Hormonal and metabolic peculiarities of occupational lumbosacral radiculopathy

2019 ◽  
pp. 15-18
Author(s):  
I. V. Lapko ◽  
V. A. Kiryakov
Keyword(s):  
Bone Metabolism ◽  
Bone Tissue ◽  
Mineral Density ◽  
Lumbosacral Radiculopathy

The study presented describes formation of osteopenic syndrome in workers exposed to physical overexertion and general vibration that is associated with changes in bone metabolism and in mineral density of bone tissue. The data obtained prove bone metabolism to be influenced by pituitary and thyroid system hormones in patients with occupational lumbosacral radiculopathy.

scholarly journals Osteoporosis and antithrombotic therapy

2021 ◽  
Vol 26 (5) ◽  
pp. 4173
Author(s):  
N. V. Brailova ◽  
E. N. Dudinskaya ◽  
V. A. Kuznesova ◽  
O. N. Tkacheva
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Bone Mineral ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Antiplatelet Agents ◽  
Mineral Density ◽  
Negative Effect

Anticoagulant and antiplatelet agents are used to prevent stroke and thromboembolic events. There is insufficient data on the effect of these drugs on bone tissue. In addition, the available data are ambiguous, which increases suspicion when used in individuals at high risk of osteoporosis. The article provides data on the effect of anticoagulant and antiplatelet agents on bone metabolism, bone mineral density and the fracture risk. Literature data indicate a negative effect of heparin on bone tissue, which is increase the risk of fractures. Low molecular weight heparins has lower effect on bone tissue than heparin. It is known that vitamin K antagonists significantly affect bone metabolism and markers of bone formation, however, data on the effect on bone mineral density and the risk of fractures are contradictory. Direct oral anticoagulants are relatively safe in relation to bone tissue. Data on the effects of antiplatelet drugs on bone are ambiguous.

Features of the structural and functional state of bone tissue in patients with generalized periodontitis who live in different anthropogenically loaded areas

2020 ◽  
Vol 33 (2) ◽  
Author(s):  
Khrystyna Kovalyshyn ◽  
Mykola Rozhko
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Functional State ◽  
Mineral Density ◽  
Tissue Mineral Density ◽  
Degree Of Severity

Introduction. A research was conducted of the features of the structural and functional state of bone tissue in patients with generalized periodontitis with rheumatoid arthritis who live in different anthropogenically loaded areas. Aim. The aim of the research is to assess the bone tissue mineral density according to the indicators of densitometric researches and the level of a marker of bone metabolism in generalized periodontitis of I and II degree of severity. Material and methods. We examined 105 patients with GP of the I and II degree of severity, among whom were patients with rheumatoid arthritis who live in environmentally favorable and unfavorable areas. Peculiarities of the structural and functional state of bone tissue were assessed using an ultrasonic densitometer Sunlight Mini Omni TM and the level of a marker of bone tissue resorption of deoxypyridinoline in urine. Results. Patients with generalized periodontitis with rheumatoid arthritis who live in environmentally unfavorable areas, found the largest number of people with signs of osteopenia, osteoporosis and elevated levels of deoxypyridinoline. In particular, in generalized periodontitis of the II degree of severity with osteopenia – 14 people (48.27%), with osteoporosis – 9 people (31%), the level of deoxypyridinoline determined in women was 12.03 ± 0.16 n/mol, which in 2.2 times significantly higher than the group of healthy (p < 0.001). Conclusions. According to densitometric parameters and the level of deoxypyridinoline in the urine, the acceleration of bone tissue resorption in patients with generalized periodontitis of the II degree of severity with rheumatoid arthritis who live in environmentally unfavorable areas was established.

scholarly journals The impact of harmful occupational risk factors on the markers of bone metabolism in industrial workers

2021 ◽  
Vol 100 (9) ◽  
pp. 964-968
Author(s):  
Kristina V. Klimkina ◽  
Inna V. Lapko
Keyword(s):  
Bone Metabolism ◽  
Bone Tissue ◽  
Cathepsin K ◽  
Phosphorus Metabolism ◽  
Industrial Workers ◽  
Mineral Density ◽  
Occupational Risk Factors ◽  
Industrial Enterprises ◽  
Calcium Phosphorus ◽  
The Impact

