scholarly journals VARIATIONS IN ANTIMICROBIAL ACTIVITY OF SYZYGIUM CUMINI OF DIFFERENT GEOGRAPHICAL LOCATIONS

2020 ◽  
pp. 1-6
Author(s):  
Pratibha ◽  
Nesari Tanuja ◽  
Ghildiyal Shivani ◽  
Vandhana
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Streptococcus Pyogenes ◽  
Antimicrobial Agents ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Syzygium Cumini ◽  
Geographical Variations ◽  
Geographical Locations

The emergence of antibiotic resistance and the evolution of new strains of disease causing agents, are of highly concern to the global health community. Plants are potential source of antimicrobial agents. They have been used traditionally for prevention of infections caused by micro-organisms. Description of Krimighana herbs enumerated in Ayurveda classics is suggestive towards the importance of this group of medicine. Jambu (Syzygium cumini (L.) Skeels) is a member of Myrtaceae family. In Raja Nighantu it is mentioned that plant Jambu is having Kriminashaka property. It has been widely used medicine in the prevention of various ailments like cough, Dysentary, Diabetes, inflammation and ringworm. It is well established fact that geographical variations effects the potential and activity of medicinal herbs. Hence, the present study was undertaken to investigate Syzygium cumini procured from different geographical locations including Delhi, Rajasthan and Maharashtra for their potential activity against human infections caused by pathogens. Method The aqueous extract of Syzygium cumini of all the three areas was prepared. The activity of the plant extract was evaluated against nine bacterial pathogens and one fungal strain, which include Staphyllococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia and Candida albicans. The activity was carried out using Disk diffusion method. Result and Conclusion: All samples of Syzygium cumini showed potential antimicrobial activity against four pathogens including Staphyllococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa and Candida albicans. MIC was also evaluated against the tested pathogenic strains. The sample from Maharashtra showed MIC i.e. 80µg, 40µg, 80µg against Staphyllococcus aureus, Streptococcus pyogenes and Candida albicans respectively which is less as compare to sample from Rajasthan and Delhi. Region wise sample from Maharashtra showed good ZOI and MIC.

scholarly journals Characterization and Antimicrobial Activity of Erbium(III) Complexes of C-3 Substituted 2-hydroxy-1,4-naphthalenedione-1-oxime Derivatives

2001 ◽  
Vol 8 (3) ◽  
pp. 159-164 ◽  
Author(s):  
S. B. Jagtap ◽  
N. N. Patil ◽  
B. P. Kapadnis ◽  
B. A. Kulkarni
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Magnetic Susceptibility ◽  
Candida Albicans ◽  
Xanthomonas Campestris ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Oxime Derivatives

Erbium(III) complexes of 2-hydroxy-l,4-naphthalenedione-1-oxime and its C-3 substituted derivatives are synthesized and characterized by elemental analysis, thermogravimetric analysis, infrared spectroscopy, magnetic susceptibility measurements 2-hydroxy-1,4-naphthalenedione-1-oxime derivatives are analysed using H1 and C13 NMR spectroscopy. The molecular composition of the synthesized complexes is found to be [ML3(H2O)2]. The antimicrobial activity of these complexes is determined by well diffusion method against the target microorganisms- Staphylococcus aureus, Xanthomonas campestris, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antimicrobial activities of 2- hydroxy-1,4-naphthalenedione-1-oximes and their complexes are compared. It is observed that 2-hydroxy-1,4-naphthalenedione-l-oximes exhibit higher antifungal activity as compared to antibacterial activity. These activities are reduced upon complexation of these oximes with Erbium.

scholarly journals In vitro antimicrobial activity and phytochemical analysis of Cassia auriculata Linn

2013 ◽  
Vol 2 (6) ◽  
pp. 105-108 ◽  
Author(s):  
Devados Kumarasamy Raja ◽  
Nattanmai Sundararaman Jeganathan ◽  
Rajappan Manavalan
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Pathogenic Bacteria ◽  
Chloroform Extract ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Cassia Auriculata

