Altered Trace Elements Levels in Hair of Prostate Cancer Patients

Backgrounds: Variations of trace element contents may be associated with several diseases including metabolic disorders, cellular growth disturbance, mutation and tumorigenesis. Prostate cancer is the second most common male cancer worldwide and stand fifth most common male cancer in Saudi Arabia. Objective: In the present study, Serum levels of selenium, zinc, copper, manganese, and iron were measured in patients with BPH and prostate cancer aiming to explore the association between these elements and prostate cancer. Patients and Methods: The study included 40 newly diagnosed prostate cancer patients, 22 patients with BPH and 30 healthy male subjects. All participant groups had similar socio-economic levels. Fasting blood samples were collected from all subjects and before any intervention for the patients. Serum PSA concentrations were analyzed by ELIZA and trace elements Se, Zn, Cu, Mn and Fe were measured by ICP-MS. Results: Serum Se, Zn, and Mn levels of prostate cancer patients were significantly decreased compared to control groups. The levels of serum Cu and Fe were significantly higher in prostate cancer patients than in control groups. Conclusion: In the present study, an association was noticed between serum trace elements disturbance and prostate cancer. The decreased levels of Se, Zn, and Mn, and increased Cu and Fe levels may play significant roles in the initiation of prostate cancer. However, future prospective studies on the causes of trace elements alteration in prostate cancer patients are needed as well as to illustrate the relation between different prostate cancer stages and trace elements concentrations.

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Correlation of Some Trace Elements Serum Levels with Prostate Cancer Progression in Saudi Patients

The Open Public Health Journal ◽

10.2174/1874944501912010212 ◽

2019 ◽

Vol 12 (1) ◽

pp. 212-218

Author(s):

Saleh A. K. Saleh ◽

Heba M. Adly ◽

Altaf A.Abdulkhaliq ◽

Anmar M. Nassir

Keyword(s):

Prostate Cancer ◽

Trace Elements ◽

Trace Element ◽

Cancer Patients ◽

Cancer Progression ◽

Specific Antigen ◽

Cancer Management ◽

Significant Difference ◽

Trace Element Levels ◽

Different Levels

Background:Trace elements, such as zinc, arsenic, cadmium and nickel are found naturally in the environment, and human exposure comes from a variety of sources, including air, drinking water, and food. Yet, there are a few studies of the association between trace element levels and prostate cancer in the country.Objective:This study aimed to investigate the changes in trace elements in prostate cancer patients with different levels of their prostate-specific antigen (PSA) values.Methods:The study included 58 patients with prostate cancer aged 70 years and older, divided into 3 different levels of PSA. Full history and clinical data were recorded for all subjects. Blood samples from all subjects and levels of Se, Zn, Cd and Cu were analyzed by inductively-coupled plasma mass spectrometry. The odds ratio of trace element levels was adjusted in accordance with socioeconomic data, family history and supplements intake.Results:Mean Se and Zn levels in serum were significantly low (p<0.05) in all prostate cancer patients. The levels of serum Se decreased by 56%, 67% and 70%, while the levels of serum Zn decreased by 35%, 41% and 47%, in subjects with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ml, respectively. Cu levels were increased significantly in prostate cancer patients, while Cd levels had no significant difference between control and prostate cancer groups.Conclusion:This study emphasizes the importance of minerals intake during prostate cancer management and follow-up period. This highlights the importance of trace elements Zn and Se intake as food supplements for prostate cancer patients.

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Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

Asian Journal of Medical Sciences ◽

10.3126/ajms.v6i1.10799 ◽

2014 ◽

Vol 6 (1) ◽

pp. 95-97 ◽

Cited By ~ 3

Author(s):

Bridget Obiageli Onyema-iloh ◽

Samuel C Meludu ◽

Emmanuel Iloh ◽

Johnkennedy Nnodim ◽

Onyema Onyegbule ◽

...

Keyword(s):

Prostate Cancer ◽

Trace Elements ◽

Vitamin A ◽

Cancer Patients ◽

High Performance ◽

Serum Levels ◽

Serum Copper ◽

Antioxidant Vitamins ◽

Copper Level ◽

Antioxidant Vitamin

Aim: This study was conducted to evaluate the serum levels of some trace-elements (zinc, copper and selenium) and antioxidant vitamins (vitamin A, C and E) in prostate cancer patients. Method: A total of 50 prostate cancer patients aged 50-70 years with PSA > 4.0 ng/dl were recruited for the study while 50 apparently healthy individual were used as control subjects. Zinc, copper and selenium were determined using atomic absorption spectrophotometer while vitamin A, C and E were determined using high performance liquid chromatography. Result: The result showed that the mean levels of Se (0.77±0.26), Zn(147.75±42.05) were significantly lower (p <0.05) when compared with the control (1.47±0.13) and (168.78±59.80) respectively. The serum copper level (187. 76±66.05) was significantly higher (p<0.05) when compared with control (126.40±31.24).The antioxidant vitamin A (0.42±0.19), vitamin C (3.62±1.81) and vitamin E (0.39±0.13) were Significantly lower p(<0.05) when compared with the control (0.68±0.32)(12.16±4.07) and (1.40±0.16) respectively. Concusion: The decreased trace elements and antioxidant vitamins may be associated with high free radicals generated due to oxidative stress in prostate cancer patient. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10799 Asian Journal of Medical Sciences Vol.6(1) 2015 95-97

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