scholarly journals Relationship between Amyloid-beta 42 Levels and Y-maze Alternation Values in Sprague Dawley Alzheimer’s Induction Received Medium-Chain Triglycerides Therapy

2020 ◽  
Vol 8 (A) ◽  
pp. 476-480
Author(s):  
Faradila Faradila ◽  
Yuliarni Syafrita ◽  
Nur Indrawaty Lipoeto
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positive Control ◽  
Pharmacological Therapy ◽  
Control Group ◽  
Sprague Dawley ◽  
Medium Chain Triglycerides ◽  
Control Group Design ◽  
Medium Chain ◽  
Y Maze

BACKGROUND: At present, there is no pharmacological therapy that can cure Alzheimer’s disease. Treatment is only limited to preventing progression and controlling risk factors that worsen Alzheimer’s. Medium-chain triglycerides (MCT) are nutritional therapies that are being studied to prevent the progression of Alzheimer’s disease. AIM: This study aims to see the effect of giving MCT to the value of percentage alternation Y-maze test and serum Aβ-42 levels as a marker of Alzheimer’s disease. MATERIALS AND METHODS: This study is an experimental study using postp-test control group design. Samples from this study were 30 Sprague Dawley rats which were divided into positive control groups, negative controls, and three treatment groups. Positive control group and treatment were induced by Alzheimer’s by ovariectomy and d-galactose. After induction, MCT were given to the treatment group for 6 weeks. After treatment, the levels of Aβ-42 serum were examined by ELISA and cognitive function was examined by Y-maze. After that, the data were analyzed by ANOVA. p < 0.05 was said to be statistically significant. RESULTS: The results showed that this study was found a moderate relationship with a positive pattern. This means that the higher the percentage alternation value, the higher the level of Aβ-42 in serum which indicates that the higher the percentage alternation value, the higher the clearance of Aβ-42. CONCLUSION: This study concluded that the group of rats given MCT has a serum Aβ-42 level higher than the group of rats that were not given MCT.

Medium-chain triglycerides given in the early stage of mild-to-moderate Alzheimer's disease enhance memory function

2017 ◽  
Vol 17 (6) ◽  
pp. 520-521 ◽  
Author(s):  
Ayako Kimoto ◽  
Tohru Ohnuma ◽  
Aiko Toda ◽  
Yuto Takebayashi ◽  
Ryoko Higashiyama ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Stage ◽  
Memory Function ◽  
Medium Chain Triglycerides ◽  
Medium Chain

Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease

2018 ◽  
Vol 64 (2) ◽  
pp. 551-561 ◽  
Author(s):  
Etienne Croteau ◽  
Christian-Alexandre Castellano ◽  
Marie Anne Richard ◽  
Mélanie Fortier ◽  
Scott Nugent ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Metabolism ◽  
Brain Energy Metabolism ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Brain Energy

scholarly journals Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice

2022 ◽  
Vol 2022 ◽  
pp. 1-10
Author(s):  
Chenxi Tan ◽  
Yang Liu ◽  
Huiyi Zhang ◽  
Cihan Di ◽  
Dechao Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Western Blot ◽  
Water Maze ◽  
Intestinal Flora ◽  
Gene Sequencing ◽  
Learning Ability ◽  
Control Group ◽  
Expression Levels ◽  
Y Maze

Alzheimer’s disease (AD) is recognized as one of the most common types of senile dementia. AD patients first suffer memory loss for recent events (short-term memory impairment). As the disease progresses, they are deprived of self-awareness. This study aims to explore the effects of a probiotic-supplemented diet on the cognitive behaviors and pathological features of mouse models of Alzheimer’s disease (AD). Mice in the control group and the 3xTg-AD group were fed a regular diet and a probiotic-supplemented diet, respectively, for 20 weeks. Behavioral experiments like Morris’s water maze and Y maze were conducted. Then, feces of mice were collected for 16S sRNA gene sequencing for microorganisms. In the end, soluble and insoluble Aβ40 and Aβ42 in the hippocampus and cortex of mice in each group were quantitatively analyzed with a double-antibody Sandwich ELISA. The expression levels of tau protein and gliocyte in the hippocampus and cortex were detected using the Western Blot method. The result of the Morris water maze experiment indicated that, in the place navigation test, the mice in the 3xTg-AD group experienced a significant decline in the learning ability and a longer escape latency and in the space exploration test, the swimming time of mice in the 3xTg-AD group in the target quadrant decreased and after being treated with the probiotic diet, mice in the 3xTg-AD group had improved learning and memory ability. The result of Y maze showed that the probiotic diet can improve the spontaneous alternation accuracy of mice in the 3xTg-AD group. The result of 16s rRNA gene sequencing showed that, compared with mice in the WT group, those in the 3xTg-AD group experienced a change in the intestinal flora. The Western Blot result displayed a decreased expression level of tau (pS202) ( P < 0.05 ) and decreased expression levels of Iba-1 and GFAP ( P < 0.05 ). The result of the ELISA experiment showed decreased levels of soluble and insoluble Aβ40 and Aβ42 in 3xTg-AD mice ( P < 0.05 ). In conclusion, a probiotic diet can prevent and treat AD by improving the intestinal flora of 3xTg-AD.

