scholarly journals International collaboration generates high quality clusters of pharmaceutical patents

2019 ◽  
Vol 8 (5) ◽  
pp. 193-202 ◽  
Author(s):  
Christian Moser ◽  
Anna M Villa ◽  
Heinz Mueller
Keyword(s):  
South Korea ◽  
Growth Curve ◽  
International Collaboration ◽  
Heterocyclic Compounds ◽  
High Quality ◽  
Pharmaceutical Patents ◽  
Time Period ◽  
Pharmaceutical Patent ◽  
The Usa ◽  
Patent Portfolio

The worldwide active patent portfolio has nearly doubled in numbers and strength since 2000. The number of active pharmaceutical patent families has tripled in the same time period. The quantitative growth results mostly from a surge of patents from China, half of them classified in A61K36 (‘medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants’). High-quality patents exhibit a slower growth curve, and cluster within the three areas biologicals; heterocyclic compounds, and cancer drugs. However, the highest concentration of high-quality patents was found when selecting patents listing inventors from at least two out of the five most important countries of origin for pharmaceutical patents: China, EP countries, Japan, South Korea and the USA.

Neurosurgical activity during COVID-19 pandemic: an experts' opinion from China, South Korea, Italy, the USA, Colombia, and the UK

2020 ◽  
Vol 64 (4) ◽  
Author(s):  
Marco M. Fontanella ◽  
Giorgio Saraceno ◽  
Ting Lei ◽  
Joshua B. Bederson ◽  
Namkyu You ◽  
...  
Keyword(s):  
South Korea ◽  
The Usa ◽  
The Uk

A Bibliometric Analysis of Global Research on Lophomonas sp. in Scopus (1933-2019)

2020 ◽  
Vol 20 ◽  
Author(s):  
Masoud Keighobadi ◽  
Maryam Nakhaei ◽  
Ali Sharifpour ◽  
Ali Akbar Khasseh ◽  
Sepideh Safanavaei ◽  
...  
Keyword(s):  
Bibliometric Analysis ◽  
International Collaboration ◽  
Research Articles ◽  
High Quality ◽  
The Real ◽  
The Us ◽  
The World ◽  
Scopus Database ◽  
Number Of Publications ◽  
Global Research

Background: This study was designed to analyze the global research on Lophomonas spp. using bibliometric techniques. Methods: A bibliometric research was carried out using the Scopus database. The analysis unit was the research articles conducted on Lophomonas spp. Results: Totally, 56 articles about Lophomonas spp. were indexed in the Scopus throughout 1933-2019 ( 87 years ) with the following information: (A) The first article was published in 1933; (B) 21 different countries contributed in studies related to Lophomonas spp.; (C) China ranked first with 16 publications about Lophomonas spp.; and (D) “Brugerolle, G” and “Beams, H.W.” from France and the US participated in 4 articles respectively, as the highest number of publications in the Lophomonas spp. network. Discussion: After 87 years, Lophomonas still remains unknown for many researchers and physicians around the world. Further studies with high quality and international collaboration are urgently needed to determine different epidemiological aspects and the real burden of the mysterious parasite worldwide.

scholarly journals The reasons women choose and stay in a geology major: a qualitative multi-case analysis

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Ron E. Gray ◽  
Alexis T. Riche ◽  
Isabel J. Shinnick-Gordon ◽  
James C. Sample
Keyword(s):  
Role Models ◽  
Critical Incident ◽  
Earth Science ◽  
Time Period ◽  
The Usa ◽  
Data Source ◽  
Introductory Classes ◽  
Iterative Coding ◽  
As Relationship

AbstractDespite earning half of all science and engineering undergraduate degrees between 2007 and 2016 in the USA, women were awarded only 39% of earth science degrees in the same time period. In order to better understand why women are both choosing and staying in geology programs, we conducted a multi-case study of nine current female undergraduate geology majors at a large public university in the USA within a department that is at gender parity among its undergraduate majors. The main data source was audio-recorded critical incident interviews of each participant. Data from the interviews were analyzed through an iterative coding process using codes adapted from previous studies that focused on factors both internal and external to the department. The students said that personal interests, influence by others outside of the department, and introductory classes attracted them to the geology program, but once declared, departmental factors such as relationship with faculty caused them to stay. We also found an emphasis on female role models, especially those teaching introductory courses. We believe this study offers important insights into the ways in which factors leading to recruitment and retention play out in the lived experiences of female geology majors.

scholarly journals A Bibliometric Evaluation of the Top 100 Cited Dimethyl Fumarate Articles

