THE ROLE OF HYSTEROSALPINGOGRAPHY IN DETECTING ENDOMETRIOSIS OF THE FALLOPIAN TUBES

2021 ◽  
Vol 2 (1) ◽  
pp. 65-67
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Reproductive System ◽  
Clinical Manifestations ◽  
Fallopian Tubes

This clinical example confirms the need for a thorough assessment of anamnestic data at the stage of pre-gravidar preparation, the need to analyze various possible causes of infertility and ectopic pregnancy, and the interpretation of data obtained by hysterosalpingography (HSG) in a patient without pronounced clinical manifestations of endometriosis, in the presence of ethologically proven risk factors for the development of this pathology, even in the absence of complaints. This method of research is informative in identifying the pathology of the reproductive system, including the fallopian tubes.

scholarly journals Metabolic Syndrome, Cognitive Impairment and the Role of Diet: A Narrative Review

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 333
Author(s):  
Matina Kouvari ◽  
Nathan M. D’Cunha ◽  
Nikolaj Travica ◽  
Domenico Sergi ◽  
Manja Zec ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Clinical Manifestations ◽  
Narrative Review ◽  
Cognitive Outcomes ◽  
Food Groups ◽  
Cardiometabolic Disorders

Background: This narrative review presents the association between metabolic syndrome (MetS), along with its components, and cognition-related disorders, as well as the potential reversal role of diet against cognitive impairment by modulating MetS. Methods: An electronic research in Medline (Pubmed) and Scopus was conducted. Results: MetS and cognitive decline share common cardiometabolic pathways as MetS components can trigger cognitive impairment. On the other side, the risk factors for both MetS and cognitive impairment can be reduced by optimizing the nutritional intake. Clinical manifestations such as dyslipidemia, hypertension, diabetes and increased central body adiposity are nutrition-related risk factors present during the prodromal period before cognitive impairment. The Mediterranean dietary pattern stands among the most discussed predominantly plant-based diets in relation to cardiometabolic disorders that may prevent dementia, Alzheimer’s disease and other cognition-related disorders. In addition, accumulating evidence suggests that the consumption of specific dietary food groups as a part of the overall diet can improve cognitive outcomes, maybe due to their involvement in cardiometabolic paths. Conclusions: Early MetS detection may be helpful to prevent or delay cognitive decline. Moreover, this review highlights the importance of healthy nutritional habits to reverse such conditions and the urgency of early lifestyle interventions.

scholarly journals Hygienic aspects of robotization: risk factors and safety principles

2021 ◽  
Vol 100 (1) ◽  
pp. 6-12
Author(s):  
Igor V. Bukhtiyarov ◽  
Eduard I. Denisov
Keyword(s):  
Risk Factors ◽  
Clinical Manifestations ◽  
Human Robot Interaction ◽  
Social Aspects ◽  
The European Union ◽  
Intelligence System ◽  
The Usa ◽  
Noise Vibration ◽  
Definition Of

The paper presents a review and essays on the hygienic aspects of the problem of robotics. The absence of generally accepted international terminology is noted. There is given a definition of basic terms as a robot, an artificial intelligence system (AIS), and a cyber-physical system (CFS) - according to authoritative sources. In the literature, the term robot is often used to mean CFS. The origin of robots in Russia is briefly described. The role of AIS as the basis of a technological breakthrough is considered. There is represented statistical data on the scientific, economic, and social aspects of the introduction of robotics. Robots are believed to be more likely to replace tasks rather than jobs and create new types of them. The medical and social aspects of robotization based on the experience of the European Union, the USA, and South Korea are examined, and the prospects of creating "smart jobs" are emphasized. The types of robots and their application in industry and medicine for diagnosis, treatment, and rehabilitation are described. It is emphasized that robots are the most advanced machines. The dangers created by robots, their causes, and possible consequences from physical (noise, vibration), chemical, electrical, ergonomic, and other perils are described. The presence of both "traditional" and new risk factors is noted. The systematics of the stages of human-robot interaction is proposed: ethical aspects in the design, communication psychology, contacts with the machine during its use and safety aspects, human physiological responses, possible clinical manifestations of health disorders. The safety principles of robots and CFS are formulated, and that the "smarter" the robots, the greater the risks of program failures and breakdowns are noted. The role of information hygiene and the need for training and health education of workers and the population are examined. Estimates are given of the prospects for the robotization of the profession. The occupation of hygienists in the era of digitalization and robotization is noted to have a future.

