scholarly journals A quantitative expression of KI-67 to assess the malignant transformation potential in oral leukoplakia and erosive lichen planus

2020 ◽  
Vol 9 (1) ◽  
pp. 42
Author(s):  
Haranath Danda ◽  
PoosarlaC Pusarla ◽  
GontuS Reddy ◽  
KattappagariK Kumar ◽  
LalithP Chandra ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Leukoplakia ◽  
Ki 67 ◽  
Quantitative Expression ◽  
Erosive Lichen Planus ◽  
Transformation Potential

Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study

2017 ◽  
Vol 8 (2) ◽  
pp. 73-76 ◽  
Author(s):  
Ruchika Garg ◽  
Arvind V Shetti ◽  
Anjana S Bagewadi
Keyword(s):  
Oral Cancer ◽  
Comparative Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Control Group ◽  
Significant Difference ◽  
Potentially Malignant ◽  
Oral Lichen

ABSTRACT Introduction Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It is preceded by various potentially malignant conditions like oral leukoplakia and oral lichen planus. Survivin is an inhibitor of apoptosis whose levels have been found increased in oral cancer as well as various potentially malignant conditions. Thus survivin can act as a biomarker and help in early detection of potentially malignant conditions which can prevent its transformation into malignancy. Aim To assess and compare the level of total human salivary survivin in oral leukoplakia, oral lichen planus, oral cancer, and control group. Materials and methods A total of 96 subjects were included in the study, which were further grouped into 24 in each group. The saliva was analyzed for survivin level among all the four groups. Survivin concentration (pg/mL) was studied in relation to clinical data. The results were analyzed using Mann—Whitney U test to derive the statistical difference. Results The average of levels of survivin in control group was 0.199 pg/mL, in oral leukoplakia group 0.312 pg/mL, in oral lichen planus group 0.380 pg/mL, and in oral cancer group 0.430 pg/mL. A comparison of all these groups revealed statistically significant difference among the groups. Conclusion Survivin may not be considered as an independent predictor of the malignant transformation for premalignant lesions but it can be an indicator for an increased risk of malignant transformation. How to cite this article Garg R, Shetti AV, Bagewadi AS. Assessment and Comparison of Salivary Survivin Biomarker in Oral Leukoplakia, Oral Lichen Planus, and Oral Cancer: A Comparative Study. World J Dent 2017;8(2):73-76.

scholarly journals Oral Lichen Planus – A Case Report with Current Trends Review of Literature

2016 ◽  
Vol 5 (1) ◽  
pp. 6
Author(s):  
Umamaheswari G ◽  
Suganya. R ◽  
Sivaramakrishnan. M ◽  
Vidyalakshmi. S
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Young Male ◽  
Skin Lesions ◽  
Hair Follicles ◽  
World Population ◽  
Cutaneous Lesions ◽  
Transformation Potential ◽  
Oral Lichen

<div><p><em>Lichen planus (LP) is an autoimmune chronic mucocutaneous dermatosis that commonly affects skin, mucous membrane, hair follicles &amp; nails. Skin lesions present as recurrent violaceous, keratotic pruritic patches whereas oral lichen planus presents with various pattern. Oral lesions of LP is approximately of 1- 2% of general population while 10-20% of patients demonstrate oral as well as cutaneous lesions. Females are most commonly affected with age group ranging from 40-70 years and showing prevalence rates varying from 0.5% to 2.6% of the world population. The malignant transformation potential of LP into oral squamous cell carcinoma (OSCC) is 0.3-3%. Epithelial dysplasia is considered to be a risk factor for malignant transformation into OSCC. The objective of this paper is to report a case of oral lichen planus showing features of dysplasia in a young male patient. <strong></strong></em></p></div>

scholarly journals Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential

2018 ◽  
Author(s):  
Eduardo Rosa ◽  
Aura Hurtado‑Puerto ◽  
Denise Falc�o ◽  
Aline Brietzke ◽  
Luiz de Almeida Prado Franceschi ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Ki 67 ◽  
Oral Lichen

scholarly journals A quantitative expression of Ki-67 to evaluate malignant transformation rate in potentially malignant disorders

