Interferon gamma gene polymorphism as a marker of some allergic diseases (allergic skin diseases and allergic conjunctivitis) in a sample of Egyptian population

Introduction. At the present stage, the occupational pathology of the skin remains one of the significant medical and social problems. In this regard, special attention is paid to the early diagnosis of sensitization to industrial chemical allergens to target occupational allergic diseases. The aim of the study was to study the changes in clinical and laboratory parameters in the formation of allergic skin diseases in workers during nickel plating. Material and methods. Three hundred eighty-nine employees of the machine-building enterprise were examined. The leading group consisted of 214 people exposed to harmful chemical factors of production. Group of intact persons 175 people is represented by employees who do not come into contact with harmful factors of the production environment. The condition of the skin of workers was analyzed. Laboratory studies of oxidative metabolism and immune status were performed according to unified methods. The nickel content in the urine was determined by voltammetry. Results. At the studied enterprise, 38,3% of workers were diagnosed with occupational skin diseases (epidermosis, allergic dermatitis, eczema). In the formation of dermatological morbidity, an increase in the activity of alkaline (ALPn) and acid (ACPn) phosphatase of neutrophils by 1,7-2.2 times and inhibition of succinate dehydrogenase (SDH) and neutrophil myeloperoxidase (MPn) by 1.2-1.5 times relative to the control group was found. On the part of the immune system, there was an activation of the suppressor function of T-lymphocytes (CD8+); B-lymphocytes (CD20+), an increase in the content of immunoglobulins IgG, total IgE, circulating immune complexes by 1.5-2.0 times and a decrease in the levels of immunoglobulins IgA, IgM by 3.0-5.0 times compared to the control. The relationship between the nickel content in the urine of workers and changes in the indicators of ACPn (r = 0.76), MPn (r = -0.87), (CD4+) (r = -0.91), (CD8+) (r = 0,86), general IgE (r = 0.92), indicating the priority role of nickel compounds in the formation of allergodermatoses in workers. Conclusion. The proposed complex of biomarkers aims to detect early the initial forms of allergodermatosis and the formation of risk groups for the timely rehabilitation of electroplating workers.

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Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016–2018: a multicenter, retrospective study

BMC Pediatrics ◽

10.1186/s12887-021-02880-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yuanyuan Qi ◽

Peng Shi ◽

Renjie Chen ◽

Yufeng Zhou ◽

Lijuan Liu ◽

...

Keyword(s):

Retrospective Study ◽

Tract Infection ◽

Respiratory Tract ◽

Respiratory Tract Infection ◽

Emergency Departments ◽

Outpatient Care ◽

Skin Diseases ◽

Allergic Diseases ◽

Age Group ◽

Allergic Skin

Abstract Background The prevalence of allergic diseases (ADs), such as asthma and allergic rhinitis (AR), is increasing worldwide in both adults and children. Although ADs are common and frequently coexist in outpatient care, city-level data regarding the characteristics of childhood AD remain limited in China. This study aimed to assess the profile and characteristics of ADs in the city of Shanghai. Methods A multicenter retrospective study was designed to collect routine administrative data from outpatient and emergency departments from 66 hospitals in Shanghai, China, from 2016 to 2018. Children with asthma, AR, allergic conjunctivitis (AC), and allergic skin diseases were investigated. Demographic characteristics, patients visit pattern, spectrum of diagnosis, and comorbidities were analyzed. Results A total of 2,376,150 outpatient and emergency visits for ADs were included in the period from 2016 to 2018. Allergic skin diseases accounted for 38.9%, followed by asthma (34.8%), AR (22.9%), and AC (3.3%), with a male predominance in all four diseases. Asthma and allergic skin diseases were most frequent in the 1 to < 4 years of age group, while AR and AC were more common in the 4 to < 7 years of age group. Asthma accounted for the greatest number of annual and emergency visits. The most frequent comorbidity of asthma was lower respiratory tract infection (LRTI) (49.3%), followed by AR (20.5%) and upper respiratory tract infection (14.1%). The most common comorbidities of AR were otitis media (23.4%), adenoid hypertrophy/obstructive sleep apnea (22.1%), followed by LRTI (12.1%), asthma (9.4%) and chronic pharyngitis (8.9%). Conclusions Asthma and allergic skin diseases were the most common ADs in outpatient and emergency departments in the study period. Respiratory tract infection was the most common comorbidity of asthma in children. More attention should be devoted to the treatment of comorbidities to improve childhood AD outcomes with a better understanding of the characteristics of ADs in outpatient care.

