High-Fat Diet Alters the Orosensory Sensitivity to Fatty Acids in Obesity-Resistant but not Obesity-Prone Rats

Abstract Large yellow croaker roe phospholipids (LYCRPLs) has great nutritional value because of containing rich docosahexaenoic acid (DHA), which is a kind of n-3 polyunsaturated fatty acids (n-3 PUFAs). In...

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Fatty Acids in a High-Fat Diet Potentially Induce Gastric Parietal-Cell Damage and Metaplasia in Mice

Gastroenterology ◽

10.1016/s0016-5085(17)31627-x ◽

2017 ◽

Vol 152 (5) ◽

pp. S418

Author(s):

Yuki Hirata ◽

Shinji Fukuda ◽

Kazuhiko Yamada ◽

Kazuhide Higuchi ◽

Yuki I. Kawamura ◽

...

Keyword(s):

Fatty Acids ◽

Parietal Cell ◽

High Fat Diet ◽

Cell Damage ◽

High Fat ◽

Gastric Parietal Cell

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Effects of a high-fat-diet supplemented with probiotics and ω3-fatty acids on appetite regulatory neuropeptides and neurotransmitters in a pig model

Beneficial Microbes ◽

10.3920/bm2019.0197 ◽

2020 ◽

Vol 11 (4) ◽

pp. 347-359

Author(s):

D. Valent ◽

L. Arroyo ◽

E. Fàbrega ◽

M. Font-i-Furnols ◽

M. Rodríguez-Palmero ◽

...

Keyword(s):

Fatty Acids ◽

Animal Model ◽

Weight Gain ◽

Food Intake ◽

High Fat Diet ◽

Control Diet ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

High Fat ◽

Brain Functions

The pig is a valuable animal model to study obesity in humans due to the physiological similarity between humans and pigs in terms of digestive and associated metabolic processes. The dietary use of vegetal protein, probiotics and omega-3 fatty acids is recommended to control weight gain and to fight obesity-associated metabolic disorders. Likewise, there are recent reports on their beneficial effects on brain functions. The hypothalamus is the central part of the brain that regulates food intake by means of the production of food intake-regulatory hypothalamic neuropeptides, as neuropeptide Y (NPY), orexin A and pro-opiomelanocortin (POMC), and neurotransmitters, such as dopamine and serotonin. Other mesolimbic areas, such as the hippocampus, are also involved in the control of food intake. In this study, the effect of a high fat diet (HFD) alone or supplemented with these additives on brain neuropeptides and neurotransmitters was assessed in forty-three young pigs fed for 10 weeks with a control diet (T1), a high fat diet (HFD, T2), and HFD with vegetal protein supplemented with Bifidobacterium breve CECT8242 alone (T3) or in combination with omega-3 fatty acids (T4). A HFD provoked changes in regulatory neuropeptides and 3,4-dihydroxyphenylacetic acid (DOPAC) in the hypothalamus and alterations mostly in the dopaminergic system in the ventral hippocampus. Supplementation of the HFD with B. breve CECT8242, especially in combination with omega-3 fatty acids, was able to partially reverse the effects of HFD. Correlations between productive and neurochemical parameters supported these findings. These results confirm that pigs are an appropriate animal model alternative to rodents for the study of the effects of HFD on weight gain and obesity. Furthermore, they indicate the potential benefits of probiotics and omega-3 fatty acids on brain function.

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Effects of dietary fat quantity and composition on fasting and postprandial levels of coagulation factor VII and serum choline-containing phospholipids

British Journal Of Nutrition ◽

10.1079/bjn2003911 ◽

2003 ◽

Vol 90 (2) ◽

pp. 329-336 ◽

Cited By ~ 3

Author(s):

Anja Schou Lindman ◽

Hanne Müller ◽

Ingebjørg Seljeflot ◽

Hans Prydz ◽

Marit Veierød ◽

...

Keyword(s):

Fatty Acids ◽

Dietary Fat ◽

High Fat Diet ◽

Unsaturated Fatty Acids ◽

Saturated Fatty Acids ◽

Coagulation Factor ◽

Factor Vii ◽

High Fat ◽

Coagulation Factor Vii ◽

Low Fat Diet

Dietary fat influences plasma levels of coagulation factor VII (FVII) and serum phospholipids (PL). It is, however, unknown if the fat-mediated changes in FVII are linked to PL. The present study aimed to investigate the effects of dietary fat on fasting and postprandial levels of activated FVII (FVIIa), FVII coagulant activity (FVIIc), FVII protein (FVIIag) and choline-containing PL (PC). In a randomized single-blinded crossover-designed study a high-fat diet (HSAFA), a low-fat diet (LSAFA), both rich in saturated fatty acids, and a high-fat diet rich in unsaturated fatty acids (HUFA) were consumed for 3 weeks. Twenty-five healthy females, in which postprandial responses were studied in a subset of twelve, were included. The HSAFA diet resulted in higher levels of fasting FVIIa and PC compared with the LSAFA and the HUFA diets (all comparisonsP≤0·01). The fasting PC levels after the LSAFA diet were also higher than after the HUFA diet (P<0·001). Postprandial levels of FVIIa and PC were highest on the HSAFA diet and different from LSAFA and HUFA (all comparisonsP≤0·05). Postprandial FVIIa was higher on the HUFA compared with the LSAFA diet (P<0·03), whereas the HUFA diet resulted in lower postprandial levels of PC than the LSAFA diet (P<0·001). Significant correlations between fasting levels of PC and FVIIc were found on all diets, whereas FVIIag was correlated to PC on the HSAFA and HUFA diet. The present results indicate that dietary fat, both quality and quantity, influences fasting and postprandial levels of FVIIa and PC. Although significant associations between fasting FVII and PC levels were found, our results do not support the assumption that postprandial FVII activation is linked to serum PC.