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1085
Author(s):  
Francisco Javier García-Fernández ◽  
Alba Estela García-Fernández ◽  
Ichiro Ikuta ◽  
Eduardo Nava ◽  
Julian Solis García del Pozo ◽  
...  
Keyword(s):  
Dimethyl Fumarate ◽  
Original Research ◽  
H Index ◽  
Early Access ◽  
Research Areas ◽  
Electronic Search ◽  
Time Period ◽  
The Usa ◽  
Immunomodulatory Drug ◽  
Number Of Citations

Dimethyl fumarate is a cytoprotective and immunomodulatory drug used in the treatment of multiple sclerosis. We performed a bibliometric study examining the characteristics and trends of the top 100 cited articles that include dimethyl fumarate in the title. On 21 September 2020 we carried out an electronic search in the Web of Science (WOS), seeking articles that include the following terms within the title: dimethyl fumarate, BG-12, or Tecfidera. To focus our investigation on original research, we refined the search to include only articles, early access, others, case report, and clinical trials. We obtained a total of 1115 items, which were cited 7169 times, had a citation density of 6.43 citations/item, and an h-index of 40. Around 2010, there was a jump in the number of published articles per year, rising from 5 articles/year up to 12 articles/year. We sorted all the items by the number of citations and selected the top 100 most cited (T100). The T100 had 4164 citations, with a density of 37 citations/year and contained 16 classic research articles. They were published between 1961 and 2018; the years 2010–2018 amassed nearly 80% of the T100. We noted 17 research areas with articles in the T100. Of these, the number one ranking went to neurosciences/neurology with 39 articles, and chemistry ranked second on the T100 list with 14 items. We noticed that the percentage of articles belonging to different journals changed depending on the time period. Chemistry held the highest number of papers during 1961–2000, while pharmacology andneurosciences/neurology led the 2001–2018 interval. A total of 478 authors from 145 institutions and 25 countries were included in the T100 ranking. The paper by Gold R et al. was the most successful with 14 articles, 1.823 citations and a density of 140.23 citations/year. The biotechnological company Biogen led the T100 list with 20 articles. With 59 published articles, the USA was the leading country in publications. We concluded that this study analyzed the use of and research on dimethyl fumarate from a different perspective, which will allow the readership (expert or not) to understand the relevance of classic and recent literature on this topic.

scholarly journals Using social media to recruit study participants for a randomized trial for hypertension

2020 ◽  
Vol 1 (1) ◽  
pp. 71-74
Author(s):  
Lida Feyz ◽  
Yale Wang ◽  
Atul Pathak ◽  
Manish Saxena ◽  
Felix Mahfoud ◽  
...  
Keyword(s):  
Social Media ◽  
Randomized Trial ◽  
Recruitment Strategies ◽  
Trial Recruitment ◽  
Efficient Strategy ◽  
Time Period ◽  
The Usa ◽  
Study Participants ◽  
Recruitment Period

Abstract Aims The present study aimed to evaluate the potential of social media as an approach to recruit hypertensive subjects. Methods and results In addition to conventional trial recruitment, Facebook ads were run. Over a 115-day recruitment period, Facebook reached 5.3 million people in 168 separate campaigns run in the proximity of 19 sites in the USA and 14 sites in Europe. A total of 182 839 participants (3.4%) clicked on the ad; of those 10 483 subjects (5.7%) completed a dedicated questionnaire. This resulted in 3632 potential candidates. A total of 285 potential candidates were recruited by various recruitment strategies in the specified time period, of which 184/285 (64.6%) came from Facebook. When comparing Facebook with a 7-day radio spot in the same time period, 48 radio spots were launched; resulting in nine inquiries with eventually five potential candidates and two consents. Conclusion Targeted social media was a successful and efficient strategy to recruit hypertensive subjects.

Mathematical modeling the epicenters of coronavirus disease-2019 (COVID-19) pandemic

2020 ◽  
Vol 9 (s1) ◽  
Author(s):  
Babak Jamshidi ◽  
Mansour Rezaei ◽  
Shahriar Jamshidi Zargaran ◽  
Farid Najafi
Keyword(s):  
Mathematical Modeling ◽  
South Korea ◽  
The Usa

AbstractIn epidemiology, the modeling of epicenters is important both conceptually and mathematically. This paper is an attempt to model epicenters mathematically. We present an algorithm to find new epicenters. Applying our model for the data related to COVID-19 pandemic, we obtain epicenters in China, South Korea, Iran, Italy, France, Germany, Spain, the USA, and Switzerland, on the days 1, 35, 42, 42, 49, 50, 50, 50, and 56, respectively. Although the number of these epicenters is less than 5% of all contaminated countries across the globe, as of March 22, 2020, they make up 74% of new cases and over 80% of total confirmed cases. Finally, we conclude that we expect to face three new epicenters between March 22 and April 1, 2020.

