Serum level of Vitamin D is associated with COVID-19 mortality rate in hospitalized patients

AbstractDilated cardiomyopathy (DCM) is the third leading cause of heart failure in pediatrics. The exact etiology of DCM is unknown in more than half of the cases. Vitamin D receptors are represented in cardiac muscles, endothelium, and smooth muscles of blood vessels suggesting that vitamin D could have a vital cardioprotective function. This study aimed to assess serum level of vitamin D in children with idiopathic DCM and to correlate the serum level of vitamin D with the left ventricular dimensions and function. This study is a descriptive cross-sectional single-center study, includes 44 children of both sexes, diagnosed as idiopathic DCM. Serum level of vitamin D was assessed and correlated with the left ventricular dimensions and function. Mean age of studied children was 6.08 ± 4.4 years. Vitamin D deficiency was found in 90.9% of children with idiopathic DCM with a mean level 13.48 ng/mL. There was a negative correlation between vitamin D level and fraction shortening and left ventricular end-diastolic diameter in children with DCM. Vitamin D level is not only significantly low in children with idiopathic DCM but it is also significantly correlated with the degree of left ventricular dysfunction.

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Strong correlation between prevalence of severe vitamin D deficiency and population mortality rate from COVID-19 in Europe

Wiener klinische Wochenschrift ◽

10.1007/s00508-021-01833-y ◽

2021 ◽

Author(s):

Isaac Z. Pugach ◽

Sofya Pugach

Keyword(s):

Vitamin D ◽

Mortality Rate ◽

Vitamin D Deficiency ◽

Strong Correlation ◽

Severe Vitamin ◽

Population Mortality

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Identification of Mortality Risks in the Advancement of Old Age: Application of Proportional Hazard Models Based on the Stepwise Variable Selection and the Bayesian Model Averaging Approach

Nutrients ◽

10.3390/nu13041098 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1098

Author(s):

Ewelina Łukaszyk ◽

Katarzyna Bień-Barkowska ◽

Barbara Bień

Keyword(s):

Vitamin D ◽

Mortality Rate ◽

Plasma Level ◽

Variable Selection ◽

Lymphocyte Count ◽

Bayesian Model ◽

Bayesian Model Averaging ◽

Multivariable Analysis ◽

Model Averaging ◽

Nutritional Risk Index

Identifying factors that affect mortality requires a robust statistical approach. This study’s objective is to assess an optimal set of variables that are independently associated with the mortality risk of 433 older comorbid adults that have been discharged from the geriatric ward. We used both the stepwise backward variable selection and the iterative Bayesian model averaging (BMA) approaches to the Cox proportional hazards models. Potential predictors of the mortality rate were based on a broad range of clinical data; functional and laboratory tests, including geriatric nutritional risk index (GNRI); lymphocyte count; vitamin D, and the age-weighted Charlson comorbidity index. The results of the multivariable analysis identified seven explanatory variables that are independently associated with the length of survival. The mortality rate was higher in males than in females; it increased with the comorbidity level and C-reactive proteins plasma level but was negatively affected by a person’s mobility, GNRI and lymphocyte count, as well as the vitamin D plasma level.

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Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis

QJM ◽

10.1093/qjmed/hcab009 ◽

2021 ◽

Cited By ~ 1

Author(s):

K Shah ◽

D Saxena ◽

D Mavalankar

Keyword(s):

Vitamin D ◽

Randomized Controlled Trials ◽

Usual Care ◽

Odds Ratio ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Hospitalized Patients ◽

