scholarly journals Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases

2016 ◽  
Vol 8 ◽  
pp. JCNSD.S32204 ◽  
Author(s):  
He Liu ◽  
Ni Song
Keyword(s):  
Transcription Factors ◽  
Growth Factors ◽  
Brain Tumors ◽  
Embryonic Development ◽  
Human Brain ◽  
Adult Neurogenesis ◽  
Review Article ◽  
Brain Diseases ◽  
Current Evidence ◽  
Epigenetic Factors

Recent advances in neuroscience challenge the old dogma that neurogenesis occurs only during embryonic development. Mounting evidence suggests that functional neurogenesis occurs throughout adulthood. This review article discusses molecular factors that affect adult neurogenesis, including morphogens, growth factors, neurotransmitters, transcription factors, and epigenetic factors. Furthermore, we summarize and compare current evidence of associations between adult neurogenesis and human brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and brain tumors.

scholarly journals Review article: transcription factors and growth factors in ulcer healing

2000 ◽  
Vol 14 ◽  
pp. 33-43 ◽  
Author(s):  
S. Szabo ◽  
T. Khomenko ◽  
Z. Gombos ◽  
X. M. Deng ◽  
M. R. Jadus ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Growth Factors ◽  
Ulcer Healing ◽  
Review Article

scholarly journals Genetic models to study adult neurogenesis.

2005 ◽  
Vol 52 (2) ◽  
pp. 359-372 ◽  
Author(s):  
Robert K Filipkowski ◽  
Anna Kiryk ◽  
Anna Kowalczyk ◽  
Leszek Kaczmarek
Keyword(s):  
Nitric Oxide ◽  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factors ◽  
Growth Factors ◽  
Olfactory Bulb ◽  
Adult Neurogenesis ◽  
Knock Out ◽  
Associated Proteins ◽  
The Central Nervous System

In the central nervous system (CNS) generation of new neurons continues throughout adulthood, when it is limited to the olfactory bulb and hippocampus. The knowledge regarding the function of newly-generated neurons remains limited and is vigorously investigated using diverse approaches. Among these are genetically modified mice, most of them of knock-out type (KO). Results from 23 diverse KO mouse models demonstrate the importance of particular proteins (growth factors, nitric oxide synthases, receptors, cyclins/cyclin-associated proteins, transcription factors, etc.) in adult neurogenesis (ANGE) as well as separate it from developmental neurogenesis. These results bring us closer to revealing the function of newly generated neurons in adult brains.

Astroglial growth factors in normal human brain and brain tumors: comparison with embryonic brain

1992 ◽  
Vol 12 (3) ◽  
pp. 205-218 ◽  
Author(s):  
Michel P. Rathbone ◽  
Galina K. Szlapetis ◽  
Rocco de Villiers ◽  
Rolando F. Del Maestro ◽  
Joseph Gilbert ◽  
...  
Keyword(s):  
Growth Factors ◽  
Brain Tumors ◽  
Human Brain ◽  
Embryonic Brain ◽  
Normal Human Brain ◽  
Normal Human

scholarly journals Human Brain Tumors and Simian Virus 40

1995 ◽  
Vol 87 (17) ◽  
pp. 1331-1331 ◽  
Author(s):  
F. MARTINI ◽  
M. D. MATTEI ◽  
L. IACCHERI ◽  
L. LAZZARIN ◽  
G. BARBANTI-BRODANO ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Human Brain Tumors

scholarly journals Therapeutic Role of Tocilizumab in SARS-CoV-2-Induced Cytokine Storm: Rationale and Current Evidence

2021 ◽  
Vol 22 (6) ◽  
pp. 3059
Author(s):  
Corrado Pelaia ◽  
Cecilia Calabrese ◽  
Eugenio Garofalo ◽  
Andrea Bruni ◽  
Alessandro Vatrella ◽  
...  
Keyword(s):  
Review Article ◽  
Lung Damage ◽  
Current Evidence ◽  
Therapeutic Effects ◽  
Cytokine Storm ◽  
Future Perspectives ◽  
Pathogenic Role ◽  
Refractory Rheumatoid Arthritis ◽  
Life Threatening

Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the worst possible scenarios is represented by the critical lung damage caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced cytokine storm, responsible for a potentially very dangerous hyperinflammatory condition. Within such a context, interleukin-6 (IL-6) plays a key pathogenic role, thus being a suitable therapeutic target. Indeed, the IL-6-receptor antagonist tocilizumab, already approved for treatment of refractory rheumatoid arthritis, is often used to treat patients with severe COVID-19 symptoms and lung involvement. Therefore, the aim of this review article is to focus on the rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as to discuss current evidence and future perspectives, especially with regard to ongoing trials referring to the evaluation of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection.

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