scholarly journals Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status

2020 ◽  
Vol 21 (18) ◽  
pp. 6728
Author(s):  
Kirill V. Bulygin ◽  
Narasimha M. Beeraka ◽  
Aigul R. Saitgareeva ◽  
Vladimir N. Nikolenko ◽  
Ilgiz Gareev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Clinical Manifestations ◽  
Therapeutic Modality ◽  
Current Status ◽  
Rna Molecules ◽  
Therapeutic Modalities ◽  
Diagnostic Role ◽  
Therapeutic Tools

Ischemic stroke is one of the leading causes of death worldwide. Clinical manifestations of stroke are long-lasting and causing economic burden on the patients and society. Current therapeutic modalities to treat ischemic stroke (IS) are unsatisfactory due to the intricate pathophysiology and poor functional recovery of brain cellular compartment. MicroRNAs (miRNA) are endogenously expressed small non-coding RNA molecules, which can act as translation inhibitors and play a pivotal role in the pathophysiology associated with IS. Moreover, miRNAs may be used as potential diagnostic and therapeutic tools in clinical practice; yet, the complete role of miRNAs is enigmatic during IS. In this review, we explored the role of miRNAs in the regulation of stroke risk factors viz., arterial hypertension, metabolic disorders, and atherosclerosis. Furthermore, the role of miRNAs were reviewed during IS pathogenesis accompanied by excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis, neurogenesis, and Alzheimer’s disease. The functional role of miRNAs is a double-edged sword effect in cerebral ischemia as they could modulate pathological mechanisms associated with risk factors of IS. miRNAs pertaining to IS pathogenesis could be potential biomarkers for stroke; they could help researchers to identify a particular stroke type and enable medical professionals to evaluate the severity of brain injury. Thus, ascertaining the role of miRNAs may be useful in deciphering their diagnostic role consequently it is plausible to envisage a suitable therapeutic modality against IS.

scholarly journals The role of gender in the prevalence of human leptospirosis in Albania

2018 ◽  
Vol 12 (03) ◽  
pp. 150-155 ◽  
Author(s):  
Edmond Puca ◽  
Pellumb Pipero ◽  
Arjan Harxhi ◽  
Erjona Abazaj ◽  
Arjet Gega ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Presentation ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Epidemiological Data ◽  
Elisa Test ◽  
Human Leptospirosis ◽  
Males And Females ◽  
The Difference

Introduction: Leptospirosis is a zoonotic spirochetal disease with global importance, which continues to have a major impact on public health in developing countries. The prevalence of the disease is much higher in males. The objectives of this study were: to give some data and to share our experience with human leptospirosis in Albania; to describe the prevalence regarding to the role of gender in the prevalence of human leptospirosis; to make a gender specific analysis of the clinical manifestations in patients diagnosed and treated for leptospirosis in our service and to make a review of literature related to this hypothesis. Methodology: We reviewed the epidemiologic data, risk factors and differences in clinical presentation between males and females’ patients with leptospirosis. These data are analysed from hospitalized patients. Diagnosis of leptospirosis was established based on clinical presentation, epidemiological data and subsequently confirmed serologically by Anti-Leptospira IgM antibodies through ELISA test. Results: Between 2005-2016, 233 cases of confirmed leptospirosis were analysed. Males were 208 (89.27%) and 25 of patients (10.72%) were females in ratio 9:1 p < 0.001. The highest prevalence was observed in the 45-64 age groups. Overall mortality was found to be 8.58%, 19 were males and one female p < 0.001. Conclusions: There is a much higher prevalence of leptospirosis in middle aged men. Mortality rate seems to be similar in males and females. While the difference in prevalence may be related to exposure to risk factors, further investigation is necessary to study gender-based genetic and immunological predisposition.