This study was performed to evaluate the antimicrobial activity of aerial parts of chloroform extract of Cassia auriculata L. The chloroform extract of C. auriculata were shown to possess an antimicrobial activity against two gram positive and two gram negative human pathogenic bacteria and fungi, viz. Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and fungus cultures Candida albicans and Aspergillus niger by using disc diffusion method. The extract showed antibacterial activity at all concentrations selected, but only the extract with the concentration of 300µg/ml showed maximum antibacterial activity against all the organisms except Pseudomonas aeruginosa which are comparable with the standard control, amikacin. The anti fungal activity of chloroform extract of C. auriculata revealed significant effect against Candida albicans and Aspergillus niger with the net inhibition zone of 14 and 14 mm, respectively at 300µg/ml concentration, which is almost comparable with standard control, ketokonazole used as an antifungal agent. The phytochemical analysis showed the presence of alkaloids, carbohydrates, fixed oils, fats, tannins, gum & mucilage, flavonoids, saponins, terpenoids, lignin and sterols. It is concluded that the antimicrobial activity showed by the plant was due to the presence of these phytochemicals. Further studies are highly needed for future drug development.DOI: http://dx.doi.org/10.3329/icpj.v2i6.14869 International Current Pharmaceutical Journal, May 2013, 2(6): 105-108

scholarly journals Isolation of antibiotic Producing Microorganisms from some water bodies within Eastern and Greater Accra Regions of Ghana

2019 ◽  
Author(s):  
Daniel Amiteye ◽  
Nicholas Tete Kwaku Dzifa Dayie ◽  
Stephen Yao Gbedema ◽  
Vivian Etsiapa Boamah ◽  
Francis Adu ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Clinical Isolate ◽  
Antimicrobial Agents ◽  
Antibacterial Activities ◽  
Salmonella Typhi ◽  
Water Bodies ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Biochemical Tests

ABSTRACTBackgroundMost antimicrobial agents used today are isolated and extracted from microbial source. The emergence of antimicrobial resistance and need for better, broad spectrum antimicrobial agent is always in high demand. In this study, a total of 112 aquatic microbial isolates from 14 sample sites of water bodies in Ghana were screened by agar-well diffusion method for the ability of antimicrobial metabolites.ResultsOut of these antibacterial activities, 10 inhibited the growth of at least one test microorganism with zones of growth inhibitions ranged between 2.5±0.5 - 35.5±0.5 mm againstStaphylococcus aureus(ATCC25923),Streptococcus pyogenes(clinical isolates), Escherichia coli(NCTC9002),Pseudomonas aeruginosa(ATCC27853),Neisseria gonorrhoeae(clinical isolate),Klebsiella pneumoniae (Clinical isolate),Bacillus subtilis(NCTC10073) andSalmonella typhi(NCTC 6017). The extracts of the isolates showed minimum inhibitory concentrations of which extract NKSEW3againstEscherichia coli, Klebsiella pneumoniaeandPseudomonas aeruginosawere 25.00, 12.50 and 25.00 mg/mL respectively while that of NKLS6were 12.50, 6.25 and 25.00 mg/mL. The isolates NKSEW3and NKLS6were identified to bePseudomonas speciesusing chromagar and biochemical tests. The GC-MS result for NKLS62 (a fraction obtained from NKLS6) revealed five compounds including; Tridecanal, 17-octadecanal, ethanol, 2-(9-octadecenyloxy)-, (Z), 2-pentadecanone, 6, 10, 14-trimethyl diisooctyl phthalate and 17-octadecanal (C18H34O) as good pharmacological agents.ConclusionMicroorganisms isolated from water bodies in Ghana have the potential of producing antimicrobial agents.Author SummaryIn this study we use the agar well-diffusion to screen the isolates of water and soil samples collected within Greater Accra and Eastern Regions in Ghana against the test organisms.

scholarly journals Chemical Composition and Antimicrobial Activity of Subcritical CO2 Extract of Lepidium latifolium L. (Brassicaceae)

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Balzhan B. Azimkhanova ◽  
Gulbaram O. Ustenova ◽  
Kamalidin O. Sharipov ◽  
Kayrolla D. Rakhimov ◽  
Galiya M. Sayakova ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Carbon Dioxide ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Biologically Active ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Lepidium Latifolium ◽  
Carbon Dioxide Extraction

