scholarly journals Evaluation of the hepatoprotective effect of different doses of curcumin and vitamin c in methotrexate-induced hepatotoxicity in mice

2021 ◽  
Vol 20 (2) ◽  
pp. 49
Author(s):  
DhekraHasan Khudair ◽  
AliI Al-Gareeb
Keyword(s):  
Vitamin C ◽  
Hepatoprotective Effect ◽  
Different Doses

scholarly journals EFFECTS OF VITAMIN C SUPPLEMENTATION ON THE CHRONIC PHASE OF CHAGAS DISEASE

2015 ◽  
Vol 57 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Ricardo Guimarães MARIM ◽  
Alex Silva de GUSMÃO ◽  
Roberto Esteves Pires CASTANHO ◽  
Rafael DEMINICE ◽  
Altino Luiz Silva THEREZO ◽  
...  
Keyword(s):  
Vitamin C ◽  
Chagas Disease ◽  
Chronic Phase ◽  
Thiobarbituric Acid ◽  
Dose Equivalent ◽  
Thiobarbituric Acid Reactive Substances ◽  
Vitamin C Supplementation ◽  
Histopathologic Analysis ◽  
Different Doses ◽  
Oxidative Insult

Introduction: In order to examine the effectiveness of vitamin C (ascorbic acid) in combating the oxidative insult caused by Trypanosoma cruzi during the development of the chronic phase of Chagas disease, Swiss mice were infected intraperitoneally with 5.0 × 104 trypomastigotes of T. cruzi QM1strain. Methods: Mice were given supplements of two different doses of vitamin C for 180 days. Levels of lipid oxidation (as indicated by thiobarbituric acid reactive substances-TBARS), total peroxide, vitamin C, and reduced glutathione were measured in the plasma, TBARS, total peroxide and vitamin C were measured in the myocardium and histopathologic analysis was undertaken in heart, colon and skeletal muscle. Results: Animals that received a dose equivalent to 500 mg of vitamin C daily showed increased production of ROS in plasma and myocardium and a greater degree of inflammation and necrosis in skeletal muscles than those that received a lower dose or no vitamin C whatsoever. Conclusion: Although some research has shown the antioxidant effect of vitamin C, the results showed that animals subject to a 500 mg dose of vitamin C showed greater tissue damage in the chronic phase of Chagas disease, probably due to the paradoxical actions of the substance, which in this pathology, will have acted as a pro-oxidant or pro-inflammatory.

scholarly journals EFEKTIVITAS PENAMBAHAN VITAMIN C (ASCORBIC ACID) PADA PAKAN KOMERSIAL UNTUK PENGENDALIAN PENYAKIT KOI HERPESVIRUS (KHV) PADA IKAN MAS, Cyprinus carpio

2016 ◽  
Vol 5 (3) ◽  
pp. 425
Author(s):  
Taukhid Taukhid ◽  
Angela Mariana Lusiastuti
Keyword(s):  
Survival Rate ◽  
Vitamin C ◽  
Clinical Symptoms ◽  
Control Group ◽  
Commercial Diet ◽  
Treatment Groups ◽  
Koi Herpesvirus ◽  
B Vitamin ◽  
Different Doses ◽  
All Treatment

