scholarly journals Male Subfertility; Challenges and advancement in the andrology clinic at Khyber Pakhtunkhwa, Pakistan

2021 ◽  
Vol 6 (6) ◽  
pp. 8-14
Author(s):  
Mir Abid Jan ◽  
Arshad Arshad ◽  
Majid Khan Kakakhel ◽  
Muhammad Hamid
Keyword(s):  
Male Infertility ◽  
Medical Treatment ◽  
Infertility Treatment ◽  
Infertile Male ◽  
Secondary Infertility ◽  
Male Subfertility ◽  
Mean Delay ◽  
Infertile Men ◽  
Male Patients ◽  
The Mean

Objective:  This study is aimed to discuss the challenges in dealing the infertile male and advances in the treatment of male infertility. Material and methods: The study included infertile male patients who presented to andrology outpatient as primary or secondary infertility between December 2018 and January 2021. The data detailed different aspects of challenges and advances in male infertility treatment. The data analysisone with SPSS. Results: Total 289 patients included, most of them (74%) presented as primary infertility and a quarter presented as secondary infertility. The mean delay in presentation was 6.8 years which were due to treatment from non-andrologist doctors of different specialities (53.9%), hakims (15.2%), quacks (13.8%), gynaecologists (10.3%) and some were reluctant to tell their problem (6.5%). The diagnosis was N.O.A (42.9%), unexplained infertility (24.2%), varicocele (22.8%), OA (6.2%), OAT syndrome (2.7%) and CABVD (1%). Different treatment option opted were vasography plus vasovasostomy or vasoepididmostomy (31.1%), ART (23.9%), MSV (22.8%) and medical treatment (22.1%). Vasography plus vasovasostomy or vasoepididmostomy and medical treatment were the available options provided. There was no ART facility and those who were counseled for referral either their unwillingness or cost resulted in a hurdle in their provision. Conclusion: There are still a number of challenges in treating infertile men. Recently provision of medical and microsurgical treatment at andrology clinic resulted in proper treatment of a large number of infertile men who previously received treatment from un- related facilities.

scholarly journals Indian Clinical Experience on Innovative Product in Treatment of Male Infertility

2013 ◽  
Vol 5 (2) ◽  
pp. 76-79
Author(s):  
KP Biswas ◽  
Jayesh Amin ◽  
Asit Kumar Dutta ◽  
Kumud Kunwar ◽  
Veena G Shinde ◽  
...  
Keyword(s):  
Male Infertility ◽  
Clinical Experience ◽  
South Asian ◽  
Clomiphene Citrate ◽  
Innovative Product ◽  
Indian Market ◽  
Infertile Male ◽  
First Line ◽  
Male Patients ◽  
Very High

ABSTRACT Rising number of infertile males in India provokes the need of evidence-based comprehensive formula addressing unattended causes of male infertility. There is an innovative product*, a combikit available in Indian market, containing 30 tablets of antioxidant, multivitamin, amino acid and mineral tablets, with documented evidence on ingredients in treatment of male infertility, and 25 tablets of clomiphene citrate which is a timetested drug in treatment of male infertility (in particular oligospermia and/or asthenospermia). In order to assess efficacy of the product in Indian infertile male patients, we undertook phase IV multicentric clinical study, at 18 centers across India in 100 patients. Very high couple pregnancy rate of 53% was reported. As first line treatment of male infertility (in particular oligospermia and/or asthenospermia), the use of this innovative product therefore holds a strong promise. How to cite this article Amin J, Mishra SK, Dutta AK, Kunwar K, Shinde VG, Chauhan A, Sud S, Maurya R, Nepal N, Sarode P, Biswas KP, Mazumder GP, Chitrabanshi M, Shibe S, Shukla R, Trivedi N, Dayal M, Sortey D, Shukla S, Gawade B. Indian Clinical Experience on Innovative Product in Treatment of Male Infertility. J South Asian Feder Obst Gynae 2013;5(2):76-79.

scholarly journals Nitric oxide, 8-hydroxydeoxyguanosine, and total antioxidant capacity in human seminal plasma of infertile men and their relationship with sperm parameters

