scholarly journals Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status

2020 ◽  
Vol 21 (18) ◽  
pp. 6728
Author(s):  
Kirill V. Bulygin ◽  
Narasimha M. Beeraka ◽  
Aigul R. Saitgareeva ◽  
Vladimir N. Nikolenko ◽  
Ilgiz Gareev ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Clinical Manifestations ◽  
Therapeutic Modality ◽  
Current Status ◽  
Rna Molecules ◽  
Therapeutic Modalities ◽  
Diagnostic Role ◽  
Therapeutic Tools

Ischemic stroke is one of the leading causes of death worldwide. Clinical manifestations of stroke are long-lasting and causing economic burden on the patients and society. Current therapeutic modalities to treat ischemic stroke (IS) are unsatisfactory due to the intricate pathophysiology and poor functional recovery of brain cellular compartment. MicroRNAs (miRNA) are endogenously expressed small non-coding RNA molecules, which can act as translation inhibitors and play a pivotal role in the pathophysiology associated with IS. Moreover, miRNAs may be used as potential diagnostic and therapeutic tools in clinical practice; yet, the complete role of miRNAs is enigmatic during IS. In this review, we explored the role of miRNAs in the regulation of stroke risk factors viz., arterial hypertension, metabolic disorders, and atherosclerosis. Furthermore, the role of miRNAs were reviewed during IS pathogenesis accompanied by excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis, neurogenesis, and Alzheimer’s disease. The functional role of miRNAs is a double-edged sword effect in cerebral ischemia as they could modulate pathological mechanisms associated with risk factors of IS. miRNAs pertaining to IS pathogenesis could be potential biomarkers for stroke; they could help researchers to identify a particular stroke type and enable medical professionals to evaluate the severity of brain injury. Thus, ascertaining the role of miRNAs may be useful in deciphering their diagnostic role consequently it is plausible to envisage a suitable therapeutic modality against IS.

Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Danica W. Y. Liu ◽  
A. Kate Fairweather-Schmidt ◽  
Richard Burns ◽  
Rachel M. Roberts ◽  
Kaarin J. Anstey
Keyword(s):  
Risk Factors ◽  
Well Being ◽  
Current Status ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Life Project ◽  
Resilience Factors ◽  
First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

The physiopathology of spontaneous hemorrhagic stroke: a systematic review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Alcivan Batista de Morais Filho ◽  
Thiago Luis de Holanda Rego ◽  
Letícia de Lima Mendonça ◽  
Sulyanne Saraiva de Almeida ◽  
Mariana Lima da Nóbrega ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Natural History ◽  
Hemorrhagic Stroke ◽  
Recent Literature ◽  
Clinical Manifestations ◽  
The Road ◽  
History Of

Abstract Hemorrhagic stroke (HS) is a major cause of death and disability worldwide, despite being less common, it presents more aggressively and leads to more severe sequelae than ischemic stroke. There are two types of HS: Intracerebral Hemorrhage (ICH) and Subarachnoid Hemorrhage (SAH), differing not only in the site of bleeding, but also in the mechanisms responsible for acute and subacute symptoms. This is a systematic review of databases in search of works of the last five years relating to the comprehension of both kinds of HS. Sixty two articles composed the direct findings of the recent literature and were further characterized to construct the pathophysiology in the order of events. The road to the understanding of the spontaneous HS pathophysiology is far from complete. Our findings show specific and individual results relating to the natural history of the disease of ICH and SAH, presenting common and different risk factors, distinct and similar clinical manifestations at onset or later days to weeks, and possible complications for both.

scholarly journals Metabolic Syndrome, Cognitive Impairment and the Role of Diet: A Narrative Review

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 333
Author(s):  
Matina Kouvari ◽  
Nathan M. D’Cunha ◽  
Nikolaj Travica ◽  
Domenico Sergi ◽  
Manja Zec ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Clinical Manifestations ◽  
Narrative Review ◽  
Cognitive Outcomes ◽  
Food Groups ◽  
Cardiometabolic Disorders

