Immune Response after Hepatitis B Vaccination among Egyptian Medical Students in Nile Delta

AbstractIntroductionMedical students are mainly exposed to needle stick and sharp object injuries in the course of their clinical activities during studying. They are at high risk due to their undeveloped skills, restricted clinical experience, lack of knowledge and risk perception. The objectives of this study were to determine the prevalence of needle stick injuries of the fourth and final year medical students, and to estimate their knowledge about blood-borne pathogens disease transmission and standard precautions.MethodsThis cross-sectional study was conducted at the Faculty of Medicine, in February 2014. The students were invited to self-administer a questionnaire of 26 closed questions prepared for this study.ResultsThe questionnaire was filled in and returned by 637 students. The prevalence of needle sticks and sharp object injuries was 29.5%. Needle stick injuries were the most common type of accidents, more frequent among the fourth compared to the sixth year students (p=0.002). The majority of accidents occurred in patient rooms (53%) and the emergency department (15%). 54% of participants reported an accident to the responsible person. Students without accidents had a significantly better perception of risk (3.79 vs. 3.35; p<0.05). Out of the total participating students, only 16.6% (106/637) received all three doses of Hepatitis B vaccination, while 16.2% were partially vaccinated.ConclusionsThere is a need for additional theoretical and practical education of our students on blood exposure via accidents, raising the awareness of the necessity of hepatitis B vaccination, and introducing the unique/comprehensive procedure for accident reporting for students and healthcare workers in the entire country.

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Hepatitis B Awareness Among Medical Students And Their Vaccination Status In A Medical College In Western UP.

10.36106/ijsr/0601604 ◽

2019 ◽

pp. 57-59

Author(s):

Rajni Dawar ◽

Tabassum Yasmin ◽

Ajay Kumar Jha

Keyword(s):

Medical Students ◽

High Risk ◽

Data Collection ◽

Hepatitis B ◽

Health Care Professionals ◽

Hepatitis B Surface Antigen ◽

Vaccination Status ◽

Hepatitis B Vaccination ◽

Universal Precautions ◽

Medical College

Background: India is in the intermediate hepatitis B virus endemicity zone with hepatitis B surface antigen prevalence among the general population ranging from 2% to 8%.Health care professionals are at a high risk of getting .Hep B infection which can be prevented by strategies like vaccination, increasing awareness and following universal precautions. The present study was conducted on medical students (3rd Semester) to evaluate their knowledge regarding HBV and to know their vaccination status. Also along with data collection, students were educated about hepatitis B vaccine and about universal precautions before they start with their clinical postings. Methods: Cross sectional study was carried out on 3rd semester MBBS students (batch 2012-2013). All the students present on the day of data collection were included in the study and interviewed using pretested questionnaire. Data was analyzed using percentages. Results: Most of the students had good knowledge about disease and modes of transmission & prevention. Surprisingly only 56.6 percent were aware of high risk of transmission to health professional and doctors. Main source of information was media (85.4percent).Nearly 82% of the students were immunized and main reason among those unimmunized was unawareness about vaccine availability. Conclusions: It is recommended that Hepatitis B vaccination should be made available for all unimmunized students who enter medical profession. The orientation and sensitization programm should be held to create awareness regarding HBV infection preferably at the time of admission into medical college ,else no later than start of their clinical posting.

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P-220 To Assess the Rate of Adequate Immune Response to Primary Hepatitis B Vaccination Series in Patients with IBD

Inflammatory Bowel Diseases ◽

10.1097/01.mib.0000480330.52952.bf ◽

2016 ◽

Vol 22 ◽

pp. S76

Author(s):

Uma Phatak ◽

Danilo Rojas-Velasquez ◽

Dinesh Pashankar

Keyword(s):

Immune Response ◽

Hepatitis B ◽

Hepatitis B Vaccination

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Effect of Oral Levamisole Supplementation to Hepatitis B Vaccination on the Rate of Immune Response in Chronic Hemodialysis Patients

Nephron ◽

10.1159/000045598 ◽

2000 ◽

Vol 84 (3) ◽

pp. 291-292 ◽

Cited By ~ 14

Author(s):

M. Deniz Ayli ◽

Cüneyt Ensari ◽

Meltem Ayli ◽

Fahri Mandiroglu ◽

Suat Mut

Keyword(s):

Immune Response ◽

Hepatitis B ◽

Hemodialysis Patients ◽

Chronic Hemodialysis ◽

Hepatitis B Vaccination

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A STUDY TO ASSESS THE SEROPREVALENCE OF HEPATITIS B AND ANTI HBS ANTIBODY LEVELS AMONGST HEALTH CARE WORKERS AND MEDICAL STUDENTS.

