scholarly journals A Review on Melocanna Baccifera

2021 ◽  
Vol 04 (03) ◽  
Author(s):  
Dr. Uma Namasudra ◽  
Keyword(s):  
Methanolic Extract ◽  
Hepatoprotective Activity ◽  
Antidiabetic Activity ◽  
Official Language ◽  
Bioactive Constituents ◽  
Food Ingredient ◽  
Sodium Potassium ◽  
The Third ◽  
Cns Depressant ◽  
Cns Depressant Activity

Young edible bamboo shoot (Muia in Kokborok-the third Official Language of Tripura, India) of Melocanna baccifera is widely used as a raw food ingredient of different dishes of Tribal of Tripura. Methanolic extract of Melocanna baccifera (MEMB) revealed the presence of different bioactive constituents like alkaloids, fixed oil, flavonoids, triterpinoids, glycosides carbohydrate, protein, and minerals like sodium, potassium, calcium, chloride, phosphate. Few pharmacological actions such as analgesic activity, antidiabetic activity and hepatoprotective activity along with antimicrobial activity also exhibited by methanolic extract of Melocanna baccifera. The extract also exhibited CNS depressant activity.

scholarly journals Pharmacological investigations of Litsea lancifolia (Roxb.) Hook. F.

2020 ◽  
Vol 49 (1) ◽  
pp. 179-183
Author(s):  
Israt Jahan Bulbul ◽  
Mohammad Rashedul Haque ◽  
Mohammad Abdur Rashid
Keyword(s):  
Ethyl Acetate ◽  
Methanolic Extract ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Bioactive Constituents ◽  
Cns Depressant ◽  
Acid Potential ◽  
Cns Depressant Activity ◽  
Soluble Fractions

The petroleum ether, chloroform and ethyl acetate soluble fractions of methanolic extract of Litsea lancifolia Roxb. leaves were subjected to different pharmacological screenings to explore its potential as anti-oxidant, antimicrobial, peripheral analgesic, hypoglycemic and CNS depressing agent. The ethyl acetate soluble fraction showed highest total phenolic content and free radical scavenging activity compared to the standard, acetyl salicylic acid. Potential antimicrobial activity was shown against P. aeruginosa (23.50 mm), E. coli (22.33 mm), B. cereus (18 mm) and S. paratyphi (18 mm). The crude extract demonstrated significant peripheral analgesic (p < 0.01) activity with 69.45 and 77.96% inhibition of acetic acid-induced writhing at 100 and 200 mg/kg b.w., respectively. The crude methanolic extract also showed significant hypoglycemic activity (p < 0.01) at a dose of 500 mg/kg/day on the 7th day of treatment. All the organic soluble fractions exhibited noteworthy (p < 0.001) CNS depressant activity. Taken together, the plant can be considered as a good material for further chemical investigation to isolate the bioactive constituents.

Ethnopharmacological investigation of the aerial part of Phragmites karka (Poaceae)

2017 ◽  
Vol 28 (3) ◽  
Author(s):  
Ramiz Ahmed Sultan ◽  
Mohammad Shah Hafez Kabir ◽  
Mir Muhammad Nasir Uddin ◽  
Mohi Uddin ◽  
Zobaer Al Mahmud ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Sleep Latency ◽  
Biological Activities ◽  
Glucose Load ◽  
Mice Model ◽  
Plant Parts ◽  
Cns Depressant ◽  
Phragmites Karka ◽  
Time Test ◽  
Cns Depressant Activity

AbstractBackground:In this ethnopharmacological study, methanolic extract of the aerial plant parts ofMethods:The cold methanolic extract of the aerial plant parts ofResults:In the mice model, the MEPK, PEFMEPK, and CTFMEPK fractions showed significant peripheral analgesic activity at a dose of 400 mg/kg body weight with percentage of inhibition of acetic acid-induced writhing 77.67 (p<0.001), 33.50 (p<0.001), and 40.29 (p<0.001), respectively, compared to the standard dichlofenac (60.68%, p<0.001) group. The hypoglycemic properties of MEPK, PEFMEPK, and CTFMEPK extracts were evaluated in normoglycemic mice where the reduction of blood glucose level after 30 min of glucose load were 69.85%, 78.91%, and 72.73%, respectively, and for standard glibenclamide, the reduction was 72.85%. All results were significant (p<0.05). In the case of the CNS depressant activity by phenobarbitone-induced sleeping time test, the crude ME significantly reduced sleep latency by 57.14% and increased the duration of sleep by 63.29% compared to the control, which were comparable to that of standard diazepam (65.71% and 77.62%, respectively). Among all the extract and fractions, methanolic extract showed the maximum antidiarrheal effect. The methanolic extract at 200 mg/kg dose induced a significant decrease in the total number of defecation in 4 h (69.05% of inhibition, p<0.001) and at 400 mg/kg dose showed 76.19% of inhibition (p<0.001).Conclusions:In light of the available literature, these findings represent the first experimental investigation of biological activities of

scholarly journals Anti-diarrhoeal and CNS Depressant Activity of Methanolic Extract of Saccharum spontaneum Linn.

