Early clinical and laboratory diagnostics of allergodermatoses in electroplating shop workers

2021 ◽  
Vol 65 (4) ◽  
pp. 365-371
Author(s):  
Elena N. Kryuchkova ◽  
Irina V. Jatcyna ◽  
Larisa I. Antoshina
Keyword(s):  
Skin Diseases ◽  
Nickel Content ◽  
Allergic Diseases ◽  
Risk Groups ◽  
Machine Building ◽  
Control Group ◽  
Laboratory Diagnostics ◽  
Production Environment ◽  
Nickel Compounds ◽  
Allergic Skin

Introduction. At the present stage, the occupational pathology of the skin remains one of the significant medical and social problems. In this regard, special attention is paid to the early diagnosis of sensitization to industrial chemical allergens to target occupational allergic diseases. The aim of the study was to study the changes in clinical and laboratory parameters in the formation of allergic skin diseases in workers during nickel plating. Material and methods. Three hundred eighty-nine employees of the machine-building enterprise were examined. The leading group consisted of 214 people exposed to harmful chemical factors of production. Group of intact persons 175 people is represented by employees who do not come into contact with harmful factors of the production environment. The condition of the skin of workers was analyzed. Laboratory studies of oxidative metabolism and immune status were performed according to unified methods. The nickel content in the urine was determined by voltammetry. Results. At the studied enterprise, 38,3% of workers were diagnosed with occupational skin diseases (epidermosis, allergic dermatitis, eczema). In the formation of dermatological morbidity, an increase in the activity of alkaline (ALPn) and acid (ACPn) phosphatase of neutrophils by 1,7-2.2 times and inhibition of succinate dehydrogenase (SDH) and neutrophil myeloperoxidase (MPn) by 1.2-1.5 times relative to the control group was found. On the part of the immune system, there was an activation of the suppressor function of T-lymphocytes (CD8+); B-lymphocytes (CD20+), an increase in the content of immunoglobulins IgG, total IgE, circulating immune complexes by 1.5-2.0 times and a decrease in the levels of immunoglobulins IgA, IgM by 3.0-5.0 times compared to the control. The relationship between the nickel content in the urine of workers and changes in the indicators of ACPn (r = 0.76), MPn (r = -0.87), (CD4+) (r = -0.91), (CD8+) (r = 0,86), general IgE (r = 0.92), indicating the priority role of nickel compounds in the formation of allergodermatoses in workers. Conclusion. The proposed complex of biomarkers aims to detect early the initial forms of allergodermatosis and the formation of risk groups for the timely rehabilitation of electroplating workers.

scholarly journals Influence of factors of electroplating production on the immunoreactivity of the body of workers

2021 ◽  
Vol 100 (9) ◽  
pp. 959-963
Author(s):  
Elena N. Kryuchkova ◽  
Larisa I. Antoshina ◽  
Anna V. Sukhova ◽  
Elena A. Preobrazhenskaya
Keyword(s):  
Work Experience ◽  
Prolonged Exposure ◽  
Negative Impact ◽  
Nickel Content ◽  
Risk Groups ◽  
The Body ◽  
Control Group ◽  
Production Environment ◽  
Priority Effect ◽  
Proinflammatory Responses