2020 ◽  
Vol 47 (1) ◽  
pp. 54-60
Author(s):  
Maryam Gholinezhad ◽  
Azadeh Aliarab ◽  
Ghasem Abbaszadeh-Goudarzi ◽  
Yousefreza Yousefnia-Pasha ◽  
Niusha Samadaian ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Male Infertility ◽  
Seminal Plasma ◽  
Total Antioxidant Capacity ◽  
Infertile Men ◽  
Sperm Counts ◽  
Semen Volume ◽  
Total Antioxidant ◽  
The Mean ◽  
Oxidative Biomarkers

Objective: Oxidative stress plays a key role in the pathogenesis of male infertility. But, the adverse effects of oxidative biomarkers on sperm quality remain unclear. This study aimed to investigate the levels of nitric oxide (NO), 8-hydroxydesoxyguanosine (8-OHdG), and total antioxidant capacity (TAC) oxidative biomarkers in seminal plasma and their relationship with sperm parameters.Methods: A total of 77 volunteers participated in the study, including fertile (n=40) and infertile men (n=37). NO, 8-OHdG, and TAC levels were measured using the ferric reducing ability of plasma, Griess reagent method and an enzyme-linked immunosorbent assay kit, respectively.Results: The mean values of sperm parameters in the infertile group were significantly lower than those in the fertile group (<i>p</i><0.001). The mean 8-OHdG in the seminal plasma of infertile men was significantly higher (<i>p</i>=0.013) than those of controls, while the mean TAC was significantly lower (<i>p</i>=0.046). There was no significant difference in NO level between the two groups. The elevated seminal 8-OHdG levels were negatively correlated with semen volume, total sperm counts and morphology (<i>p</i><0.001, <i>p</i>=0.001 and <i>p</i>=0.052, respectively). NO levels were negatively correlated with semen volume, total sperm counts and morphology (<i>p</i>=0.014, <i>p</i>=0.020 and <i>p</i>=0.060, respectively). Positive correlations between TAC and both sperm count and morphology (<i>p</i>=0.043 and <i>p</i>=0.025, respectively) were also found.Conclusion: These results suggested that increased levels of NO and 8-OHdG in seminal plasma could have a negative effect on sperm function by inducing damage to the sperm DNA hence their fertility potentials. Therefore, these biomarkers can be useful in the diagnosis and treatment of male infertility.

scholarly journals The Treatment of Male Infertility After Allograft Renal Transplantation: A Case Series

2019 ◽  
Vol 12 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Daiji Takamoto ◽  
Takashi Kawahara ◽  
Teppei Takeshima ◽  
Shinnosuke Kuroda ◽  
Taku Mochizuki ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Male Infertility ◽  
Semen Analysis ◽  
Case Series ◽  
Infertility Treatment ◽  
Testicular Sperm Extraction ◽  
Childbearing Age ◽  
Male Patients ◽  
Autosomal Dominant Polycystic Kidney

Background: Renal transplantation is a useful option for allowing female renal failure patients of childbearing age to achieve pregnancy. However, there have been a few reports on the effects of renal transplantation on infertility treatment in male renal failure patients. We herein report two cases in which male patients underwent infertility treatment after renal transplantation. Case Presentation: Case 1: A 51-year-old Asian (Japanese) man underwent transplantation (the donor was his wife) for renal failure due to Autosomal Dominant Polycystic Kidney Disease (ADPKD). At two years after transplantation, he visited the reproduction center in our institute due to infertility. A semen analysis revealed oligoasthenozoospermia. He ultimately failed to achieve pregnancy and gave up on infertility treatment. Case 2: A 47-year-old Asian (Japanese) man underwent renal transplantation (the donor was his sister) due to renal failure caused by diabetes mellitus. At three years after renal transplantation, he visited the reproduction center in our institute for infertility. Due to ejaculation disability and the absence of sperm in the patient’s urine after masturbation, he was diagnosed with anejaculation. Thus, testicular sperm extraction (TESE) was performed. Twenty-three motile spermatozoa were successfully retrieved by microdissection TESE (micro-TESE). ICSI was subsequently performed and a good embryo was transferred. His wife achieved pregnancy and is expected to deliver this October. Conclusion: We report two cases of male infertility treatment after renal transplantation.