1970 ◽  
Vol 1 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Md Mynol Islam Vhuiyan ◽  
Israt Jahan Biva ◽  
Moni Rani Saha ◽  
Muhammad Shahidul Islam
Keyword(s):  
Castor Oil ◽  
Methanolic Extract ◽  
Experimental Models ◽  
Saccharum Spontaneum ◽  
Cns Depressant ◽  
Whole Plant ◽  
The Central Nervous System ◽  
Dose Dependent Decrease ◽  
Cns Depressant Activity ◽  
Dose Dependent

Preliminary phytochemical screening of the methanolic extract of the whole plant of Saccharum spontaneum Linn. (Family- Gramineae) revealed the presence of alkaloids, flavonoids, reducing sugar, tannins and saponins. The antidiarrhoeal activity of the extract (200 and 400 mg/kg) was assessed on experimental animal and a dose dependent decrease in the total number of faecal dropping was obsereved in castor oil induced diarrhoea in mice. The plant extract was also assessed for effect on the central nervous system (CNS) using a number of neuropharmacological experimental models in mice. The extract produced a dosedependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field and hole cross tests. These results suggest that the extract possesses antidiarrhoeal and CNS depressant activity. Key Words: Saccharum spontaneum, Castor oil, Loperamide, Pentobarbitone.     doi:10.3329/sjps.v1i1.1810 S. J. Pharm. Sci. 1(1&2): 63-68

scholarly journals In vivo CNS Activity of Methanolic Extract of Ficus racemosa Fruits in Experimental Animals

2018 ◽  
Vol 21 (2) ◽  
pp. 139-144
Author(s):  
Mst Shirajum Munira ◽  
Md Shariful Islam ◽  
Md Baharuddin ◽  
Sabiha Ferdowsy Koly
Keyword(s):  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Tail Suspension ◽  
Experimental Animals ◽  
Cns Depressant ◽  
Cns Activity ◽  
Ficus Racemosa ◽  
Cns Depressant Activity ◽  
Dose Dependent

The purpose of the study was to evaluate the CNS activity of the methanolic extract of Ficus racemosa fruits. The powdered fruits of F. racemosa were extracted with methanol to investigate the effect on central nervous system in Swiss albino mice. The CNS depressant activity was evaluated by observing the reduction of locomotor activity by open field and hole cross tests. The anti-depressant activity was tested by forced swimming and tail suspension methods. For CNS activity, two test doses of the extracts such as 200 and 400 mg/kg body weight were used. However, the extracts showed significant dose dependent CNS depressant activity when compared to the control in animal models. From our research, it can be concluded that the methanolic extract of F. racemosa fruits possesses significant CNS depressant activity. So, further studies are recommended for the isolation of compounds responsible for this activity.Bangladesh Pharmaceutical Journal 21(2): 139-144, 2018

Antioxidant and hepatoprotective activity of Tragopogon porrifolius methanolic extract

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
M Mroueh ◽  
C Daher ◽  
M El Sibai ◽  
C Tenkerian
Keyword(s):  
Methanolic Extract ◽  
Hepatoprotective Activity

scholarly journals Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Praneetha Pallerla ◽  
Narsimha Reddy Yellu ◽  
Ravi Kumar Bobbala
Keyword(s):  
Methanolic Extract ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Liver Homogenate ◽  
Reducing Power ◽  
Hepatoprotective Activity ◽  
Total Phenolic ◽  
Effective Fraction

