scholarly journals Stability and Efficacy Enhancement of Vitamin C Powder via Developing a Serum – Two Phase System, A New Inception in Vitamin C Delivery

2021 ◽  
Vol 4 (2) ◽  
pp. 109-110
Author(s):  
Vishal Saxena ◽  
Krishana Yadav
Keyword(s):  
Vitamin C ◽  
Water Content ◽  
Active Site ◽  
Low Ph ◽  
Phase System ◽  
Two Phase ◽  
System A ◽  
Ph Reduction ◽  
And Storage ◽  
Vit C

Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. In this article, we highlighted the multiple applications of Vit C and the development of novel serum formulation to enhance its delivery and stability during the application.

scholarly journals Partition Behavior in Aqueous Two-Phase System and Antioxidant Activity of Flavonoids from Ginkgo biloba

2018 ◽  
Vol 8 (11) ◽  
pp. 2058 ◽  
Author(s):  
Can Liu ◽  
Shuochen Liu ◽  
Lingli Zhang ◽  
Xiaoxue Wang ◽  
Lanqing Ma
Keyword(s):  
Antioxidant Activity ◽  
Polyethylene Glycol ◽  
Free Radical ◽  
Vitamin C ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Phase System ◽  
Two Phase ◽  
Extraction Parameters ◽  
Partition Behavior

In this work, the aqueous two-phase extraction parameters and in vitro antioxidant activity of total flavonoids from Ginkgo biloba were investigated. The partition behavior of the flavonoids in an aqueous two-phase system (ATPS) was analyzed, the extraction parameters were optimized using response surface methodology, and the antioxidant activity of the flavonoids was determined by free-radical scavenging tests (1,1-diphenyl-2-picrylhydrazyl (DPPH) assay) and the ferric reducing/antioxidant power (FRAP) assay. The results showed that the concentration of ammonium sulfate was negatively correlated with the phase-volume ratio, whereas the concentration of polyethylene glycol was positively correlated. The maximum yield of flavonoids (4.11 mg g−1) was obtained under the following optimal extraction conditions: Concentration of polyethylene glycol (PEG)1500 30% and (NH4)2SO4 22% (mass fraction), and liquid/solid ratio 40:1 (mL g−1). The antioxidant activity tests showed that the flavonoids from the G. biloba leaf exhibited free-radical scavenging activity, with an IC50 of 2.66 mg L−1, which was superior to that of vitamin C. The free-radical scavenging ability of the flavonoids was proportional to the flavonoid concentration. The total reducing power of the Ginkgo flavonoids was slightly lower than that of vitamin C. In this study, the distribution of flavonoids in an ATPS was analyzed and a mathematical model for the ATPS extraction of Ginkgo flavonoids was established, which provides a reference for further development and utilization of G. biloba.

Extraction of estrogen hormones from water samples using an aqueous two-phase system: a new approach for sample preparation in the analysis of emerging contaminants

2021 ◽  
pp. 106231
Author(s):  
Junielly Tomaz Domingues ◽  
Ricardo Mathias Orlando ◽  
Mariana Ramos Almeida ◽  
Leandro Rodrigues de Lemos ◽  
Aparecida Barbosa Mageste ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Water Samples ◽  
Emerging Contaminants ◽  
Phase System ◽  
Two Phase ◽  
New Approach ◽  
Aqueous Two Phase System ◽  
System A

Carbodiimide-Mediated Amide Formation in a Two-Phase System. A High-Yield and Low-Racemization Procedure for Peptide Synthesis

1995 ◽  
Vol 60 (11) ◽  
pp. 3569-3570 ◽  
Author(s):  
Guo-Jie Ho ◽  
Khateeta M. Emerson ◽  
David J. Mathre ◽  
Richard F. Shuman ◽  
Edward J. J. Grabowski
Keyword(s):  
Peptide Synthesis ◽  
High Yield ◽  
Phase System ◽  
Two Phase ◽  
System A ◽  
Amide Formation

RADIOIMMUNOASSAYS EMPLOYING IMMUNOSORBENTS

1969 ◽  
Vol 62 (1_Suppl) ◽  
pp. S207-S221 ◽  
Author(s):  
Leif Wide
Keyword(s):  
Liquid Phase ◽  
Cyanogen Bromide ◽  
Solid Phase ◽  
Binding Capacity ◽  
Phase System ◽  
Two Phase ◽  
System A ◽  
Technical Procedure ◽  
Particle Form ◽  
Insoluble Polymers

ABSTRACT The use of a reaction between compounds in a two phase system – a solid phase and a liquid phase – has simplified the technical procedure of the radioimmunoassays. Antigens or antibodies can be coupled covalently to insoluble polymers to form stable conjugates with retention of immunological binding capacity. Such immunosorbents can be used in radioimmunoassays in many different ways and with the solid phase in different forms. Some of these techniques seem to be universally applicable for the assay of antigens or antibodies. In one of these, antigens or antibodies are chemically coupled to cyanogen bromide activated insoluble polysaccharides in a particle form. This method which has several advantages when compared with most other radioimmunological methods is discussed in particular. Finally, a detailed description of the preparation of an immunosorbent and its use in such a radioimmunoassay system is given.

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