Background: This narrative review presents the association between metabolic syndrome (MetS), along with its components, and cognition-related disorders, as well as the potential reversal role of diet against cognitive impairment by modulating MetS. Methods: An electronic research in Medline (Pubmed) and Scopus was conducted. Results: MetS and cognitive decline share common cardiometabolic pathways as MetS components can trigger cognitive impairment. On the other side, the risk factors for both MetS and cognitive impairment can be reduced by optimizing the nutritional intake. Clinical manifestations such as dyslipidemia, hypertension, diabetes and increased central body adiposity are nutrition-related risk factors present during the prodromal period before cognitive impairment. The Mediterranean dietary pattern stands among the most discussed predominantly plant-based diets in relation to cardiometabolic disorders that may prevent dementia, Alzheimer’s disease and other cognition-related disorders. In addition, accumulating evidence suggests that the consumption of specific dietary food groups as a part of the overall diet can improve cognitive outcomes, maybe due to their involvement in cardiometabolic paths. Conclusions: Early MetS detection may be helpful to prevent or delay cognitive decline. Moreover, this review highlights the importance of healthy nutritional habits to reverse such conditions and the urgency of early lifestyle interventions.

scholarly journals Current status and novel directions in triple negative breast cancer patients. Risk factors. Role of the platinum-based chemotherapy

2016 ◽  
Vol 11 (2) ◽  
pp. 122-126
Author(s):  
Olivia IONESCU ◽  
◽  
Irina BALESCU ◽  
Nicolae BACALBASA ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Clinical Trials ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Controlled Vocabulary ◽  
Current Status ◽  
Platinum Based Chemotherapy ◽  
Therapeutic Possibilities

Rationale. Breast cancer (BC) has been recognized to be the most common type of cancer in women all over the world. One of the most aggressive subtype of BC is the triple negative breast cancer (TNBC) which is defined by the absence of estrogen receptor (ER) and progesterone receptor (PR) as well as the lack of overexpression of the human epidermal growth factor 2 (HER 2). Aim. As the estrogen and progesterone receptors as well as the expression of HER2 are lacking, a targeted therapy with anti-hormone agents and anti-HER2 cannot be utilized, the therapeutic possibilities for TNBC women are limited. The aim of this review is to present the current scientific data as well as the latest research in TNBC with focus on the risk factors as well as the current role of platinum-based chemotherapeutic agents and their future implications in TNBC treatment. Method. Information about the risk factors associated to TNBC as well as the chemotherapeutic regimens was searched through Pubmed and Medline using controlled vocabulary (e.g. breast cancer) and key words (e.g. neoadjuvant, triple negative, platinum). Systematic reviews, randomized and controlled clinical trials were analyzed. No restrictions regarding date or language were used. Conclusions. TNBC is a complex and heterogeneous disease, divided into many subtypes and with an aggressive evolution. Premenopausal women and African American women are far more likely to develop TNBC. More research is required in order to confirm the association between obesity, BMI, parity, use of oral contraceptives, alcohol and cigarette smoking and TNBC. Randomized clinical trials presented at the San Antonio Symposium suggest that platinum chemotherapy play an important role in the treatment of TNBC, especially early stage TNBC. Tumor-based measures of genomic instability will help to clarify the optimal use and activity of platinum in TNBC. However, it is clear than more epidemiological studies as well as the discovery of novel therapeutic possibilities are mandatory in order to unravel the complexity of this BC subtype, hence offering a chance to women diagnosed with TNBC.

scholarly journals Fibrinogen and LDL Influence on Blood Viscosity and Outcome of Acute Ischemic Stroke Patients in Indonesia

2019 ◽  
Vol 26 (3-4) ◽  
pp. 30-34
Author(s):  
Al Rasyid ◽  
Salim Harris ◽  
Mohammad Kurniawan ◽  
Taufik Mesiano ◽  
Rakhmad Hidayat
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Blood Viscosity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Bivariate Analysis ◽  
Stroke Patients ◽  
Factors Affecting

Background: To assess the role of risk factors of metabolic syndrome on blood viscosity and the prognosis of acute ischemic stroke in Indonesia based on the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Methods: This study included 135 patients with acute ischemic stroke. Patients underwent measurements of viscosity and risk factor assessment. Analysis was performed to assess the role of these risk factors for blood viscosity and outcomes of acute ischemic stroke with NIHSS and mRS as indicators. NIHSS was assessed at <3 days after onset and 7 days after onset, while mRS was assessed 1 month post treatment. Bivariate analysis was performed using chi-square test, and variables with p < 0.25 were further analyzed in multivariate analysis using logistic regression. Results: Factors affecting blood viscosity are fibrinogen, low-density lipoprotein (LDL), and hematocrit. Factors affecting NIHSS and mRS are fibrinogen and LDL. Conclusion: Fibrinogen and LDL affect the viscosity of blood and outcomes in acute ischemic stroke patients, so it is necessary to treat in the primary and secondary prevention of ischemic stroke.

