scholarly journals Acute toxicity studies of potassium permanganate in Swiss albino mice

2010 ◽  
Vol 23 (1-2) ◽  
Author(s):  
S.A Saganuwan ◽  
V.M Ahur ◽  
C.A Yohanna
Keyword(s):  
Acute Toxicity ◽  
Potassium Permanganate ◽  
Swiss Albino Mice ◽  
Toxicity Studies ◽  
Albino Mice

Evaluation of acute and sub-acute oral toxicity of ethanolic root extract of Tetracera akara (Burm. f.) Merr., an ethnomedicinal plant used by the Kani tribe of Kerala

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
Ragesh R Nair
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Root Extract ◽  
Oral Toxicity ◽  
Swiss Albino Mice ◽  
Toxicity Studies ◽  
Biochemical Profiles ◽  
Albino Mice ◽  
Group Sex

The aim of the study was to evaluate the acute oral and sub-acute toxicity of ethanolic root extract of Tetracera akara in Swiss albino mice and Wistar rats. Tetracera akara (Burm. f.) Merr. has been used as traditional medicine by the Kani tribe of Kerala to cure liver diseases. In acute toxicity studies, four groups of mice (n = 5/group/sex) were orally treated with doses of 0.625 g, 1.25 g, 2.5 g and 5.0 g/kg and mortality were recorded. In the sub-acute toxicity study, animals received T. akara extract at the doses of 0.1 g, 0.5 g and 2.5 g/kg/day (n = 5/group/sex) for 28 days, biochemical, hematological, morphological and histopathological parameters were determined. T. akara did not produce any mortality in the acute toxicity studies, showing LD50 higher than 5 g/kg. Sub-acute treatment with T. akara didn’t cause any changes in body weight gain, hematological, biochemical profiles when compared to normal control. In addition, no changes in morphological and histopathological aspect of organs were observed in the animals. Taking all factors into consideration, administration of Tetracera akara does not produce acute toxicity in Swiss albino mice or sub-acute toxicity in Wistar rats, suggesting it’s safe use by humans.

scholarly journals Acute and sub-acute toxicity studies on the effect of Senna alata in Swiss Albino mice

2016 ◽  
Vol 2 (1) ◽  
pp. 1272166 ◽  
Author(s):  
S. Roy ◽  
B. Ukil ◽  
L.M. Lyndem ◽  
Hani El-Nezami
Keyword(s):  
Acute Toxicity ◽  
Swiss Albino Mice ◽  
Toxicity Studies ◽  
Albino Mice ◽  
Senna Alata

scholarly journals In vivo antiplasmodial properties of fractions and flavonoids of Pseudarthria hooheri Wight & Arn. (Fabaceae)

2022 ◽  
Author(s):  
Joseph Tchamgoue ◽  
Amelework N. Eyado ◽  
Boniface P. Kamdem Kamdem ◽  
Yvan Anderson T. Ngandjui Ngandjui ◽  
Jean Claude Tchouankeu ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Malaria Treatment ◽  
Antiplasmodial Activity ◽  
Swiss Albino Mice ◽  
Treatment Situation ◽  
Healthy Female ◽  
Etoac Fraction ◽  
Albino Mice ◽  
Main Components

Malaria is regarded as one of the most lethal diseases. Resistance to artemisinin and its derivatives jeopardises effective malaria treatment. Finding novel antimalarial chemicals is critical given the existing treatment situation. This work aimed to examine the antiplasmodial capabilities of <i>Pseudarthria hookeri</i> fractions and flavonoids in vivo. The fractions and compounds antiplasmodial activity were evaluated on male Swiss albino mice infected with <i>Plasmodium berghei</i>, and on healthy female Swiss albino mice, the crude extract's acute toxicity was assessed. The EtOAc fraction had significant antiplasmodial activity (32.53 percent suppression at 500 mg/kg BW) and considerably prolonged the survival period of infected mice (9.8 days) compared to control mice (7.8 days). Parasitaemia was dramatically reduced (85.01, 59.41, and 70.39 percent), and the mean survival time extended (11.33, 10.00, and 9.33 days) with 15, 20 and 35 mg/kg of quercetin (<b>1</b>), 7-O-benzyl-6-prenylpinocembrin (<b>6</b>) and 6,8-diprenyleriodictyol (<b>11</b>) (isolates of the EtOAc fraction), respectively. BW loss and PCV reduction were also averted. Moreover, at 2500 mg/kg, the crude extract of <i>P. hookeri</i> showed no acute toxicity in mice. LC-MS analysis of the EtOAc fraction enabled the identification of nine flavonoids, with <b>8</b> and <b>11</b> being the main components. The present investigation confirmed <i>P. hookeri</i>'s antiplasmodial action, substantiating its ethnomedicinal application for malaria treatment.