scholarly journals Molecular microdeletion analysis of infertile men with karyotypic Y chromosome abnormalities

2017 ◽  
Vol 46 (1) ◽  
pp. 307-315 ◽  
Author(s):  
Yuan Pan ◽  
Hong-guo Zhang ◽  
QI Xi ◽  
Han Zhang ◽  
Rui-xue Wang ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Chromosome Abnormality ◽  
Karyotype Analysis ◽  
Northeastern China ◽  
Chromosome Abnormalities ◽  
Infertile Male ◽  
Metaphase Chromosomes ◽  
Sequence Tagged Sites ◽  
Infertile Men ◽  
Male Patients

Objectives To investigate azoospermic factor (AZF) microdeletions in infertile men from northeastern China with karyotypic Y chromosome abnormalities. Methods G-banding of metaphase chromosomes and karyotype analysis were performed in all infertile male patients. Genomic DNA was isolated and used to analyze classical AZF microdeletions by PCR. The regions and sequence-tagged sites of AZFa (SY86, SY84), AZFb (SY127, SY134, SY143), and AZFc (SY152, SY254, SY255, SY157) were sequenced by multiplex PCR. Results A total of 190 Y chromosome abnormality carriers were found, of whom 35 had AZF microdeletions. These were most common in 46,X,Yqh− patients, followed by 45,X/46,XY patients. Most microdeletions were detected in the AZFb + c region, including 48.57% of all AZF microdeletion cases. AZF partial deletions were also seen in these patients. Overall, AZF microdeletions were detected in 38.5% Y chromosome abnormality carriers, and most were observed in 46,X,Yqh− individuals. Loss of SY152 was seen in all 35 patients, with SY254/SY255 detected in 34 of 35 patients. Conclusions AZF microdeletions were detected in 38.5% of Y chromosome abnormality carriers. This indicates that AZF microdeletion screening is advisable for individuals with karyotypic Y chromosome abnormalities.

scholarly journals A Comparative Analysis of the Altered Levels of Human Seminal Plasma Constituents as Contributing Factors in Different Types of Male Infertility

2021 ◽  
Vol 43 (3) ◽  
pp. 1307-1324
Author(s):  
Ashutosh Vashisht ◽  
Pankaj Kumar Ahluwalia ◽  
Gagandeep Kaur Gahlay
Keyword(s):  
Male Infertility ◽  
Seminal Plasma ◽  
Clinical Stage ◽  
Control Group ◽  
Obstructive Azoospermia ◽  
Infertile Male ◽  
Contributing Factors ◽  
Immunological Markers ◽  
Different Types ◽  
Male Patients

(1) Background: The relationships between the biochemical and immunological components in seminal plasma and their physiological effects on male reproductive system have been underreported. In this study, we evaluated the potential of several seminal plasma biochemical and immunological markers in the pathophysiological developments of the infertile male patients. The study was designed to identify and assess different markers that may be associated with semen functions in different types of male infertility. (2) Methods: A total of 50 infertile male patients who underwent checkup for fertility assessment and 50 fertile controls were included in this study. The complete medical history of each recruited participant was reviewed. The infertile sub-groups (non-obstructive azoospermia (NOA), asthenozoospermia (AS), normozoospermic infertile (NI), and oligozoospermia (OZ)) were characterized based on sperm motility and concentration, while NI patients were included after a thorough check up of their female partners as well. We investigated each sample for 21 different analytes, enzymes, trace elements, and immunological markers to find crucial markers posing as contributing factors to a specific type of male infertility. (3) Results: The levels of 15 out of 21 markers, assayed from the seminal plasma of infertile males, were significantly altered in comparison to fertile controls (p < 0.05). For the first time, microprotein levels were also analyzed. The presence of monocytes, lymphocytes, and granulocytes was limited to semen from NOA patients, while a significant increase in the level of platelets was observed in AS. Hierarchical clustering and ROC-AUC analysis identified the three most significant markers (zinc, LDH, and TG) for the healthy control group and asthenozoospermic group (AUC, of 0.92 and 0.81, respectively). (4) Conclusions: The altered levels of biochemical and immunological markers in seminal plasma might be associated with the different male infertility profiles and could be required for the sperm metabolism and maintenance. However, a larger sample size and follow up analysis is required for establishing the hypothesized panel of markers as biomarkers at clinical stage.