The genus Lepidium L. from Brassicaceae Burnett. family covers over 150 species with an almost cosmopolitan spread. In Kazakhstan, 21 species are described, of which four species are characterized by medicinal properties (L. crassifolium Waldst. et Kit., L. perfoliatum L., L. ruderale L., and L. latifolium L.), used in folk medicine as means of antibacterial, irritant, laxative, antitumor, analgesic, and anthelmintic action. Methods. Raw materials were collected from Almaty region (Republic of Kazakhstan). Lepidium latifolium L. herb’s carbon dioxide extract (CO2 extract) was obtained by subcritical carbon dioxide extraction. A gas chromatograph with a mass spectrometric detector was used to determine the component composition of the extract. Antimicrobial activity was determined by two methods: the micromethod of serial dilution and the disc-diffusion method. Four microbial test strains were used: Staphylococcus aureus ATCC 6538-P, Escherichia coli ATCC 8739, Klebsiella pneumonia ATCC 10031, and Candida albicans ATCC 10231. Results. The technology of carbon dioxide extraction has undoubted advantages over traditional methods of extraction: it has a controlled selectivity in relation to groups of biologically active substances, allows deep extraction, and maximizes the release of rich complexes of compounds contained in plants. In this study, firstly, the CO2 extract was obtained under subcritical conditions from the aerial part of L. latifolium L., and the composition was determined. Hexane was the best solvent for CO2 extract, and 40 components were identified. Screening of antimicrobial activity of the L. latifolium’s CO2 extract showed the essential activity of all clinically significant strains tested: Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Candida albicans. Conclusions. This research showed that the CO2 extract of the raw material of Lepidium latifolium L. contains biologically active compounds exhibiting an essential antimicrobial effect, and therefore it is possible to recommend for the development of various drugs for use in medical practice.

scholarly journals Invitro antibacterial activity of Cassia fistula Linn methanolic leaf extracts

2019 ◽  
Vol 8 (2) ◽  
pp. 270
Author(s):  
Bindhu R. Kamath ◽  
Sabeena Kizhedath
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Cassia Fistula ◽  
Leaf Extracts ◽  
E Coli

Background: Cassia fistula Linn is a plant which is widely grown in India and is used for medicinal purposes. The study was carried out with an objective to demonstrate the antimicrobial activity of leaves of Cassia fistula Linn. The aim of the study is to assess antibacterial and antifungal activity of methanolic leaf extract of Cassia fistula Linn against selected clinical isolates.Methods: The antimicrobial activity of methanolic extract of Cassia fistula was evaluated using agar well diffusion method and to zone of inhibition of extract was determined. Clinical isolates of Staphyloccocus aureus, MRSA, Pseudomonas aeruginosa, E. coli and Proteus were screened.Results: The methanolic extracts exhibited antibacterial activity against Staphylococcus aureus. The extract was not active against E. coli, Proteus, MRSA, Pseudomonas aeruginosa. The extract also failed to demonstrate antifungal activity against Candida albicans and Aspergillus niger.Conclusions: The global emergence of multidrug resistant bacterial strains is increasing, limiting the effectiveness of current drugs and treatment failure of infections. A novel approach to the prevention of antibiotic resistance of pathogenic species is the use of new compounds that are not based on existing synthetic antimicrobial agents.

scholarly journals Nickel (II) and Cobalt (II) Complexes of Some Amino Acid-based Surfactants with Antimicrobial Activity

2019 ◽  
Vol 70 (2) ◽  
pp. 361-364
Author(s):  
Dana Varasteanu ◽  
Irina Chican ◽  
Sanda Maria Doncea ◽  
Iuliana Raut ◽  
Mariana Calin ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Amino Acid ◽  
Complex Formation ◽  
Bacillus Cereus ◽  
Aspergillus Flavus ◽  
Antimicrobial Agents ◽  
Cobalt Complexes ◽  
Bacteria And Fungi