Controlled Trials ◽

Randomized Controlled

Abstract Objective: Current meta-analysis aims to understand the effect of oral supplementation of vitamin D on intensive care unit (ICU) requirement and mortality in hospitalized COVID-19 patients. Methods: Databases PubMed, preprint servers, and google scholar were searched from December 2019 to December 2020. Authors searched for the articles assessing role of vitamin D supplementation on COVID-19. Cochrane RevMan tool was used for quantitative assessment of the data, where heterogeneity was assessed using I2 and Q statistics and data was expressed using odds ratio with 95% confidence interval. Results: Final meta-analysis involved pooled data of 532 hospitalized patients (189 on vitamin D supplementation and 343 on usual care/placebo) of COVID-19 from three studies (Two randomized controlled trials, one retrospective case-control study). Statistically (p<0.0001) lower ICU requirement was observed in patients with vitamin D supplementation as compared to patients without supplementations (odds ratio: 0.36; 95% CI: 0.210-0.626). However, it suffered from significant heterogeneity, which reduced after sensitivity analysis. In case of mortality, vitamin D supplements has comparable findings with placebo treatment/usual care (odds ratio: 0.93; 95% CI: 0.413-2.113; p=0.87). The studies did not show any publication bias and had fair quality score. Subgroup analysis could not be performed due to limited number of studies and hence dose and duration dependent effect of vitamin D could not be evaluated. Conclusions: Although the current meta-analysis findings indicate potential role of vitamin D in improving COVID-19 severity in hospitalized patients, more robust data from randomized controlled trials are needed to substantiate its effects on mortality.

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Effect of prolactin and estrogen on the serum level of 1,25-dihydroxy vitamin D and FGF23 in female rats

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-020-05567-6 ◽

2020 ◽

Vol 302 (1) ◽

pp. 265-271

Author(s):

Forough Saki ◽

Faezeh Sadeghian ◽

Seyed Reza Kasaee ◽

Farhad Koohpeyma ◽

Gholam Hossein Ranjbar Omrani

Keyword(s):

Vitamin D ◽

Serum Level ◽

Female Rats

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Prevalence of Hyponatremia and Its Associated Morbimortality in Hospitalized Patients Receiving Parenteral Nutrition

Annals of Nutrition and Metabolism ◽

10.1159/000477675 ◽

2017 ◽

Vol 71 (1-2) ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Emilia Gómez-Hoyos ◽

Martín Cuesta ◽

Nayade Del Prado-González ◽

Pilar Matía ◽

Natalia Pérez-Ferre ◽

...

Keyword(s):

Body Mass Index ◽

Mortality Rate ◽

Parenteral Nutrition ◽

Demographic Data ◽

Tertiary Hospital ◽

Hospital Length ◽

Hospitalized Patients ◽

Hospital Length Of Stay ◽

Control Subjects ◽

Comorbidity Index

Background: The objective of the study was to determine the prevalence of hyponatremia (HN) and its associated morbimortality in hospitalized patients receiving parenteral nutrition (PN). Methods: A retrospective study including 222 patients receiving total PN (parenteral nutrition group [PNG]) over a 7-month period in a tertiary hospital and 176 matched to 179 control subjects without PN (control subjects group [CSG]). Demographic data, Charlson Comorbidity Index (CCI), date of HN detection-(serum sodium or SNa <135 mmol/L)-intrahospital mortality, and hospital length-of-stay (LOS) were registered. In the PNG, body mass index (BMI) and SNa before, during, and after PN were recorded. Results: HN was more prevalent in the PNG: 52.8 vs. 35.8% (p = 0.001), and independent of age, gender, or CCI (OR 1.8 [95% CI 1.1-2.8], p = 0.006). In patients on PN, sustained HN (75% of all intraindividual SNa <135 mmol/L) was associated with a higher mortality rate independent of age, gender, CCI, or BMI (OR 7.38 [95% CI 1.07-50.8], p = 0.042). The absence of HN in PN patients was associated with a shorter hospital LOS (<30 days) and was independent of other comorbidities (OR 3.89 [95% CI 2.11-7.18], p = 0.001). Conclusions: HN is more prevalent in patients on PN. Sustained HN is associated with a higher intrahospital mortality rate. Absence of HN is associated with a shorter hospital LOS.

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