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Peculiarities of the clinical course of allergic dermatoses in children (literature review)

Modern pediatrics. Ukraine ◽

10.15574/sp.2020.111.58 ◽

2020 ◽

pp. 58-63

Author(s):

O.M. Mochulska ◽

◽

K.T. Hlushko ◽

Keyword(s):

Skin Diseases ◽

Clinical Course ◽

Clinical Manifestations ◽

Allergic Diseases ◽

Skin Lesions ◽

Stevens Johnson Syndrome ◽

Clinical Criteria ◽

Johnson Syndrome ◽

Allergic Skin ◽

Allergic Contact

The prevalence of allergic diseases is constantly growing around the world. According to WHO forecasts, most of the world's population will suffer from various allergies by 2050, at the same time any substance can be an allergen, and the XXI century will be the era of allergies. In the structure of allergic diseases in children the leading place is occupied by allergic skin lesions — allergic dermatoses, which are characterized by pronounced clinical polymorphism, acute or chronic stage with the development of concomitant pathological changes in many systems of the growing child's body. Allergic dermatoses are a large group of skin diseases, including: simple and allergic contact dermatitis, atopic dermatitis, various forms of eczema, acute and chronic allergic urticaria, Quincke's edema, multiforme exudative erythema (Stevens-Johnson syndrome), acute epidermal necrolysis (Lyell's syndrome), toxicodermias, as well as less common dermatoses, in the pathogenesis of which are leading allergic reactions. Purpose — to describe clinical criteria for the differential diagnosis of allergodermatoses in children in order to increase its effectiveness. Conclusions. Allergodermatoses in children are characterized by polymorphism of clinical manifestations, which depends on the specific nosology. There is a tendency to increase the frequency of allergic skin diseases in children, especially severe forms with recurrent course, resistant to traditional pharmacotherapy. Comprehensive detailed study of clinical manifestations of allergic dermatoses in children will contribute to the development of differential diagnostic criteria for allergic dermatoses in children, to verify accurate diagnosis and to prescribe the pathogenesis-based treatment for various allergic skin diseases in time. No conflict of interest was declared by the authors. Key words: children, allergy, allergic dermatoses, clinical criteria.

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The art of shampoos in canine and feline dermatology: Treatment and prevention strategies

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.15080 ◽

2017 ◽

Vol 56 (2) ◽

pp. 162

Author(s):

D. N. CARLOTTI ◽

H. GATTO

Keyword(s):

Skin Diseases ◽

Topical Therapy ◽

Allergic Diseases ◽

Parasitic Diseases ◽

Prevention Strategies ◽

Bacterial Diseases ◽

Current Technology ◽

Treatment And Prevention ◽

Allergic Skin ◽

Microbiological Agents

This paper reviews the current technology pertaining to veterinary shampoos used for dogs and cats. The criteria used to evaluate their efficacy are presented. The indications for the use of shampoos in keratoseborrhoeic disorders, parasitic diseases, bacterial diseases, fungal diseases and allergic diseases are reviewed. In keratoseborrhoeic disorders both keratomodulating and antiseborrhoeic agents are used. Antiparasitic shampoos are not frequendy used in veterinary dermatology and their indications and limitations are discussed. Antibacterial, antifungal and antiseptic agents are included in shampoos designed to treat dermatoses resulting from microbiological agents. Their indications and efficacy are presented. Shampoos are used nowadays in conjunction with other forms of therapy to treat allergic skin diseases. The benefits of such adjunctive topical therapy are discussed. Lastly, the properties of moisturizers are presented and the value of their use in combination with therapeutic shampoos is emphasized.

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The structure of occupational skin diseases among workers of diverse industrial sectors of the Republic of Bashkortostan

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT ◽

10.35627/2219-5238/2017-292-7-30-32 ◽

2017 ◽

pp. 30-32

Author(s):

A.B. Bakirov ◽

E.T. Valeyeva ◽

A.U. Shagalina ◽

A.A. Faskhutdinova ◽

E.R. Abdrakhmanova ◽

...

Keyword(s):

Healthcare Workers ◽

Skin Diseases ◽

Average Length ◽

Allergic Diseases ◽

Occupational Skin Diseases ◽

Industrial Sectors ◽

Republic Of Bashkortostan ◽

Allergic Skin ◽

Medium Level ◽

The Republic

We have analysed the structure of occupational skin diseases diagnosed in workers of diverse industrial sectors of the Republic of Bashkortostan. It has been shown that allergic skin diseases rank first among occupational dermatoses which currently amount to 52 %. Average length of work employment in hazardous working conditions is 13,7 ± 12,2 years. Occupational allergic diseases are more common among medium-level healthcare workers. Occupational hyperkeratoses and skin cancer are mainly detected in continuous fiberglass workers.

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Humoral Status in Children with Acute Allergic Skin Diseases in the Kyrgyz Republic

Bulletin of Science and Practice ◽

10.33619/2414-2948/50/07 ◽

2020 ◽

Vol 6 (1) ◽

pp. 71-78

Author(s):

B. Turdalieva ◽

E. Kondratieva

Keyword(s):

Toxic Epidermal Necrolysis ◽

Hospital Admissions ◽

Skin Diseases ◽

Allergic Diseases ◽

Kyrgyz Republic ◽

Acute Urticaria ◽

Allergic Skin ◽

Severity Of The Disease ◽

Immunological Protection

The article presents the results of a survey of children with acute allergic diseases with regard to hospital admissions, which made it possible to obtain information about the links of pathogenesis when the allergic process starts. Showing information for acute urticaria, angioedema, urticaria, combined with acute angioedema and toxic epidermal necrolysis. An association was established between the severity of the disease and significant changes in immunological protection.

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