X. Pei ◽  
Y. Zhao ◽  
Z. Li ◽  
C.H. Chen ◽  
...  
Keyword(s):  
Finite Element ◽  
Bone Formation ◽  
Finite Element Modeling ◽  
Direct Contact ◽  
Osteotomy Site ◽  
New Bone Formation ◽  
Element Modeling ◽  
Implant Placement ◽  
Osteocyte Death ◽  
Immediate Implant

The aim of this study was to gain insights into the biology and mechanics of immediate postextraction implant osseointegration. To mimic clinical practice, murine first molar extraction was followed by osteotomy site preparation, specifically in the palatal root socket. The osteotomy was positioned such that it removed periodontal ligament (PDL) only on the palatal aspect of the socket, leaving the buccal aspect undisturbed. This strategy created 2 distinct peri-implant environments: on the palatal aspect, the implant was in direct contact with bone, while on the buccal aspect, a PDL-filled gap existed between the implant and bone. Finite element modeling showed high strains on the palatal aspect, where bone was compressed by the implant. Osteocyte death and bone resorption predominated on the palatal aspect, leading to the loss of peri-implant bone. On the buccal aspect, where finite element modeling revealed low strains, there was minimal osteocyte death and robust peri-implant bone formation. Initially, the buccal aspect was filled with PDL remnants, which we found directly provided Wnt-responsive cells that were responsible for new bone formation and osseointegration. On the palatal aspect, which was devoid of PDL and Wnt-responsive cells, adding exogenous liposomal WNT3A created an osteogenic environment for rapid peri-implant bone formation. Thus, we conclude that low strain and high Wnt signaling favor osseointegration of immediate postextraction implants. The PDL harbors Wnt-responsive cells that are inherently osteogenic, and if the PDL tissue is healthy, it is reasonable to preserve this tissue during immediate implant placement.

scholarly journals Evaluation of different grafting materials for alveolar cleft repair in the context of orthodontic tooth movement in rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Stephan Christian Möhlhenrich ◽  
Kristian Kniha ◽  
Zuzanna Magnuska ◽  
Benita Hermanns-Sachweh ◽  
Felix Gremse ◽  
...  
Keyword(s):  
Bone Formation ◽  
Gold Standard ◽  
Tooth Movement ◽  
Volume Fraction ◽  
Bone Substitutes ◽  
New Bone Formation ◽  
Mineral Density ◽  
Complete Continuity ◽  
Bone Volume Fraction ◽  
Grafting Materials

AbstractTo minimize the postoperative risks posed by grafting autologous transplants for cleft repair, efforts are being made to improve grafting materials for use as potential alternatives. The aim of this study was to compare the bone graft quality of different bone substitutes including the gold standard autografts during the healing processes after cleft repair in the context of orthodontic treatment. In 21 Wistar rats, a complete, continuity-interrupting cleft was created. After 4 weeks, cleft repair was performed using autografts from the hips’ ischial tuberosity, human xenografts, or synthetic bone substitutes [beta-tricalcium phosphate (β-TCP)/hydroxyapatite (HA)]. After another 4 weeks, the first molar movement was initiated in the reconstructed jaw for 8 weeks. The bone remodeling was analyzed in vivo using micro-computed tomography (bone mineral density and bone volume fraction) and histology (new bone formation). All the grafting materials were statistically different in bone morphology, which changed during the treatment period. The β-TCP/HA substitute demonstrated less resorption compared to the autologous and xenogeneic/human bone, and the autografts led to a stronger reaction in the surrounding bone. Histologically, the highest level of new bone formation was found in the human xenografts, and the lowest was found in the β-TCP/HA substitute. The differences between the two bone groups and the synthetic materials were statistically significant. Autografts were confirmed to be the gold standard in cleft repair with regard to graft integration. However, parts of the human xenograft seemed comparable to the autografts. Thus, this substitute could perhaps be used as an alternative after additional tissue-engineered modification.

scholarly journals The influence of hyperbaric oxygen therapy (HBOT) to intercausal relationship between blood vessels, osteoblast, and new bone formation during maxillary suture expansion

2020 ◽  
Vol 32 (1) ◽  
pp. 14
Author(s):  
Noengki Prameswari ◽  
Iwa Rahmat Sunaryo ◽  
Dian Widya Damaiyanti ◽  
Agni Febrina
Keyword(s):  
Bone Formation ◽  
Blood Vessels ◽  
Guinea Pigs ◽  
Tooth Movement ◽  
Bone Cells ◽  
Negative Control ◽  
Control Group ◽  
New Bone Formation ◽  
Control Group Design ◽  
Regression Test

Introduction: Expansion appliance that can imply tooth movement and opening maxilla suture might affect the blood vessels, bone cells, and formation of the new bone. HBOT accelerated the rate of osteoblast differentiation leading to an increase in bone formation during osteonecrosis. Research about HBOT during maxillary suture expansion has never been investigated. The purpose of this research was to correlate the blood vessels number, osteoblast by administered 2.4 ATA HBOT from day 8-14 to imply new bone formation during maxillary suture expansion. Methods: Eighteen male guinea pigs with randomised post-test only control group design divided into 3 groups. Negative control group K(-), positive control with expansion appliance K(+), expansion appliance and HBOT (P). After 14 days guinea pigs were decapitated. Histological slide of the blood vessels number, osteoblast, and new bone formation were examined under a light microscope then were analysed by regression test. Results: Descriptive test showed increasing blood vessels number, osteoblast, and new bone formation on the administration of HBOT during maxillary suture expansion. Regression test showed that there was a strong correlation between the blood vessels number and osteoblast to the new bone formation with R=6.95 during maxillary suture expansion. Conclusion: 2.4 ATA HBOT influences the intercausal relationship between increasing blood vessels number, increasing osteoblast, and new bone formation during maxillary suture expansion.

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