Riset dengan tujuan untuk mengevaluasi teknik pengendalian penyakit KHV pada ikan mas melalui penggunaan imunostimulan yaitu penambahan vitamin C pada pakan komersial dengan dosis yang berbeda telah dilakukan pada skala laboratorium. Perlakuan yang diterapkan adalah penambahan vitamin C jenis CFC-90 (microencapsulated vitamin C) pada pakan komersial dengan berbagai dosis yaitu: (A) tanpa vitamin C, sebagai kontrol, (B) vitamin C sebanyak 250 mg/kg pakan, (C) vitamin C sebanyak 500 mg/kg pakan, (D) vitamin C sebanyak 750 mg/kg pakan, dan (E) vitamin C sebanyak 1.000 mg/kg pakan. Masing-masing perlakuan dilakukan pengulangan sebanyak 3 (tiga) kali. Pada hari ke-15, seluruh kelompok perlakuan diinfeksi KHV secara buatan dengan teknik kohabitasi. Pengamatan dilakukan terhadap tingkah laku, gejala klinis, dan mortalitas ikan uji yang dilakukan setiap hari hingga akhir percobaan. Rataan persen sintasan ikan uji tertinggi pada akhir riset diperoleh pada penambahan vitamin C sebanyak 750 mg/kg pakan yaitu sebesar 82,22%; diikuti dengan penambahan vitamin C 250 mg/kg pakan sebesar 70,00%; vitamin C 1.000 mg/kg pakan sebesar 61,11%; vitamin C 500 mg/kg pakan sebesar 58,89%; sedangkan rataan sintasan terendah diperoleh pada kelompok kontrol yaitu sebesar 27,78%.Research with the aim to evaluate the technique of KHV disease control carp through the use of immunostimulatory namely the addition of vitamin C in commercial diet with different doses have been performed in a laboratorial scale. The treatment applied was the addition of vitamin C of CFC-90 (microencapsulated vitamin C) in the commercial diet with different doses, namely: (A) without vitamin C, as control, (B) Vitamin C 250 mg/kg feed, (C) vitamin C of 500 mg/kg feed, (D) Vitamin C 750 mg/kg feed, and (E) of vitamin C as much as 1,000 mg/kg feed. Each treatment was repeated three times. On day 15th, all treatment groups were artificially infected with KHV using cohabitation techniques. Observations conducted to monitor behavior, clinical symptoms and mortality of fish tests were done every day until the end of the experiment. The highest mean percent of survival rate was recorded in treatment D by adding vitamin C as much as 750 mg/kg of feed that was equal to 82.22%, followed by the addition of vitamin C 250 mg/kg diets at 70.00% (treatment B), Vitamin C 1,000 mg/kg feed amounted to 61.11% (treatment E), vitamin C 500 mg/kg diets at 58.89% (treatment C), while the lowest average of survival rate was obtained in the control group that was equal to 27.78%.

scholarly journals Hepatoprotective Effect of Vitamin C (Ascorbic Acid)

2013 ◽  
Vol 04 (01) ◽  
pp. 84-92 ◽  
Author(s):  
Elias Adikwu ◽  
Oputiri Deo
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Hepatoprotective Effect

scholarly journals Effect of Different Doses and Sources of Nitrogen on Postharvest Quality of Cauliflower

2021 ◽  
pp. 19-26
Author(s):  
Hom Nath Giri
Keyword(s):  
Weight Loss ◽  
Vitamin C ◽  
Field Experiment ◽  
Poultry Manure ◽  
Nitrogen Management ◽  
Postharvest Quality ◽  
Late Season ◽  
Different Doses ◽  
Plot Design

In Nepal, there is lacking of proper nitrogen management regarding postharvest quality of cauliflower in the Terai region of Nepal. In order to address these problems, a field experiment was conducted in a split-plot design to determine the appropriate dose of nitrogen and combined effect of urea and poultry manure for better postharvest quality of cauliflower in Rampur, Chitwan. The study was carried out in nine treatment combinations from two different factors, with four replications in a late season variety, Bishop from November 2017 to March 2018. The plots consisted of three treatments of 260, 200, and 140 kg N/ha, while the sub-plots were 100 % N from urea; 50% N from urea and 50% N from poultry manure; and 100% N from poultry manure. Significantly higher vitamin C content of 52.4 mg/100 g was found in 140 kg N/ha than other treatments. Similarly, higher TSS content of 6.3°Brix was found in 260 kg N/ha. More compact and acceptable curds were produced in 260 kg N/ha. Similarly, higher vitamin C content of 52.0 mg/100 g and higher TSS content of 6.0°Brix was produced by 50% N from urea plus 50% N from poultry manure. Significantly more tastier and compact curds were produced by 100% N from poultry manure along with 50% N from urea and 50% N from poultry manure. Higher physiological weight (30.3%) was found in 260 kg N/ha while lower physiological weight loss (24.4%) was found in 50% N from urea and 50% N from poultry manure. From this study, it was concluded that 200 kg nitrogen combination with poultry manure instead of inorganic fertilizer can improve the postharvest quality of cauliflower in Terai region of Nepal.

