scholarly journals Features of biochemical indices and content of enzymes in the serum of syphilis patients with viral hepatites B and C in the course of treatment

2021 ◽  
Vol 26 (3) ◽  
pp. 107-113
Author(s):  
S.V. Zakharov ◽  
V.K. Zakharov ◽  
V.V. Gorbuntsov
Keyword(s):  
Functional State ◽  
Biochemical Parameters ◽  
Early Stage ◽  
Serum Levels ◽  
Test Methods ◽  
Comprehensive Examination ◽  
Before And After ◽  
Biochemical Indices ◽  
Increased Activity ◽  
Latent Syphilis

Objective – before and after the treatment to determine the functional state of the liver, serum levels of enzymes and biochemical indices in syphilis patients with viral hepatites B and C. The results of the study are based on the data from a comprehensive examination of 35 patients with syphilis alone and 127 patients with syphilis co-infected with viral hepatites B and C before and after treatment. Test methods: hepatology, rheogeopathography, enzyme content and biochemical parameters determined in the serum. According to the results of radionuclide hepatology it has been established that disorders of the functional capacity of the liver already occur in the early stages of the disease. The most significant disorders have been in the patients with the prescription of infection for more than 12 months and in the patients co-infected with viral hepatites B and C. A disorder of pigment metabolism and increased activity of trans­aminases have been revealed in early latent syphilis. In co-infection with viral hepatites B and C an increase in total bilirubin, Lactate dehydrogenase, Alanine transaminase, Aspartate aminotransferase and albumin has been revealed. Dysproteinemia has been revealed in patients with early latent syphilis co-infected with hepatitis C. Patients with early latent syphilis treated with immunomodulators tend to normalize these indices. In patients with syphilis a disorder of the functional state of the liver have been revealed already at an early stage of the disease. The most pronounced disorder of biochemical parameters and activity of liver enzymes are observed in syphilis patients with viral hepatites B and C, as well as in patients with early latent syphilis only with the prescription of the infection for more than 12 months; in such a case it is advisable to use drugs affecting the immune system.

scholarly journals Evaluation of Liver Enzymes and calculation of AST to ALT ratio in patients with acute viral hepatitis

2021 ◽  
Vol 3 (2) ◽  
pp. 83-86
Author(s):  
Arun Pandeya ◽  
Naveen Kumar Shreevastva ◽  
Arun Dhungana ◽  
Anup Pandeya ◽  
Binita Pradhan
Keyword(s):  
Viral Hepatitis ◽  
Healthy Subjects ◽  
Biochemical Parameters ◽  
Liver Enzymes ◽  
Acute Viral Hepatitis ◽  
Early Stage ◽  
Calculated Data ◽  
Serum Levels ◽  
Appropriate Care ◽  
Control Serum

Background: Acute viral hepatitis is a common liver-associated abnormality encountered in clinical practice. The number of biochemical parameters is estimated to detect a hepatic abnormality, which can measure the severity and types of damage to hepatocytes, among which liver enzymes and bilirubin levels are assessed routinely which are raised in acute viral hepatitis.Objective: This study aims to assess the liver enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, and calculation of AST to ALT ratio in acute viral hepatitis and to compare these parameters with the control group.Methodology: This study included a total of 81 subjects diagnosed with acute viral hepatitis as cases and age and sex-matched, the same number of healthy subjects as control. Serum levels of AST and ALT, alkaline phosphatase (ALP), and bilirubin were analyzed using standard methods. Serum AST to ALT ratio was calculated. Data analysis was done using SPSS Version 17.0 and the results were expressed as mean ±standard deviation (SD).Results: A mean serum activities of aminotransferases were statistically significantly raised in viral hepatitis compared to that in control.AST (514.85±350.66 VS 25.65±5.29; p<0.001) and ALT (781.65±525.69 VS 27.94±6.50; p<0.001). Similarly, serum levels of(ALP)were significantly increased in acute viral hepatitis compared to that in control (202.17±75.46 VS 98.83±27.99; p<0.001. However, a ratio of AST to ALT was decreased significantly (0.66±0.15 VS 0.94±0.21; p= 0.001) in acute viral hepatitis compared to that in control.Conclusion: Both the aminotransferases and bilirubin levels are raised significantly, where, a rise in ALT is greater than a rise in AST, hence, the ratio of AST to ALT is decreased significantly in acute viral hepatitis than that in control. Thus, this decreased pattern of AST to ALT can diagnose acute viral hepatitis at an early stage and can help appropriate care and treatment to the patients.

