scholarly journals Diagnosis value of some acute-phase proteins in purulent-inflammatory diseases of uterine appendages

2006 ◽  
Vol 5 (3) ◽  
pp. 112-116
Author(s):  
S. V. Shramko ◽  
S. V. Arkhipova ◽  
L. G. Bazhenova ◽  
R. M. Zorina
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases ◽  
Treatment Options ◽  
Organic Destruction ◽  
Monospecific Antiserum ◽  
Inflammatory Processes ◽  
Diagnostic Criterion ◽  
The Given ◽  
Selection Of

We investigated concentrations of acute-phase proteins a-2-macroglobulin (MG) and lactoferrin (LF) in blood serum of 78 women with various types of uterine appendages inflammatory processes. Coefficient MG/LF was used as an additional diagnostic criterum of purulent-necrotic destruction of organs and tissues and allowed us to choose proper treatment options. MG values were assessed by method of rocket immune electroforesis using monospecific antiserum to the given protein, LF level was assessed by enzyme linked immunoassay based method (ELISA). Standard was performed when coefficient MG/LF was greater than 1, and if value of coefficient MG/LF was less than 1, we performed surgical treatment. Using coefficient MG/LF as a diagnostic criterion of existence of organic destruction in uterine appendages allowed us to optimize the selection of treatment program.

scholarly journals Inhibition of the activity of pro-inflammatory secretory phospholipase A2by acute phase proteins

1996 ◽  
Vol 5 (3) ◽  
pp. 196-201 ◽  
Author(s):  
W. Pruzanski ◽  
E. Stefanski ◽  
P. Vadas
Keyword(s):  
Acute Phase ◽  
Inhibitory Activity ◽  
Acute Phase Proteins ◽  
Acute Phase Reaction ◽  
Phase Reaction ◽  
Protective Mechanisms ◽  
Spla2 Activity ◽  
Pancreatic Phospholipase ◽  
Inflammatory Processes ◽  
Bacteriostatic Property

Pro-Inflammatory non-pancreatic phospholipase A2(sPLA2) is markedly over-expressed in acute systemic and chronic local inflammatory processes. Since in acute phase reaction sPLA2is often over-expressed simultaneously with acute phase proteins (APP), it is important to determine whether APP interacts with sPLA2. We tested ten APPs for interaction with sPLA2using as a substrate multilamellar Hposomes composed either of PC:Lyso PC or PE:Lyso PE. Using PC:Lyso PC substrate, CRP, lactoferrin and SAP were found to inhibit sPLA2activity with an IC50of 25 μg/ml, 7.5 μg/ml and 50 μg/ml, respectively, corresponding to 0.21 μM, 0.1 μM and 0.21 μM respectively. Using PE:Lyso PE substrate only SAP was inhibitory, with an IC50of 10 μg/ml (0.04 μM). Phosphorylcholine abolished the inhibitory activity of CRP but not of SAP or lactoferrin. Addition of phosphorylethanolamine or of excess calcium had no effect on the inhibitory activity of APP. Limulin, lysozyme, transferrin, β2-microglobulin, α2-macroglobulin, human and bovine albumins had no effect on sPLA2 activity. Therefore neither the structure of pentraxins, or ironbinding, bacteriostatic property or amyloidogenic property preclude whether APP modulates sPLA2activity. Inhibition of pro-inflammatory sPLA2by APP may be one of the protective mechanisms of the acute phase reaction.

scholarly journals Acute Phase Proteins in Prototype Rheumatic Inflammatory Diseases

10.5772/18350 ◽  
2011 ◽  
Author(s):  
Katja Lakota ◽  
Mojca Frank ◽  
Olivio Buzan ◽  
Matija Tomsic ◽  
Blaz Rozman ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases

scholarly journals Glycosylation Changes on Serum Glycoproteins in Ovarian Cancer May Contribute to Disease Pathogenesis

2008 ◽  
Vol 25 (4-5) ◽  
pp. 219-232 ◽  
Author(s):  
Radka Saldova ◽  
Mark R. Wormald ◽  
Raymond A. Dwek ◽  
Pauline M. Rudd
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Acute Phase ◽  
Iron Homeostasis ◽  
Acute Phase Proteins ◽  
Sialyl Lewis X ◽  
Altered Glycosylation ◽  
Serum Ca125 ◽  
Inflammatory Processes ◽  
Parenchymal Cells

Ovarian cancer is the most lethal of all gynaecological cancers among women. Serum CA125 is the only biomarker that is used routinely and there is a need for further complementary biomarkers both in terms of sensitivity and specificity.N-glycosylation changes in ovarian cancer serum glycoproteins include a decrease in galactosylation of IgG and an increase in sialyl Lewis X (SLex) on haptoglobinβ-chain,α1-acid glycoprotein andα1-antichymotrypsin. These changes are also present in chronic inflammation but not in malignant melanoma, where there are low levels of inflammatory processes. Acute phase proteins carrying increased amounts of SLexhave an increased half-life. Sialylation of acute phase proteins also decreases apoptosis favouring survival of cancer cells. Cancer cells produce inflammatory cytokines which influence glycosylation processing in liver parenchymal cells. Altered glycosylation of the acute phase protein transferrin plays an important role in iron homeostasis. Glycosylated transferrin and its glycans have anti-apoptotic properties and many transferrin receptors in carcinoma could play a role in development of anaemia. Decreased galactosylation and sialylation of IgG increases the cytotoxicity of natural killer cells and complement activation via mannose-binding lectin (MBL). Altered glycosylation of acute phase proteins and IgG suggests that cancer regulates certain pathways favouring cancer cells survival.