scholarly journals Effect of L-Ascorbyl-2-Phosphate Magnesium as a Vitamin C Source in Different Doses on Growth of Patin Pangasius Hypophthalmus Fingerlings

2007 ◽  
Vol 5 (1) ◽  
pp. 21
Author(s):  
D. Jusadi ◽  
B.A. Dewantara ◽  
I. Mokoginta
Keyword(s):  
Vitamin C ◽  
Feed Efficiency ◽  
Optimum Dose ◽  
Daily Growth Rate ◽  
Daily Growth ◽  
Protein Retention ◽  
Isocaloric Diets ◽  
Average Size ◽  
Different Doses ◽  
Phosphate Magnesium

<p>This study was aimed to determine optimum dose of L-Ascorbyl-2-Phosphate Magnesium in the diet of patin, <em>Pangasius hypophthalmus</em> fingerlings.  Five isoprotein and isocaloric diets containing different dose of L-Ascorbyl-2-Phosphate Magnesium, i.e. 0, 25, 75 and 100 mg/kg diet were used in this experiment.  Fish with an average size of 5.00±0.11 g were maintained at a density of 15 fish per aquarium.  Fish were fed three times a day <em>at satiation</em>, for 40 days.  The results of study shows that vitamin C content in fish body increased as the vitamin C level of the diet increased.  Similar pattern to vitamin C content was also found in protein retention, lipid retention, daily growth rate, and feed efficiency (<em>p</em>< 0.05).  Thus, it can  be concluded that the most optimum dose of L-Ascorbyl-2-Phosphate Magnesium as vitamin C source for patin fingerlings in this experiment was 100 mg Vit C/kg diet. Higher dose of L-Ascorbyl-2-Phosphate Magnesium than 100 mg/kg diet however need to be further verified.</p> <p>Keywords: vitamin C, patin, <em>Pangasius hypophthalmus</em>.</p> <p> </p> <p>ABSTRAK</p> <p>Penelitian ini bertujuan untuk menentukan kadar optimum L-Ascorbyl-2-Phosphate Magnesium dalam pakan ikan patin, <em>Pangasius hypophthalmus</em> ukuran sejari. Lima macam pakan isoprotein dan isokalori mempunyai kandungan L-Ascorbyl-2-Phosphate Magnesium berbeda, berturut-turut 0, 25, 50, 75 dan 100 mg/kg pakan telah digunakan dalam penelitian ini. Benih berukuran rata-rata 5,00±0,11 g dipelihara dalam akuarium dengan kepadatan 15 ekor per akuarium. Ikan diberi pakan tiga kali sehari, secara <em>at satiation</em>, selama 40 hari. Hasil penelitian menunjukkan bahwa kadar vitamin C tubuh meningkat sejalan dengan kadar vitamin C pakan. Demikian pula retensi protein, retensi lemak laju pertumbuhan harian, efisiensi pakan mengikuti pola yang sama seperti kandungan vitamin C tubuh (p<0,05). Dengan demikian dapat disimpulkan bahwa kadar vitamin C L-Ascorbyl-2-Phosphate Magnesium terbaik dalam pakan ikan patin adalah 100 mg/kg pakan, namun perlu diteliti lebih lanjut kadar L-Ascorbyl-2 Phosphate Magnesium yang lebih tinggi dari 100 mg/kg pakan.</p> <p>Kata kunci: vitamin C, ikan patin, <em>Pangasius hypophthalmus</em>.</p>

scholarly journals Physicochemical, microbiological and bioactive evaluations of ‘Araçá-Boi’ (Eugenia stipitata Mc Vaugh) pulp exposed to Gamma Irradiation

