scholarly journals Clinical Significance of Platelet-Derived Growth Factor-C Expression in Colorectal Cancer

2014 ◽  
Vol 05 (01) ◽  
pp. 11-20 ◽  
Author(s):  
Shinichi Yamauchi ◽  
Satoru Iida ◽  
Megumi Ishiguro ◽  
Toshiaki Ishikawa ◽  
Hiroyuki Uetake ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Clinical Significance ◽  
Platelet Derived Growth Factor ◽  
Factor C

scholarly journals Clinical significance of platelet derived growth factor-C and -D in gastric cancer

2015 ◽  
Vol 10 (6) ◽  
pp. 3495-3501 ◽  
Author(s):  
NORIHITO OGAWA ◽  
MIKITO INOKUCHI ◽  
YOKO TAKAGI ◽  
HIROFUMI SUGITA ◽  
KEIJI KATO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Clinical Significance ◽  
Platelet Derived Growth Factor ◽  
Factor C

scholarly journals On-line hemodiafiltration modulates atherosclerosis signaling in peripheral lymphomonocytes of hemodialysis patients

2021 ◽  
Author(s):  
Simona Simone ◽  
Annarita Chieti ◽  
Paola Pontrelli ◽  
Federica Rascio ◽  
Giuseppe Castellano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Networks ◽  
Mononuclear Cells ◽  
Expression Profiles ◽  
Hemodialysis Patients ◽  
Monoamine Oxidase A ◽  
Platelet Derived Growth Factor ◽  
Peripheral Blood Mononuclear ◽  
On Line ◽  
Factor C

Abstract Background Hemodialysis patients present a dramatic increase in cardiovascular morbidity/mortality. Circulating immune cells, activated by both uremic milieu and dialysis, play a key role in the pathogenesis of dialysis-related vascular disease. The aim of our study was to identify, through a high-throughput approach, differences in gene expression profiles in the peripheral blood mononuclear cells (PBMCs) of patients treated with on-line hemodiafiltration and bicarbonate hemodialysis. Methods The transcriptomic profile was investigated in PBMCs isolated from eight patients on on-line hemodiafiltration and eight patients on bicarbonate hemodialysis by microarray analysis. The results were evaluated by statistical and functional pathway analysis and validated by real time PCR (qPCR) in an independent cohort of patients (on-line hemodiafiltration N = 20, bicarbonate hemodialysis n = 20). Results Eight hundred and forty-seven genes were differentially expressed in patients treated with  on-line hemodiafiltration and bicarbonate hemodialysis. Thirty-seven functional gene networks were identified and atherosclerosis signaling was the top canonical pathway regulated by on-line hemodiafiltration. Among the genes of this pathway, on-line hemodiafiltration was associated with a reduced expression of Platelet-derived growth factor A chain (PDGF A), Clusterin, Monoamine Oxidase A, Interleukin-6 (IL-6) and Vascular Endothelial Growth Factor C (VEGF-)C and with an increase of Apolipoprotein E. qPCR confirmed the microarray results. Platelet derived growth factor AA (PDGF-AA), IL-6 and VEGF-C serum levels were significantly lower in the on-line hemodiafiltration group. Finally, 10 patients previously on bicarbonate hemodialysis  were switched to on-line hemodiafiltration and PBMCs were harvested after 6 months. The qPCR results from this perspective group confirmed the modulation of atherosclerotic genes observed in the cross-sectional analysis. Conclusions Our data suggest that type of dialysis (on-line hemodiafiltration versus bicarbonate hemodialysis) may modulate the expression of several genes involved in the pathogenesis of atherosclerotic disease.

scholarly journals Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

2005 ◽  
Vol 102 (9) ◽  
pp. 3389-3394 ◽  
Author(s):  
J. S. Campbell ◽  
S. D. Hughes ◽  
D. G. Gilbertson ◽  
T. E. Palmer ◽  
M. S. Holdren ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Liver Fibrosis ◽  
Platelet Derived Growth Factor ◽  
Factor C

scholarly journals Clinical Significance of Fibroblast Growth Factor (FGF) Expression in Colorectal Cancer

2014 ◽  
Vol 99 (5) ◽  
pp. 493-499 ◽  
Author(s):  
Norie Jibiki ◽  
Noboru Saito ◽  
Shingo Kameoka ◽  
Makio Kobayashi
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cancer Patients ◽  
Clinical Significance ◽  
Stage Iv ◽  
Serum Levels ◽  
Lymphatic Invasion ◽  
Fibroblast Growth ◽  
Clinicopathological Factors

Abstract In this study, we serologically and pathologically examined the clinical significance of fibroblast growth factor (FGF) expression in patients with colorectal cancer. Serum basic FGF (bFGF) levels in 92 surgical colorectal cancer patients and 31 controls were measured, and the relationship between those levels and clinicopathological factors were examined. Immunohistochemical study was also conducted on specimens from 51 cancer patients, and the association between bFGF staining and serum levels were investigated. An examination of clinicopathological factors revealed significant differences in bFGF levels between stage 0-IIIb and stage IV cancers (P = 0.013). Lymphatic invasion was one factor that differed significantly. Patients with a tumor 30 mm or smaller had a bFGF level of 7.65 ± 1.11 pg/ml while patients with a tumor 31 mm or larger had a bFGF level of 8.53 ± 3.22 pg/ml; significant differences in these bFGF levels were noted (P < 0.05). Patients with a tumor that had no lymphatic invasion (ly0) had a bFGF level of 7.25 ± 0.66 pg/ml, those with a tumor that had minimal lymphatic invasion (ly1) had a bFGF level of 7.99 ± 1.68 pg/ml, and those with a tumor that had moderate lymphatic invasion (ly2) had a bFGF level of 9.17 ± 4.23 pg/ml. bFGF levels differed significantly for tumors with no/minimal lymphatic invasion (ly0-ly1) and those with moderate lymphatic invasion (ly2) (P < 0.0001). Serological examination of bFGF levels during the proliferation of colorectal cancer revealed that moderate lymphatic invasion can be readily distinguished.

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