scholarly journals Ayurvedic management of Koshtashrita Kamala (Hepatocellular Jaundice) - A Case report

2021 ◽  
Vol 12 (2) ◽  
pp. 405-408
Author(s):  
Ashwini C Amargol ◽  
Ashvini Kumar M
Keyword(s):  
Clinical Signs ◽  
Signs And Symptoms ◽  
Liver Disorder ◽  
The Body ◽  
Function Test ◽  
Effect Of Treatment ◽  
Hepatocellular Jaundice ◽  
Clinical Signs And Symptoms ◽  
High Level ◽  
Specific Diet

Kamala is a type of Liver disorder mentioned in our classics. It is caused by vitiation of pitta with the signs and symptoms like Haridra netra (yellow eyes),  twak nakha (yellowish skin and nails) and Dourbalya (weakness), based on these clinical features, it can be well understood under the purview of Jaundice. The condition where yellowish discoloration of skin and sclera of the eyes due to high level of serum bilirubin is known as Jaundice.  The pitta present in the body aggravates due to specific diet and life style, attains sthana samshraya in koshta due to kha vaigunya, further causes dagdhatwa of Rakta and Mamsa this condition is known as Koshtashirita Kamala. A case presented with  Peeta Netrata, Peeta Varnyata Mutra, Aruchi, Agnimandhya etc was diagnosed as Koshtashrita Kamala it was intervened successfully with  Shodhana and Shamana oushadi with proper pathya  for a period of 11 days. The effect of treatment was assessed based on improvement in clinical signs and symptoms along with Liver Function Test. There was significant improvement in the condition by 60% thus Kamala can be well managed by Ayurvedic intervention. 

scholarly journals Cerebellar Infarction — Review of Recent Experiences

1980 ◽  
Vol 7 (2) ◽  
pp. 97-99 ◽  
Author(s):  
W.B. Woodhurst
Keyword(s):  
Clinical Presentation ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Clinical Syndrome ◽  
Clinical Suspicion ◽  
Cerebellar Infarction ◽  
Tissue Mass ◽  
Clinical Signs And Symptoms ◽  
High Level ◽  
Infarcted Tissue

SUMMARY:Six cases of acute cerebellar infarction seen on a neurosurgery service in a general hospital during a twenty-six month period are reviewed. The clinical presentation, course, and treatment are presented and discussed. This is an important clinical syndrome which requires a high level of clinical suspicion for detection. The diagnosis rests primarily upon the clinical signs and symptoms. The C.T. Scan may provide useful confirmatory evidence and clarifies the differential diagnosis. Surgial treatment by resection of the infarcted tissue — mass lesion is urgently required for those patients who deteriorate progressively.

scholarly journals Successful treatment of herpes simplex-associated erythema multiforme with a combination of acyclovir and prednisone

2017 ◽  
Vol 2 (3) ◽  
pp. 191
Author(s):  
Arny E. Muryah ◽  
Irna Sufiawati
Keyword(s):  
Erythema Multiforme ◽  
Complete Blood Count ◽  
Leukocyte Adhesion ◽  
Clinical Success ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
The Body ◽  
Vascular Integrity ◽  
Patient Reported ◽  
Clinical Signs And Symptoms

Objective: Erythema Multiforme (EM) is an acute mucocutaneous hypersensitivity reaction triggered by certain infections and medications. EM induced by virus infection termed as Herpes- associated Erythema Multiforme (HAEM). The use of corticosteroids for treating HAEM has been a long debate issue. The aim of this case report is to present a patient with HAEM who was successfully treated with acyclovir combined with prednisone.Methods:A 31-years-old female, presented with a complaint of pain and diffuse ulcers in mouth. The patient reported recurrent episode of the ulcers of the mouth during the last two years. On extra oral examination, lips were crusted and bleeding. Intraoral examination revealed multiple diffuse ulcerations on mucosa. Nolesions were seen in other part of the body. Laboratory investigation revealed normal complete blood count and positive HSV-1 serology. The patient was diagnosed as HAEM.The patient was treated with acyclovir (1000 mg/day) and prednisone (10mg/day), topical mixture corticosteroid, chlorhexidine gluconate 0.2% and multivitaminduring seven days.Results:All lesions healed without any further clinical sequelae within 7 days.The clinical success of corticosteroids as effective anti-inflammatory agents is largely attributed to their ability to reduce the expression of pro-inflammatory genes, help to maintain vascular integrity and decrease the expression of leukocyte adhesion molecules.Conclusions:The addition of prednisone to acyclovir for HAEM resulted in a significant reduction of clinical signs and symptoms during the first week. The combination of acyclovir and corticosteroids may play an important role in the standard care for HAEM.