2020 ◽  
Vol 9 (8) ◽  
pp. e131985453
Author(s):  
Romário Oliveira de Andrade ◽  
Gustavo Santos de Lima ◽  
Saul Ramos de Oliveira ◽  
Ana Raquel Carmo de Lima ◽  
Auryclennedy Calou de Araújo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Gamma Irradiation ◽  
Water Activity ◽  
Physicochemical Parameters ◽  
Microbiological Quality ◽  
Agricultural Practices ◽  
The Other ◽  
Brazilian Legislation ◽  
Different Doses

The aim of this research was to evaluate the physicochemical, microbiological and bioactive quality of ‘Araçá-Boi’ pulps exposed to Gamma Irradiation. Manual harvesting was done in the morning, using good agricultural practices, and fruits were packed in thermal boxes and transported to the ‘Laboratório de Armazenamento e Processamento de Produtos Agrícolas’ of the ‘Universidade Federal de Campina Grande’, to obtain the pulp. The ‘Araçá-Boi’ pulp was irradiated in the ‘Laboratório de Irradiação Gama do Centro de Desenvolvimento de Tecnologia Nuclear’ (CDTN), located at UFPE - Recife, PE, where three doses of Gamma Irradiation (2, 3, 4 kGy) were applied for later comparison with the non-irradiated sample (control). After irradiation, the microbiological, physicochemical parameters and the quantification of vitamin C and flavonoids were evaluated it can be observed that dose 6 is grouped in a set with differential characteristics of the other treatments, as it provided higher AA, pH, luminosity and water activity (Aw). It was observed that there was no microorganism development after irradiation in all analyzed treatments. It can be concluded that the different doses of Gamma Irradiation guaranteed the microbiological quality of the ‘Araçá-Boi’ pulp, remaining fit for consumption and in compliance with the Brazilian legislation.

scholarly journals Effect of NPK fertilizers on growth, yield and yield attributes of okra (Abelmoschus esculentus (L.) Moench.)

2013 ◽  
Vol 41 (2) ◽  
pp. 131-134
Author(s):  
MA Rahman ◽  
Ferdousi Akter
Keyword(s):  
Vitamin C ◽  
Growth Yield ◽  
Main Stem ◽  
Abelmoschus Esculentus ◽  
Carotenoid Content ◽  
Stem Number ◽  
Fresh Weight ◽  
Npk Fertilizers ◽  
Yield Attributes ◽  
Different Doses

Five different doses of NPK fertilizers, viz. To (0N0P0K), T1 (1N1P1K), T2 (0N1P1K), T3 (1N0P1K) and T4 (1N1P0K) were applied and the growth, yield and yield attributes of okra were studied. The length of main stem, number of nodes and leaves were maximum at T1. The fresh weight, length, circumference, diameter per fruit and yield per plant were the highest at T1. The carotenoid content of leaves and vitamin C contents of fruits were maximum at T1. The total NPK concentration of both plants and fruits were the highest at T3. DOI: http://dx.doi.org/10.3329/bjb.v41i2.13436 Bangladesh J. Bot. 41(2): 131-134, 2012 (December)

scholarly journals Efecto de la radiación gamma sobre la vitamina C

2019 ◽  
pp. 26-29
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Gamma Radiation ◽  
Orange Juice ◽  
Fruits And Vegetables ◽  
Water Solution ◽  
Initial Content ◽  
Effects Of Radiation ◽  
The One ◽  
Different Doses

