A More Specific Strategy for Remediation:

2021 ◽  
pp. 137-178
Author(s):  
Walter E. Dunson
Keyword(s):  
Specific Strategy

scholarly journals A New Transmission Route for the Propagation of the SARS-CoV-2 Coronavirus

Biology ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 10
Author(s):  
Antoine Danchin ◽  
Tuen Wai Ng ◽  
Gabriel Turinici
Keyword(s):  
Compartmental Model ◽  
Transmission Route ◽  
Future Trends ◽  
Prevention Measures ◽  
Public Records ◽  
Specific Strategy ◽  
Virus Tropism ◽  
The World ◽  
Novel Coronavirus ◽  
Existing Data

Background: Starting late 2019, a novel coronavirus spread from the capital of the Hubei province in China to the rest of the country, then to most of the world. To anticipate future trends in the development of the pandemic, we explore here, based on public records of infected persons, how variation in the virus tropism could end up in different patterns, warranting a specific strategy to handle the epidemic. Methods: We use a compartmental model to describe the evolution of an individual through several possible states: susceptible, infected, alternative infection, detected, and removed. We fit the parameters of the model to the existing data, taking into account significant quarantine changes where necessary. Results: The model indicates that Wuhan quarantine measures were effective, but that alternative virus forms and a second propagation route are compatible with available data. For the Hong Kong, Singapore, and Shenzhen regions, the secondary route does not seem to be active. Conclusions: Hypotheses of an alternative infection tropism (the gut tropism) and a secondary propagation route are discussed using a model fitted by the available data. Corresponding prevention measures that take into account both routes should be implemented to the benefit of epidemic control.

Fostering Statistical Literacy in Greece

2021 ◽  
pp. 1-12
Author(s):  
Athanasios C. Thanopoulos ◽  
Christina Karamichalakou
Keyword(s):  
Official Statistics ◽  
Statistical Literacy ◽  
Daily Lives ◽  
Specific Strategy ◽  
Statistical Institute ◽  
Convincing Case ◽  
Institutional Foundations ◽  
Of Greece ◽  
Dual Capacity

The Hellenic Statistical Authority (ELSTAT), the National Statistical Institute of Greece, as the guarantor of the quality of official statistics in Greece, has been pursuing, since 2016, an ambitious strategy aiming to foster Statistical Literacy, focusing on strengthening ties with citizens in their dual capacity both as providers of data and ultimately as users of statistics, and thus, operate as crucial enablers of a smoothly functioning virtuous circle of official statistics. Objectives include the development of an understanding of basic methodologies and tools used in official statistics, along with the awareness of its institutional foundations and core principles. This critically contributes to the value of official statistics being spread and effectively communicated, making, at the same time, a convincing case for fact-based decision making in the daily lives of the main stakeholders. This article motivates the approach followed in developing a specific strategy on statistical literacy, outlines its philosophy and main objectives and browses through the array of initiatives and actions undertaken over the last five years. In addition, it explores the responsiveness of citizens to these initiatives and the extent to which these initiatives lead to an increased engagement of key targeted stakeholders.

scholarly journals Differential Responses of Two Broccoli (Brassica oleraceaL. var Italica) Cultivars to Salinity and Nutritional Quality Improvement

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Chokri Zaghdoud ◽  
Carlos Alcaraz-López ◽  
César Mota-Cadenas ◽  
María del Carmen Martínez-Ballesta ◽  
Diego A. Moreno ◽  
...  
Keyword(s):  
Nutritional Quality ◽  
Genetic Background ◽  
Nutritional Value ◽  
Soluble Sugars ◽  
Root Hydraulic Conductance ◽  
Nutritional Properties ◽  
Specific Strategy ◽  
Nutritional Characteristics ◽  
Salinity Levels

The comparative responses of two broccoli cultivars (Brassica oleraceavar. Italica, cv. Parthenon and cv. Naxos) to a 15 d exposure to different NaCl levels were investigated. Salinity led to increased concentrations of Na+and Cl−ions in both cultivars, a disruption of the endogenous minerals levels in the shoots and roots—that varied with the cultivar and salt concentration—and decreases in the osmotic potential (Ψπ), root hydraulic conductance (L0), and stomatal conductance (Gs). The reduced biomass of Naxos at moderate NaCl indicates greater sensitivity to salinity, compared with Parthenon. Parthenon accumulated more soluble sugars, for osmotic adjustment, whereas Naxos accumulated proline, which gave the two cultivars differing nutritional characteristics. The total glucosinolates (GSLs) content was not affected by salinity in Parthenon while it decreased significantly in Naxos as a consequence of the decrease in the indole GSL. However, Naxos accumulated more aliphatic GSLs under salt stress than Parthenon, which confers on this cultivar a greater nutritional value when cultivated under salinity.These results suggest that, at distinct salinity levels, each broccoli cultivar adopts a specific strategy, indicating the crucial role of the genetic background on the organoleptic and nutritional properties that each cultivar acquires.