scholarly journals Role of Antioxidants Supplementation in the Treatment of Male Infertility

2021 ◽  
Author(s):  
Houda Amor ◽  
Nyaz Shelko ◽  
Massooma Mohammed ◽  
Peter Michael Jankowski ◽  
Mohamad Eid Hammadeh
Keyword(s):  
Male Infertility ◽  
Semen Quality ◽  
Reproductive Function ◽  
Infertility Treatment ◽  
Review Article ◽  
Semen Parameters ◽  
Male Subfertility ◽  
Positive Effect ◽  
Assisted Reproduction Treatment

Nutritional utilization of antioxidants, such as vitamins C, E, ß-Carotene and micronutrients, such as folate and zinc, have been shown to be critically essential for normal semen quality and reproductive function. However, it is still, a large knowledge gap exists concerning the role of antioxidants on semen parameters and the role in treatment of male subfertility. Therefore, the current review article designed to find out the positive effect of antioxidants on semen quality, alterations in physiological functions of spermatozoa and infertility treatment It is advisable that patients with oxidative DNA disruption should be asked to take a simple course of antioxidants prior to undertaking assisted reproduction treatment (ART). In conclusion, antioxidant may be employed as a potent antioxidant and may improve infertility treatment outcomes with ART.

scholarly journals GENETIC FACTORS OF MALE INFERTILITY, THEIR COMBINATIONS AND THE SPERMATOLOGICAL CHARACTERISTICS OF MEN WITH FERTILITY FAILURES

2018 ◽  
Vol 19 (2) ◽  
pp. 40-51
Author(s):  
N. Yu. Safina ◽  
T. A. Yamandi ◽  
V. B. Chernykh ◽  
L. V. Akulenko ◽  
S. V. Bogolyubov ◽  
...  
Keyword(s):  
Male Infertility ◽  
Genetic Factors ◽  
Sex Chromosome ◽  
Gene Mutations ◽  
Normal Karyotype ◽  
Chromosome Abnormalities ◽  
Cag Repeats ◽  
Infertile Men ◽  
Sex Chromosome Abnormalities ◽  
Male Patients

The objectiveis to study the occurrence of common genetic factors of male infertility in men with reproductive problems, their combinations and spermatological characteristics.Materials and methods. 393 men with infertility in marriage were examined. According to the results of the cytogenetic study, the sample is divided into 3 groups: 135 men with numerical sex chromosome abnormalities; 58 male patients with a balanced structural rearrangement; 200 men with normal karyotype. Y chromosome microdeletions, CFTR gene mutations and CAG-repeats polymorphism of AR gene were analyzed.Results. The Y-chromosome microdeletions partially AZFc deletions were detected in 13 % male patients with sex chromosome abnormalities. A combination of chromosomal abnormalities with AZF deletions and/or CFTR gene mutations and long CAG repeats of AR gene was found in 19 % infertile men with balanced chromosome rearrangements. Infertile men with normal male karyotype presented the frequency of common genetic factors of male infertility was almost 2 times higher than the combined frequency of these factors in groups of patients with chromosomes abnormalities. Azoospermia in men with normal karyotype and patients with chromosome abnormalities was diagnosed with the same frequency (58 %). In all men who have identified the presence of two or more genetic factors of male infertility, severe forms of pathozoospermia (azoospermia and severe oligozoospermia) were found.Conclusion. The combination of genetic factors of male infertility is accompanied by severe forms of pathozoospermia that indicates a possible additive effect of negative effect on spermatogenesis and male fertility. 

scholarly journals A férfiak férfimeddőséggel kapcsolatos ismeretei és a támogatás lehetőségei: kockázati tényezők és egyéni válaszreakciók

2018 ◽  
Vol 159 (31) ◽  
pp. 1262-1268 ◽  
Author(s):  
Angelika Szatmári ◽  
Zsuzsanna Fejes ◽  
István Király
Keyword(s):  
Male Infertility ◽  
Coping Strategies ◽  
Information Seeking ◽  
Supportive Therapy ◽  
Point Of View ◽  
Reproductive Age ◽  
Infertile Male ◽  
Individual Support ◽  
Male Patients ◽  
The Individual

