scholarly journals ROLE OF KRISNADI CHURNA IN THE MANAGEMENT OF TAMAKA SWAS (BRONCHIAL ASTHMA)

2021 ◽  
Vol 9 (10) ◽  
pp. 2297-2302
Author(s):  
T. Rosylin L. Mawlong ◽  
Bishnu Prasad Sarma
Keyword(s):  
Risk Factors ◽  
Treatment Period ◽  
Respiratory Disease ◽  
Bronchial Asthma ◽  
Marked Improvement ◽  
Clinical Manifestations ◽  
Prior Consent ◽  
Ancient Times ◽  
Ethical Clearance

Since ancient times, humans are constantly threatened by diseases of respiratory disorders and Bronchial Asthma is one of them1. Ayurveda referred to Bronchial Asthma as “Tamaka Swas" which is a well-documented disease comparable to the parameters of etiopathology, risk factors, clinical manifestations and treatment principles. This study was conducted to evaluate the role of Krisnadi Churna in the management of Tamaka Swas (Bronchial Asthma). Ethical clearance was obtained from the Ethical Committee of Govt Ayurvedic College & Hospital, Gu- wahati and prior consent was taken from the patients before conducting the study The patients were given Krisnadi Churna for a period of 2 months in the Dept. of Kayachikitsa, Govt. Ayurvedic College & Hospital, Guwahati. There was a marked improvement in the symptoms as well as the Sr. IgE and AEC of the patients at the end of the treatment period. Keywords: TamakaSwas, Bronchial Asthma, Krisnadi Churna, respiratory disease

scholarly journals Metabolic Syndrome, Cognitive Impairment and the Role of Diet: A Narrative Review

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 333
Author(s):  
Matina Kouvari ◽  
Nathan M. D’Cunha ◽  
Nikolaj Travica ◽  
Domenico Sergi ◽  
Manja Zec ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Clinical Manifestations ◽  
Narrative Review ◽  
Cognitive Outcomes ◽  
Food Groups ◽  
Cardiometabolic Disorders

Background: This narrative review presents the association between metabolic syndrome (MetS), along with its components, and cognition-related disorders, as well as the potential reversal role of diet against cognitive impairment by modulating MetS. Methods: An electronic research in Medline (Pubmed) and Scopus was conducted. Results: MetS and cognitive decline share common cardiometabolic pathways as MetS components can trigger cognitive impairment. On the other side, the risk factors for both MetS and cognitive impairment can be reduced by optimizing the nutritional intake. Clinical manifestations such as dyslipidemia, hypertension, diabetes and increased central body adiposity are nutrition-related risk factors present during the prodromal period before cognitive impairment. The Mediterranean dietary pattern stands among the most discussed predominantly plant-based diets in relation to cardiometabolic disorders that may prevent dementia, Alzheimer’s disease and other cognition-related disorders. In addition, accumulating evidence suggests that the consumption of specific dietary food groups as a part of the overall diet can improve cognitive outcomes, maybe due to their involvement in cardiometabolic paths. Conclusions: Early MetS detection may be helpful to prevent or delay cognitive decline. Moreover, this review highlights the importance of healthy nutritional habits to reverse such conditions and the urgency of early lifestyle interventions.

scholarly journals FEATURES OF CLINICAL SYMPTOMS AND THE INFLUENCE OF RISK FACTORS ON THE OCCURRENCE OF BRONCHIAL ASTHMA IN CHILDREN OF LVIV REGION OF DIFFERENT AGES

2021 ◽  
pp. 96-101
Author(s):  
O. R. Trutiak ◽  
O. L. Lychkovska ◽  
R. R. Holovyn ◽  
M. I. Dats-Opoka
Keyword(s):  
Risk Factors ◽  
Preschool Children ◽  
Bronchial Asthma ◽  
Clinical Symptoms ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Physical Development ◽  
Shortness Of Breath ◽  
Different Ages ◽  
Asthma In Children