Nickel and cobalt complexes of lauroyl-glycine, lauroyl-glycylglycine and 1,12-dodecandioyl-diglycylglycine were synthesized. The FTIR spectroscopy confirmed the complex formation. The antimicrobial activity of synthesized nickel and cobalt complexes was investigated against several bacteria and fungi: Bacillus cereus, Pseudomonas aeruginosa, Candida albicans, and Aspergillus flavus. Generally, the nickel and cobalt complexes of the investigated surfactants showed no antimicrobial activity on Pseudomonas aeruginosa, a moderate one on Bacillus cereus and Aspergillus flavus. The most susceptible microorganism was Candida albicans, which is considered one of most common nosocomial infections. The results suggest the potential application of tested compounds as antimicrobial agents against targeted pathogens.

scholarly journals UJI AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL ORGANISME LAUT SPONS Ianthella basta TERHADAP BEBERAPA MIKROBA PATOGEN

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 100
Author(s):  
Syifa Sari Katili ◽  
Defny S Wewengkang ◽  
Henki Rotinsulu
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Marine Organism ◽  
Ethanol Extract ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Paper Disc

ABSTRACTSponges are multicellular metazoa animals belonging to the Porifera phylum, which has a different structure from other metazoans. The purpose of this study was to determine whether ethanol extracts from the marine organism sponge Ianthella basta have antimicrobial activity against several pathogenic microbes Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The extraction method used is maceration with 96% ethanol solvent. The method used is the Diffusion Method (Disc Diffusion Kirby and Bauer). The antimicrobial activity test uses a 6 mm paper disc with 50 µL absorption per disc. The results of crude ethanol extract of Ianthella basta sponge from all test microbes, namely Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, were seen to provide the greatest inhibitory activity against Staphylococcus aureus bacteria with an average of inhibitory zone of 7.00 mm categorize as intermediate The results obtained showed that the crude extract of the sponge Ianthella basta has antimicrobial activity because it can inhibit the growth of Staphylococcus aureus, Escherichia coli and Candida albicans microbes even though the inhibition zone is categorized as intermediate. Keywords: Ianthella basta, antimicrobial, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans. ABSTRAKSpons adalah hewan metazoa multiseluler tergolong ke dalam filum Porifera, yang memiliki perbedaan struktur dengan metazoan lainnya. Tujuan penelitian ini ialah untuk mengetahui apakah ekstrak etanol dari organisme laut spons Ianthella basta memiliki aktivitas antimikroba terhadap beberapa mikroba patogen Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa dan Candida albicans. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 96%. Metode yang digunakan yaitu Metode Difusi (Disc Diffusion Kirby and Bauer).  Pengujian aktivitas antimikroba ini menggunakan kertas cakram (paper disc) berukuran 6 mm dengan daya serap 50 µL tiap cakram. Hasil ekstrak kasar etanol Spons Ianthella basta dari semua mikroba uji yaitu Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa dan Candida albicans, terlihat yang memberikan daya hambat paling besar terdapat pada bakteri Staphylococcus aureus dengan jumlah rata – rata zona hambat yaitu 7,00 mm dengan kategori sedang. Hasil penelitian yang diperoleh menunjukkan bahwa ekstrak kasar dari Spons Ianthella basta memiliki aktivitas antimikroba karena mampu menghambat pertumbuhan mikroba uji Staphylococcus aureus, Escherichia coli dan Candida albicans walaupun dengan zona hambat yang  dikategorikan sedang. Kata Kunci : Ianthella basta, antimikroba, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Some Novel 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Derivatives

2015 ◽  
Vol 11 (6) ◽  
pp. 3635-3641
Author(s):  
Monther Mahdi
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Research Work ◽  
Aromatic Aldehydes ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Pyrazole Derivative ◽  
Keto Ester ◽  
Derivatives Of

The present research work deals with synthesize a series of various substituted benzothiazole containing 6-amino- 4-(substituted aryl)- tetrahydropyrano[2,3-c]pyrazole-5-carbonitrilic by reacting 2-mercaptobenzothiazole with hydrazine hydrate to synthesize hydrazine derivatives of benzothiazole (1), which then reacted with β- keto ester to develop pyrazole derivative (2), and then finally reacted with malononitrile and different aromatic aldehydes to obtain the final compounds (3a-3f). The structures of the intermediates and final compounds are assigned by using FTIR and 1H-NMR. The final compounds were screened for their antibacterial activity against four tested bacteria as G+ and G- using a well diffusion method. The results of antibacterial activity exhibited that the species Klebsiella pneumonia was the most effected types, while Pseudomonas aeruginosa was least the effected in general. 