Introduction. Modern electroplating production is the leader in air pollution of the working area with substances containing highly toxic compounds. Therefore, early detection of the negative impact of harmful factors on the body of workers is of paramount importance. The purpose of the study: to evaluate changes in individual parts of the immune system under prolonged exposure to chemical factors of the production environment. Materials and methods. 195 employees of electroplating production (the leading group) and 67 employees who are not in contact with harmful factors of the production environment (the control group) were examined. Cytochemical and immunological studies were performed according to standard and unified methods. The nickel content in the urine was determined by the voltammetric method. Results. With an increase in the work experience of workers, there is a decrease in the activity of myeloperoxidase of neutrophils MPn (r = -0.89) and an increase in the activity of acid phosphatase of neutrophils AcPN, alkaline phosphatase of neutrophils AlPN (r = 0,88-0,91). There was a destabilization of the cellular component of the immune response, characterized by a decrease in the immunoregulatory index by 2.0 times, and activation of the humoral component with an increase in the levels of IgM, IgE and circulating immune complexes by 1.4-1.8 times relative to the control. An imbalance of cytokine regulation was established, where proinflammatory responses with increased cytokine production by 1.5-3.5 times (IL-1β, TNF-α, IL-4) prevail. The relationship between the concentration of nickel in the urine and changes in the parameters of AcPN (r = 0.87), MPn (r = -0.84), IgA (r = -0.72); IL-1β, IL-4, IgE, (r = 0.62-0.71), confirming the priority effect of nickel compounds on the established changes. Conclusion. The identified violations of the immunoreactivity of the workers ‘ body can contribute to the development of immunodeficiency, allergic and autoimmune conditions that underlie occupational and industrial-related diseases. The proposed biomarkers are recommended to be used for early diagnosis of health disorders in workers of electroplating production, formation of “risk groups”, evaluation of the effectiveness of timely preventive and rehabilitation measures.

scholarly journals Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016–2018: a multicenter, retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuanyuan Qi ◽  
Peng Shi ◽  
Renjie Chen ◽  
Yufeng Zhou ◽  
Lijuan Liu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Emergency Departments ◽  
Outpatient Care ◽  
Skin Diseases ◽  
Allergic Diseases ◽  
Age Group ◽  
Allergic Skin

Abstract Background The prevalence of allergic diseases (ADs), such as asthma and allergic rhinitis (AR), is increasing worldwide in both adults and children. Although ADs are common and frequently coexist in outpatient care, city-level data regarding the characteristics of childhood AD remain limited in China. This study aimed to assess the profile and characteristics of ADs in the city of Shanghai. Methods A multicenter retrospective study was designed to collect routine administrative data from outpatient and emergency departments from 66 hospitals in Shanghai, China, from 2016 to 2018. Children with asthma, AR, allergic conjunctivitis (AC), and allergic skin diseases were investigated. Demographic characteristics, patients visit pattern, spectrum of diagnosis, and comorbidities were analyzed. Results A total of 2,376,150 outpatient and emergency visits for ADs were included in the period from 2016 to 2018. Allergic skin diseases accounted for 38.9%, followed by asthma (34.8%), AR (22.9%), and AC (3.3%), with a male predominance in all four diseases. Asthma and allergic skin diseases were most frequent in the 1 to < 4 years of age group, while AR and AC were more common in the 4 to < 7 years of age group. Asthma accounted for the greatest number of annual and emergency visits. The most frequent comorbidity of asthma was lower respiratory tract infection (LRTI) (49.3%), followed by AR (20.5%) and upper respiratory tract infection (14.1%). The most common comorbidities of AR were otitis media (23.4%), adenoid hypertrophy/obstructive sleep apnea (22.1%), followed by LRTI (12.1%), asthma (9.4%) and chronic pharyngitis (8.9%). Conclusions Asthma and allergic skin diseases were the most common ADs in outpatient and emergency departments in the study period. Respiratory tract infection was the most common comorbidity of asthma in children. More attention should be devoted to the treatment of comorbidities to improve childhood AD outcomes with a better understanding of the characteristics of ADs in outpatient care.

scholarly journals Peculiarities of the clinical course of allergic dermatoses in children (literature review)

2020 ◽  
pp. 58-63
Author(s):  
O.M. Mochulska ◽  
◽  
K.T. Hlushko ◽  
Keyword(s):  
Skin Diseases ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Stevens Johnson Syndrome ◽  
Clinical Criteria ◽  
Johnson Syndrome ◽  
Allergic Skin ◽  
Allergic Contact