Bronchial asthma (BA) is a common chronic pathology of the lower respiratory tract in children. The first manifestations of the disease can begin at any age, but the clinical features, of the course, are different in different periods of childhood. Manifestations and course of asthma may disappear or progress with age. Therefore, it is likely that there are differences in the pathophysiology, inflammatory response of the body and the features of the clinic of asthma in children of different ages, which affects the diagnosis and treatment. The aim of the study was to determine the features of clinical symptoms and the influence of risk factors for asthma on its occurrence in children of different ages. Materials and methods. We analyzed the anamnesis and clinical symptoms of 57 children aged 3 to 18 years, who were treated from September 2020 to June 2021 in the Lviv Regional Children's Clinical Hospital “OHMATDYT” and in the Lviv Municipal City Children's Clinical Hospital. The age groups did not differ statistically in the severity of asthma (P> 0.05). Thus, in group 1 was 1 patient (9.09%) with mild form, 1 patient (9.09%) - moderate persistent form, 8 patients (72.73%) - with severe persistent form. Among patients of age group 2 was 1 patient (3.85%) with mild persistent form, 3 children (11.54%) - moderate and 21 children (80.77%) - with severe persistent form. In group 3 was 1 patient (5%) with a mild persistent form, 6 patients (30%) - moderate and 12 children (80%) - with a severe persistent form. The vast majority of patients were boys (84.21 ± 4.83%). All patients underwent general clinical examinations, spirometry, and allergy tests. We used the clinical-anamnestic method to perform the tasks of the work, which consisted in collecting a detailed somatic and genealogical anamnesis during the parents` questionnaire. Physical development of children was assessed using centile tables. Statistics were evaluated by calculating Student's t-test and Pearson's consistency test. Preschool children with asthma were more likely to experience shortness of breath during exercise and a wet low-yielding cough, and children of primary and secondary school age were more characterized by concomitant allergic rhinitis. Autumn was more unfavorable period for the exacerbation of clinical manifestations of asthma in children of Lviv region was period. We did not find correlation of birth weight on the timing of asthma. However, a burdensome obstetric history contributed to the early development of clinical manifestations of asthma. Preschool children were more likely to be exposed to nicotine during the antenatal period and had a shorter duration of breastfeeding, which may be a probable risk factor for asthma in preschool children. In 77% of children from different age groups were burdened with a history of allergies, with 66% of cases more pronounced in the maternal line. An analysis of physical development revealed that most preschool children were overweight. Conclusions. Asthma has features of clinical symptoms in children of different ages - shortness of breath during exercise and whooping cough are characteristic of preschool children, and concomitant chronic persistent rhinitis - for older age groups. Seasonal exacerbations are characteristic of asthma in children; in particular, the autumn period is more unfavorable, common for asthmatics in children of all ages among patients in Lviv region. Maternal smoking during pregnancy has a significant effect on the risk of developing asthma in children. Also, a burdened maternal allergy history and overweight child contributes to the development of asthma in children.

scholarly journals Characteristics and Role of Neutrophil Extracellular Traps in Asthma

Inflammation ◽  
2021 ◽  
Author(s):  
Fei Chen ◽  
Min Yu ◽  
Yonghong Zhong ◽  
Lina Wang ◽  
Huaqiong Huang
Keyword(s):  
Systematic Review ◽  
Protective Effect ◽  
Allergic Asthma ◽  
Respiratory Disease ◽  
Bronchial Asthma ◽  
Inflammatory Cells ◽  
Neutrophil Extracellular Traps ◽  
Chronic Respiratory Disease ◽  
Extracellular Traps

Abstract Asthma is a common chronic respiratory disease that affects millions of people worldwide. The incidence of asthma has continued to increase every year. Bronchial asthma involves a variety of cells, including airway inflammatory cells, structural cells, and neutrophils, which have gained more attention because they secrete substances that play an important role in the occurrence and development of asthma. Neutrophil extracellular traps (NETs) are mesh-like structures composed of DNA, histones, and non-histone molecules that can be secreted from neutrophils. NETs can enrich anti-bacterial substances and limit pathogen migration, thus having a protective effect in case of inflammation. However, despite of their anti-inflammatory properties, NETs have been shown to trigger allergic asthma and worsen asthma progression. Here, we provide a systematic review of the roles of NETs in asthma.

THE ROLE OF HYSTEROSALPINGOGRAPHY IN DETECTING ENDOMETRIOSIS OF THE FALLOPIAN TUBES

2021 ◽  
Vol 2 (1) ◽  
pp. 65-67
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Reproductive System ◽  
Clinical Manifestations ◽  
Fallopian Tubes

This clinical example confirms the need for a thorough assessment of anamnestic data at the stage of pre-gravidar preparation, the need to analyze various possible causes of infertility and ectopic pregnancy, and the interpretation of data obtained by hysterosalpingography (HSG) in a patient without pronounced clinical manifestations of endometriosis, in the presence of ethologically proven risk factors for the development of this pathology, even in the absence of complaints. This method of research is informative in identifying the pathology of the reproductive system, including the fallopian tubes.

scholarly journals Hygienic aspects of robotization: risk factors and safety principles

