EVALUATION OF PREDICTIVE CAPABILITIES OF TIRADS, EU-TIRADS, TLA_RU SYSTEMS IN THE ULTRASOUND DIAGNOSIS OF THYROID NODULAR PATHOLOGY

2021 ◽  
pp. 29-38
Author(s):  
Vladimir G. Stepanov ◽  
Lyubov A. Timofeeva ◽  
Sergey V. Alekseev ◽  
Marina A. Yusova
Keyword(s):  
Thyroid Cancer ◽  
Ultrasound Examination ◽  
Standard Procedure ◽  
Benign Tumors ◽  
Quality Test ◽  
Multivariate Statistical ◽  
Excellent Quality ◽  
Ultrasound Diagnostics ◽  
Thyroid Cancer Risk ◽  
Multiparametric Ultrasound

The aim of the study was to evaluate the prognostic capabilities of EU-TIRADS, TIRADS, TLA_RU systems in ultrasound diagnostics of thyroid nodular masses. A retrospective independent continuous blind study of ultrasound examination protocols was conducted in 665 patients, 241 patients had benign non-cancerous thyroid diseases, 86 patients had benign tumors (adenomas), 338 patients had thyroid cancer. During the preoperative examination, all patients underwent a multiparametric ultrasound examination of the neck organs according to the standard procedure, with the registration of identified thyroid nodes, with examining the prognostic capabilities of stratification systems – TIRADS, EU-TIRADS, TLA_RU. It was found that the TIRADS system has a sensitivity of 91.04%, specificity – 91.41%. Focusing on the scale of AUC values reflecting the quality of the diagnostic test, it can be stated that TIRADS is a test with excellent quality (AUC =0.972). Basing on the results of the analyzing the data obtained by the EU-TIRADS system, it was revealed that it is a high-quality test (AUC=0.826), but its predictive capabilities are worse than those of TIRADS. The original TLA_RU model has 87.5% sensitivity and 95.7% specificity. During the ROC analysis, it was found that the AUC is equal to 0.954±0.00894, which suggests that the TLA_RU model is an excellent quality test in the differential diagnosis of thyroid nodular masses. Multivariate statistical comparative analysis of thyroid imaging assessment systems (TIRADS, EU-TIRADS and TLA_RU) from the standpoint of evidence-based medicine has shown that thyroid cancer risk stratification systems based on the assessment of multiparametric ultrasound signs have great diagnostic capabilities.

INFORMATIVE VALUE OF SONOELASTOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF FOLLICULAR THYROID CANCER

2021 ◽  
pp. 73-78
Author(s):  
Lyubov A. Timofeeva ◽  
Tatiana N. Aleshina ◽  
Marina E. Baranova ◽  
Marina A. Yusova ◽  
Natalia N. Nikolaeva
Keyword(s):  
Thyroid Cancer ◽  
Preoperative Diagnosis ◽  
Surgical Intervention ◽  
Ultrasound Examination ◽  
Shear Wave Elastography ◽  
Diagnostic Methods ◽  
Follicular Thyroid Cancer ◽  
Leading Role ◽  
Quantitative Characteristics ◽  
Multiparametric Ultrasound

In recent years, the opportunities of radiation diagnostic methods have stepped far ahead and today they play a leading role at the stage of preoperative diagnosis of thyroid diseases. The most promising of them is multiparametric ultrasound examination, as well as sonoelastography associated with it. Strain elastography and shear wave elastography make it possible to determine the boundaries of pathological formation and quantitative characteristics of nodular stiffness, which is important when determining the boundaries of invasive tumor growth, primarily thyroid cancer, when planning an upcoming surgical intervention. The article describes a clinical case of radiation diagnosis made for follicular thyroid cancer; it shows the importance of multiparametric ultrasound, including sonoelastography, in the early detection of thyroid cancer. A timely diagnosis and a correct chosen tactics for treating follicular thyroid cancer resulted in a favorable disease outcome.

