DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance on SD rats with a high-fat diet

2021 ◽  
Author(s):  
Xiaodan Lu ◽  
Rongbin Zhong ◽  
Ling Hu ◽  
Luyao Huang ◽  
Lijiao Chen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
High Fat Diet ◽  
Nutritional Value ◽  
Metabolic Disorders ◽  
Large Yellow Croaker ◽  
High Fat ◽  
Sd Rats

Abstract Large yellow croaker roe phospholipids (LYCRPLs) has great nutritional value because of containing rich docosahexaenoic acid (DHA), which is a kind of n-3 polyunsaturated fatty acids (n-3 PUFAs). In...

scholarly journals Evaluation of Anti-Obesity Activity, Acute Toxicity, and Subacute Toxicity of Probiotic Dark Tea

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 99 ◽  
Author(s):  
Wang Ling ◽  
Shungeng Li ◽  
Xingcai Zhang ◽  
Yongquan Xu ◽  
Ying Gao ◽  
...  
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
The Body ◽  
High Fat ◽  
Water Group ◽  
Subacute Toxicity ◽  
Infusion Group ◽  
Sd Rats ◽  
Group Ii

: Probiotic dark tea (PDT) is a novel kind of dark tea produced by fresh albino tea leaves and fermented with specific probiotics. Our study demonstrates that PDT can ameliorate high-fat diet-induced overweight and lipid metabolic disorders and shows no acute or subacute toxicity in Sprague-Dawley (SD) rats. Daily intragastric administration of 5% PDT infusion for 14 days caused no obvious effect on general physiological features and behaviors of rats. Oral administration of 1%, 2%, and 3% of PDT infusion for six weeks had no influence on the biochemistry and histopathology of rats’ organs and blood, as well as the body weight and ratios of organ/body weight. To investigate its anti-obesity activity, SD rats were randomly divided into four groups, treated with normal diet + water (Group I), high-fat diet + water (Group II), high-fat diet + 3% traditional dark tea infusion (Group III), high-fat diet + 3% PDT infusion (Group IV). After six weeks, the body weight, serum total triacylglycerol (TG) and serum total cholesterol (TC) levels of rats in Group II were significantly increased and the high-density lipoprotein cholesterol (HDL) levels were significantly decreased compared with those in the other three groups. Both traditional dark tea and PDT treatment effectively counteracted the adverse effect of a high-fat diet in SD rats. These results suggest that PDT could be applied for the prevention of obesity, which ameliorates overweight and lipid metabolic disorders and which shows no acute or subacute toxicity.

scholarly journals Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Lei Zhao ◽  
Shan Zhong ◽  
Haiyang Qu ◽  
Yunxia Xie ◽  
Zhennan Cao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Chronic Inflammation ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Obese Mice ◽  
High Fat

scholarly journals Polyunsaturated Fatty Acids Stimulate De novo Lipogenesis and Improve Glucose Homeostasis during Refeeding with High Fat Diet

2017 ◽  
Vol 8 ◽  
Author(s):  
Raffaella Crescenzo ◽  
Arianna Mazzoli ◽  
Rosa Cancelliere ◽  
Francesca Bianco ◽  
Antonia Giacco ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Glucose Homeostasis ◽  
High Fat Diet ◽  
De Novo ◽  
De Novo Lipogenesis ◽  
High Fat

Endogenous n-3 polyunsaturated fatty acids prevent azoxymethane-induced colon tumorigenesis in mice fed a high-fat diet

2018 ◽  
Vol 48 ◽  
pp. 439-447
Author(s):  
An-Jun Yao ◽  
Jia-Hui Chen ◽  
Yan Xu ◽  
Zhuang-Wei Zhang ◽  
Zu-Quan Zou ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
High Fat Diet ◽  
High Fat ◽  
Colon Tumorigenesis

scholarly journals Obesity-Related Metabolome and Gut Microbiota Profiles of Juvenile Göttingen Minipigs—Long-Term Intake of Fructose and Resistant Starch