The Japanese National Large Telescope

1991 ◽  
Vol 9 (1) ◽  
pp. 52-54 ◽  
Author(s):  
Tomakazu Kogure ◽  
Keiichi Kodaira
Keyword(s):  
International Collaboration ◽  
New Technologies ◽  
Study Phase ◽  
Large Telescope ◽  
High Quality ◽  
Quality Performance ◽  
Final Study ◽  
Technical Features ◽  
Active Mirror

AbstractThe Japanese National Large Telescope is an 8-metre class optical-infrared reflector with a monolithic thin meniscus mirror, to be constructed at the Mauna Kea summit, Hawaii. The JNLT will be characterised by high quality performance in the optical and infrared regions, achieved by adopting new technologies such as active mirror support, fast optics and a thermally controlled dome. In particular, high infrared qualities are regarded as the most important characteristics among various design goals.The JNLT project is now close to the final study phase before construction. This paper reviews the scientific motivations and the special technical features of the JNLT. Finally, the promotion of international collaboration around the JNLT is emphasised.

Current Status and Future Prospects for Harvesting and Resource Management of the Agarophyte in Japan

1976 ◽  
Vol 33 (4) ◽  
pp. 1024-1030 ◽  
Author(s):  
Nobuo Yamada
Keyword(s):  
Resource Management ◽  
South Korea ◽  
Conservation Management ◽  
Resource Conservation ◽  
Current Status ◽  
Future Prospects ◽  
Annual Output ◽  
The Usa

Agar-agar manufacturing was Japan’s monopoly for about 300 yr from 1644 until about 1920, when its production was initiated in the USA by introducing techniques from Japan, and then was begun in South Korea, Indonesia, and many other countries. Today the average annual output of agar-agar of over 20 countries amounts to 6000 tons, half of which is produced in Japan.Agarophytes are harvested in many countries and traded among them. In Japan, nearly 14,000 tons are consumed in a year, two thirds of which are imported from about 20 countries.Under these circumstances, there is a worldwide demand for appropriate measures for resource conservation, effective harvesting, and utilization of agarophytes.This paper presents the results of basic and applied investigations on the agarophytes and the existing state of harvesting and resource-conservation management in Japan.

scholarly journals Analyses of clinical outcomes after severe pelvic fractures: an international study

2018 ◽  
Vol 3 (1) ◽  
pp. e000238 ◽  
Author(s):  
Kyoungwon Jung ◽  
Shokei Matsumoto ◽  
Alan Smith ◽  
Kyungjin Hwang ◽  
John Cook-Jong Lee ◽  
...  
Keyword(s):  
Mortality Rate ◽  
South Korea ◽  
Trauma Center ◽  
Data Bank ◽  
Pelvic Fractures ◽  
Older Age ◽  
Inhospital Mortality ◽  
Cox Regression Analysis ◽  
Factors Associated ◽  
The Usa

BackgroundThis study aimed to compare treatment outcomes between patients with severe pelvic fractures treated at a representative trauma center that was established in Korea since 2015 and matched cases treated in the USA.MethodsTwo cohorts were selected from a single institution trauma database in South Korea (Ajou Trauma Data Bank (ATDB)) and the National Trauma Data Bank (NTDB) in the USA. Adult blunt trauma patients with a pelvic Abbreviated Injury Scale >3 were included. Patients were matched based on covariates that affect mortality rate using a 1:1 propensity score matching (PSM) approach. We compared differences in outcomes between the two groups, performed survival analysis for the cohort after PSM and identified factors associated with mortality. Lastly, we analyzed factors related to outcomes in the ATDB dataset comparing a period prior to the implementation of the trauma center according to US standards, an interim period and a postimplementation period.ResultsAfter PSM, a total of 320 patients (160 in each cohort) were identified for comparison. Inhospital mortality was significantly higher in the ATDB cohort using χ2 test, but it was not statistically significant when using Kaplan-Meier survival curves and Cox regression analysis. Moreover, the mortality rate was similar comparing the NTDB cohort to ATDB data reflecting the post-trauma center establishment period. Older age, lower systolic blood pressure (SBP) and Glasgow Coma Scale (GCS) at admission were factors associated with mortality.DiscussionMortality rate after severe pelvic fractures was significantly associated with older age, lower SBP and GCS scores at admission. Efforts to establish a trauma center in South Korea led to improvement in outcomes, which are comparable to those in US centers.Level of evidenceLevel IV.

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