scholarly journals An effect of Ayurvedic formulations orally and Karanj Tailam topically in the management of Vicharchika WSR to Eczema- A case study.

2020 ◽  
Vol 4 (06) ◽  
Author(s):  
KALYANI PURUSHOTTAMRAO NALKANDE
Keyword(s):  
Skin Diseases ◽  
Clinical Signs ◽  
Chronic Phase ◽  
Signs And Symptoms ◽  
The Body ◽  
Two Phase ◽  
Affected Area ◽  
Inflammatory Conditions ◽  
Clinical Signs And Symptoms

Abstract:-                         Skin diseases commonly known as Dermatitis, are occurs all over the world at significant levels. The skin is most important part of the body which protects the body from various external factors.                                     In the ayurvedic literature all skin diseases were included under the “Kushtharog” which is classified in two divisions i.e. Mahakushtha and kshudrakushtha. In ayurveda vicharchika is described under kshudrakushtha. All the clinical features of vicharchika are similar to eczema in modern dermatology.                                        Eczema which is also known as Atopic dermatitis , is refers to a group of inflammatory conditions, it affects the outer layer of the skin the epidermis.characterized by dry  itchy skin, which is classified in two phase i.e. acute phase and chronic phase. Dermatitis results from a variety of different causes and has various patterns.                        In ayurveda there are many formulations for internal and topical application mentioned by the different Acharays in samhitas, which can shows significant effect on vicharchika. Methodology:-  In this case Arogyavardhini vati and Gandhak rasayan administer orally and Karanj tailam topically   given to the patient. Result:- There is significant effect on clinical signs and symptoms of patient and size of affected area. Conclusion:- In this case study combine use of  Arogyavardhini vati and gandhak rasayan orally and Karanj tailam topically was very effective in reducing signs, symptoms, and size of affected area of vicharchika. .  

scholarly journals A scoping review protocol to identify clinical signs, symptoms and biomarkers indicative of biofilm presence in chronic wounds

2021 ◽  
Vol 4 ◽  
pp. 71
Author(s):  
John D. Ivory ◽  
Akke Vellinga ◽  
James O'Gara ◽  
Georgina Gethin
Keyword(s):  
Chronic Wounds ◽  
Evidence Synthesis ◽  
Demographic Data ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Third Party ◽  
Scoping Reviews ◽  
Clinical Signs And Symptoms ◽  
High Level

Introduction: Wound healing is characterised by haemostatic, inflammatory, proliferative and remodelling phases. In the presence of comorbidities such as diabetes, healing can stall and chronic wounds may result. Infection is detrimental to these wounds and associated with poor outcomes. Wounds are contaminated with microbes and debris, and factors such as host resistance, bacterial virulence, species synergy and bioburden determine whether a wound will deteriorate to critically colonised/infected states. Biofilms are sessile microbial communities, exhibiting high-level antibiotic tolerance and resistance to host defences. Biofilm in critically colonised wounds can contribute to delayed healing. Little is known about clinical presentation and diagnosis of wound biofilms. Objective: To identify from the literature clinical signs, symptoms and biomarkers that may indicate biofilm in chronic wounds. Methods: This review will be guided by the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews (PRISMA-ScR), and the Joanna Briggs Institute Manual for Evidence Synthesis. Studies of any design in any language recruiting adult patients with  venous, diabetic, pressure or mixed arterial-venous ulcers and reporting data on clinical signs/symptoms of biofilm are eligible. Searches of Medline, Embase, CINAHL, Cochrane Central, Scopus, Web of Science, Google scholar and BASE will be conducted from inception to present. Reference scanning and contact with content experts will be employed. Title/abstract screening and full text selection will be executed by two reviewers independently. Discrepancies will be resolved by discussion between reviewers or through third party intervention. Data will be extracted by a single reviewer and verified by a second. Clinical signs and symptoms data will be presented in terms of study design, setting and participant demographic data. Discussion: Understanding biofilm impact on chronic wounds is inconsistent and based largely on in vitro research. This work will consolidate clinical signs, symptoms and biomarkers of biofilm in chronic wounds reported in the literature.

