scholarly journals Clinical Conditions and Risk Factors of Acinetobacter Baumannii Producing Metallo Beta-Lactamases Among Hospitalized Patients

2021 ◽  
Vol 2 (4) ◽  
pp. 11-17
Author(s):  
Sulaiman Alhusam
Keyword(s):  
Risk Factors ◽  
Endotracheal Intubation ◽  
Culture Media ◽  
Hospitalized Patients ◽  
Clinical Samples ◽  
Sensitivity Testing ◽  
Antimicrobial Sensitivity ◽  
Carbapenem Resistant ◽  
The Difference ◽  
Clinical Conditions

Purpose: The study aimed to determine the clinical conditions and risk factors associated with MBL produced by A.bumannii among hospitalized patients. Subjects and Methods: The clinical samples were collected from inpatients and subcultured on routine culture media for growth. Identification of bacteria along with antimicrobial sensitivity testing was done by VITEK®2 compact (bioMerieux). Isolates that were resistant to Meropenem and/or Imipenem were followed to detection of MBL by using metallo-β-lactamases by imipenem EDTA combined disc test (IMP-EDTA CDT) method. Demographic and clinical data of each patient were collected in terms of the type of infection, hospital-stay, associated factors, and outcome till discharge. Results: A number of 73(86.9%) isolates of A.baumannii were resistant to carbapenem. out of 73 carbapenem-resistant isolates, 64(87.7%) were found to be MBL positive. The patients with age more than 60 years i.e.  35.9% (23/64) were found to be more common in MBL positive isolates of A. baumannii. The difference in the distribution of MBL positive and MBL negative cases with endotracheal intubation and in Surgery during the last 30 days of incubation was found to be statistically significant. The mortality rate of patients infected by MBL positive isolates of A.baumannii was 12.5%. Conclusion: The MBL positive strains among carbapenem-resistant isolates of A.baumannii were high. endotracheal intubation and Surgery during the last 30 days were independently associated with MBL positive cases.

Risk Factors for the Acquisition of Carbapenem-Resistant Klebsiella pneumoniae among Hospitalized Patients

2005 ◽  
Vol 11 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Yee Gyung Kwak ◽  
Sang-Ho Choi ◽  
Eun Ju Choo ◽  
Jin-Won Chung ◽  
Jin-Yong Jeong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Klebsiella Pneumoniae ◽  
Hospitalized Patients ◽  
Carbapenem Resistant

Risk factors for the acquisition of carbapenem-resistant Escherichia coli among hospitalized patients

2008 ◽  
Vol 62 (4) ◽  
pp. 402-406 ◽  
Author(s):  
Min-Hyok Jeon ◽  
Sang-Ho Choi ◽  
Yee Gyung Kwak ◽  
Jin-Won Chung ◽  
Sang-Oh Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Escherichia Coli ◽  
Hospitalized Patients ◽  
Carbapenem Resistant

scholarly journals A multicenter study of risk factors and outcome of hospitalized patients with infections due to carbapenem-resistant Acinetobacter baumannii

2010 ◽  
Vol 14 (9) ◽  
pp. e764-e769 ◽  
Author(s):  
Wang-Huei Sheng ◽  
Chun-Hsing Liao ◽  
Tsai-Ling Lauderdale ◽  
Wen-Chien Ko ◽  
Yao-Shen Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acinetobacter Baumannii ◽  
Multicenter Study ◽  
Hospitalized Patients ◽  
Carbapenem Resistant

scholarly journals Urinary Tract Infection: Prevalence, Risk Factors, Bacterial Etiologies and Antimicrobial Resistance Profile among Egyptian Diabetic Patients

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Dalia E. Desouky ◽  
Hala M. Gabr ◽  
Mohammed El-Helbawy ◽  
Hanan M. Hathout
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Significant Risk ◽  
Diabetic Patients ◽  
Infection Prevalence ◽  
Sensitivity Testing ◽  
Duration Of Diabetes ◽  
Antimicrobial Sensitivity