2021 ◽  
Vol 100 (1) ◽  
pp. 6-12
Author(s):  
Igor V. Bukhtiyarov ◽  
Eduard I. Denisov
Keyword(s):  
Risk Factors ◽  
Clinical Manifestations ◽  
Human Robot Interaction ◽  
Social Aspects ◽  
The European Union ◽  
Intelligence System ◽  
The Usa ◽  
Noise Vibration ◽  
Definition Of

The paper presents a review and essays on the hygienic aspects of the problem of robotics. The absence of generally accepted international terminology is noted. There is given a definition of basic terms as a robot, an artificial intelligence system (AIS), and a cyber-physical system (CFS) - according to authoritative sources. In the literature, the term robot is often used to mean CFS. The origin of robots in Russia is briefly described. The role of AIS as the basis of a technological breakthrough is considered. There is represented statistical data on the scientific, economic, and social aspects of the introduction of robotics. Robots are believed to be more likely to replace tasks rather than jobs and create new types of them. The medical and social aspects of robotization based on the experience of the European Union, the USA, and South Korea are examined, and the prospects of creating "smart jobs" are emphasized. The types of robots and their application in industry and medicine for diagnosis, treatment, and rehabilitation are described. It is emphasized that robots are the most advanced machines. The dangers created by robots, their causes, and possible consequences from physical (noise, vibration), chemical, electrical, ergonomic, and other perils are described. The presence of both "traditional" and new risk factors is noted. The systematics of the stages of human-robot interaction is proposed: ethical aspects in the design, communication psychology, contacts with the machine during its use and safety aspects, human physiological responses, possible clinical manifestations of health disorders. The safety principles of robots and CFS are formulated, and that the "smarter" the robots, the greater the risks of program failures and breakdowns are noted. The role of information hygiene and the need for training and health education of workers and the population are examined. Estimates are given of the prospects for the robotization of the profession. The occupation of hygienists in the era of digitalization and robotization is noted to have a future.

scholarly journals Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status

2020 ◽  
Vol 21 (18) ◽  
pp. 6728
Author(s):  
Kirill V. Bulygin ◽  
Narasimha M. Beeraka ◽  
Aigul R. Saitgareeva ◽  
Vladimir N. Nikolenko ◽  
Ilgiz Gareev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Clinical Manifestations ◽  
Therapeutic Modality ◽  
Current Status ◽  
Rna Molecules ◽  
Therapeutic Modalities ◽  
Diagnostic Role ◽  
Therapeutic Tools

Ischemic stroke is one of the leading causes of death worldwide. Clinical manifestations of stroke are long-lasting and causing economic burden on the patients and society. Current therapeutic modalities to treat ischemic stroke (IS) are unsatisfactory due to the intricate pathophysiology and poor functional recovery of brain cellular compartment. MicroRNAs (miRNA) are endogenously expressed small non-coding RNA molecules, which can act as translation inhibitors and play a pivotal role in the pathophysiology associated with IS. Moreover, miRNAs may be used as potential diagnostic and therapeutic tools in clinical practice; yet, the complete role of miRNAs is enigmatic during IS. In this review, we explored the role of miRNAs in the regulation of stroke risk factors viz., arterial hypertension, metabolic disorders, and atherosclerosis. Furthermore, the role of miRNAs were reviewed during IS pathogenesis accompanied by excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis, neurogenesis, and Alzheimer’s disease. The functional role of miRNAs is a double-edged sword effect in cerebral ischemia as they could modulate pathological mechanisms associated with risk factors of IS. miRNAs pertaining to IS pathogenesis could be potential biomarkers for stroke; they could help researchers to identify a particular stroke type and enable medical professionals to evaluate the severity of brain injury. Thus, ascertaining the role of miRNAs may be useful in deciphering their diagnostic role consequently it is plausible to envisage a suitable therapeutic modality against IS.

scholarly journals The role of gender in the prevalence of human leptospirosis in Albania

2018 ◽  
Vol 12 (03) ◽  
pp. 150-155 ◽  
Author(s):  
Edmond Puca ◽  
Pellumb Pipero ◽  
Arjan Harxhi ◽  
Erjona Abazaj ◽  
Arjet Gega ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Presentation ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Epidemiological Data ◽  
Elisa Test ◽  
Human Leptospirosis ◽  
Males And Females ◽  
The Difference