Prostaglandin E2 receptor 4 (EP4): a promising therapeutic target for the treatment of cancer and inflammatory diseases

2020 ◽  
Vol 14 ◽  
Author(s):  
Debasis Das ◽  
Jian Hong
Keyword(s):  
Prostaglandin E2 ◽  
Inflammatory Diseases ◽  
Treatment Options ◽  
Cancer Therapeutics ◽  
Receptor Subtypes ◽  
Ep4 Receptor ◽  
Promising Therapeutic Target ◽  
Inflammatory Processes ◽  
Prostaglandin E2 Receptor ◽  
Bone Deposition

: Prostaglandin E2 (PGE2) is involved in several biological processes including inflammation, pain, fever, renal function, mucosal integrity, angiogenesis and tumor growth. PGE2 receptor subtypes (EP1-4) play pivotal roles in PGE2- mediated biological events. Recent studies revealed the fact that EP4 is commonly upregulated in cancer, to stimulate cell proliferation, migration, invasion, and metastasis. Additionally, EP4 receptor has a role in several anti-inflammatory processes, bone formation and hemostasis. EP4 receptor modulators can be used as drugs of specific interests. A number of EP4 receptor agonists and antagonists are at different stages of clinical developments. The agonists for EP4 receptors showed promising results for ulcerative colitis (UC), bone deposition and facilitated bone resorption. The uses of EP4 antagonists, particularly in combination with chemotherapy, endocrine therapy, or immune based therapies may be the treatment options for cancer. Several EP4 antagonists are being progressed in clinical trials and hope the results will show usefulness of EP4 receptor as a target for cancer therapeutics. In this review, we have summarized the EP4 receptor and the possible therapeutic applications of EP4 receptor selective agonists and antagonists.

scholarly journals Blocking IL-1 in systemic inflammation

2005 ◽  
Vol 201 (9) ◽  
pp. 1355-1359 ◽  
Author(s):  
Charles A. Dinarello
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Acute Phase ◽  
Systemic Inflammation ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases ◽  
Common Mechanism ◽  
Loss Of Control ◽  
Local Inflammation ◽  
Rapid Resolution ◽  
Systemic Onset

A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.

scholarly journals THE EFFECTS OF STRESS ON ACUTE PHASE PROTEINS OF CATTLE

2016 ◽  
Vol 18 (4(72)) ◽  
pp. 107-113
Author(s):  
S.M. Sevgisunar ◽  
S. Şahinduran
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Clinical Signs ◽  
Stress Factors ◽  
Stress Effect ◽  
Hormonal Changes ◽  
Acid Glycoprotein ◽  
Amyloid A ◽  
Inflammatory Processes

Stress occurs with the pressure of external and internal (infectious or non–infectious) causes which forces change in animals. This stress not only emerge with behavioral or clinical signs, but also will result with immune response formed by body. Understanding and evaluating this subclinic response is also possible with the help of Acute Phase Proteins (APP–AFP) which are released by tissues and organs when exposed to external and internal changes as well as known hormonal changes. Cattle are fed because of their economical importance and the inflammatory processes have influence on their yield levels. Because the stress is laying under all these health problems, also it is getting attention how stress effect the animals. Stress can be divided into main four groups: physical (mechanical), inflammatory (infectious), behavioral and other stress factors. The main APPs which all groups mostly using in their studies are serum amyloid A (SAA) haptoglobin (Hp), ceruloplasmin (Cp), fibrinogen (Fb), lipopolisakkarit binding protein (LBP) ve α1–Acid Glycoprotein (AGP).

scholarly journals MATRIX METALLOPROTEINASES AND ACUTE PHASE PROTEINS IN INFLAMMATORY PROCESSES OF THE LUNGS IN CHILDREN

2016 ◽  
Vol 0 (2) ◽  
pp. 10
Author(s):  
Nikolay Alekseevich Dorokhov ◽  
Evgeny Vasilevich Skudarnov ◽  
Denis Aleksandrovich Antropov ◽  
Olga Vyacheslavovna Nevskaya
Keyword(s):  
Matrix Metalloproteinases ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Processes

Acute phase proteins in relation to various inflammatory diseases of calves

2011 ◽  
Vol 21 (5) ◽  
pp. 1037-1042 ◽  
Author(s):  
Csilla Tóthová ◽  
Oskar Nagy ◽  
Herbert Seidel ◽  
Gabriel Kováč
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Inflammatory Diseases
Sign in / Sign up

Export Citation Format

Share Document