2018 ◽  
Vol 7 (3) ◽  
pp. 185
Author(s):  
ManiD Chitipothu ◽  
KiranK Kattappagari ◽  
Divyasri Godavarthy ◽  
Chandrashekar Poosarla ◽  
SridharR Gountu ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Transformation Rate ◽  
Ki 67 ◽  
Quantitative Expression ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals Detection of Human Papillomavirus 33 in Erosive Oral Lichen Planus

2020 ◽  
Vol 13 (10) ◽  
Author(s):  
Sareh Farhadi ◽  
Donia Sadri ◽  
Mojgan Bandehpour ◽  
Mana Akbari ◽  
Elnaz Jafarzadeh ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Normal Mucosa ◽  
Pcr Analysis ◽  
Hpv Dna ◽  
Transformation Potential ◽  
Oral Lichen ◽  
Hpv 18

Background: A correlation is suggested between oral lichen planus (OLP) and the human papillomavirus (HPV) with possible malignant transformation potential in OLP. Objectives: The present study aimed at evaluating the prevalence of HPV-16 and HPV-18 as the most recognized oncogenic subtypes and relatively recently introduced subtype HPV33 in OLP samples. Methods: This retrospective study was carried out on 32 OLP samples (consisting of 12 reticular and 20 erosive forms) and 20 healthy oral mucosa samples. Polymerase chain reaction (PCR) was undertaken to identify HPV Deoxyribonucleic Acid (DNA). Subsequently, the samples positive for HPV DNA underwent PCR analysis again with the specific primers. The data were analyzed statistically by Fisher’s exact test regarding the significance level of lower than 0.05. Results: Eight out of 32 OLP samples (25%) and none of the 20 normal mucosa samples (0%) exhibited HPV DNA. The presence of HPV in the OLP group was significantly higher than that in the normal mucosa (P = 0.014). Also, all the samples that exhibited HPV DNA were registered as the erosive form. Besides, one sample (3.12%) exhibited the 873-bp band, which was attributed to HPV-18, and 7 samples (21.87%) exhibited the 300-bp band, which was attributed to HPV-33. Conclusions: Based on the recent findings in the current study of the Iranian population, the presence of high-risk HPV subtypes, whether primarily or as a secondary infection, can suggest the malignant transformation potential for the studied OLP samples. The exclusive presence of these subtypes in the erosive type of this lesion and the noticeable presence of HPV-33 might reflect this issue’s importance. However, further studies are necessary to evaluate the possibility of a higher proliferation rate of HPV in erosive lichen planus and identify its possible malignant transformation mechanism.

scholarly journals Prevention of Malignant Transformation of Oral Leukoplakia and Oral Lichen Planus Using Laser: An Observational Study

2018 ◽  
Vol 19 (12) ◽  
pp. 3635-3641 ◽  
Author(s):  
Karandeep Singh Arora ◽  
Rahul Bansal ◽  
Shreeyam Mohapatra ◽  
Akshay Verma ◽  
Sakshi Sharma ◽  
...  
Keyword(s):  
Observational Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Leukoplakia ◽  
Oral Lichen

scholarly journals Autologous micrografts and methotrexate in plantar erosive lichen planus: healing and pain control. A case report

2020 ◽  
Vol 7 (1) ◽  
pp. 134-138
Author(s):  
G. Miotti ◽  
N. Zingaretti ◽  
G. F. Guarneri ◽  
V. Manfrè ◽  
E. Errichetti ◽  
...  
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Pain Control ◽  
Erosive Lichen Planus

scholarly journals Histopathological specialized staining of oral lichen planus-induced fibrotic changes and surgical treatment of associated restricted mouth opening: a case report