scholarly journals CLEC-2 promotes inflammatory peritoneal macrophage emigration to draining lymph nodes during endotoxemia

2020 ◽  
Author(s):  
Joshua H. Bourne ◽  
Nonantzin Beristain-Covarrubias ◽  
Malou Zuidscheroude ◽  
Joana Campos ◽  
Ying Di ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lymph Nodes ◽  
Chronic Inflammation ◽  
Peritoneal Macrophages ◽  
Sterile Inflammation ◽  
Mesenteric Lymph Nodes ◽  
Specific Strategy ◽  
Inflammatory Macrophages ◽  
Draining Lymph Nodes ◽  
Macrophage Accumulation

AbstractMacrophage recruitment during sterile inflammation and infection is essential to clear pathogens, apoptotic cells and debris. However, persistent macrophage accumulation leads to chronic inflammation. Platelets are emerging as key modulators of the inflammatory response. Here, we identify that platelet C-type-lectin-like receptor-2 (CLEC-2) is a crucial immunomodulatory receptor through the interaction with podoplanin, upregulated on inflammatory macrophages.Mechanistically, platelet CLEC-2 upregulates the expression of podoplanin and its co-ligands CD44 and ERM proteins, leading to actin rearrangement and promotion of cell migration; this is mimicked by recombinant CLEC-2-Fc (rCLEC-2-Fc). Treatment of LPS-challenged mice with rCLEC-2-Fc induces a rapid emigration of peritoneal macrophages to mesenteric lymph nodes, through a gradient generated by the podoplanin ligand, CCL21, to prime T cells. We propose that crosslinking podoplanin using rCLEC-2-Fc is a novel, cell-specific strategy to accelerate macrophage removal from the site of inflammation, and hence promote the resolution of the inflammatory response.Visual AbstractSummaryPersistent macrophage accumulation in inflamed tissue leads to chronic inflammation and organ damage. Bourne et al. identify recombinant CLEC-2-Fc crosslinking podoplanin on inflammatory macrophages, as a cell-specific strategy to accelerate their emigration to draining lymph nodes, and reduce local inflammation.

scholarly journals The strategy of demagoguery in Donald Trump’s thankful speech

2019 ◽  
Keyword(s):  
Political Discourse ◽  
Expressive Language ◽  
Global Strategy ◽  
Specific Strategy ◽  
The People ◽  
Political Views ◽  
National Convention ◽  
Local Strategy ◽  
The Masses ◽  
Linguistic Means

The article is focused on identifying local and speech strategies (tactics) that are subjected to the global strategy of demagoguery in American political discourse. The article concerns analysis of the definitions and synonyms of the term demagoguery. Such analysis confirmed the appropriateness of considering demagoguery as a specific strategy of political discourse. The results of the research ascertain that the term demagoguery is perceived differently in Ukrainian and English linguistic cultures. Ukrainians perceive demagoguery as a tool for deceiving and manipulation, while Englishmen think of it as of a method of leading a political game and broadening the voter base. The recipients of demagoguery in Ukrainian linguistic culture are uneducated groups of people, while in English linguistic culture the recipient is the people as a whole. Demagoguery as a specific strategy of political discourse is mainly used to influence the electorate through appealing to the feelings, instincts, and prejudices and through forming required political views and preferences. The analysis of the American sociologists’ works enabled us to identify the main features of demagoguery. They are the following: the focus on broadening the audience, using propaganda for manipulating the masses and entertaining character. Analysis of empirical evidence, Donald Trump's thankful speech, which was given at the Republican national convention in 2016, allows us to single out local strategies of demagoguery. The local strategies of demagoguery, which are typical for American political discourse, are the following: populism, manipulation, subjectivation, fascination, and information simplification. Moreover, the article identifies and describes speech tactics that are typical for each local strategy. Among them, there are tactics of empty promises, lies, accusing, ridicule, using slogans, vulgarization, intimidation, and a tactic of finding a scapegoat. The research also concerns analysis of the linguistic means used for the realization of every local strategy and speech tactic. The most frequently used linguistic means are usage of expressive language with positive and negative meaning, repetition, anthroponomy, and subjectivation.