Increased thyroid cancer risk in acromegaly

2013 ◽  
Author(s):  
Selcuk Dagdelen ◽  
Nese Cinar ◽  
Tomris Erbas
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Cancer Risk

Opportunities of ultrasound diagnostics of lung injury in SARS-CoV-2 infection (COVID-19): a clinical case

2020 ◽  
Vol 98 (11) ◽  
pp. 51-56
Author(s):  
G. V. Neklyudova ◽  
А. V. Chernyak ◽  
N. А. Tsareva ◽  
S. N. Аvdeev
Keyword(s):  
Lung Injury ◽  
Clinical Case ◽  
Ultrasound Examination ◽  
Recovery Period ◽  
Early Recovery ◽  
Acute Period ◽  
Ultrasound Diagnostics ◽  
Early Recovery Period

The article describes a clinical case demonstrating the results of the lungs ultrasound examination in the COVID-19 patient during the acute period of the disease and early recovery period.

scholarly journals The association between diabetes and thyroid cancer risk: a hospital-based case-control study in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Meng Wang ◽  
Wei-Wei Gong ◽  
Feng Lu ◽  
Ru-Ying Hu ◽  
Qing-Fang He ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Family History ◽  
Case Control Study ◽  
Positive Family History ◽  
Case Control ◽  
Diabetes Duration ◽  
Family History Of Diabetes ◽  
Thyroid Cancer Risk ◽  
History Of ◽  
Control Study

Abstract Background Previous studies have indicated inconsistent relationships of diabetes with thyroid cancer risk, yet little is known in China. In this study, we aimed to investigate the associations between diabetes, diabetes duration and the risk of thyroid cancer in Chinese population. Methods A 1:1 matched case-control study was performed between 2015 and 2017 in Zhejiang Province including 2,937 thyroid cancer cases and 2,937 healthy controls. Odds ratios (ORs) with 95 % confidence intervals (CIs) for thyroid cancer were estimated in logistic regression models. Specific effects stratified by age, as well as sex, body mass index (BMI) and family history of diabetes were also examined. Results Overall, neither diabetes (OR = 0.75, 95 % CI: 0.21–2.73) nor diabetes duration (OR = 0.14, 95 % CI: 0.02–1.22 for diabetes duration ≦ 5 years; OR = 2.10, 95 % CI: 0.32–13.94 for diabetes duration > 5 years) was significantly associated with thyroid cancer. In stratified analyses, significant lower risk of thyroid cancer was observed among subjects with diabetes and shorter diabetes duration ( ≦ 5 years), but limited to those who were aged more than 40 years, female, overweight/obese and had positive family history of diabetes. Conclusions Diabetes and shorter diabetes duration were significantly associated with decreased risk of thyroid cancer in individuals characterized by older age, female sex, higher BMI and positive family history of diabetes.

scholarly journals Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
QingAn Yu ◽  
XiaoYing Lv ◽  
KunPeng Liu ◽  
DaKun Ma ◽  
YaoHua Wu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Clomiphene Citrate ◽  
Positive Association ◽  
Female Infertility ◽  
Cochrane Library ◽  
Significant Positive Association ◽  
Fertility Drugs ◽  
Increased Risk ◽  
Thyroid Cancer Risk

Associations have been demonstrated between fertility drugs and a variety of hormone-sensitive carcinomas. The purpose of this study was to determine the relationship between fertility drugs used in the treatment of female infertility and the risk of thyroid cancer. To investigate the clinical significance of fertility drugs used for the treatment of female infertility and the risk associated with thyroid cancer, we performed a literature search using PubMed, MEDLINE, the Cochrane Library, the Web of Science, and EBSCOHOST for comparative studies published any time prior to July 21, 2017. The studies included women who were treated for infertility with fertility drugs, such as clomiphene citrate, gonadotropins, or other unspecified fertility agents, which reported the incidence of thyroid cancer as the main outcome. Eight studies were included in the meta-analyses. Among women with infertility, there was a significant positive association between thyroid cancer risk and the use of fertility drugs (relative risk [RR] = 1.35; 95% confidence interval [CI] 1.12–1.64; P=0.002). Additionally, among women with infertility, the use of clomiphene citrate was associated with an increased risk of thyroid cancer compared to women who did not use fertility drugs (RR = 1.45; 95% CI 1.12–1.88; P=0.005). After pooling results, we found that the parity status of infertile women using fertility drugs was not associated with thyroid cancer risk (RR = 0.99; 95% CI 0.61–1.58, P=0.95). In summary, clomiphene citrate (the most commonly used fertility drug) and other fertility drugs are associated with an increased risk of thyroid cancer.