Introduction: Leptospirosis is a zoonotic spirochetal disease with global importance, which continues to have a major impact on public health in developing countries. The prevalence of the disease is much higher in males. The objectives of this study were: to give some data and to share our experience with human leptospirosis in Albania; to describe the prevalence regarding to the role of gender in the prevalence of human leptospirosis; to make a gender specific analysis of the clinical manifestations in patients diagnosed and treated for leptospirosis in our service and to make a review of literature related to this hypothesis. Methodology: We reviewed the epidemiologic data, risk factors and differences in clinical presentation between males and females’ patients with leptospirosis. These data are analysed from hospitalized patients. Diagnosis of leptospirosis was established based on clinical presentation, epidemiological data and subsequently confirmed serologically by Anti-Leptospira IgM antibodies through ELISA test. Results: Between 2005-2016, 233 cases of confirmed leptospirosis were analysed. Males were 208 (89.27%) and 25 of patients (10.72%) were females in ratio 9:1 p < 0.001. The highest prevalence was observed in the 45-64 age groups. Overall mortality was found to be 8.58%, 19 were males and one female p < 0.001. Conclusions: There is a much higher prevalence of leptospirosis in middle aged men. Mortality rate seems to be similar in males and females. While the difference in prevalence may be related to exposure to risk factors, further investigation is necessary to study gender-based genetic and immunological predisposition.

scholarly journals POS1140 RISK FACTORS FOR THE DEVELOPMENT OF DIABETES MELLITUS IN PATIENTS WITH GOUT ACCORDING TO A 6-YEAR PROSPECTIVE FOLLOW-UP STUDY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 849.2-849
Author(s):  
O. Sheliabina ◽  
M. Elisеev ◽  
A. Novikova ◽  
M. Chikina
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Family History ◽  
Clinical Manifestations ◽  
Reactive Protein ◽  
Follow Up Study ◽  
Lowering Therapy

Background:Gout is often associated with diabetes mellitus (DM), but the role of serum uric acid (sUA) and urate-lowering drugs in its development in patients with gout remains controversial [1].Objectives:To study risk factors for DM in patients with gout based on the results of long-term prospective follow-up study.Methods:The prospective study included 444 patients with a crystal-verified diagnosis of gout, aged ≥18 years, 49 (11%) women, 395 (89%) men. Patients were followed up at the V.A. Nasonova Research Institute of Rheumatology from 2010 to January 2021, the median follow-up was 6.1 [2.8; 7.8] years. The exclusion criteria were the presence of other rheumatic diseases with symptoms of arthritis, DM. DM was diagnosed on the 1998 WHO criteria. The following parameters were considered as risk factors: gender, family history for diabetes mellitus, body mass index (BMI)>25 kg/m2 and > 30 kg/m2, waist volume ≥88 cm for women and ≥102 cm for men, alcohol consumption > 20 units per week, chronic kidney disease (CKD), intake of diuretics and glucocorticoids, and serum total cholesterol >5 mmol/l, triglycerides>2.25 mmol/l, serum C-reactive protein (CRP) level> 5 mg/l, as well as clinical manifestations of gout: subcutaneous tophi, polyarthritis (simultaneous involvement of ≥5 joints), intake of urate-lowering drugs, sUA (> 480 μmol/L,> 420 μmol/L,> 360 μmol/L,> 300 μmol/L). Statistica 12.0 package was used for statistical data processing.Results:A total of 444 patients were included, the mean age was 51.0±12.9 years, the median follow-up was 6.1 [2.8; 7.8] years. In dynamics: 35 (8%) patients died, 6 (1%) patients were not available, 403 patients were examined (44 (11%) - women and 359 (89%) - men). 290 (72%) patients received urate-lowering therapy (263 (65%) patients used allopurinol, 27 (7%) - febuxostat). The target sUA <360 μmol/L was reached by 165 (41%) patients and <300 μmol/L - by 92 (23%) patients. All patients with sUA<300 μmol/L received urate-lowering therapy, 62 (67%) patients used allopurinol, 17 (18%) - febuxostat, 13 (14%) - uricosuric drugs. Diabetes mellitus was developed in 106 (26%) patients. The factors influencing the risk of developing diabetes were - the presence of diabetes in family history (odds ratio (OR) 2.27, 95% confidence interval (CI) 1.37; 3.76); BMI> 30 kg / m2 (OR 1.79, 95% CI 1.14; 2.80), diuretics (OR 2.32, 95% CI 1.36; 3.96) and sUA> 300 μmol / l (OR 2.89, 95% CI 1.50, 5.56).Conclusion:The risk of developing DM in patients with gout is associated with sUA> 300 μmol/l, which may be one of the probable reasons for choosing this as a target level. Large prospective studies are needed to confirm the antidiabetic effect of urate-lowering drugs.References:[1]Chang HW, Lin YW, Lin MH, Lan YC, Wang RY. Associations between urate-lowering therapy and the risk of type 2 diabetes mellitus. PLoS One. 2019 Jan 7;14(1):e0210085. doi: 10.1371/journal.pone.0210085.Disclosure of Interests:Olga Sheliabina: None declared, Maxim Elisеev Speakers bureau: Berlin Chemie Menarini Group, Novartis International AG, EGIS, Aleksandra Novikova: None declared, Maria Chikina: None declared.