scholarly journals Biochemical responses to a non-standard exercise in horses trained for jumping

2013 ◽  
Vol 82 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Vladimír Hura ◽  
Franišek Novotný ◽  
Martin Boldižár ◽  
Martin Rédl ◽  
Jana Noskovičová ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Prolonged Exercise ◽  
Metabolic Stress ◽  
Muscle Membrane ◽  
Exercise Regimen ◽  
Before And After ◽  
Exercise Induced ◽  
Biochemical Indices ◽  
Training Control ◽  
Increased Activity

The aims of this study were to analyze the indices of mineral, enzymatic, protein and lipid metabolism, and the antioxidant status in horses trained for jumping after prolonged exercise. A total of 10 Slovak warmblood horses (aged 6–15 years) trained for jumping were used. Blood samples were taken before and after the jumping training (control), immediately after prolonged exercise and after the following 36 h of rest. Control samplings showed no signs of exercise-induced dehydration, but an increase of haematological indices, increased concentration of lactate and increased activity of lactate dehydrogenase whose changes may be indicative of splenic blood efflux and activation of anaerobic metabolism. On the other hand, changes of biochemical indices (such as: increased alanine aminotrasferase, lactate dehydrogenase and creatine phosphokinase, decreased K and Fe, increased malondialdehyde and glutathione peroxidase) that are indicative for the muscle membrane leakage, oxidative stress and electrolyte imbalances, and alterations of intermediary metabolism were found due to the non-standard prolonged exercise. Although this study demonstrates that trained horses adapted to a certain exercise regimen are exposed to oxidative and metabolic stress by non-standard prolonged workload, further research is required to assign an appropriate resting regime needed to compensate for the induced biochemical changes.

scholarly journals MELATONIN EXCHANGE AT MULTIMORBID CARDIOVASCULAR PATHOLOGYWITH ANXIETY AND DEPRESSIVE DISORDERS IN YOUNG AND MIDDLE-AGED MEN

2015 ◽  
Vol 7 (3) ◽  
pp. 60-65
Author(s):  
M A Aflitonov ◽  
S A Partsernyak ◽  
A N Mironenko ◽  
A S Partsernyak ◽  
A A Topanova
Keyword(s):  
Standard Therapy ◽  
Depressive Disorders ◽  
Severe Depression ◽  
Simple Random Sampling ◽  
Reference Intervals ◽  
Test Methods ◽  
Mild Depression ◽  
Before And After ◽  
Group 2 ◽  
Biochemical Indices

Evaluate melatonin (MT) patterns excretion at multimorbid cardiovascular pathology (MCVP) (coronary artery disease (CAD), hypertension, metabolic syndrome (MS)) with non-psychot- ic mental disorders (NPMD) anxiety/ depressive type. Identify the effectiveness of visual-auditory ef- fects in the treatment of these pathologies. Design and methods: The study included 70 men (mean age 37,46±6,74) with MCVP divided into 4 groups by simple random sampling, and 20 healthy men (mean age 38,3±6,73 g). Patients in Group 1 (n = 22) received standard therapy CAD, hypertension and NPMD, in group 2 (n = 25) standard therapy CAD, hypertension, NPMD and visual-auditory correction. Patients of group 3 (n = 23) received standard therapy CAD, hypertension, NPMD, visual-auditory correction and psychotherapy. Used in the study: complex psychological test methods and laboratory-instrumental evaluation of the cardiovascular system. Definition of 6-sulfatoxymelatonin (6-SMT) performed by ELI- SA using kits BÜHLMANNEK-M6S. Results: Identified change normal «dipper» pattern to «non- dip- per» and «night-peaker» (daily index blood pressure and 0-10% <0% (p <0,001) in all treatment groups. Patients 3 group observed achievement reference values of the night excretion after treatment 458±64-» 798±32 (before and after treatment, respectively) (p <0,001). In all groups after treatment was observed significantly change the type of NDP «severe depression», «clinical anxiety» to «mild depression»; «sub- clinical anxiety» (p <0,001). Conclusions: Patients with MCVP have abnormalities of MT content char- acterized by a decrease in nocturnal excretion of 6-SMT. Night pattern of 6-SMT excretion significantly correlated with severity of anxiety/ depression before and after treatment. Results of patients treated with visual auditory correction significantly better than patients of other groups (obtained reference intervals MT excretion, biochemical indices and normalization of psychological tests).

