This chapter looks at the relationship between commerce and health, some of the choices involved, and the impacts they have on total health. Public health specialists and policymakers have only recently begun to explore the complex relationship between commerce and health, what it has been in the past, what it is now, and importantly what it could look like as we re-build society post COVID-19. The role that work and employers play in our individual, family, and collective health, security, and prosperity has developed over time, and the dependence of companies on the health of their workforce, and their vulnerability when employees are ill, has changed too. The private sector can contribute to health in its immediate community, and nationally through the products it promotes, the working conditions for its employees, and the causes it supports.