Contribution of industrial density and socioeconomic status to the spatial distribution of thyroid cancer risk in Hangzhou, China

2018 ◽  
Vol 613-614 ◽  
pp. 679-686 ◽  
Author(s):  
Xufeng Fei ◽  
Zhaohan Lou ◽  
George Christakos ◽  
Qingmin Liu ◽  
Yanjun Ren ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Spatial Distribution ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Cancer Risk

scholarly journals FREQUENCY OF DETERMINATION OF PARENCHYMAL ORGANS DISTURBANCES DURING ULTRASOUND EXAMINATION OF REPRODUCTIVE TRACT

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Strahinja ĆIBIĆ ◽  
Miloš PAVLOVIĆ
Keyword(s):  
Genital Tract ◽  
Reproductive Tract ◽  
Ultrasound Examination ◽  
Non Invasive ◽  
Follicular Cyst ◽  
Pathological Conditions ◽  
Ultrasound Diagnostics ◽  
Liver And Pancreas ◽  
Invasive Method

Ultrasound Real time 2D diagnostics, being an available and non-invasive method, issuccessfully used in human medicine, veterinary medicine and biology to diagnose bothphysiological and pathological conditions. In the case of small animals, the ultrasound is often usedto diagnose gravidity, number, size and vitality of fetuses as well as to diagnose pathologicalconditions present in the genital tract, and is also used to examine testicles and prostate of maleanimals. Today's advanced use of the ultrasound diagnostics provides us with an opportunity todetect numerous pathological conditions of reproductive tract of both female and male animals, andthose conditions directly affect health status of other internal organs. The aim of this study is todiagnose primary genital tract disorders using the ultrasound diagnostics, as well as proving itsconnection to the changes in parenchymal organs. The ultrasound examination was performed onthe total of 12 dogs, 6 male and 6 female dogs. Ovaries, uterus and the organs in the abdominal areawere examined using a transducer ranging from 5 to 8 MHz. A transducer of 7.5 MHz was used toexamine prostates and testicles. The patients were in dorsal position. Three out of six examined maledogs exhibited changes on their prostates, and the remaining one had a tumor on the testicles. Cystitisand hyperplasia of prostate were also found upon the examination of these dogs. One out of sixexamined female dogs, had cystic endometrial hyperplasia, three of them had pyometra, and one ofthem was diagnosed with an follicular cyst. In addition to these pathological conditions, changeswere noticed in the liver and pancreas. Along with the detection of primary changes in the genitaltract of both male and female animals, the ultrasound diagnostics can be used to discover consequentchanges in parenchymal organs.

scholarly journals PARENTS’ ASSESSMENT OF CONDITIONS OF ULTRASOUND EXAMINATION OF CHILDREN

2020 ◽  
Vol 8 (4) ◽  
pp. 524-530
Author(s):  
I.А. Krotov ◽  
◽  
O.E. Konovalov ◽  
◽  
Keyword(s):  
Correlation Analysis ◽  
Outpatient Clinic ◽  
Questionnaire Survey ◽  
Medical Service ◽  
Ultrasound Examination ◽  
Aim Analysis ◽  
National Medical ◽  
Ultrasound Diagnostics ◽  
Mathematical Processing

Aim. Analysis of the results of parents' assessment of the conditions of US diagnostics of children. Materials and Methods. Assessment of the conditions for receiving ultrasound examination, based on the results of a questionnaire survey of 424 parents of children who underwent this medical service at the National Medical Research Center of Children's Health of the Ministry of Health of Russia, is presented. Mathematical processing of the obtained data was carried out using the methods of variation statistics and correlation analysis. Results. 83.5% of parents surveyed were satisfied with the ultrasound diagnostic services provided to their children, 12.3% – were satisfied only partially. According to respondents’ opinions, the main reasons for dissatisfaction were insufficient qualification of specialist and low quality of the equipment used. The majority of individuals participating in the survey, considered waiting for ultrasound not long, in 77.6% of cases it was carried out within 1-2 days after the appointment. Ultrasonography in an outpatient clinic and in a hospital was mainly carried out free of charge, as part of compulsory medical insurance – in 86.1 and 87.5% of cases, respectively. Only 14.3% of respondents noted that they had the financial ability to pay for examination of the child from personal funds. It was found that 12.7% of parents had to refuse, for this or that rea-son, from the proposed ultrasound methods of examination of the child. Conclusion. The vast majority of the parents surveyed were satisfied with the ultrasound diagnostics services provided to their child. The main reasons for refusing from ultrasound were a sharply negative reaction of the child, as well as the opinion about the possible harm of the examination and the expected pain from the procedure.

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