scholarly journals POS1140 RISK FACTORS FOR THE DEVELOPMENT OF DIABETES MELLITUS IN PATIENTS WITH GOUT ACCORDING TO A 6-YEAR PROSPECTIVE FOLLOW-UP STUDY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 849.2-849
Author(s):  
O. Sheliabina ◽  
M. Elisеev ◽  
A. Novikova ◽  
M. Chikina
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Family History ◽  
Clinical Manifestations ◽  
Reactive Protein ◽  
Follow Up Study ◽  
Lowering Therapy

Background:Gout is often associated with diabetes mellitus (DM), but the role of serum uric acid (sUA) and urate-lowering drugs in its development in patients with gout remains controversial [1].Objectives:To study risk factors for DM in patients with gout based on the results of long-term prospective follow-up study.Methods:The prospective study included 444 patients with a crystal-verified diagnosis of gout, aged ≥18 years, 49 (11%) women, 395 (89%) men. Patients were followed up at the V.A. Nasonova Research Institute of Rheumatology from 2010 to January 2021, the median follow-up was 6.1 [2.8; 7.8] years. The exclusion criteria were the presence of other rheumatic diseases with symptoms of arthritis, DM. DM was diagnosed on the 1998 WHO criteria. The following parameters were considered as risk factors: gender, family history for diabetes mellitus, body mass index (BMI)>25 kg/m2 and > 30 kg/m2, waist volume ≥88 cm for women and ≥102 cm for men, alcohol consumption > 20 units per week, chronic kidney disease (CKD), intake of diuretics and glucocorticoids, and serum total cholesterol >5 mmol/l, triglycerides>2.25 mmol/l, serum C-reactive protein (CRP) level> 5 mg/l, as well as clinical manifestations of gout: subcutaneous tophi, polyarthritis (simultaneous involvement of ≥5 joints), intake of urate-lowering drugs, sUA (> 480 μmol/L,> 420 μmol/L,> 360 μmol/L,> 300 μmol/L). Statistica 12.0 package was used for statistical data processing.Results:A total of 444 patients were included, the mean age was 51.0±12.9 years, the median follow-up was 6.1 [2.8; 7.8] years. In dynamics: 35 (8%) patients died, 6 (1%) patients were not available, 403 patients were examined (44 (11%) - women and 359 (89%) - men). 290 (72%) patients received urate-lowering therapy (263 (65%) patients used allopurinol, 27 (7%) - febuxostat). The target sUA <360 μmol/L was reached by 165 (41%) patients and <300 μmol/L - by 92 (23%) patients. All patients with sUA<300 μmol/L received urate-lowering therapy, 62 (67%) patients used allopurinol, 17 (18%) - febuxostat, 13 (14%) - uricosuric drugs. Diabetes mellitus was developed in 106 (26%) patients. The factors influencing the risk of developing diabetes were - the presence of diabetes in family history (odds ratio (OR) 2.27, 95% confidence interval (CI) 1.37; 3.76); BMI> 30 kg / m2 (OR 1.79, 95% CI 1.14; 2.80), diuretics (OR 2.32, 95% CI 1.36; 3.96) and sUA> 300 μmol / l (OR 2.89, 95% CI 1.50, 5.56).Conclusion:The risk of developing DM in patients with gout is associated with sUA> 300 μmol/l, which may be one of the probable reasons for choosing this as a target level. Large prospective studies are needed to confirm the antidiabetic effect of urate-lowering drugs.References:[1]Chang HW, Lin YW, Lin MH, Lan YC, Wang RY. Associations between urate-lowering therapy and the risk of type 2 diabetes mellitus. PLoS One. 2019 Jan 7;14(1):e0210085. doi: 10.1371/journal.pone.0210085.Disclosure of Interests:Olga Sheliabina: None declared, Maxim Elisеev Speakers bureau: Berlin Chemie Menarini Group, Novartis International AG, EGIS, Aleksandra Novikova: None declared, Maria Chikina: None declared.

