scholarly journals Coconut Oil and its Constituents as a Treatment for Alzheimer's Dementia

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Rodney Guttmann ◽  
Peyton Sims ◽  
Catherine Churchill ◽  
Caitlyn Waters ◽  
Bailey Berry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lauric Acid ◽  
Ketone Body ◽  
Ketone Bodies ◽  
Coconut Oil ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Cellular Processes

In recent years, there has been an increased number of studies focusing on the properties of coconut oil as a therapeutic supplement for patients with Alzheimer's disease.  Primarily, benefits of coconut oil are attributed to the presence of medium-chain triglycerides, lauric acid, or ketone bodies found in the oil. Research of these constituents within coconut oil has been shown to cause the onset of cellular processes such as autophagy, ketone body regulation, and the reduction of oxidative stress, among other nonspecific pathways.  A discussion of the potential for coconut oil within the context of these theoretical mechanisms to impact Alzheimer's disease is provided, suggesting that the validity of coconut oil claims should be viewed with skepticism.

Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease

2020 ◽  
Vol 186 ◽  
pp. 111209 ◽  
Author(s):  
Pratishtha Chatterjee ◽  
Malika Fernando ◽  
Binosha Fernando ◽  
Cintia B. Dias ◽  
Tejal Shah ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Coconut Oil ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Prevention And Treatment

Medium-chain triglycerides given in the early stage of mild-to-moderate Alzheimer's disease enhance memory function

2017 ◽  
Vol 17 (6) ◽  
pp. 520-521 ◽  
Author(s):  
Ayako Kimoto ◽  
Tohru Ohnuma ◽  
Aiko Toda ◽  
Yuto Takebayashi ◽  
Ryoko Higashiyama ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Stage ◽  
Memory Function ◽  
Medium Chain Triglycerides ◽  
Medium Chain

P2-255: Ketone bodies, sodium oxybate and Alzheimer's disease: Oxidative stress and neuroprotection

2010 ◽  
Vol 6 ◽  
pp. S389-S389 ◽  
Author(s):  
Mortimer Mamelak ◽  
Sarah Delaney ◽  
K. Yang ◽  
Peter J. O'Brien
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ketone Bodies ◽  
Sodium Oxybate

scholarly journals Relationship between Amyloid-beta 42 Levels and Y-maze Alternation Values in Sprague Dawley Alzheimer’s Induction Received Medium-Chain Triglycerides Therapy

2020 ◽  
Vol 8 (A) ◽  
pp. 476-480
Author(s):  
Faradila Faradila ◽  
Yuliarni Syafrita ◽  
Nur Indrawaty Lipoeto
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positive Control ◽  
Pharmacological Therapy ◽  
Control Group ◽  
Sprague Dawley ◽  
Medium Chain Triglycerides ◽  
Control Group Design ◽  
Medium Chain ◽  
Y Maze

BACKGROUND: At present, there is no pharmacological therapy that can cure Alzheimer’s disease. Treatment is only limited to preventing progression and controlling risk factors that worsen Alzheimer’s. Medium-chain triglycerides (MCT) are nutritional therapies that are being studied to prevent the progression of Alzheimer’s disease. AIM: This study aims to see the effect of giving MCT to the value of percentage alternation Y-maze test and serum Aβ-42 levels as a marker of Alzheimer’s disease. MATERIALS AND METHODS: This study is an experimental study using postp-test control group design. Samples from this study were 30 Sprague Dawley rats which were divided into positive control groups, negative controls, and three treatment groups. Positive control group and treatment were induced by Alzheimer’s by ovariectomy and d-galactose. After induction, MCT were given to the treatment group for 6 weeks. After treatment, the levels of Aβ-42 serum were examined by ELISA and cognitive function was examined by Y-maze. After that, the data were analyzed by ANOVA. p < 0.05 was said to be statistically significant. RESULTS: The results showed that this study was found a moderate relationship with a positive pattern. This means that the higher the percentage alternation value, the higher the level of Aβ-42 in serum which indicates that the higher the percentage alternation value, the higher the clearance of Aβ-42. CONCLUSION: This study concluded that the group of rats given MCT has a serum Aβ-42 level higher than the group of rats that were not given MCT.

Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease

2018 ◽  
Vol 64 (2) ◽  
pp. 551-561 ◽  
Author(s):  
Etienne Croteau ◽  
Christian-Alexandre Castellano ◽  
Marie Anne Richard ◽  
Mélanie Fortier ◽  
Scott Nugent ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Metabolism ◽  
Brain Energy Metabolism ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Brain Energy

scholarly journals Short-Term Influence of Caffeine and Medium-Chain Triglycerides on Ketogenesis: A Controlled Double-Blind Intervention Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Anna Baumeister ◽  
Joachim Gardemann ◽  
Manfred Fobker ◽  
Verena Spiegler ◽  
Tobias Fischer
Keyword(s):  
Side Effects ◽  
Intervention Study ◽  
Ketone Bodies ◽  
Coconut Oil ◽  
Medium Chain Triglycerides ◽  
Double Blind ◽  
Continuous Increase ◽  
Medium Chain ◽  
Ketogenic Diets ◽  
Decaffeinated Coffee

Background. Ketone bodies are a highly relevant topic in nutrition and medicine. The influence of medium-chain triglycerides (MCT) on ketogenesis is well known and has been successfully used in ketogenic diets for many years. Nevertheless, the effects of MCTs and coconut oil on the production of ketone bodies have only partially been investigated. Furthermore, the increased mobilisation of free fatty acids and release of catabolic hormones by caffeine suggest an influence of caffeine on ketogenesis. Methods. In a controlled, double-blind intervention study, seven young healthy subjects received 10 mL of tricaprylin (C8), tricaprin (C10), C8/C10 (50% C8, 50% C10), or coconut oil with or without 150 mg of caffeine, in 250 mL of decaffeinated coffee, over ten interventions. At baseline and after every 40 minutes, for 4 h, ßHB and glucose in capillary blood as well as caffeine in saliva were measured. Furthermore, questionnaires were used to survey sensory properties, side effects, and awareness of hunger and satiety. Results. The interventions with caffeine caused an increase in ßHB levels—in particular, the interventions with C8 highly impacted ketogenesis. The effect decreased with increased chain lengths. All interventions showed a continuous increase in hunger and diminishing satiety. Mild side effects (total = 12) occurred during the interventions. Conclusions. The present study demonstrated an influence of caffeine and MCT on ketogenesis. The addition of caffeine showed an additive effect on the ketogenic potential of MCT and coconut oil. C8 showed the highest ketogenicity.

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