Abstract Background The objective of the study is to evaluate the hepatoprotective activity of methanolic extract fractions of Lindernia ciliata (LC) and development of qualitative analytical profile of the bioactive fraction using HPLC fingerprinting analysis. All the fractions of methanolic extract of Lindernia ciliata (LCME) are assessed for their total phenolic, flavonoid contents and in vitro antioxidant properties by using DPPH, superoxide, nitric oxide, hydroxyl radical scavenging activities and reducing power assay. Acute toxicity study was conducted for all the fractions and the two test doses 50 and 100 mg/kg were selected for the hepatoprotective study. Liver damage was induced in different groups of rats by administering 3 g/kg.b.w.p.o. paracetamol and the effect of fractions were tested for hepatoprotective potential by evaluating serum biochemical parameters and histology of liver of rats. The effective fraction was evaluated for its antihepatotoxic activity against D-Galactosamine (400 mg/kg b.w. i.p.) and in vivo antioxidant parameters viz., Glutathione (GSH), Melondialdehyde (MDA) and Catalase (CAT) levels are estimated using liver homogenate. Results Among all the fractions, butanone fraction of LCME, (BNF-LCME) has shown better hepatoprotective activity and hence it is selected to evaluate the antihepatotoxicity against D-GaIN. The activity of BNF-LCME is well supported in in vitro and in vivo antioxidant studies and may be attributed to flavonoidal, phenolic compounds present in the fraction. Hence, BNF-LCME was subjected to the development of qualitative analytical profile using HPLC finger printing analysis. Conclusions All the fractions of LCME exhibited significant hepatoprotective activity and BNF-LCME (50 mg/kg) was identified as the most effective fraction.

scholarly journals Antioxidant and antidiabetic properties of isolated fractions from methanolic extract derived from the whole plant of Cleome viscosa L.

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yarrappagaari Suresh ◽  
Gutha Rajasekar ◽  
Thopireddy Lavanya ◽  
Benne Lakshminarsimhulu ◽  
Kesireddy Sathyavelu Reddy ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Antidiabetic Activity ◽  
Total Phenolic ◽  
Whole Plant ◽  
Glucose Diffusion ◽  
Ft Ir ◽  
Study Support ◽  
Important Medicinal Plant ◽  
Cleome Viscosa

Abstract Background Cleome viscosa is considered as an important medicinal plant extensively used in India, China, Bangladesh, and a few countries in Africa. In the present study, in vitro anti-radical and antidiabetic potential of isolated fractions of methanolic extract of C. viscosa whole plant (MeCV) has been investigated. The identification of polyphenols and their related functional groups in the bioactive fraction was categorized by using HPLC and FT-IR. Results The total phenolic and flavonoid contents of F-D were higher than those of F-A, F-B, and F-C. The F-D exhibited superior antioxidant capacity when compared with the remaining three fractions. However, the F-D showed the highest glucose diffusion activity over the 30 min–27 h incubation period and also inhibited both α-glucosidase and α-amylase enzyme activity. HPLC analysis revealed the presence of the two known compounds (protocatechuic acid hexoside, rutin) and six unknown compounds in the F-D. FTIR spectrum confirmed the presence of phenol group. Conclusion The isolated F-D obtained from MeCV displayed superior antioxidant and antidiabetic activity which indicate the presence of polyphenols in the fraction. The data findings of the present study support the traditional uses of the whole plant of C. viscosa as a promising natural source of biological medicines for oxidative stress and diabetes.

scholarly journals Beyond symptom control: Research in psychosocial and existential issues in palliative care

2004 ◽  
Vol 2 (1) ◽  
pp. 1-2 ◽  
Author(s):  
WILLIAM BREITBART
Keyword(s):  
Palliative Care ◽  
European Association ◽  
Symptom Control ◽  
Official Language ◽  
Research Committee ◽  
Care Research ◽  
The Third ◽  
Control Research ◽  
Existential Issues ◽  
Important Milestone

Stresa, a small town on the shores of the Lago Maggiore, about one hour north of Milan, Italy, was the site of the Third Research Forum of the European Association for Palliative Care (EAPC). From June 3 through 6, 2004, researchers from all across Europe, as well as investigators from North America, Australia, Japan, and Israel, gathered to review the state of palliative care research and set an agenda for the future. The setting was bucolic and tranquil; the official language was English; the accents were diverse; the accommodations were grand; the ambiance was intimate and insouciant; the dinners were elegant; the dress was stylish; the organization was impeccable; and the scholarship was of the highest level. All this, perhaps, was to be expected of an EAPC event, hosted by an Executive Scientific Committee and Research Committee headed by Franco De Conno of the Instituto di Tumori of Milano, Italy, and his colleagues. What was unexpected, however, was the prominence of research on psychosocial, existential, and spiritual aspects of palliative care at this critically important, international, palliative care research forum. Clearly, 2004 marks an important milestone for the entry of research in psychosocial and existential issues into the mainstream of academic palliative care. Palliative and Supportive Care, having just successfully completed its inaugural year of publication in 2003, is now extraordinarily and uniquely well placed to be the preeminent international palliative care journal for research in the psychosocial, existential, and spiritual aspects of palliative care.

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