scholarly journals Mucociliary apparatus of the fallopian tubes and related pathogenetic aspects contributing to infertility and prospects for correction (analytical review)

2021 ◽  
Vol 15 (5) ◽  
pp. 586-598
Author(s):  
V. I. Kobylyansky
Keyword(s):  
Reproductive System ◽  
Pathological Process ◽  
Cochrane Library ◽  
Fallopian Tubes ◽  
System A ◽  
Genetic Features ◽  
Analytical Review ◽  
The One ◽  
Genetically Determined

Introduction. The mucociliary apparatus (MCA) of the fallopian tubes (MTр) represents one of the key mechanisms and arms in functioning of female reproductive system. A prominent role of impaired MCA in the pathogenesis of reproductive system diseases and infertility, on the one hand, as well as insufficient knowledge and elucidation of this topic, on the other hand, spurred current study.Aim: to improve our understanding about a role for reproductive system MCA and its impairment in developing diseases and infertility, as well as to identify potential perspectives for their correction.Materials and Methods. We searched for publications and analyzed literature data from 1980 to 2020 using various scientific databases, including Index Medicus, PubMed/MEDLINE, Embase, Cochrane Library and Russian scholarly journals related to gynecology, obstetrics and reproduction.Results. The analysis conducted allowed to originally assess the morpho-functional, structural-genetic features and other important aspects of MCA MTр. In addition, we demonstrated an impact of various factors on developing diverse types of pathological processes, including those capable of causing infertility. Moreover, we also elucidated a state of MCA MTр coupled to various diseases, including genetically determined disorders.Conclusion. The role of impaired MCA MTр in developing pathological process and infertility was of tremendous importance and deserves close attention, because they are often remained undiagnosed by standard methods and require use of morphological and functional research methods for verification. Perspectives for diagnostics and correction of MCA MTр disorders are further discussed. 

scholarly journals Clinical presentation and outcome of ectopic pregnancy

2021 ◽  
Author(s):  
Mohammed Sidhiq Chundakkadan ◽  
Chandramathy K. ◽  
Neethu Selvest
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Clinical Presentation ◽  
Excellent Result ◽  
Clinical Manifestations ◽  
Uterine Cavity ◽  
Antenatal Visit ◽  
Medical College ◽  
History Of ◽  
Selection Of

Background: An ectopic pregnancy is defined as blastomere implants anywhere other than the endometrial lining of the uterine cavity. The incidence was around 1-1.5%. Commonest site in fallopian tube (95%). Even the incidence was small, it accounted for 3% of the pregnancy related deaths. The objective of this study was to evaluate the clinical presentation of various types of ectopic pregnancy, any risk factors, various types of management and the outcome.Methods: This was a prospective COHORT study of 102 ectopic patients admitted at government medical college, Kozhikode during 18 November 2020 to 17 August 2021 with various clinical manifestations. Depends on clinical features, USG findings and HCG estimation, patients were treated by expectant, medical and surgical management. Patients followed up for 2 weeks after discharge.Results: 102 cases were admitted in study period. 98 cases were tubal ectopic. 69.6% with history of various risk factors. Commonest age group was 26-35 years. 70.6% were multiparous. HCG <5000 responded very well to medical management (92.8% success rate).Conclusions: Most common ectopic pregnancy is tubal ectopic and commonly associated with various risk factors. Triad of symptoms will be present in most cases. Early antenatal visit will reduce the number of ruptured ectopic. Careful selection of cases by HCG value and size of ectopic will give excellent result.