scholarly journals An under sampled k-means approach for handlingimbalanced data using diversified distribution

2018 ◽  
Vol 7 (1.8) ◽  
pp. 113 ◽  
Author(s):  
G Shobana ◽  
Bhanu Prakash Battula
Keyword(s):  
Research Issue ◽  
Minority Class ◽  
Effective Utilization ◽  
Specific Strategy ◽  
Open Research ◽  
Novel Approach ◽  
Under Sampling ◽  
F Measure

Some true applications uncover troubles in taking in classifiers from imbalanced information. Albeit a few techniques for enhancing classifiers have been presented, the distinguishing proof of conditions for the effective utilization of the specific strategy is as yet an open research issue. It is likewise worth to think about the idea of imbalanced information, qualities of the minority class dissemination and their impact on arrangement execution. In any case, current investigations on imbalanced information trouble factors have been predominantly finished with manufactured datasets and their decisions are not effortlessly material to this present reality issues, likewise on the grounds that the techniques for their distinguishing proof are not adequately created. In this paper, we recommended a novel approach Under Sampling Utilizing Diversified Distribution (USDD) for explaining the issues of class lopsidedness in genuine datasets by thinking about the systems of recognizable pieces of proof and expulsion of marginal, uncommon and anomalies sub groups utilizing k-implies. USDD utilizes exceptional procedure for recognizable proof of these kinds of cases, which depends on breaking down a class dissemination in a nearby neighborhood of the considered case utilizing k-closest approach. The exploratory outcomes recommend that the proposed USDD approach performs superior to the looked at approach as far as AUC, accuracy, review and f-measure.

scholarly journals Estimating cellular pathways from an ensemble of heterogeneous data sources

2014 ◽  
Author(s):  
Alexander Franks ◽  
Florian Markowetz ◽  
Edoardo Airoldi
Keyword(s):  
Systems Biology ◽  
Expert Knowledge ◽  
Mapk Pathway ◽  
Heterogeneous Data ◽  
Data Sources ◽  
Pheromone Response ◽  
Specific Strategy ◽  
Heterogeneous Data Sources ◽  
Cellular Pathways

Building better models of cellular pathways is one of the major challenges of systems biology and functional genomics. There is a need for methods to build on established expert knowledge and reconcile it with results of high-throughput studies. Moreover, the available data sources are heterogeneous and need to be combined in a way specific for the part of the pathway in which they are most informative. Here, we present a compartment specific strategy to integrate edge, node and path data for the refinement of a network hypothesis. Specifically, we use a local-move Gibbs sampler for refining pathway hypotheses from a compendium of heterogeneous data sources, including novel methodology for integrating protein attributes. We demonstrate the utility of this approach in a case study of the pheromone response MAPK pathway in the yeast S. cerevisiae.

scholarly journals D.E. Serebrennikov [Rev.] Ehrlich E. Fundamental Principles of the Sociology of Law. [Russ. ed.: Erlikh O. Osnovopolozhenie sociologii prava. Transl. from Germ. by M.V. Antonov; Ed. by V.G. Grafskiy, Yu.I. Grevtsov. St Petersburg: OOO “Universitetskii izdatel’skii konsortsium” publ., 2011.]

2020 ◽  
Vol 26 (1) ◽  
pp. 183-189
Author(s):  
Dmitrii E. Serebrennikov
Keyword(s):  
English Language ◽  
Scientific Discipline ◽  
Sociology Of Law ◽  
Specific Strategy ◽  
Modern Reader ◽  
English Language Literature ◽  
Language Literature

It’s commonly believed that the book “Fundamental Principles of the Sociology of Law” (1913) of Eugen Erlich (1862–1922) was historically the first work in which was made an attempt to create a sociology of law as a specific scientific discipline. However the translation and publication of this work in Russian (2011) was insignificant to the sociological community, while in the English-language literature of the last decades we can observe a growing interest to the classic. The author of the article tries to emphasize the main points and advantages of the theory of the “living law” of Ehrlich, showing how the “Fundamental principles...” may be interesting for the modern reader. For this, the author of the article offers a specific strategy for reading the book.

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