scholarly journals A scoping review protocol to identify clinical signs, symptoms and biomarkers indicative of biofilm presence in chronic wounds

2021 ◽  
Vol 4 ◽  
pp. 71
Author(s):  
John D. Ivory ◽  
Akke Vellinga ◽  
James O'Gara ◽  
Georgina Gethin
Keyword(s):  
Chronic Wounds ◽  
Evidence Synthesis ◽  
Demographic Data ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Third Party ◽  
Scoping Reviews ◽  
Clinical Signs And Symptoms ◽  
High Level

Introduction: Wound healing is characterised by haemostatic, inflammatory, proliferative and remodelling phases. In the presence of comorbidities such as diabetes, healing can stall and chronic wounds may result. Infection is detrimental to these wounds and associated with poor outcomes. Wounds are contaminated with microbes and debris, and factors such as host resistance, bacterial virulence, species synergy and bioburden determine whether a wound will deteriorate to critically colonised/infected states. Biofilms are sessile microbial communities, exhibiting high-level antibiotic tolerance and resistance to host defences. Biofilm in critically colonised wounds can contribute to delayed healing. Little is known about clinical presentation and diagnosis of wound biofilms. Objective: To identify from the literature clinical signs, symptoms and biomarkers that may indicate biofilm presence in chronic wounds. Methods: This review will be guided by the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews (PRISMA-ScR), and the Joanna Briggs Institute Manual for Evidence Synthesis. Studies of any design in any language recruiting adult patients with  venous, diabetic, pressure or mixed arterial-venous ulcers and reporting data on clinical signs/symptoms of biofilm are eligible. Searches of Medline, Embase, CINAHL, Cochrane Central and BASE will be conducted from inception to present. Reference scanning and contact with content experts will be employed. Title/abstract screening and full text selection will be executed by two reviewers independently. Discrepancies will be resolved by discussion between reviewers or through third party intervention. Data will be extracted by a single reviewer and verified by a second. Clinical signs and symptoms data will be presented in terms of study design, setting and participant demographic data. Discussion: Understanding biofilm impact on chronic wounds is inconsistent and based largely on in vitro research. This work will consolidate clinical signs, symptoms and biomarkers of biofilm in chronic wounds reported in the literature.

High level of oxysterols in neonatal cholestasis: a pitfall in analysis of biochemical markers for Niemann-Pick type C disease

2016 ◽  
Vol 54 (7) ◽  
Author(s):  
Giulia Polo ◽  
Alessandro Burlina ◽  
Francesca Furlan ◽  
Thilini Kolamunnage ◽  
Mara Cananzi ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Gene Mutations ◽  
Signs And Symptoms ◽  
Niemann Pick Disease ◽  
Liquid Chromatography Tandem Mass ◽  
Type C ◽  
Clinical Signs And Symptoms ◽  
Niemann Pick ◽  
High Level ◽  
Negative Controls