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High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to prevent high-fat diet-induced metabolic syndrome and mitochondrial dysfunction in mice

The Journal of Nutritional Biochemistry ◽

10.1016/j.jnutbio.2019.108330 ◽

2020 ◽

Vol 79 ◽

pp. 108330 ◽

Cited By ~ 4

Author(s):

Run Liu ◽

Lei Chen ◽

Yan Wang ◽

Guanfei Zhang ◽

Ying Cheng ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Mitochondrial Dysfunction ◽

High Fat Diet ◽

High Ratio ◽

High Fat

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The effect of inulin supply to high‐fat diet rich in saturated fatty acids on pork quality and profile of sarcoplasmic protein in meat exudate

Journal of Animal Physiology and Animal Nutrition ◽

10.1111/jpn.13039 ◽

2018 ◽

Author(s):

Wiesław Przybylski ◽

Danuta Jaworska ◽

Piotr Sałek ◽

Monika Sobol ◽

Maciej Branicki ◽

...

Keyword(s):

Fatty Acids ◽

High Fat Diet ◽

Saturated Fatty Acids ◽

Pork Quality ◽

High Fat ◽

Sarcoplasmic Protein

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The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids

Food and Chemical Toxicology ◽

10.1016/j.fct.2011.02.004 ◽

2011 ◽

Vol 49 (5) ◽

pp. 1129-1140 ◽

Cited By ~ 93

Author(s):

Mohamed A. El-Moselhy ◽

Ashraf Taye ◽

Sara Shaaban Sharkawi ◽

Suzan F.I. El-Sisi ◽

Ahmed Fahmy Ahmed

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

High Fat Diet ◽

High Fat ◽

Antihyperglycemic Effect ◽

Tnf Α

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Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids

Journal of Clinical Biochemistry and Nutrition ◽

10.3164/jcbn.12-06 ◽

2012 ◽

Vol 51 (3) ◽

pp. 163-169 ◽

Cited By ~ 6

Author(s):

Wataru Motomura ◽

Takayuki Yoshizaki ◽

Nobuhiko Takahashi ◽

Shima Kumei ◽

Yusuke Mizukami ◽

...

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

Lipid Accumulation ◽

High Fat Diet ◽

High Fat

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Tea Seed Oil Prevents Obesity, Reduces Physical Fatigue, and Improves Exercise Performance in High-Fat-Diet-Induced Obese Ovariectomized Mice

Molecules ◽

10.3390/molecules24050980 ◽

2019 ◽

Vol 24 (5) ◽

pp. 980 ◽

Cited By ~ 2

Author(s):

Yu-Tang Tung ◽

Yi-Ju Hsu ◽

Yi-Wen Chien ◽

Chi-Chang Huang ◽

Wen-Ching Huang ◽

...

Keyword(s):

Fatty Acids ◽

Body Weight ◽

Exercise Performance ◽

High Fat Diet ◽

Seed Oil ◽

Physical Fatigue ◽

High Fat ◽

Tea Seed Oil ◽

Ovariectomized Mice ◽

Total Fat

Menopause is associated with changes in body composition (a decline in lean body mass and an increase in total fat mass), leading to an increased risk of metabolic syndrome, nonalcoholic fatty liver disease, and heart disease. A healthy diet to control body weight is an effective strategy for preventing and treating menopause-related metabolic syndromes. In the present study, we investigated the effect of long-term feeding of edible oils (soybean oil (SO), tea seed oil (TO), and lard oil (LO)) on female ovariectomized (OVX) mice. SO, TO, and LO comprise mainly polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFA), and saturated fatty acids (SFA), respectively. However, there have been quite limited studies to investigate the effects of different fatty acids (PUFA, MUFA, and SFA) on physiological adaption and metabolic homeostasis in a menopausal population. In this study, 7-week-old female Institute of Cancer Research (ICR) mice underwent either bilateral laparotomy (sham group, n = 8) or bilateral oophorectomy (OVX groups, n = 24). The OVX mice given a high-fat diet (HFD) were randomly divided into three groups: OVX+SO, OVX+TO, and OVX+LO. An HFD rich in SO, TO, or LO was given to the OVX mice for 12 weeks. Our findings revealed that the body weight and relative tissues of UFP (uterus fatty peripheral) and total fat (TF) were significantly decreased in the OVX+TO group compared with those in the OVX+SO and OVX+LO groups. However, no significant difference in body weight or in the relative tissues of UFP and TF was noted among the OVX+SO and OVX+LO groups. Furthermore, mice given an HFD rich in TO exhibited significantly decreased accumulation of liver lipid droplets and adipocyte sizes of UFP and brown adipose tissue (BAT) compared with those given an HFD rich in SO or LO. Moreover, replacing SO or LO with TO significantly increased oral glucose tolerance. Additionally, TO improved endurance performance and exhibited antifatigue activity by lowering ammonia, blood urea nitrogen, and creatine kinase levels. Thus, tea seed oil (TO) rich in MUFA could prevent obesity, reduce physical fatigue, and improve exercise performance compared with either SO (PUFA)- or LO(SFA)-rich diets in this HFD-induced obese OVX mice model.

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