The prevalence of allergic diseases is constantly growing around the world. According to WHO forecasts, most of the world's population will suffer from various allergies by 2050, at the same time any substance can be an allergen, and the XXI century will be the era of allergies. In the structure of allergic diseases in children the leading place is occupied by allergic skin lesions — allergic dermatoses, which are characterized by pronounced clinical polymorphism, acute or chronic stage with the development of concomitant pathological changes in many systems of the growing child's body. Allergic dermatoses are a large group of skin diseases, including: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, as well as less common dermatoses, in the pathogenesis of which are leading allergic reactions. Purpose — to describe clinical criteria for the differential diagnosis of allergodermatoses in children in order to increase its effectiveness. Conclusions. Allergodermatoses in children are characterized by polymorphism of clinical manifestations, which depends on the specific nosology. There is a tendency to increase the frequency of allergic skin diseases in children, especially severe forms with recurrent course, resistant to traditional pharmacotherapy. Comprehensive detailed study of clinical manifestations of allergic dermatoses in children will contribute to the development of differential diagnostic criteria for allergic dermatoses in children, to verify accurate diagnosis and to prescribe the pathogenesis-based treatment for various allergic skin diseases in time. No conflict of interest was declared by the authors. Key words: children, allergy, allergic dermatoses, clinical criteria.

scholarly journals The art of shampoos in canine and feline dermatology: Treatment and prevention strategies

2017 ◽  
Vol 56 (2) ◽  
pp. 162
Author(s):  
D. N. CARLOTTI ◽  
H. GATTO
Keyword(s):  
Skin Diseases ◽  
Topical Therapy ◽  
Allergic Diseases ◽  
Parasitic Diseases ◽  
Prevention Strategies ◽  
Bacterial Diseases ◽  
Current Technology ◽  
Treatment And Prevention ◽  
Allergic Skin ◽  
Microbiological Agents

This paper reviews the current technology pertaining to veterinary shampoos used for dogs and cats. The criteria used to evaluate their efficacy are presented. The indications for the use of shampoos in keratoseborrhoeic disorders, parasitic diseases, bacterial diseases, fungal diseases and allergic diseases are reviewed. In keratoseborrhoeic disorders both keratomodulating and antiseborrhoeic agents are used. Antiparasitic shampoos are not frequendy used in veterinary dermatology and their indications and limitations are discussed. Antibacterial, antifungal and antiseptic agents are included in shampoos designed to treat dermatoses resulting from microbiological agents. Their indications and efficacy are presented. Shampoos are used nowadays in conjunction with other forms of therapy to treat allergic skin diseases. The benefits of such adjunctive topical therapy are discussed. Lastly, the properties of moisturizers are presented and the value of their use in combination with therapeutic shampoos is emphasized.

scholarly journals CLINICAL AND DIAGNOSTIC VALUE OF DETERMINATION OF NEOPTERIN IN ATOPIC DERMATITIS IN CHILDREN

2018 ◽  
Vol 25 (3) ◽  
pp. 24-27
Author(s):  
M. M. BEN ◽  
E. YU. YANCHEVSKAYA ◽  
O. A. MESNYANKINA
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Clinical Manifestations ◽  
Diagnostic Value ◽  
Laboratory Method ◽  
Control Group ◽  
Allergic Skin ◽  
Monitoring And Forecasting

Aim. To improve the diagnosis of allergic skin diseases in childrenMaterials and methods. 135 children aged from 2 to 6 with atopic dermatitis were examined during exacerbation. They were on inpatient treatment in the skin and venereologic department of the Regional skin and venereologic dispensary and the Department of Allergology of the Regional children's clinical hospital. At the same time, 103 people (the main group) had uncomplicated course of the disease, 32 patients had complications of atopic dermatitis in the form of secondary infection. The control group consisted of 29 children aged 2 to 6. Neopterin in serum was determined by enzyme-linked immunosorbent analysis using test kits "Neopterin ELISA" (Germany). Statistical reliability of the obtained data was evaluated using The Student's test.Results. Atopic dermatitis in children, regardless of clinical manifestations, is accompanied by an increase in the content of neopterin in serum. The nature of the increase in the level of neopterin is determined by the duration of the disease, while its highest values are characteristic of the prolonged course of the process (over 4 years).Conclusion. The determination of neopterin in children with atopic dermatitis is a promising laboratory method for assessing the severity of dermatosis, monitoring and forecasting the further course of the process, as well as evaluating the effectiveness of therapeutic measures.