AbstractNiemann-Pick disease type C (NPC) is a rare lipid storage disorder characterized by progressive neurological deterioration. Diagnosing NPC is challenging as clinical signs and symptoms are variable and non-specific. Two oxysterols, cholestane-3β,5α,6β-triol (triol) and 7-ketocholesterol (7KC), have been proposed as biomarkers for aiding diagnosis of NPC. This study evaluated the use of triol and 7KC as biomarkers in cholestatic neonates with suspected NPC.Plasma triol and 7KC were analysed as dimethylglycine esters using an liquid chromatography – tandem mass spectrometry (LC-MS/MS) assay in selected neonates with severe cholestasis and suspected NPC (n=7), adults with cholestasis (n=15), patients with confirmed NPC (positive controls; n=11 [one child and 10 adults]), healthy subjects (negative controls; n=40 [20 children and 20 adults]), and cholestatic adults (comparative reference; n=15). The LC-MS/MS method was subjected to a number of tests for accuracy and consistency.Triol and 7KC levels were substantially and significantly increased in NPC positive patients compared with healthy controls (p<0.001). However, positive results (markedly increased levels of both oxysterols) were identified in 6/7 (86%) neonates with cholestasis. Genetic testing confirmed NPC only in one neonate who had increased triol and 7KC, and increased oxysterol levels among neonates with no identified NPC gene mutations were considered likely due to biliary atresia (BA).While the potential of oxysterols as NPC biomarkers has been well evaluated in older patient populations (without cholestasis), our data suggest that cholestasis might represent a pitfall in oxysterol measurements intended to aid diagnosis of NPC in affected patients.

scholarly journals Giant posterior gastric perforation in a 40 years old male: a case report

2021 ◽  
Vol 8 (6) ◽  
pp. 1907
Author(s):  
Raheel Hussan Naqvi ◽  
Khushwant Singh ◽  
Rahul Singh
Keyword(s):  
Gastric Perforation ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
The Body ◽  
Clinical Entity ◽  
Delayed Presentation ◽  
Relative Paucity ◽  
Life Saving ◽  
Clinical Signs And Symptoms ◽  
High Index Of Suspicion

Posterior perforation of gastric ulcer is a rare clinical entity and has a propensity for delayed presentation and missed diagnosis. By virtue of their location, posterior gastric perforations may rupture into the retroperitoneum which leads to abscess formation and development of adhesions and consequently, leads to a delay in the onset of symptoms. Alternatively, ulcers located in the fundus or the body of the stomach may perforate into the lesser sac, which results in sealing off the perforation and less dramatic clinical signs and symptoms. This delay in presentation contributes to higher morbidity, higher infection rates and higher mortality. Thus, it is essential to have a high index of suspicion for this condition, particularly in patients with a protracted clinical presentation and classical risk factors so that timely, life-saving intervention is possible. We report a case of giant posterior gastric perforation with benign histopathology in a 40-years-old male. This case is being presented due to the rarity of this clinical entity and the relative paucity of literature on the same.

scholarly journals Oral and Dermal Candidiasis Among Infants in Al-Battol Teaching Hospital

2020 ◽  
Vol 19 (2) ◽  
pp. 147-156
Author(s):  
Raghad H Khaleefa ◽  
Luma T Ahmed ◽  
Dawood S Hameed
Keyword(s):  
Teaching Hospital ◽  
Intestinal Tract ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
The Body ◽  
Candida Spp ◽  
Isolation And Identification ◽  
Laboratory Procedure ◽  
Oral Thrush ◽  
Clinical Signs And Symptoms

