Mechanism and Clinical Significance of IL-6 Combined with TNF-α or IL-1 for the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Soken Nakazawa J Song
Keyword(s):  
Clinical Significance ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases ◽  
Tnf Α

Immune Alterations, Lipid Peroxidation, and Muscle Damage Following a Hill Race

2005 ◽  
Vol 30 (2) ◽  
pp. 196-211 ◽  
Author(s):  
Richard J. Simpson ◽  
Martin R. Wilson ◽  
James R. Black ◽  
James A. Ross ◽  
Greg P. Whyte ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Muscle Damage ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Acute Phase Proteins ◽  
Venous Blood ◽  
Total Antioxidant Status ◽  
Phase Response ◽  
Tnf Α

Hill races usually include large downhill running sections, which can induce significant degrees of muscle damage in a field setting. This study examined the link between muscle damage, oxidative stress, and immune perturbations following a 7-km mountainous hill race with 457 m of ascent and 457 m of descent. Venous blood samples were taken from 7 club level runners before, immediately after, and 48 hrs postrace. Samples were analysed for total and differential leukocyte counts, markers of muscle damage (CK), lipid peroxidation (MDA), and acute phase proteins (CRP; fibrinogen; α-1-ACT). The total antioxidant status (TEAC) and plasma levels of the proinflammatory cytokines IL-6, IL-8, and TNF-α were also determined. Subjective pain reports, and plasma activities of CK, MDA, and circulatory monocytes reached peak values at 48 hrs postrace (p <  0.05). TEAC and the cytokine IL-8 increased immediately after the race (p <  0.05). Plasma TNF-α remained unchanged (p > 0.05). Despite the reports of muscle damage and soreness, no evidence of an acute phase response was observed (p > 0.05), which may be explained by the failure of the race to induce a plasma TNF-α response. Future studies should examine the link between muscle damage, oxidative stress, and the acute phase response following hill races of longer duration with larger eccentric components. Key words: acute phase response, cytokines, antioxidant capacity, creatine kinase, field study

scholarly journals CLINICAL AND IMMUNOLOGICAL INFLAMMATORY PATTERNS OF BRONCHIAL ASTHMA IN OBESE PATIENTS

2019 ◽  
Vol 1 (1) ◽  
pp. 59-63
Author(s):  
A. Yu. Konischeva ◽  
V. B. Gervazieva ◽  
S. A. Mazurina
Keyword(s):  
Bronchial Asthma ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Serum Levels ◽  
Asthma Severity ◽  
The Body ◽  
Excess Body Weight ◽  
Biochemical Tests ◽  
Chronic Inflammatory Condition ◽  
Tnf Α

We aimed to investigate immunological patterns of inflammation and autoimmunity, in bronchial asthma (BA) associated with obesity. Materials and methods. 109 people aged from 17 to 58 years with various body weights have been examined in total, including 64 individuals with allergic diseases as bronchial asthma (BA) and allergic rhinitis (AR). We performed the measurement of the body mass index according to WHO criteria, and evaluation of the asthma severity and comorbid conditions. In the samples of peripheral blood we measured biochemical tests (cholesterol and its fractions), spontaneous and PHA-induced production of cytokines: IL-4, IL-10, IL-17, TNF-, and serum levels of C-reactive protein (CRP), leptin, total IgE and IgE-autoAT, specific for a number of tissue AH (epithelial keratin, collagen 3 and 6 types, elastin and myosin). Results. Our study showed that in both groups of adults, the obesity was associated with increasing of acute phase proteins, CRP, leptin and TNF-α in serum, being most enhanced in asthma group. Individuals with excess body weight are characterized by significantly an increased level of acute phase proteins (Westergren ESR, CRP) and pro-inflammatory cytokines (TNF-α) in serum, thereby confirming the involvement of systemic inflammation in the obesity pathogenesis. The phenotype of BA with obesity is characterized by overproduction of CRP and leptin, along with increased spontaneous production of IL-4 and TNF-α, and also revealed sIgE to self-antigen as keratin, that in total could indicate more prominent inflammatory pathways with the impairment of immune regulation in this endotype of patients. Conclusion. The revealed associations confirm the link between obesity, as a chronic inflammatory condition, with atopy and development of asthma with further immune-mediated inflammation of the conduction airways.