The structure of occupational skin diseases among workers of diverse industrial sectors of the Republic of Bashkortostan

2017 ◽  
pp. 30-32
Author(s):  
A.B. Bakirov ◽  
E.T. Valeyeva ◽  
A.U. Shagalina ◽  
A.A. Faskhutdinova ◽  
E.R. Abdrakhmanova ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Skin Diseases ◽  
Average Length ◽  
Allergic Diseases ◽  
Occupational Skin Diseases ◽  
Industrial Sectors ◽  
Republic Of Bashkortostan ◽  
Allergic Skin ◽  
Medium Level ◽  
The Republic

We have analysed the structure of occupational skin diseases diagnosed in workers of diverse industrial sectors of the Republic of Bashkortostan. It has been shown that allergic skin diseases rank first among occupational dermatoses which currently amount to 52 %. Average length of work employment in hazardous working conditions is 13,7 ± 12,2 years. Occupational allergic diseases are more common among medium-level healthcare workers. Occupational hyperkeratoses and skin cancer are mainly detected in continuous fiberglass workers.

scholarly journals Humoral Status in Children with Acute Allergic Skin Diseases in the Kyrgyz Republic

2020 ◽  
Vol 6 (1) ◽  
pp. 71-78
Author(s):  
B. Turdalieva ◽  
E. Kondratieva
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Hospital Admissions ◽  
Skin Diseases ◽  
Allergic Diseases ◽  
Kyrgyz Republic ◽  
Acute Urticaria ◽  
Allergic Skin ◽  
Severity Of The Disease ◽  
Immunological Protection

The article presents the results of a survey of children with acute allergic diseases with regard to hospital admissions, which made it possible to obtain information about the links of pathogenesis when the allergic process starts. Showing information for acute urticaria, angioedema, urticaria, combined with acute angioedema and toxic epidermal necrolysis. An association was established between the severity of the disease and significant changes in immunological protection.

The emotionally-valuable attitude to themselves in adolescents with chronic allergic diseases

2016 ◽  
Vol 7 (1) ◽  
pp. 167-172
Author(s):  
Ekaterina A Leushina
Keyword(s):  
Skin Diseases ◽  
Allergic Diseases ◽  
Chronically Ill ◽  
Psychological Research ◽  
Self Control ◽  
Control Group ◽  
Growing Up ◽  
Temporal Perspective ◽  
Advantages And Disadvantages ◽  
Sick People

In the following work are presented the results of experimental psychological research on suffering from chronic allergic respiratory and skin diseases adolescents’ emotionally-valuable attitude to themselves. As the results of study at 51 adolescents suffering from bronchial asthma concomitant with allergic rhinitis and atopic dermatitis have been found that chronically ill adolescents tend to identify themselves as sick people, both currently and in the suture, more than their conditionally healthy peers (p ≤ 0.05). However, both boys and girls suffering from the allergic diseases tend to expect to become less ill that now (p ≤ 0.01 for boys and p ≤ 0.05 for girls). After considering the features of their gender identity have been found suffering from allergic diseases adolescents do not expect an increase in their typically male features in the process of growing up, that is typical for their healthy peers (p ≤ 0.01). Moreover, the research has shown that boys with the chronic allergic disease do not expect a decrease of immature deeds in their behavior, which are typical for childhood, that occurs in the normal case of growth. Generally, both adolescents from the experimental and from control group tend to positively react to their personalities taking into account all the existing advantages and disadvantages, marking the lack of self-control in their behavior its dependence on external factors and also a low level of personal activity. After considering the temporal perspective of the personality has been shown that chronically ill and conditionally healthy adolescents see themselves more active, stronger and more respectable in the futures.