10.36106/ijsr/8002609 ◽

2021 ◽

pp. 84-85

Author(s):

Aditya Rana ◽

Anuradha Sood

Keyword(s):

Medical Students ◽

Hepatitis B ◽

Healthcare Workers ◽

Base Material ◽

Hepatitis B Vaccination ◽

Continuous Exposure ◽

Cross Sectional ◽

Antibody Titres ◽

Antibody Titers ◽

Antibody Levels

Background: Hepatitis B(HBV) is a blood borne virus and it is one of the most important occupational hazards among healthcare workers (HCWs) & Medical students. This study aimed to measure the anti-HBs titres and to assess the seroprevalence of Hepatitis B in HCW and medical students. It was a prospective,descriptive and cross sectional hospital base Material and method: d study. Medical students and healthcare workers who had received all three doses of hepatitis B vaccination were included in the study. A total of 200 subjects , aged between 18 and Result: 62 years were taken. 182 were vaccinated and 18 were unvaccinated. 85 were males and 115 females. Seroprevalence of Hepatitis B was nil. Antibody titres were >100mIU/ml in 51.6% , 10-100mIU/ml in 16.4% & <10 mIU/ml in 31.8% respectively.Negative correlation of decreasing antibiotic titer and age was seen. HCW and medical students are at hi Conclusion: gher risk due to their continuous exposure to blood products. Vaccination should be compulsory to the HCW and medical workers in the institution as Hepatitis B is a preventable disease. Monitoring of antibody titers should be done from time to time to see waning off antibody titers after vaccination

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Evaluation of hepatitis B vaccination status and immune response among clinicians in a tertiary care hospital in South India

The Journal of Clinical and Scientific Research ◽

10.4103/jcsr.jcsr_52_19 ◽

2019 ◽

Vol 8 (2) ◽

pp. 74

Author(s):

N Ramakrishna ◽

R Jayaprada ◽

B Vasavi ◽

B Venkataramana ◽

KK Sharma

Keyword(s):

Immune Response ◽

Hepatitis B ◽

South India ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Vaccination Status ◽

Hepatitis B Vaccination ◽

Care Hospital

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Hepatitis B vaccination status and vaccine immune response among children in rural Senegal

European Journal of Public Health ◽

10.1093/eurpub/ckz185.592 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

L Perieres ◽

M Coste ◽

S Ndiour ◽

P Halfon ◽

C Sokhna ◽

...

Keyword(s):

Immune Response ◽

Hepatitis B ◽

Chronic Infection ◽

Vaccination Status ◽

Hbv Infection ◽

Hepatitis B Vaccination ◽

Chronic Hbv Infection ◽

Hbv Vaccination ◽

Chronic Hbv ◽

Vaccine Immunity

Abstract Background Hepatitis B vaccination during childhood is key to reduce the prevalence of Hepatitis B virus (HBV) infection. In Senegal, a highly endemic country, the three-dose hepatitis B vaccine and the birth dose vaccine were introduced in the Expanded Programme on Immunization (EPI) in 2004 and 2016 respectively. This study aimed to determine chronic HBV infection prevalence, hepatitis B vaccination status and vaccine immunity among children in Senegal. Methods A cross-sectional study including HBV screening was conducted at home among children aged 6 months to 15 years (i.e. born after the introduction of the HBV vaccine in the EPI) in the rural zone of Niakhar. Dried Blood Spot (DBS) samples were collected for the detection of HBsAg, anti-HBc Ab and anti-HBs Ab using chemoluminescence. Vaccination status was assessed using information on vaccination cards. Detectable vaccine immunity was defined with an adjusted DBS threshold of DOI≥0.36 IU/mL (corresponding to 10 IU/mL in venous blood sampling). Results Between October and December 2018, 455 children were enrolled. Preliminary results show that 7/455 (1.5%) had been in contact with HBV (positive anti-HBc Ab) and 5/455 (1.1%) had chronic HBV infection (positive HBsAg). Only 161/455 (35.4%) children had a vaccination card available. Among those, 150/161 (93.2%) received at least 3 doses of hepatitis B vaccine, of which 83/150 (55.3%) had detectable vaccine immunity. The proportion of children with detectable vaccine immunity was significantly higher in children <5 years than in children aged 5-9 and 10-15 (72.3% versus 47.3%, p = 0.006 and 72.3% versus 14.3%, p < 0.001). Conclusions Preliminary results suggest a low prevalence of HBV chronic infection among children born after the introduction of HBV vaccination in Senegal. However, detectable vaccine immunity rapidly decreases with age among vaccinated children, signalling a need for further studies on the immune response to HBV vaccination in this context. Key messages HBV chronic infection is low among children born after the introduction of HBV vaccination in Senegal. Further studies on the immune response to HBV vaccination in this context are needed.

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