scholarly journals Acute Phase Proteins in Prototype Rheumatic Inflammatory Diseases

10.5772/18350 ◽  
2011 ◽  
Author(s):  
Katja Lakota ◽  
Mojca Frank ◽  
Olivio Buzan ◽  
Matija Tomsic ◽  
Blaz Rozman ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases

IL-8 and TNF-α from peripheral neutrophils and acute-phase proteins in periodontitis

2002 ◽  
Vol 29 (2) ◽  
pp. 123-128 ◽  
Author(s):  
M. Fredriksson ◽  
K. Bergström ◽  
B. Åsman
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Tnf Α

scholarly journals Diagnosis value of some acute-phase proteins in purulent-inflammatory diseases of uterine appendages

2006 ◽  
Vol 5 (3) ◽  
pp. 112-116
Author(s):  
S. V. Shramko ◽  
S. V. Arkhipova ◽  
L. G. Bazhenova ◽  
R. M. Zorina
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases ◽  
Treatment Options ◽  
Organic Destruction ◽  
Monospecific Antiserum ◽  
Inflammatory Processes ◽  
Diagnostic Criterion ◽  
The Given ◽  
Selection Of

We investigated concentrations of acute-phase proteins a-2-macroglobulin (MG) and lactoferrin (LF) in blood serum of 78 women with various types of uterine appendages inflammatory processes. Coefficient MG/LF was used as an additional diagnostic criterum of purulent-necrotic destruction of organs and tissues and allowed us to choose proper treatment options. MG values were assessed by method of rocket immune electroforesis using monospecific antiserum to the given protein, LF level was assessed by enzyme linked immunoassay based method (ELISA). Standard was performed when coefficient MG/LF was greater than 1, and if value of coefficient MG/LF was less than 1, we performed surgical treatment. Using coefficient MG/LF as a diagnostic criterion of existence of organic destruction in uterine appendages allowed us to optimize the selection of treatment program.

scholarly journals Antibody-Based Therapeutics for Atherosclerosis and Cardiovascular Diseases

2021 ◽  
Vol 22 (11) ◽  
pp. 5770
Author(s):  
Eunhye Ji ◽  
Sahmin Lee
Keyword(s):  
Cardiovascular Diseases ◽  
Apolipoprotein B ◽  
Animal Studies ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Disease ◽  
Clinical Effects ◽  
Rheumatic Arthritis ◽  
Chronic Inflammatory Diseases ◽  
Cholesterol Levels ◽  
Tnf Α

Cardiovascular disease is the leading cause of death worldwide, and its prevalence is increasing due to the aging of societies. Atherosclerosis, a type of chronic inflammatory disease that occurs in arteries, is considered to be the main cause of cardiovascular diseases such as ischemic heart disease or stroke. In addition, the inflammatory response caused by atherosclerosis confers a significant effect on chronic inflammatory diseases such as psoriasis and rheumatic arthritis. Here, we review the mechanism of action of the main causes of atherosclerosis such as plasma LDL level and inflammation; furthermore, we review the recent findings on the preclinical and clinical effects of antibodies that reduce the LDL level and those that neutralize the cytokines involved in inflammation. The apolipoprotein B autoantibody and anti-PCSK9 antibody reduced the level of LDL and plaques in animal studies, but failed to significantly reduce carotid inflammation plaques in clinical trials. The monoclonal antibodies against PCSK9 (alirocumab, evolocumab), which are used as a treatment for hyperlipidemia, lowered cholesterol levels and the incidence of cardiovascular diseases. Antibodies that neutralize inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-17, and IL-12/23) have shown promising but contradictory results and thus warrant further research.

scholarly journals Blocking IL-1 in systemic inflammation

2005 ◽  
Vol 201 (9) ◽  
pp. 1355-1359 ◽  
Author(s):  
Charles A. Dinarello
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Acute Phase ◽  
Systemic Inflammation ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases ◽  
Common Mechanism ◽  
Loss Of Control ◽  
Local Inflammation ◽  
Rapid Resolution ◽  
Systemic Onset

A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.

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