Diabetic patients are more prone to infections due to impaired immune status. One of most frequent infections in diabetic patients are urinary tract infection (UTI). The aim of the work was to study the prevalence and associated risk factors of UTI among diabetic patients attending the outpatient clinics of Menoufia university hospital, and to assess the pattern of antimicrobial sensitivity of isolated organisms. A pre-designed questionnaire was used to collect information about age, sex and residence, smoking habits, and type and duration of diabetes. Laboratory investigations including blood analysis for glucose level, HBA1c, leucocytic count, urine culture and antimicrobial sensitivity testing were done. The prevalence of UTI was 51.3%, and the most significant risk factors associated with infection were older age, being female, BMI > 30, duration of diabetes > 10 years, together with uncontrolled diabetes. Residence, smoking, and type of diabetes were found to be insignificantly associated with UTI. Age, duration of diabetes, and HBA1c were found to be independently associated with UTI. Common isolated organisms in order of frequency were E. coli, Klebsiella, and Coagulase negative staph. More than 50% of isolates were resistant to one or more antibiotic on antimicrobial antibiotic sensitivity testing. The study concluded a high prevalence of UTI among studied patients. Proper control of diabetes with regular screening for HBA1c and UTI among diabetic patients is needed.

scholarly journals Antimicrobial Sensitivity Pattern of Pseudomonas Aeruginosa Isolated from a Tertiary Care Hospital

2020 ◽  
Vol 19 (2) ◽  
pp. 70-74
Author(s):  
Sabita Bhatta ◽  
Manoj Pradhan ◽  
Alina Singh ◽  
Raina Chaudhary ◽  
Yankpam Ibotomba Singh
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Care Hospital ◽  
Sensitivity Testing ◽  
Time Duration ◽  
Disk Diffusion Test ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern

Introduction: Pseudomonas aeruginosa (P. aeruginosa) is one of the major cause of nosocomial infection. Multi-drug-resistant P. aeruginosa (MDR PA) are increasingly encountered in clinical samples .Therefore, this study was undertaken to know the sensitivity pattern of P. aeruginosa and to detect MDR PA from clinical samples. Methods: This was a laboratory based retrospective-cross sectional study conducted at Department of Microbiology at a tertiary care referral centre in Kathmandu, Nepal from December 2018 to December 2019. Total of 200 isolates of P. aeruginosa were isolated from clinical samples. Non repetitive sample per patient was included in the study. Samples were processed according to standard methodology and antimicrobial sensitivity testing (AMST) was carried out by Modified Kirby Bauer disk diffusion test as per Clinical Laboratory Standard Institute guideline. MDR was defined as strains resistant to one or more agent of ≥ 3 groups of antimicrobial categories. Results: Highest number of P. aeruginosa were isolated from sputum (93), followed by wound swab (35), and pus (29). AMST revealed the most sensitive drug to be Amikacin (91.51%) followed by Meropenem (78.5%) and Piperacillin/Tazobactam (77.50%). Out of 200 isolates, 69 (34.5%) were MDRPA. Conclusions: The information regarding sensitivity pattern of P. aeruginosa will help clinicians to choose most effective antimicrobials for the treatment of patients thus saving the time duration and total cost of patient management and also it will play a key role in setting antimicrobial stewardship policy.

scholarly journals Predictive Models for Identification of Hospitalized Patients Harboring KPC-Producing Klebsiella pneumoniae

2014 ◽  
Vol 58 (6) ◽  
pp. 3514-3520 ◽  
Author(s):  
Mario Tumbarello ◽  
Enrico Maria Trecarichi ◽  
Fabio Tumietto ◽  
Valerio Del Bono ◽  
Francesco Giuseppe De Rosa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Klebsiella Pneumoniae ◽  
Clinical Specimen ◽  
Venous Catheter ◽  
Hospitalized Patients ◽  
Clinical Samples ◽  
Content Type ◽  
Receiver Operating Characteristic Curves ◽  
Infection Models ◽  
Independent Risk Factors

ABSTRACTThe production ofKlebsiella pneumoniaecarbapenemases (KPCs) byEnterobacteriaceaehas become a significant problem in recent years. To identify factors that could predict isolation of KPC-producingK. pneumoniae(KPCKP) in clinical samples from hospitalized patients, we conducted a retrospective, matched (1:2) case-control study in five large Italian hospitals. The case cohort consisted of adult inpatients whose hospital stay included at least one documented isolation of a KPCKP strain from a clinical specimen. For each case enrolled, we randomly selected two matched controls with no KPCKP-positive cultures of any type during their hospitalization. Matching involved hospital, ward, and month/year of admission, as well as time at risk for KPCKP isolation. A subgroup analysis was also carried out to identify risk factors specifically associated with true KPCKP infection. During the study period, KPCKP was isolated from clinical samples of 657 patients; 426 of these cases appeared to be true infections. Independent predictors of KPCKP isolation were recent admission to an intensive care unit (ICU), indwelling urinary catheter, central venous catheter (CVC), and/or surgical drain, ≥2 recent hospitalizations, hematological cancer, and recent fluoroquinolone and/or carbapenem therapy. A Charlson index of ≥3, indwelling CVC, recent surgery, neutropenia, ≥2 recent hospitalizations, and recent fluoroquinolone and/or carbapenem therapy were independent risk factors for KPCKP infection. Models developed to predict KPCKP isolation and KPCKP infection displayed good predictive power, with the areas under the receiver-operating characteristic curves of 0.82 (95% confidence interval [CI], 0.80 to 0.84) and 0.82 (95% CI, 0.80 to 0.85), respectively. This study provides novel information which might be useful for the clinical management of patients harboring KPCKP and for controlling the spread of this organism.