scholarly journals Antimicrobial activity of different substituted meso-porphyrin derivatives

2020 ◽  
Vol 28 (2) ◽  
pp. 205-216 ◽  
Author(s):  
Luminița Sălăgeanu ◽  
Delia Muntean ◽  
Horhat Florin George ◽  
Anca Lascu ◽  
Diana Anghel ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Streptococcus Pyogenes ◽  
Antimicrobial Agents ◽  
Water Soluble ◽  
Diffusion Method ◽  
Dilution Method ◽  
Moderate Activity ◽  
Porphyrin Derivatives

AbstractThe increasing resistance against classical antibiotic treatment forces the researchers to develop novel non-toxic antimicrobial agents. The aim of this study was to determine the antimicrobial properties of seven different porphyrins having distinctive hydrophobicity/hydrophilicity: P1 meso-tetra(4-methoxy-phenyl)porphyrin, P2 Zn(II)-meso-5,10,15,20-tetrapyridylporphyrin, P3 meso-tetra(p-tolyl)porphyrin, P4 5,10,15,20-tetraphenylporphyrin; P5 (5,10,15,20-tetraphenylporphinato) dichlorophosphorus(V) chloride, P6 5,10,15,20-tetrakis-(N-methyl-4-pyridyl) porphyrin-Zn(II) tetrachloride, P7 Zn(II)-5,10,15,20-meso-tetrakis-(4-aminophenyl)porphyrin. The meso-porphyrin derivatives were screened for their antimicrobial activity against six reference strains: Streptococcus pyogenes ATCC 19615, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603, Pseudomonas aeruginosa ATCC27853 and Candida albicans ATCC 10231. The antimicrobial activity of these samples was evaluated by the agar disk diffusion method and dilution method, with the determination of the minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC) and the minimum fungicidal concentration (MFC). The most significant result is provided by the water-soluble P5 manifesting an obvious antimicrobial activity against Streptococcus pyogenes. On the other hand, P6 is a moderately active derivative against Streptococcus pyogenes and Escherichia coli and P7 presents moderate activity against Streptococcus pyogenes and Staphylococcus aureus. All the tested porphyrin bases, presenting hydrophobic character, have no antimicrobial activity under the investigated conditions. The common characteristics of the porphyrins that act as promising antimicrobial agents in the non-irradiated methods are: the cationic nature, the increased hydrophilicity and the presence of both amino functional groups grafted on the porphyrin ring and the coordination with Zn or phosphorus in the inner core.

scholarly journals Antibacterial and Antifungal Activity of the Triiodide [Na(12-Crown-4)2]I3 on the Pathogens Escherichia coli, Streptococcus pyogenes, Streptococcus faecalis, Bacillus subtilis, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae and Candida albicans

2017 ◽  
Author(s):  
Zehra Edis ◽  
Samir Haj Bloukh ◽  
Hamed Abu Sara
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Candida Albicans ◽  
Klebsiella Pneumoniae ◽  
Streptococcus Pyogenes ◽  
Proteus Mirabilis ◽  
Gram Negative Bacteria ◽  
Gram Negative

New antibacterial agents are needed to overcome the increasing number of infectious diseases caused by pathogenic microorganisms due to the emergence of multi-drug resistant strains.  In this context, halogens, especially Iodine is known since ages for its antimicrobial activity. Therefore, especially triiodides encapsulated in organometallic complexes can be helpful as new agents against microorganisms. The aims of this work was to study the biological activity of [Na(12-Crown-4)2]I3 against gram positive Streptococcus pyogenes, Streptococcus faecalis, the spore forming bacteria Bacillus subtilis and gram negative bacteria Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumoniae, as well as the yeast Candida albicans. The antimicrobial and antifungal activities of the triiodide were determined by zone of inhibition plate studies. [Na(12-Crown-4)2]I3 exhibited potent antimicrobial activity on gram positive Streptochocci and the yeast C. albicans. Furthermore, the gram negative bacteria P. aeruginosa and K. pneumoniae were less effectively inhibited, while E. coli and P. mirabilis proved to be even resistant.

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