Background: Candida spp. is the yeast caused infection termed candidiasis; this is naturally found on the skin and inner the body, in an area like the gut, intestines, throat, vagina, and mouth, with the absence inciting any problems. Candida albicans is yeast naturally found in the skin; intestinal tract; vaginal and mouth. This is a polymorphic yeast (that capable of growing either as avoid shaped budding yeast, when it affect the mouth, it is typically termed oral thrush, and when it affect the dermal (diaper area) called diaper rash. clinical signs and symptoms involve white patches on the or other areas of the mouth and throat, `other signs may involve soreness and problems of swallowing. Objective: To study detection, isolation, and identification of C. albicans from infants in Al-Battol Teaching Hospital in Diyala Province by routine laboratory procedure, and identification of other species of Candida. Patients and Methods: Two hundred samples were taken from infants less than 2 years who attended Al-Battol teaching Hospital in Diyala, province during the period from October 2019 to February 2020. Method of this study by making a routine and confirmative diagnosis processes involve a microscopic examination, culture on Sabouraud’s dextrose agar for diagnosis of primary invasive candidiasis, and culture on chrome agar for differentiating between C. albicans and other spp. Results: The results of this study showed the isolates of oral samples were 12 (24%) C. albicans and 18(36.0%) C. non albicans; for dermal isolates were 10(20.0%) C. albicans and 17(34.0%) C. non albicans; and for both isolates oral and dermal samples were 13(26.0%) C. albicans and 21 (42.0) C. non albicans. Conclusion: In this study found that the male are more infected by Candida than female. And also we concluded that small age children more infected than large age. Keywords: C. albican, non-albicans Candida spp. , infants

scholarly journals Maintaining Optimum Health Requires Longer-Term Stable Vitamin D Concentrations

2020 ◽  
pp. 1-5
Author(s):  
Sunil Wimalawansa ◽  
Sunil Wimalawansa
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Respiratory Infections ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Healthy Person ◽  
Immune Defense ◽  
The Body ◽  
Steady Level ◽  
Clinical Signs And Symptoms

Humans are constantly invaded by environmental microbes. The body is protected from pathogen attacks by the immune defense system. In 99.8% of the time, our innate immune system is capable of getting rid of these organisms without before these can cause harm. Those who are with weaker immune systems constantly get infections and having chronic diseases. Among many factors contributing to maintaining a robust immune system, vitamin D has the highest impact. It has a major protective effect against acute respiratory infections and subduing both communicable and non-communicable diseases. A healthy person with stronger immunity may not manifest clinical signs and symptoms of COVID-19-silent, asymptomatic carriers of the virus and can be infectious. Whereas not all PCR positive persons are infectious. A rapid response occurs through the innate system that is followed by the adaptive response that lasts a longer period. Vitamin D kick starts both systems. However, the protective immune and other functions are damped in the presence of hypovitaminosis and also when the levels are fluctuating. Thus, the importance of maintaining serum 25(OH)D at a steady level above 30 ng/mL. When maintaining such, among all nutrients vitamin D has the widest benefits to multiple body systems. Thus, this sunshine vitamin (a steroid hormone) has been modulated through evolution to emerge as a key survival mechanism in humans. Nevertheless, vitamin D is not a panacea.

Review on etio-pathogenesis and diagnostic approach of Amavata.

2020 ◽  
Vol 8 (06) ◽  
Author(s):  
Sanjay Gamaji Pairkao ◽  
Arun Dudhamal
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Early Stage ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Poor Quality ◽  
The Body ◽  
Quality Life ◽  
Wide Range ◽  
Clinical Signs And Symptoms

Amavata is a one of the difficult disease for clinicians due to it’s chronicity, incurability, complications, and morbidity. It is chronic disease as it needs repeated hospitalization so it put economic burden on family members and poor quality life. Madhavkara had described etiopathoganesis and clinical presentation of the disease briefly before thousands of years. Amavata is a multisystemic illness can be caused by vitiation of Vata and generation of Ama in the body which has articular as well as extra articular manifestations. Rheumatisim and Amavata have great similarities in the clinical presentation. Amavata can be clinically identical with any of the rheumatic disorder. Diagnosis of Amavata is not difficult in patient when it’s clinical presentation is classical but it may be confusing in a early stage.  In Amavata most of the clincical features are nominal and categorical there is wide range of clinical signs and symptoms narrated in Madhavakara So the diagnosis often made by some degree of subjective interpretation of clinician. To make a valid, reliable, consistent diagnosis of Amavata some pathological investigations can be included in the diagnostic criteria of Amavata. This study gives insight into review of diagnostic criteria of Amavata .

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