Effect of dietary aflatoxins (AFB1) on hematological and biochemical indices of male buffaloes

2017 ◽  
Author(s):  
Omer Naseer ◽  
Jawaria Ali Khan ◽  
Muhammad Sarwar Khan ◽  
Muhammad Ovais Omer ◽  
Junaid Naseer ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Feed Intake ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Serum Levels ◽  
Serum Biochemical Parameters ◽  
Control Serum ◽  
Serum Biochemical ◽  
Biochemical Indices ◽  
To Receive

The objective of the study was to determine the effect of dietary aflatoxin B1 (AFB1) in growing male buffaloes in terms of feed intake, hematological and serum biochemical parameters. Thirty six bovine growing male buffaloes between 6 months to 12 months of age were divided into four groups to receive diet having no AFB1, 0.6mg/kg, 0.8mg/kg and 1.0mg/kg AFB1 of feed per animal per day for 28 days. The results indicate that the average daily feed intake of AFB1-treated growing male buffaloes significantly declined (P > 0.05) compared with the control. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatinine were significantly increased (P > 0.05) in response to AFB1, However change in blood urea nitrogen (BUN) levels was non-significant values of all hematological parameters decreased significantly (P > 0.05) in1.0mg/kg AFB1 group as compared to other groups after day 14 onward.

Abstract 11964: Circulating Levels of 2-Aminobutyric Acid Reflect Myocardial Redox State in Patients With Atrial Septal Defects

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Yasuhiro Irino ◽  
Ryuji Toh ◽  
Takeshige Mori ◽  
Manabu Nagao ◽  
Tomoyuki Honjo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Volunteers ◽  
Mechanical Stress ◽  
Redox State ◽  
Early Stage ◽  
Mechanical Stretch ◽  
Serum Levels ◽  
Water Soluble ◽  
Aminobutyric Acid ◽  
Before And After

Heart failure (HF) is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectrometry. We found the mean level of 2-Aminobutyric acid (2-AB) in ASD patients was significantly higher than that in healthy volunteers, and 1 month after transcatherter closure of ASD using the Amplatzer septal occluder, serum 2-AB levels in patients decreased to almost the same levels as healthy volunteers (healthy-volunteers: 15.74±1.75 μM, ASD (pre-closure): 22.38±1.99 μM, ASD (post-closure):15.50±1.50 μM, P=0.017). In contrast, serum levels of brain natriuretic peptide (BNP), frequently used as the biomarker in heart disease, did not show such relationships. In addition, 2-AB concentration had a significant correlation with tricuspid regurgitation peak gradient (TRPG) (R2=0.517, P=0.029). Because TRPG reflects right ventricular loading conditions, we examined whether mechanical stress to cardiomyocyte induces 2-AB. Mechanical stretch induced an accumulation of 2-AB, suggesting that circulating 2-AB increased in ASD patients were derived from their hearts. Next, we tried to identify the 2-AB synthesis pathway. 2-AB is known as a key molecule in the biosynthesis of ophthalmic acid that is an analogue of glutathione (GSH) and indicates GSH depletion under oxidative stress. We revealed that 2-AB was produced as the byproduct of GSH synthesis reactions. We also demonstrated that oxidative stress lead to 2-AB production by H2O2 stimulation in cardiomyocyte. Mechanical stress-induced 2-AB accumulation might be mediated by oxidative stress. In summary, circulating 2-AB levels changed before and after closure of ASD and indicated heart condition more efficiently than BNP. We also demonstrated that 2-AB reflects myocardial redox state. Thus, 2-AB monitoring may facilitate the early diagnosis strategy for HF.