Metabolites ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 456
Author(s):  
Mihai V. Curtasu ◽  
Valeria Tafintseva ◽  
Zachary A. Bendiks ◽  
Maria L. Marco ◽  
Achim Kohler ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Resistant Starch ◽  
High Fat Diet ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
High Fat ◽  
Obesity And Diabetes ◽  
Ad Libitum ◽  
Chain Fatty Acids

The metabolome and gut microbiota were investigated in a juvenile Göttingen minipig model. This study aimed to explore the metabolic effects of two carbohydrate sources with different degrees of risk in obesity development when associated with a high fat intake. A high-risk (HR) high-fat diet containing 20% fructose was compared to a control lower-risk (LR) high-fat diet where a similar amount of carbohydrate was provided as a mix of digestible and resistant starch from high amylose maize. Both diets were fed ad libitum. Non-targeted metabolomics was used to explore plasma, urine, and feces samples over five months. Plasma and fecal short-chain fatty acids were targeted and quantified. Fecal microbiota was analyzed using genomic sequencing. Data analysis was performed using sparse multi-block partial least squares regression. The LR diet increased concentrations of fecal and plasma total short-chain fatty acids, primarily acetate, and there was a higher relative abundance of microbiota associated with acetate production such as Bacteroidetes and Ruminococcus. A higher proportion of Firmicutes was measured with the HR diet, together with a lower alpha diversity compared to the LR diet. Irrespective of diet, the ad libitum exposure to the high-energy diets was accompanied by well-known biomarkers associated with obesity and diabetes, particularly branched-chain amino acids, keto acids, and other catabolism metabolites.

scholarly journals Dietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell Death

2019 ◽  
Vol 87 (8) ◽  
Author(s):  
Sara L. Svahn ◽  
Saray Gutiérrez ◽  
Marcus A. Ulleryd ◽  
Intawat Nookaew ◽  
Veronica Osla ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cell Death ◽  
Polyunsaturated Fatty Acids ◽  
High Fat Diet ◽  
Saturated Fatty Acids ◽  
High Fat ◽  
Neutrophil Accumulation ◽  
Dual Effect ◽  
Dietary Polyunsaturated Fatty Acids ◽  
Neutrophil Cell

ABSTRACTNeutrophils are the most abundant circulating leukocytes in humans and are essential for the defense against invading pathogens. Like many other cells of an organism, neutrophils can be highly influenced by the diet. We have previously described that mice fed a high-fat diet rich in polyunsaturated fatty acids (HFD-P) present a higher frequency of neutrophils in bone marrow than mice fed a high-fat diet rich in saturated fatty acids (HFD-S). Interestingly, such an increase correlated with improved survival against bacterium-induced sepsis. In this study, we aimed to investigate the effects of dietary polyunsaturated and saturated fatty acids on neutrophil homeostasis. We found that HFD-P specifically induced the accumulation of neutrophils in the marginal pools of the spleen and liver. The accumulation of neutrophils in the spleen was a result of a dual effect of polyunsaturated fatty acids on neutrophil homeostasis. First, polyunsaturated fatty acids enhanced the recruitment of neutrophils from the circulation into the spleen via chemokine secretion. Second, they delayed neutrophil cell death in the spleen. Interestingly, these effects were not observed in mice fed a diet rich in saturated fatty acids, suggesting that the type of fat rather than the amount of fat mediates the alterations in neutrophil homeostasis. In conclusion, our results show that dietary polyunsaturated fatty acids have a strong modulatory effect on neutrophil homeostasis that may have future clinical applications.

scholarly journals Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Shoji Yamada ◽  
Nobuhiko Kamada ◽  
Takeru Amiya ◽  
Nobuhiro Nakamoto ◽  
Toshiaki Nakaoka ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Saturated Fatty Acids ◽  
High Fat
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