THE ROLE OF HYSTEROSALPINGOGRAPHY IN DETECTING ENDOMETRIOSIS OF THE FALLOPIAN TUBES

2021 ◽  
Vol 2 (1) ◽  
pp. 65-67
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Reproductive System ◽  
Clinical Manifestations ◽  
Fallopian Tubes

This clinical example confirms the need for a thorough assessment of anamnestic data at the stage of pre-gravidar preparation, the need to analyze various possible causes of infertility and ectopic pregnancy, and the interpretation of data obtained by hysterosalpingography (HSG) in a patient without pronounced clinical manifestations of endometriosis, in the presence of ethologically proven risk factors for the development of this pathology, even in the absence of complaints. This method of research is informative in identifying the pathology of the reproductive system, including the fallopian tubes.

scholarly journals MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Anjie Min ◽  
Chao Zhu ◽  
Shuping Peng ◽  
Saroj Rajthala ◽  
Daniela Elena Costea ◽  
...  
Keyword(s):  
Low Income ◽  
Noncoding Rna ◽  
Current Knowledge ◽  
Human Cancer ◽  
Low Income Countries ◽  
Rna Molecules ◽  
Therapeutic Modalities ◽  
Oral Carcinogenesis ◽  
Significant Attention

Oral cancer, represented mainly by oral squamous cell carcinoma (OSCC), is the eighth most common type of human cancer worldwide. The number of new OSCC cases is increasing worldwide, especially in the low-income countries, and the prognosis remains poor in spite of recent advances in the diagnostic and therapeutic modalities. MicroRNAs (miRNAs), 18–25 nucleotides long noncoding RNA molecules, have recently gained significant attention as potential regulators and biomarkers for carcinogenesis. Recent data show that several miRNAs are deregulated in OSCC, and they have either a tumor suppressive or an oncogenic role in oral carcinogenesis. This review summarizes current knowledge on the role of miRNAs as tumor promotors or tumor suppressors in OSCC development and discusses their potential value as diagnostic and prognostic markers in OSCC.

Arterial ischemic stroke in childhood: the role of plasma-phase risk factors

2002 ◽  
Vol 15 (2) ◽  
pp. 139-144 ◽  
Author(s):  
Eirini Nestoridi ◽  
Ferdinando S. Buonanno ◽  
Robin M. Jones ◽  
Kalpathy Krishnamoorthy ◽  
P. Ellen Grant ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Arterial Ischemic Stroke ◽  
Plasma Phase

scholarly journals Hygienic aspects of robotization: risk factors and safety principles

2021 ◽  
Vol 100 (1) ◽  
pp. 6-12
Author(s):  
Igor V. Bukhtiyarov ◽  
Eduard I. Denisov
Keyword(s):  
Risk Factors ◽  
Clinical Manifestations ◽  
Human Robot Interaction ◽  
Social Aspects ◽  
The European Union ◽  
Intelligence System ◽  
The Usa ◽  
Noise Vibration ◽  
Definition Of

The paper presents a review and essays on the hygienic aspects of the problem of robotics. The absence of generally accepted international terminology is noted. There is given a definition of basic terms as a robot, an artificial intelligence system (AIS), and a cyber-physical system (CFS) - according to authoritative sources. In the literature, the term robot is often used to mean CFS. The origin of robots in Russia is briefly described. The role of AIS as the basis of a technological breakthrough is considered. There is represented statistical data on the scientific, economic, and social aspects of the introduction of robotics. Robots are believed to be more likely to replace tasks rather than jobs and create new types of them. The medical and social aspects of robotization based on the experience of the European Union, the USA, and South Korea are examined, and the prospects of creating "smart jobs" are emphasized. The types of robots and their application in industry and medicine for diagnosis, treatment, and rehabilitation are described. It is emphasized that robots are the most advanced machines. The dangers created by robots, their causes, and possible consequences from physical (noise, vibration), chemical, electrical, ergonomic, and other perils are described. The presence of both "traditional" and new risk factors is noted. The systematics of the stages of human-robot interaction is proposed: ethical aspects in the design, communication psychology, contacts with the machine during its use and safety aspects, human physiological responses, possible clinical manifestations of health disorders. The safety principles of robots and CFS are formulated, and that the "smarter" the robots, the greater the risks of program failures and breakdowns are noted. The role of information hygiene and the need for training and health education of workers and the population are examined. Estimates are given of the prospects for the robotization of the profession. The occupation of hygienists in the era of digitalization and robotization is noted to have a future.

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