scholarly journals HPLC characterization, acute and sub-acute toxicity evaluation of bark extract of Rhizophora mucronata in Swiss Albino mice

Heliyon ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e03108
Author(s):  
Jairaman Chitra ◽  
Syed Ali Mohamed Yacoob ◽  
Sivanesan Senthil Kumar ◽  
Anuradha Venkataraman ◽  
Rajagopalan Vijayaraghavan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Bark Extract ◽  
Rhizophora Mucronata ◽  
Toxicity Evaluation ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals TOXICITY PROFILE OF CELASTRUS PANICULATUS SEEDS: A PRECLINICAL STUDY

2020 ◽  
pp. 115-118
Author(s):  
BHARAT MISHRA ◽  
ELEZABETH JOHN ◽  
KRUPAMOL JOY ◽  
BADMANABAN R ◽  
ALEESHA R
Keyword(s):  
Seed Oil ◽  
Preclinical Study ◽  
Tween 20 ◽  
Toxicity Profile ◽  
Swiss Albino Mice ◽  
Subacute Toxicity ◽  
Toxicity Studies ◽  
Group I ◽  
Celastrus Paniculatus ◽  
Albino Mice

Objective: The objective of the study was to evaluate the toxicity profile of Celastrus paniculatus (CP) by performing a preclinical study on Swiss albino mice and demonstrate a safety description through monitoring their autonomic, neurological, behavioral, physical, and biochemistry profiles. Methods: The toxicity profiles (acute and subacute) of CP were evaluated using Swiss albino mice in which they were divided into four groups: Group I received 1% Tween 20 and dimethyl sulfoxide. Group II, III, and IV received CP seed oil orally, at doses of 300, 2000, and 5000 mg/kg body weight for both acute and subacute toxicity studies in accordance with Organization for Economic Cooperation and Development guidelines No. 423. Special attention was given during the first 4 h and daily thereafter for a total of 14 days. Behavioral profile, physical state changes, and other parameters such as tremors, convulsion, lethargy were noted. Clinical signs were observed daily during the 28 days of the treatment period. Body weights were measured once a week. On the 29th day, the animals were kept to overnight and blood samples were collected through retro-orbital puncture for biochemical analysis. Results: In both acute and subacute toxicity studies, the treatment with CP did not affect the normal health status of animals. It is suggestive that CP is considered practically non-toxic. Conclusion: The toxicity profile of CP seed oil was evaluated and found to be safe until 2000 mg/kg dose.

In vivo protection studies of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl) acetamide derivatives (HNK oximes) against tabun and soman poisoning in Swiss albino mice

2017 ◽  
Vol 36 (12) ◽  
pp. 1270-1285 ◽  
Author(s):  
P Kumar ◽  
D Swami ◽  
DP Nagar ◽  
KP Singh ◽  
J Acharya ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Ache Activity ◽  
Lethal Dose ◽  
Acute Poisoning ◽  
Control Group ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Brain Ache Activity ◽  
Protection Index

The study reports antidotal efficacy of three HNK [ bis quaternary 2-(hydroxyimino)-N-(pyridin-3yl) acetamide derivatives] and pralidoxime (2-PAM), against soman and tabun poisoning in Swiss albino mice. Protection index (PI) was determined (treatment doses: HNK oximes, ×0.20 of their median lethal dose (LD50) and 2-PAM, 30 mg/kg, intramuscularly (im)) together with atropine (10 mg/kg, intraperitoneally). Probit log doses with difference of 0.301 log of LD50 of the nerve agents administered and inhibition of acetylcholinesterase (AChE) activity by 50% (IC50) was calculated at optimized time in brain and serum. Using various doses of tabun and soman (subcutaneously (sc)), in multiples of their IC50, AChE reactivation ability of the oximes was studied. Besides, acute toxicity (0.8× LD50, im, 24 h postexposure) of HNK-102 and 2-PAM was also compared by determining biochemical, hematological variables and making histopathological observations. Protection offered by HNK-102 against tabun poisoning was found to be four times higher compared to 2-PAM. However, nearly equal protection was noted with all the four oximes against soman poisoning. HNK-102 reactivated brain AChE activity by 1.5 times more than 2-PAM at IC50 dose of soman and tabun. Acute toxicity studies of HNK-102 and 2-PAM showed sporadic changes in urea, uric acid, aspartate aminotransferase, and so on compared to control group, however, not supported by histopathological investigations. The present investigation showed superiority of newly synthesized HNK-102 oxime over standard 2-PAM, as a better antidote, against acute poisoning of tabun (4.00 times) and soman (1.04 times), in Swiss albino mice.

Sign in / Sign up

Export Citation Format

Share Document