Introduction. Unfavourable factors of the working environment affect bone tissue, increasing the risk of developing osteoporosis in workers of harmful industries, which is an urgent social and hygienic problem due to the high prevalence and severity of medical and social consequences. The aim of the study was to investigate the impact of industrial vibration and physical overload on the markers of bone metabolism in industrial workers. Materials and methods. One hundred fifty-two employees of mining and mechanical engineering enterprises in contact with industrial vibration and physical overload were examined. The assessment of bone tissue metabolism in the workers was carried out by the method of solid-phase enzyme immunoassay to determine biochemical markers of bone metabolism: bone alkaline phosphatase, osteocalcin, C-terminal serum telopeptide, cathepsin K, as well as indicators of calcium-phosphorus metabolism. X-ray densitometry was used to assess bone mineral density. Results. There was a significant decrease in the markers of osteogenesis: the concentration of CSF (14.26 ± 4.13 and 18.69±5.28, respectively, p< 0.05) and osteocalcin (12.23±4.15 and 17.84±5.17, respectively, p < 0.05) and an increase in the markers of bone resorption: the level of beta-CrossLaps (0.629±0.162 and 0.361±0.095, respectively, p = 0.002) and the level of cathepsin K (12.49±5.28 and 0.59±0.02, respectively, p < 0.001) in workers of industrial enterprises exposed to physical factors of production. The correlation between the markers of bone metabolism and the experience of exposure to adverse working conditions was established. Conclusion. Combined exposure to physical labour factors is a predictor of calcium-phosphorus metabolism and bone metabolism disorders, increasing the risk of metabolic osteopathy in industrial workers.

scholarly journals Diagnostic value of biochemical markers of bone metabolism in treatment of generalized periodontitis in patients with age-related osteoporosis

2018 ◽  
Vol 9 (3) ◽  
pp. 315-321 ◽  
Author(s):  
O. O. Fastovets ◽  
I. V. Masheiko ◽  
H. B. Peleshenko
Keyword(s):  
Bone Metabolism ◽  
Bone Tissue ◽  
Biochemical Markers ◽  
Alveolar Bone ◽  
Periodontal Diseases ◽  
Tartrate Resistant Acid Phosphatase ◽  
Type I ◽  
Mineral Density ◽  
Age Related ◽  
Normal Bone Mineral Density

The topicality of the problem of periodontal diseases is due to their significant prevalence. The purpose of this work is to study the dynamics of markers of bone metabolism in the process of treatment of generalized periodontitis of the II–III levels of severity in patients with age-related osteoporosis and without osteoporotic changes in the skeleton. The examination and treatment of 104 patients, aged 63–78, equal ratio of men and women, was conducted. Among the selected patients, 49 persons had normal bone mineral density, while the remaining 55 had osteoporotic changes in the bone tissue of involutory genesis. All subjects were assessed for the following indicators ; mineral density of jaw bone tissue (BMD) according to the results of the computer tomography, the concentration of C-Propeptide of Type I Procollagen (CICP) in blood plasma, the activity of tartrate-resistant acid phosphatase (TRAP), bone alkaline phosphatase (BAP), osteocalcin, parathyroid hormone in blood serum, concentration of β-CrossLaps in urine, total calcium and inorganic phosphorus content in blood with calculation of the Ca/P index. It was established that in patients with periodontitis of the II–III degree there was a decrease in the BMD of the alveolar bone in comparison with the control values (P ˂ 0.05), whereas the presence of systemic osteopenia worsened the indices (P ˂ 0.001). The least osteoregenerative activity, which was characterized by the decrease in BAP, TRAP and CICP levels, was registered in patients with generalized periodontitis of the III degree on the background of age-related osteoporosis (P ˂ 0.05). In the patients with generalized periodontitis of the III degree of severity, at the beginning of treatment, a weak negative correlation was found between BMD and TRAP activity (r = –0.292, P < 0.05) and mean strength correlation – with β-CrossLaps in urine (r = –0.348, P < 0.01). The concentration of CICP positively correlated with the mineral density of bone tissue from the third month after the start of treatment (r = 0.312, P < 0.05). As a conclusion, the mineral density of alveolar bone in the process of treatment varies unevenly depending on the severity of generalized periodontitis and the character of osteoporotic changes in the skeleton. The biochemical markers of bone metabolism allow the balance of processes of bone resorption and formation to be determined in order to correct treatment of generalized periodontitis.

scholarly journals DYNAMICS OF CHANGES IN THE SERUM MINERAL METABOLISM OF YOUNG PEOPLE WITH GENERALIZED PERIODONTITIS ON THE BACKGROUND OF PRIMARY HYPOTHYROIDISM

2021 ◽  
Vol 21 (1) ◽  
pp. 81-84
Author(s):  
O.M. Repetska ◽  
M.M. Rozhko ◽  
T.M. Dmytryshyn ◽  
A.B. Kostyshyn
Keyword(s):  
Young People ◽  
Thyroid Hormones ◽  
Bone Metabolism ◽  
Bone Tissue ◽  
Primary Hypothyroidism ◽  
The Body ◽  
Phosphorus Metabolism ◽  
Mineral Density ◽  
Periodontal Tissues ◽  
Calcium Phosphorus