Efecto de la radiación gamma sobre la vitamina C Effect of gamma radiation on vitamin C Johnny Vargas R. Instituto Peruano de Energía Nuclear. Av. Canadá 1470 Lima 41 DOI: https://doi.org/10.33017/RevECIPeru2011.0005/ RESUMEN Uno de los compuestos orgánicos más sensibles a la temperatura, almacenamiento y radiaciones es el ácido ascórbico. En una planta de irradiación para el tratamiento cuarentenario, se procesarán frutas y hortalizas frescas; vegetales portadores de vitamina C. Se irradió a una determinada concentración la vitamina C (42,24 mg/100 ml) contenida en 3 diferentes sustratos: en jugo de naranja, en solución de agua y acido ascórbico puro en cristales, diluida posteriormente en agua; se aplicaron diferentes dosis de radiación gamma (0; 0,1; 1,0; y 10 kGy), la tasas de dosis fue 7,433 Gy/min. Los resultados mostraron que los mayores porcentajes de destrucción vitamina C irradiada a las dosis respectivas se presentaron en la solución de vitamina C contenida en agua,(15,62; 64,11 y 84,38 %) debido al efecto indirecto de la radiación gamma, luego en la vitamina C contenida en el jugo de naranja,(5,25; 7,33 y 50,50 %) esto es debido a que los otros constituyentes del jugo de naranja, tienen un efecto protector en la vitamina C contra las radiaciones, la vitamina C en cristales fue la que presentó los menores porcentajes de destrucción (3,13; 4,60 y 6,74%). Las diferentes muestras presentaron un contenido inicial de 42,24 mg de vitamina C por 100 ml del sustrato seleccionado. A la dosis de 0,1 kGy el porcentaje de destrucción en la solución de agua fue de 15,62 % mientras en el jugo de naranja y en cristales fue de 5,25 % y 3,13 % respectivamente; a la dosis de 1 kGy presentaron los siguientes porcentajes de destrucción solución 64,11; jugo 7,33 y cristales 4,60% respectivamente y a la dosis de 10 kGy la destrucción de la vitamina C en solución fue de 84,38; en jugo de naranja 50,50 % y en cristales 6, 79% demostrándose que el tipo de sustrato y la dosis juega un papel importante en los efectos de la radiación sobre la vitamina C. En una planta de irradiación para el tratamiento cuarentenario de frutas y hortalizas frescas se aplicaran dosis alrededor de 0,1 kGy, por lo que las pérdidas en vitamina C serán mínimas. Descriptores: Irradiación, Vitamina C, dosis, tratamiento cuarentenario. ABSTRACT One of the organic compounds more sensitive to temperature, storage and radiation is ascorbic acid. In an irradiation plant quarantine treatment, be processed fruits and vegetables, vegetable carriers of vitamin C. Was irradiated at a given concentration of vitamin C (42.24 mg/100 ml) contained in 3 different media: orange juice in water solution and pure ascorbic acid crystals, then diluted in water, we applied different doses of radiation Gamma (0, 0.1, 1.0, and 10 kGy), the dose rate was 7.433 GY / min.The results showed that higher percentages of vitamin C destruction irradiated to the respective doses were presented in the solution of vitamin C contained in water, (15.62, 64.11 and 84.38%) due to the indirect effect of gamma radiation , then vitamin C contained in orange juice, (5.25, 7.33 and 50.50%) This is because the other constituents of orange juice, have a protective effect of vitamin C against radiation, vitamin C crystals, was the one with the lowest percentages of Destruction (3.13, 4.60 and 6.74%). The different samples showed an initial content of 42.24 mg of vitamin C per 100 ml of the selected substrate. A dose of 0.1 kGy the percentage of destruction in the water solution was 15.62% while in the orange juice and glasses was 5.25% and 3.13% respectively, at a dose of 1 kGy showed the following percentages of destruction solution 64.11; juice crystals and 7.33 respectively 4.60% and the dose of 10 kGy the destruction of vitamin C in solution was 84.38, in orange juice 50.50 % and in crystals 6, 79% demonstrated that the type of substrate and the dose plays an important role in the effects of radiation on vitamin C. In an irradiation facility for quarantine treatment of fruits and vegetables are applied about 0.1 kGy dose, so the vitamin C losses will be minimal. Keywords: Irradiation, Vitamin C, dose, quarantine treatment.

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