Abstract: In recent decades, the incidence of male infertility has been increasing continuously both worldwide and in Hungary and is becoming a more and more central issue. Millions of men at the reproductive age are affected by male infertility. In addition to the known organic reasons, many life-style and environmental factors can be expected to contribute to this. The biopsychosocial theoretical model of infertility allows us to interpret the lack of fertility not only from the medical point of view, but also as a psychosocial phenomenon. Men’s coping strategies, health information seeking habits, and knowledge of infertility are similar to women’s, but there are several different points in their responses given to the problem. So medical, nursing and other health professionals dealing with infertile male patients should devote special and high attention to patients’ conducting and paramedical counselling as supportive therapy. Within the framework of this – besides giving information – the individual support contributes to the elaboration of information, arising effects and experiences, furthermore to the developement of adaptive coping strategies for stress, and to the modification of direct or indirect changes in health behavior affecting reproductive health during the treatment period. Orv Hetil. 2018; 159(31): 1262–1268.

Clinical patterns and major causes of infertility among Sudanese couples

2008 ◽  
Vol 38 (4) ◽  
pp. 243-244 ◽  
Author(s):  
Elsir A Elussein ◽  
Yagoub M Magid ◽  
Maha M Omer ◽  
Ishag Adam
Keyword(s):  
Standard Deviation ◽  
Male Infertility ◽  
Clinical Management ◽  
African Countries ◽  
Male Factor ◽  
Secondary Infertility ◽  
Male And Female ◽  
Common Cause ◽  
Primary Infertility ◽  
The Mean

An understanding of the medical causes of infertility is crucial in order to reduce incidences of Infertility and for improving the clinical management of infertility. Although there were much data on infertility in other African countries, no data exist on infertility in Sudan. Seven hundred and ten Sudanese couples were investigated for the infertility in Khartoum Fertility Center, Sudan: 443 (62.4%) had primary infertility and 267 (37.6%) had secondary infertility. The mean (standard deviation) duration of the infertility was 5.2 (4.3) years. A positive male factor alone was found in 257 (36.2%) couples and a female factor in 350 (49.3%) couples: eleven (1.5%) couples had a combination of male and female factors: and the cause of infertility was unexplained in 92 (13.0%) couples. Oligozoospermia and asthenozoospermia were factors responsible for 16.8% and 17.5% of male infertility, respectively. Failure of ovulation (60.3%) was the most common cause of female infertility. The study revealed a high proportion of secondary infertility and a greater contribution of the female factors to infertility.

scholarly journals Relation between BMI and Semen parameters in male infertility patients in west of Algeria

2020 ◽  
Vol 10 (2-s) ◽  
pp. 64-67
Author(s):  
Dalila Ferrag ◽  
Abbassia Demmouche ◽  
Charaf Khalloua Zine
Keyword(s):  
Body Mass Index ◽  
Male Infertility ◽  
Body Mass ◽  
Semen Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Semen Parameters ◽  
Infertile Men ◽  
The Mean ◽  
The Impact

Introduction: Body mass index BMI is a risk factor that influences semen quality and reduces male fertility. The aim of this study was to determine the impact of body mass index (BMI) on semen parameters in infertile men. Subject and method: A total of 446 infertile men, the study population was divided into four groups depending on their BMI , underweight (<18.5 kg/), normal weight (18.5-24.99 kg/m2 ), overweight 25-29.99 kg/m2), and obese >30.0 kg/.semen parameters (PH, volume, concentration ,total semen count ,vitality, morphology and motility ) were compared across the four BMI groups. Results: The mean of age was 41.91±6.39, the mean infertility duration was 4.92±3.28, 351(78.7٪) had primary infertility and 95(21.3٪) had secondary infertility. The mean BMI was 29.38± 4.85 and the most of patients 45.2٪ were obese. Conclusion: This study has found evidence of an association between BMI and semen parameters (Sperm concentration, Total sperm count, motility, and vitality) and no correlation between Semen volume, morphology and BMI. Keywords: Body mass index, male infertility, semen quality, west of Algeria

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