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Atsushi Shudo
Keyword(s):  
Surgical Treatment ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Histopathological Examination ◽  
Mouth Opening ◽  
Ki 67 ◽  
Collagen Formation ◽  
Immune Mediated ◽  
Cytokeratin 13 ◽  
Oral Lichen

Abstract Background Oral lichen planus is a chronic inflammatory and immune-mediated disease that affects the oral mucosa. Recent findings have suggested that oral lichen planus is often associated with submucosal fibrotic changes. Fibrotic changes in the buccal submucosa may cause restricted mouth opening. This report discusses the histopathological examination (including specialized staining) and surgical treatment for oral lichen planus-induced fibrotic changes. Case presentation Here, we describe a 63-year-old woman who had oral lichen planus with fibrotic changes. Her maximum mouth opening distance was approximately 30 mm due to submucosal fibrotic changes, and she exhibited gradual fibrosis progression. Histological examinations were performed to assess the oral lichen planus-induced fibrotic changes. Then, double Z-plasty were performed as treatment for restricted mouth opening. The immunohistochemical staining results were negative for cytokeratin 13 and positive in some layers for cytokeratin 17 and Ki-67/MIB-1. Masson's trichrome staining showed enhanced collagen formation. Postoperative mouth opening training enabled the patient to achieve a mouth opening distance of > 50 mm. Conclusion Our findings suggest that histopathological examination with specialized staining can aid in the evaluation of oral lichen planus-induced fibrotic changes, and that Z-plasty is effective for the treatment of restricted mouth opening due to oral lichen planus.

scholarly journals Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 194
Author(s):  
Jutta Ries ◽  
Abbas Agaimy ◽  
Falk Wehrhan ◽  
Christoph Baran ◽  
Stella Bolze ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Malignant Transformation ◽  
Immune Escape ◽  
Checkpoint Inhibitors ◽  
Precancerous Lesions ◽  
Death Receptor ◽  
Oral Leukoplakia ◽  
Significant Difference

Background: The programmed cell death ligand 1/programmed cell death receptor 1 (PD-L1/PD-1) Immune Checkpoint is an important modulator of the immune response. Overexpression of the receptor and its ligands is involved in immunosuppression and the failure of an immune response against tumor cells. PD-1/PD-L1 overexpression in oral squamous cell carcinoma (OSCC) compared to healthy oral mucosa (NOM) has already been demonstrated. However, little is known about its expression in oral precancerous lesions like oral leukoplakia (OLP). The aim of the study was to investigate whether an increased expression of PD-1/PD-L1 already exists in OLP and whether it is associated with malignant transformation. Material and Methods: PD-1 and PD-L1 expression was immunohistologically analyzed separately in the epithelium (E) and the subepithelium (S) of OLP that had undergone malignant transformation within 5 years (T-OLP), in OLP without malignant transformation (N-OLP), in corresponding OSCC and in NOM. Additionally, RT-qPCR analysis for PD-L1 expression was done in the entire tissues. Additionally, the association between overexpression and malignant transformation, dysplasia and inflammation were examined. Results: Compared to N-OLP, there were increased levels of PD-1 protein in the epithelial and subepithelial layers of T-OLP (pE = 0.001; pS = 0.005). There was no significant difference in PD-L1 mRNA expression between T-OLP and N-OLP (p = 0.128), but the fold-change increase between these groups was significant (Relative Quantification (RQ) = 3.1). In contrast to N-OLP, the PD-L1 protein levels were significantly increased in the epithelial layers of T-OLP (p = 0.007), but not in its subepithelial layers (p = 0.25). Importantly, increased PD-L1 levels were significantly associated to malignant transformation within 5 years. Conclusion: Increased levels of PD-1 and PD-L1 are related to malignant transformation in OLP and may represent a promising prognostic indicator to determine the risk of malignant progression of OLP. Increased PD-L1 levels might establish an immunosuppressive microenvironment, which could favor immune escape and thereby contribute to malignant transformation. Hence, checkpoint inhibitors could counteract tumor development in OLP and may serve as efficient therapeutic strategy in patients with high-risk precancerous lesions.

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