scholarly journals CONCENTRATIONS OF CYSTEINYL LEUKOTRIENES IN VARIOUS BIOLOGICAL FLUIDS OF CHILDREN WITH BRONCHIAL ASTHMA, ATOPIC DERMATITIS AND FOOD PROTEIN INDUCED ENTEROCOLITIS

2019 ◽  
Vol 4 ◽  
pp. 3-8
Author(s):  
Halyna Haiduchyk ◽  
Oleg Shadrin
Keyword(s):  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Skin Diseases ◽  
Rank Correlation ◽  
Control Group ◽  
Food Protein ◽  
Spearman Rank Correlation ◽  
Cysteinyl Leukotrienes ◽  
Spearman Rank ◽  
Allergic Skin

Clinical manifestation of food allergy is characterized by polymorphic cutaneous, respiratory and gastrointestinal syndromes. Leukotrienes occupy a key place in the pathogenesis of a wide range of inflammatory diseases, including bronchial asthma, allergic rhinitis, atopic dermatitis, hives, allergic conjunctivitis, atherosclerotic cardio-vascular lesions system, inflammatory bowel disease, multiple sclerosis, cancer, etc. Better understanding of general pathophysiological mechanisms of allergic realization put the focus on the studying of cysteinyl leukotrienes biological effects in infants with atopic dermatitis and food-protein induced enterocolitis important. Aim. To optimize the diagnosis of allergic lesions of the gastrointestinal tract in children. Methods. The study was conducted in the allergy center and children clinic of the «Institute Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of NAMS of Ukraine». Children were included from September 2017 to June 2018. We examined 60 patients aged from 3 months to 3 years old, including 22 patients with atopic dermatitis, 18 children with food-protein induced enterocolitis, 8 patients with bronchial asthma in the stage of aggravation and 12 practically healthy children (control group). Medical examination have been perfomed, general IG E and specific serum IG E were defined by ImmunoCAP (Phadia, 100), as well as concentrations of cysteinyl leukotrienes (LTB4, LTC4, LTE4) in biological liquids (serum, saliva, urine) using immunoenzyme method using the production sets of the "Enzolifescience" (USA) company on the analyzer-photometer Multiskan Plus "Labsystems". The results of the received data were processed statistically. The probability of differences was estimated with Student’s t-test and Tau Kendall rank correlation test. The difference was considered significant at p <0.05. Results. A significant increase in the concentrations of cysteinyl leukotrienes (C4, D4, E4) in the blood, urine and saliva was found in infants with allergic skin diseases, gastro-intestinal and respiratory tract surveyed during manifestation the disease compared with the control group. Comparison of concentrations of leukotrienes in urine and saliva of children with atopic dermatitis (AD), food-protein induced enterocolitis (FPIE) and asthma did not find credible. However, in the serum of patients with asthma, the concentration of cysteinyl leukotrienes was significantly higher (703.9±68.7) pg / ml than in children with enterocolitis induced by dietary proteins (509.3±57.4) pg / ml and significantly did not differ from patients with atopic dermatitis (695.2±46.3) pg / ml. According to the results of Kendall Tau correlation test, no significant Spearman rank correlation was found between the cysteinyl leukotrienes concentration in blood and urine – r=0.14 (p>0.05), blood and saliva r=0.07 (p>0.05), urine and saliva r=–0.52 (p>0.05). Conclusions. Increase in cysteinyl leukotrienes concentrations in serum, urine and saliva of children of early age with allergic skin diseases, respiratory and gastrointestinal tract was found. The absence of significant Spearman rank correlation between concentrations of leukotrienes in blood and urine, blood and saliva, saliva and urine shows that it is possible to select any biological fluid, saliva or urine, as a non-invasive way to determine the leukotriene concentrations for monitoring activity of allergic inflammation.

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