scholarly journals Serum Levels of Asymmetric Dimethylarginine and Apelin as Potential Markers of Vascular Endothelial Dysfunction in Early Rheumatoid Arthritis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Manuela Di Franco ◽  
Francesca Romana Spinelli ◽  
Alessio Metere ◽  
Maria Chiara Gerardi ◽  
Virginia Conti ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Asymmetric Dimethylarginine ◽  
Inflammatory Diseases ◽  
Early Stage ◽  
Serum Levels ◽  
Joint Disease ◽  
Baseline Serum ◽  
Before And After ◽  
Treatment Naïve

Objectives. Impaired endothelial function represents the early stage of atherosclerosis, which is typically associated with systemic inflammatory diseases like rheumatoid arthritis (RA). As modulators of endothelial nitric oxide synthase expression, asymmetric-dimethylarginine (ADMA) and apelin might be measured in the blood of RA patients to detect early atherosclerotic changes. We conducted a prospective, case-control study to investigate serum ADMA and apelin profiles of patients with early-stage RA (ERA) before and after disease-modifying antirheumatic drug (DMARD) therapy.Methods. We enrolled 20 consecutively diagnosed, treatment-naïve patients with ERA and 20 matched healthy controls. Serum ADMA and apelin levels and the 28-joint disease activity scores (DAS28) were assessed before and after 12 months of DMARDs treatment. All patients underwent ultrasonographic assessment for intima-media tickness (IMT) evaluation.Results. In the ERA group, ADMA serum levels were significantly higher than controls at baseline(P=0.007)and significantly decreased after treatment (P=0.012versus controls). Baseline serum apelin levels were significantly decreased in this group (P=0.0001versus controls), but they were not significantly altered by treatment. IMT did not show significant changes.Conclusions. ERA is associated with alterations of serum ADMA and apelin levels, which might be used as biomarkers to detect early endothelial dysfunction in these patients.

scholarly journals Relationship between administration of statins and blood serum levels of selected biochemical parameters

2021 ◽  
Vol 9 (1) ◽  
pp. 83-90
Author(s):  
Tatiana Ďurčeková ◽  
Ján Mocák ◽  
Ján Balla ◽  
Gabriela Gromanová ◽  
Katarína Boronová
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Lipoprotein Metabolism ◽  
Serum Levels ◽  
Patient Data ◽  
Biochemical Tests ◽  
Blood Samples ◽  
Software Packages ◽  
Before And After

Results of biochemical tests of 172 patient data (among them 84 men data and 88 women data, resp.) before and after administration of statins were studied. All monitored patients are characterized by lipoprotein metabolism failure or other kind of lipidaemia. The calculations were performed using several chemometrical methods pursuing visualization of most important biochemical parameters and classification of the patient blood samples by means of up-to-date software packages. The dependences of the content of most common biochemical parameters upon the treatment of patients by statins were elucidated in detail.

POSTOPERATIVE COMPLIANCE OF BARIATRIC SURGERY PATIENTS REGARDING THE ASSESSMENT OF SERUM LEPTIN LEVELS AND INSULIN RESISTANCE

2019 ◽  
Vol 49 (1/2019) ◽  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Serum Levels ◽  
Medical Laboratory ◽  
Leptin Resistance ◽  
Obese Patients ◽  
Laboratory Assessment ◽  
Serum Leptin ◽  
Before And After ◽  
Bariatric Patients

Background and aims: Overweight and obese patients who undergo bariatric surgery require a rigorous clinical and paraclinical assessment both before and after the surgery at 3, 6, and 12 months.The present study aims the assessment of serum leptin levels and insulin resistance status in compliant bariatric patients to scheduled medical laboratory assessment at 6 months after surgery. Material and Method: The study included 109 eligible patients selected for bariatric surgery, 48 of whom attended the scheduled visit at 6 months after the surgery. Laboratory assessing regarded the insulin resistance by determining before meal the serum levels of leptin, glucose and insulin, as well as HOMA 1 and HOMA 2 indexes. Results: Patients who underwent bariatric treatment experienced a significant decrease in insulin resistance status. A higher percentage in the preoperative group was recorded in women, feature which was also recorded in the postoperative group that attended the scheduled visit at 6 months after surgery. Age is also an important factor that significantly influences the behavioral adherence to postoperative visits. Conclusions: Insulin resistance status improved significantly in 6 months after bariatric surgery among the fully compliant patients. The percentage of attendance at scheduled visits is higher among women, and decreases with age. Keywords: obesity surgery, leptin resistance, insulin resistance, HOMA index, compliance