scholarly journals ROLE OF KRISNADI CHURNA IN THE MANAGEMENT OF TAMAKA SWAS (BRONCHIAL ASTHMA)

2021 ◽  
Vol 9 (10) ◽  
pp. 2297-2302
Author(s):  
T. Rosylin L. Mawlong ◽  
Bishnu Prasad Sarma
Keyword(s):  
Risk Factors ◽  
Treatment Period ◽  
Respiratory Disease ◽  
Bronchial Asthma ◽  
Marked Improvement ◽  
Clinical Manifestations ◽  
Prior Consent ◽  
Ancient Times ◽  
Ethical Clearance

Since ancient times, humans are constantly threatened by diseases of respiratory disorders and Bronchial Asthma is one of them1. Ayurveda referred to Bronchial Asthma as “Tamaka Swas" which is a well-documented disease comparable to the parameters of etiopathology, risk factors, clinical manifestations and treatment principles. This study was conducted to evaluate the role of Krisnadi Churna in the management of Tamaka Swas (Bronchial Asthma). Ethical clearance was obtained from the Ethical Committee of Govt Ayurvedic College & Hospital, Gu- wahati and prior consent was taken from the patients before conducting the study The patients were given Krisnadi Churna for a period of 2 months in the Dept. of Kayachikitsa, Govt. Ayurvedic College & Hospital, Guwahati. There was a marked improvement in the symptoms as well as the Sr. IgE and AEC of the patients at the end of the treatment period. Keywords: TamakaSwas, Bronchial Asthma, Krisnadi Churna, respiratory disease

Conservative therapy of interstitial pregnancy in deep infiltrative endometriosis

2020 ◽  
Vol 69 (5) ◽  
pp. 77-86
Author(s):  
Armine R. Khachaturyan ◽  
Maria I. Yarmolinskaya ◽  
Anna A. Tsypurdeyeva ◽  
Eduard N. Popov ◽  
Alexandra I. Rudikova
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Clinical Case ◽  
Conservative Therapy ◽  
Tubal Pregnancy ◽  
Interstitial Pregnancy ◽  
Laparoscopic Removal ◽  
Deep Infiltrative Endometriosis

This article summarizes data on the prevalence, risk factors and the role of external genital endometriosis in the development of ectopic pregnancy. The existing algorithms for the use of conservative therapy of ectopic pregnancy of rare localizations are discussed. The authors presented a clinical case of using methotrexate in the treatment of a patient with infiltrative endometriosis and trophoblast persistence after laparoscopic removal of interstitial tubal pregnancy.

scholarly journals The role of risk factors in the incidence and recurrence of ectopic pregnancy

2021 ◽  
Vol 68 (1) ◽  
pp. 87-91
Author(s):  
Catalina Diana Stanica ◽  
◽  
Adrian Neacsu ◽  
Romina Marina Sima ◽  
Raluca Gabriela Ioan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Abdominal Surgery ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Risk Of Recurrence ◽  
Life Threatening ◽  
Common Risk Factors ◽  
Control Study

The increase in the incidence of ectopic pregnancy in the last 20 years, with the serious compromise of the woman's obstetric future and the life-threatening complications caused by it, makes ectopic pregnancy a very current problem, frequently encountered in Obstetrics-Gynecology clinics The aim of this study is to compare how risk factors and management can influence the incidence and the risk of recurrence of ectopic pregnancy. This paper presents a prospective case-control study for 65 patients, who have been diagnosed serologically and ultrasonically. In the present study, the most common risk factors involved were: pelvic inflammatory disease (46%), ectopic pregnancy (20%), smoking (85%), abortions (55%), and abdominal surgery (43%). In the group of patients studied, patients required surgical and medical treatment, and also a management of expectation. The risk factors that influence recurrence were smoking (100%), pelvic inflammatory disease (84.6%), abortions (53.8%), abdominal surgery (46%). By the type of surgery (laparoscopy or laparotomy), the risk of recurrence varies between 6 and 10% and does not seem to be influenced by it.

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