At present, there is no definitive opinion on the effect of thyroid hormones on bone metabolism, as the dualism of their effects has been proven. Various studies show mixed data on metabolic changes in periodontal tissues on the background of thyroid dysfunction. Bone tissue plays a key role in the complex system of mechanisms of regulation of calcium and phosphorus homeostasis in the body. The processes of modeling and remodeling of bone and its mineralization are closely related to calcium metabolism. The biochemical manifestation of osteoporotic processes in the cell bone in generalized periodontitis is a violation of calcium-phosphorus homeostasis on the background of altered markers of bone metabolism. According to the literature, it is known that the main indicator of calcium-phosphorus metabolism is the content of calcium in the serum. However, for the metabolic characteristics of the inflammatory-dystrophic process in the cell bone, it is necessary to study the level of inorganic phosphorus and calculate the molar ratio of calcium / phosphorus. The calcium / phosphorus ratio in the blood is important for the study of calcium deposits in bone tissue. Maintenance of normal bone structure depends on the exchange of phosphates between blood and bone tissue. Magnesium along with calcium is needed to achieve optimal bone mineral density. Magnesium helps maintain normal levels of calcium in bone tissue, its constant renewal in bone, prevents calcium loss. With limited intake of magnesium, the formation of calcium phosphate is inhibited. In order to establish indicators that would reflect the peculiarities of metabolic disorders in the organic matrix of the cell process, which is the main component of the periodontium, we conducted biochemical studies, which included the study of calcium-phosphorus metabolism and serum magnesium in patients with primary hypothyroidism and persons without endocrine pathology. According to the results of studies, in young people with generalized periodontitis on the background of reduced thyroid function, there were violations of calcium-phosphorus metabolism in the serum, which consisted of hypocalcemia and decreased calcium-phosphorus ratio. This may indicate abnormalities in calcium intake and absorption in patients with hypothyroidism. We attribute this fact to the fact that for the normal absorption and metabolism of calcium, thyroid hormones are needed, the production of which is reduced in this endocrine pathology. Data on the negative changes of calcium-phosphorus homeostasis, and especially the violation of calcium absorption by patients with generalized periodontitis in young people with primary hypothyroidism, should be considered when developing schemes for the treatment and prevention of periodontal disease in this category of patients.

Results of study of biochemical markers of bone metabolism in men with coronary heart disease

2020 ◽  
pp. 39-43
Author(s):  
A. V. Voronkina ◽  
T. A. Raskina ◽  
M. V. Letaeva ◽  
Yu. V. Averkieva ◽  
O. S. Malyshenko ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Coronary Atherosclerosis ◽  
Cathepsin K ◽  
Arterial Calcification ◽  
Mineral Density ◽  
Bone Remodeling Markers

The development of atherosclerosis is closely related to the calcification of the vessel intima and fibrous plaques, being a complex and multifactorial process, in which the markers of bone formation and resorption play an important role. Objective. To study the biochemical markers of bone metabolism in men with stable coronary heart disease (CHD). Material and methods. The study included 102 men with verified CHD. Data were evaluated by densitometry, coronary angiography, multispiral computed tomography, color duplex scanning of brachiocephalic arteries, serum lipids (total cholesterol, triglycerides [TG], high-density [LHD] and low-density lipoprotein cholesterol), concentrationsin the blood of osteocalcin (OC), bone alkaline phosphatase (BAP), cathepsin K and C-telopeptides (CTx). Results. Concentrations of BAP, cathepsin K and CTx in patients with CHD were significantly higher than in men without CHD. The concentration of OC in men with normal bone mineral density was significantly lower than in patients with osteopenic syndrome. There was a direct correlation between OC and antiatherogenic HDL cholesterol and the inverse correlation between OC and TG, CTx and TG. There was no correlation between the level of bone remodeling markers and coronary artery (CA) lesion variant and the severity of coronary atherosclerosis on SYNTAX scale. The correlation analysis did not reveal the connection of biochemical markers of bone metabolism with the severity of coronary atherosclerosis and calcification and thickness of intima-media complex of carotid arteries. Absolute values of bone formation indices (BAP, OC) were significantly higher in patients with severe СA calcification than in patients without signs of calcification. Summary. Increased rates of osteogenesis and osteoresorption characterize the accelerated process of bone metabolism and indicate in favor of high rates of bone loss in men with CHD, which confirms the likelihood of common pathophysiological mechanisms of bone resorption and arterial calcification.