Konkurrenz zwischen Stieleiche und Buche auf Lothar-Sturmflächen | Competition between pedunculate oak and European beech on Lothar windthrow areas

2009 ◽  
Vol 160 (5) ◽  
pp. 114-123 ◽  
Author(s):  
Daniel Otto ◽  
Sven Wagner ◽  
Peter Brang
Keyword(s):  
Large Scale ◽  
Early Stage ◽  
Tree Height ◽  
European Beech ◽  
Threshold Value ◽  
Test Methods ◽  
Permanent Plots ◽  
Pedunculate Oak ◽  
Competitive Pressure ◽  
Competition Index

The competitive pressure of naturally regenerated European beech (Fagus sylvatica) saplings on planted pedunculate oak (Quercus robur) was investigated on two 1.8 ha permanent plots near Habsburg and Murten (Switzerland). The plots were established with the aim to test methods of artificial oak regeneration after large-scale windthrow. On both plots, 80 oaks exposed to varying levels of competitive pressure from at most 10 neighbouring beech trees were selected. The height of each oak as well as stem and branch diameters were measured. The competitive pressure was assessed using Schütz's competition index, which is based on relative tree height, crown overlap and distance from competing neighbours. Oak trees growing without or with only slight competition from beech were equally tall, while oaks exposed to moderate to strong competition were smaller. A threshold value for the competition index was found above which oak height decreased strongly. The stem and branch diameters of the oaks started to decrease even if the competition from beech was slight, and decreased much further with more competition. The oak stems started to become more slender even with only slight competition from beech. On the moderately acid beech sites studied here, beech grow taller faster than oak. Thus where beech is competing with oak and the aim is to maintain the oak, competitive pressure on the oak must be reduced at an early stage. The degree of the intervention should, however, take the individual competitive interaction into account, with more intervention if the competition is strong.

Effects of use of an eHealth platform e-Vita for COPD patients on disease specific quality of life domains

2020 ◽  
Keyword(s):  
Quality Of Life ◽  
Functional State ◽  
Mental State ◽  
Self Management ◽  
Copd Patients ◽  
Before And After ◽  
Ehealth Intervention ◽  
The Impact ◽  
Disease Specific

Background: Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and maintain a healthier lifestyle. Eventhough there is mixed evidence of the impact of eHealth on quality of life (QoL) in different settings. Aim: The primary aim of the e-Vita-COPD-study was to investigate the effect of use of eHealth patient platforms on disease specific QoL of COPD patients. Methods: We evaluated the impact of an eHealth platform on disease specific QoL measured with the clinical COPD questionnaire (CCQ), including subscales of symptoms, functional state and mental state. Interrupted time series (ITS) design was used to collect CCQ data at multiple time points. Multilevel linear regression modelling was used to compare trends in CCQ before and after the eHealth intervention. Results: Of 742 invited COPD patients, 244 signed informed consent. For the analyses, we only included patients who actually used the eHealth platform (n = 123). The decrease of CCQ-symptoms was 0,20% before the intervention and 0,27% after the intervention; this difference was statistically significant (P=0.027). The decrease of CCQ-mental was 0,97% before the intervention and after the intervention there was an increase of 0,017%; this difference was statistically significant (P=0,01). No significant difference was found in the slopes of CCQ (P=0,12) and CCQ-function (P=0,11) before and after the intervention. Conclusion: The e-Vita eHealth platform had a potential beneficial impact on the CCQ-symptoms of COPD patients, but not on functional state. The CCQ-mental state remained stable after the intervention, but this was a deterioration compared to the improving situation before the start of the eHealth platform. In conclusion, this study shows that after the introduction of the COPD platform, patients experienced fewer symptoms, but their mental state deteriorated slightly at the same time. Therefore, health care providers should be aware that, although symptoms improve, there might be a slight increase in anxiety and depression after introducing an eHealth intervention to support self-management.

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