scholarly journals Effects of Acupuncture at Ht7 on Glucose Metabolism in a Rat Model of Alzheimer's Disease: An 18F-FDG-PET study

2016 ◽  
Vol 34 (3) ◽  
pp. 215-222 ◽  
Author(s):  
Xinsheng Lai ◽  
Jie Ren ◽  
Yangjia Lu ◽  
Shaoyang Cui ◽  
Junqi Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucose Metabolism ◽  
Metabolic Activity ◽  
Rat Model ◽  
Fdg Pet ◽  
Nucleus Basalis ◽  
Control Group ◽  
Model Of Alzheimer’S Disease ◽  
Y Maze

Objective To explore the effects of acupuncture at HT7 on different cerebral regions in a rat model of Alzheimer's disease (AD) with the application of 18F-2-fluoro-deoxy-D-glucose positron emission tomography (FDG-PET). Methods Sixty Wistar rats were included after undergoing a Y-maze electric sensitivity test. Ten rats were used as a healthy control group. The remaining 50 rats were injected stereotaxically with ibotenic acid into the right nucleus basalis magnocellularis and injected intraperitoneally with D-galactose. AD was successfully modelled in 36 rats, which were randomly divided into three groups (n=12 each): the AD group, which remained untreated; the AD+HT7 group, which received 20 sessions of acupuncture at HT7 over 1 month; and the AD+Sham group, which received acupuncture at a distant non-acupuncture point. Total reaction time (TRT) was measured by Y-maze and 18F-FDG-PET scans were conducted on day 1 and 30. PET images were processed with Statistical Parametric Mapping 8.0. Results Pre-treatment, TRT was greater in all AD groups versus controls (mean±SD 24.10±2.48 vs 41.34±5.00 s). Post-treatment, TRT was shortened in AD+HT7 versus AD+Sham and AD groups (p<0.0001, two-way analysis of variance). Glucose metabolic activity in the hippocampus, thalamus, hypothalamus, frontal lobe, and temporal lobe was decreased in AD rats compared with healthy controls and relatively elevated after HT7 acupuncture. Compared with sham acupuncture, HT7 needling had a greater positive influence on brain glucose metabolism. Conclusions Needling at HT7 can improve memory ability and cerebral glucose metabolic activity of the hippocampus, thalamus, hypothalamus, and frontal/temporal lobes in an AD rat model.

Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease

2020 ◽  
Vol 186 ◽  
pp. 111209 ◽  
Author(s):  
Pratishtha Chatterjee ◽  
Malika Fernando ◽  
Binosha Fernando ◽  
Cintia B. Dias ◽  
Tejal Shah ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Coconut Oil ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Prevention And Treatment

scholarly journals Coconut Oil and its Constituents as a Treatment for Alzheimer's Dementia

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Rodney Guttmann ◽  
Peyton Sims ◽  
Catherine Churchill ◽  
Caitlyn Waters ◽  
Bailey Berry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lauric Acid ◽  
Ketone Body ◽  
Ketone Bodies ◽  
Coconut Oil ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Cellular Processes

In recent years, there has been an increased number of studies focusing on the properties of coconut oil as a therapeutic supplement for patients with Alzheimer's disease.  Primarily, benefits of coconut oil are attributed to the presence of medium-chain triglycerides, lauric acid, or ketone bodies found in the oil. Research of these constituents within coconut oil has been shown to cause the onset of cellular processes such as autophagy, ketone body regulation, and the reduction of oxidative stress, among other nonspecific pathways.  A discussion of the potential for coconut oil within the context of these theoretical mechanisms to impact Alzheimer's disease is provided, suggesting that the validity of coconut oil claims should be viewed with skepticism.

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