Pulmonary embolism

2007 ◽  
pp. 177-188
Keyword(s):  
Risk Factors ◽  
Pulmonary Embolism ◽  
Pulmonary Angiography ◽  
Hospitalized Patients ◽  
Pulmonary Emboli ◽  
Ct Pulmonary Angiography ◽  
Clinical Probability ◽  
Clinical Conditions ◽  
Specific Symptoms ◽  
Symptoms And Signs

Introduction 178 Risk factors 178 Clinical probability 179 Submassive PE 180 Massive PE 185 Further investigation of patients following PE 187 Prevention of pulmonary emboli 187 Pulmonary embolism (PE) can present with numerous non-specific symptoms and signs and hence mimics several other clinical conditions. The annual incidence of PE is approximately 60–70 cases in 100 000. Half occur in hospitalized patients, with a quarter having clear risk factors and the remainder being idiopathic. Most hospitals will have their own protocol for investigation; some still use ventilation–perfusion scintigraphy if they have on-site facilities, but most now use multi-detector CT pulmonary angiography (CTPA)....

scholarly journals Residence in Skilled Nursing Facilities Is Associated with Tigecycline Nonsusceptibility in Carbapenem-Resistant Klebsiella pneumoniae

2015 ◽  
Vol 36 (8) ◽  
pp. 942-948 ◽  
Author(s):  
David van Duin ◽  
Eric Cober ◽  
Sandra S. Richter ◽  
Federico Perez ◽  
Robert C. Kalayjian ◽  
...  
Keyword(s):  
Risk Factors ◽  
Klebsiella Pneumoniae ◽  
Susceptibility Testing ◽  
Skilled Nursing Facility ◽  
Positive Culture ◽  
Hospitalized Patients ◽  
Skilled Nursing Facilities ◽  
Nursing Facilities ◽  
Skilled Nursing ◽  
Carbapenem Resistant

OBJECTIVETo determine the rates of and risk factors for tigecycline nonsusceptibility among carbapenem-resistant Klebsiella pneumoniae (CRKPs) isolated from hospitalized patientsDESIGNMulticenter prospective observational studySETTINGAcute care hospitals participating in the Consortium on Resistance against Carbapenems in Klebsiella pneumoniae (CRaCKle)PATIENTSA cohort of 287 patients who had CRKPs isolated from clinical cultures during hospitalizationMETHODSFor the period from December 24, 2011 to October 1, 2013, the first hospitalization of each patient with a CRKP during which tigecycline susceptibility for the CRKP isolate was determined was included. Clinical data were entered into a centralized database, including data regarding pre-hospital origin. Breakpoints established by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) were used to interpret tigecycline susceptibility testing.RESULTSOf 287 patients included in the final cohort, 155 (54%) had tigecycline-susceptible CRKPs. Of all index isolates, 81 (28%) were tigecycline-intermediate and 51 (18%) were tigecycline resistant. In multivariate modeling, independent risk factors for tigecycline nonsusceptibility were (1) admission from a skilled nursing facility (OR, 2.51; 95% CI, 1.51–4.21; P=.0004), (2) positive culture within 2 days of admission (OR, 1.82; 95% CI, 1.06–3.15; P=.03), and (3) receipt of tigecycline within 14 days (OR, 4.38, 95% CI, 1.37–17.01, P=.02).CONCLUSIONSIn hospitalized patients with CRKPs, tigecycline nonsusceptibility was more frequently observed in those admitted from skilled nursing facilities and occurred earlier during hospitalization. Skilled nursing facilities are an important target for interventions to decrease antibacterial resistance to antibiotics of last resort for treatment of CRKPs.Infect Control Hosp Epidemiol 2015;36(8):942–948

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