scholarly journals Psychosomatic aspects of bronchial asthma: mechanisms of development, peculiarities of diagnostics, clinical manifestations and treatment

2009 ◽  
Vol 6 (3) ◽  
pp. 26-38
Author(s):  
Gleb Borisovich Fedoseev ◽  
V I Trofimov ◽  
M V Eliseeva ◽  
O Yu Babkina ◽  
KN Kryakunov ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Clinical Manifestations ◽  
Disease Course ◽  
Psychosomatic Disorders ◽  
Psychosomatic Aspects ◽  
Mechanisms Of Development

Article is devoted to the role of psychosomatic disorders in onset and development of bronchial asthma, to the diagnostics and treatment of neuropsychical variant of the disease course and possibilities of psychotherapeutic correction.

scholarly journals Characteristics of diseases in children with inherited α1-antitrypsin deficiency

2021 ◽  
pp. 55-65
Author(s):  
O.L. Tsymbalista ◽  
Keyword(s):  
Liver Cirrhosis ◽  
Liver Disease ◽  
Liver Function ◽  
Respiratory Disease ◽  
Bronchial Asthma ◽  
Pulmonary Emphysema ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Antitrypsin Deficiency ◽  
Pathogenetic Therapy

The article presents the current views on genetics, features of metabolic disorders, course of various clinical manifestations, diagnostic criteria, and treatment principles for monogenic enzymopathy — an inherited α1;antitrypsin (AAT) deficiency. Inherited AAT deficiency manifests itself as four clinical syndromes: respiratory disease (pulmonary emphysema, chronic obstructive pulmonary disease (COPD), bronchial asthma, spontaneous pneumothorax, bronchiectasis); liver disease and blood vessel damage. Respiratory disease manifests itself between the ages of 20–40 years. Chronic pulmonary emphysema is typical for homozygous PiZZ gene carriers. The most unfavorable clinical course variant including persistent cough, COPD development, bronchial asthma, pneumonia, co-existence of various respiratory diseases and severe disorders of external respiration is the PISZ phenotype. Bronchial asthma has severe clinical course with torpid purulent endobronchitis; is often uncontrolled despite background therapy. In COPD patients, exacerbations are frequent, severe, and prolonged. The reduction in the vessels of the pulmonary circulation results in pulmonary hypertension, right ventricular failure. In AAT deficiency, there is a high incidence of bronchiectasis, lung cancer. Liver diseases manifest themselves as neonatal hepatitis, biliary atresia, liver cirrhosis, infectious complications. Chronic form is characterized by subclinical changes in the biochemical parameters of liver function most of which (up to 70%) normalize before the age of 18 years. In patients until the age of 20 years, disease slowly progresses and leads to the development of liver cirrhosis in 30% of cases, while older patients develop liver cirrhosis in 30–50% of cases. Some patients have a benign course of liver disease and present with hepatomegaly. Hemorrhagic syndrome occurs when protease inhibitor gene product acquires the properties of antithrombin. Vascular disease manifests itself as necrotizing panniculitis, severe hemorrhagic vasculitis with serum antineutrophil cytoplasmic antibodies to proteinase (С-АNСА). AAT deficiency may coexist with systemic vasculitis, vascular aneurysm, many other diseases, as well as with the development of aplastic processes of various localization. In addition to clinical manifestations, diagnosis of inherited AAT deficiency includes screening programs, instrumental (X-ray, spirometry, ECG, ultrasound), laboratory (liver function, coagulation profile, immunogram, serum AAT concentration), genetic investigations, exclusion testing for cystic fibrosis, viral hepatitis, and other diseases. Treatment of patients with inherited AAT deficiency consists in adequate nutrition and physical activity; treatment of pre-existing conditions; prevention and timely therapy for respiratory infections; pathogenetic therapy. Pathogenetic therapy for AAT deficiency is a replacement (augmentation) therapy with exogenous α1-antitrypsin concentrate. Replacement therapy is indicated only in patients >18 years of age with the PiZZ phenotype or other rare AAT phenotypes. No conflict of interest was declared by the author. Key words: children, inherited α1-antitrypsin deficiency, diagnosis, therapy.

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