Body composition and adipokines influence upon bone mineral density and bone metabolism in renal transplant receivers

2020 ◽  
Author(s):  
Anca Matei ◽  
Stefana Bilha ◽  
Daniela Constantinescu ◽  
Petru Cianga ◽  
Adrian Covic ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Renal Transplant ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Density

Changes in bone metabolism associated with exposure to industrial vibration

2020 ◽  
pp. 766-766
Author(s):  
A. V. Sukhova ◽  
E. N. Kryuchkova
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Local Vibration ◽  
Markers Of Bone Formation

The influence of general and local vibration on bone remodeling processes is investigated. The interrelations between the long - term exposure of industrial vibration and indicators of bone mineral density (T-and Z-criteria), biochemical markers of bone formation (osteocalcin, alkaline phosphatase) and bone resorption (ionized calcium, calcium/creatinine) were established.

Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism

2019 ◽  
Vol 19 (3) ◽  
pp. 259-273 ◽  
Author(s):  
Neelam Kaushal ◽  
Divya Vohora ◽  
Rajinder K Jalali ◽  
Sujeet Jha
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Uric Acid ◽  
Bone Metabolism ◽  
Serum Uric Acid ◽  
Bone Mineral ◽  
Molecular Mechanisms ◽  
Association Studies ◽  
Mineral Density ◽  
Age Related

Background And Objective:Osteoporosis is a common bone disorder that increases susceptibility to fragility bone fractures. The clinical and public health repercussions of osteoporosis are huge due to the morbidity, mortality, and cost of medical care linked with fragility fractures. Clinical assessment of osteoporotic risk factors can help to identify candidates at an early stage that will benefit from medical intervention and potentially lowering the morbidity and mortality seen with fractures and complications. Given this, research is ongoing to evaluate the association of osteoporosis with some novel or less well-studied risk factors/bio-markers such as uric acid (UA).Discussion:Uric acid’s antioxidant activity has been proposed to be one of the factors responsible for increasing longevity and lowering rates of age-related cancers during primate evolution, the level of which increased markedly due to loss of uricase enzyme activity (mutational silencing). Accumulated evidence shows that oxidative stress is the fundamental mechanism of age-related bone loss and acts via enhancing osteoclastic activity and increasing bone resorption. Antioxidant substances such as ascorbic acid scavenge free radicals are positively related to bone health. Thus, it is hypothesized that uric acid holds bone-protective potential owing to its potent antioxidative property. Several correlation studies have been conducted globally to investigate the relationship between serum uric acid with bone mineral density and osteoporosis. Few pre-clinical studies have tried to investigate the interaction between uric acid and bone mineral density and reported important role played via Runt-related transcription factor 2 (RUNX2)/core-binding factor subunit alpha-1 (CBF-alpha-1), Wingless-related integration site (Wnt)-3a/β-catenin signaling pathway and 11β Hydroxysteroid Dehydrogenase type 1.Conclusion:In this review, the authors provided a comprehensive summary of the literature related to association studies reported in humans as well work done until date to understand the potential cellular and molecular mechanisms that interplay between uric acid and bone metabolism.

scholarly journals Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 341
Author(s):  
Małgorzata Kałużna ◽  
Krzysztof Pawlaczyk ◽  
Krzysztof Schwermer ◽  
Krzysztof Hoppe ◽  
Aisha Yusuf Ibrahim ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Glucose Tolerance ◽  
Bone Metabolism ◽  
Mineral Metabolism ◽  
Peptide Hormone ◽  
Normal Glucose Tolerance ◽  
Indirect Measurement ◽  
Chronic Hemodialysis ◽  
Mineral Density ◽  
Patients With Diabetes

Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropometric and biochemical parameters related to bone metabolism were studied in 73 patients on chronic hemodialysis (48 males, 25 females; mean age of 57 years; HD vintage of 69.7 months). Of these subjects, 36 patients had diabetes or impaired glucose tolerance (DM/IGT), and 37 patients had normal glucose tolerance (NGT). Dual-energy X-ray absorptiometry of the femoral neck and lumbar spine were also performed. Results: No differences were observed in preptin levels between DM/IGT and NGT HD patients. Preptin was positively correlated with HD vintage (r = 0.312, p = 0.007). Negative correlations between preptin and bone mineral density (BMD), T-score, and Z-score in the lumbar spine (L2-L4) were observed (r = −0.319, p = 0.009; r = −0.341, p = 0.005; r = −0.375, p = 0.002). Preptin was positively correlated with parathormone (PTH) levels (r = 0.379, p < 0.001) and osteocalcin levels (r = 0.262, p = 0.027). Conclusions: The results indicate that preptin may reflect on bone and mineral metabolism disturbances seen in HD patients. The significant correlation of preptin with PTH and osteocalcin suggests that preptin may be important in indirect measurement of bone turnover in HD patients.

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