scholarly journals ASSESSMENT OF TECHNICAL POSSIBILITIES FOR PRODUCTION OF PK- TYPE TERMINALS FOR SEPARATE RAIL FASTENING OF THE RAILWAY TRACK

2021 ◽  
pp. 74-82
Author(s):  
Mykolai Bahrov ◽  
Keyword(s):  
Life Experience ◽  
Real Life ◽  
National Standards ◽  
Railway Track ◽  
Product Certification ◽  
Stable Production ◽  
Certification Procedure ◽  
Certification Body ◽  
The Stability

The availability of the production certificate gives an advantage to any company that cares about improving the efficiency of processes and quality of work. The production certificate is first of all necessary for the enterprises which plan to take partin tenders for supply of products for railway transport and its infrastructure. The production certification procedure involves checking the compliance of regulatory, technological, metrological support, personnel qualification level, organizational arrangements aimed at ensuring the stability of quality indicators of products or services provided, assessment of technical capabilities of the applicant company to ensure stable production/services that meet the requirements of current regulations in Ukraine (national standards, enterprise standards, etc.). Therefore, the assessment of the technical capabilities of the manufacturer, including PC-type terminals of separate rail fastening of the railway track, is the main and integral part of the production certification process. The information and data provided in this paper are based on the real-life experience of the certification body and relate to the quantitative assessment of the technical capabilities of the enterprise that manufactures PK-type terminals. Key words: product certification, assessment of technical capabilities, production certificate, certification body, technological accuracy reserve.

scholarly journals Patient-Reported Outcomes, Health-Related Quality of Life, and Clinical Outcomes for Urothelial Cancer Patients Receiving Chemo- or Immunotherapy: A Real-Life Experience

2021 ◽  
Vol 10 (9) ◽  
pp. 1852
Author(s):  
Gry Assam Taarnhøj ◽  
Henriette Lindberg ◽  
Christoffer Johansen ◽  
Helle Pappot
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Patient Reported Outcomes ◽  
Life Experience ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Real Life ◽  
Oncological Treatment ◽  
Patient Reported

Patients with urothelial cell carcinoma (UCC) often have comorbidities, which cause trouble for the completion of oncological treatment, and little is known about their quality of life (QoL). The aim of the present study was to obtain and describe patient-reported outcomes (PRO) and QoL data from UCC patients in the treatment for locally advanced muscle-invasive or metastatic UCC. A total of 79 patients with UCC completed four questionnaires (EORTC QLQ-C30, QLQ-BLM30, HADS, and select PRO-CTCAE™ questions) once weekly during their treatment. From those, 26 patients (33%) underwent neoadjuvant treatment for local disease while 53 patients (67%) were treated for metastatic disease. Of all patients, 54% did not complete the planned treatment due to progression, nephrotoxicity, death, or intolerable symptoms during treatment. The five most prevalent PRO-CTCAE grade ≥ 2 symptoms were frequent urination (37%), fatigue (35%), pain (31%), dry mouth (23%), and swelling of the arms or legs (23%). The baseline mean overall QoL was 61 (±SD 24) for all patients (neoadjuvant (73, ±SD 19) and metastatic (54, ±SD 24)) and remained stable over the course of treatment for both groups. A stable overall QoL was observed for the patients in this study. More than half of the patients did not, however, complete the planned treatment. Further supportive care is warranted for bladder cancer patients.

scholarly journals Assessment of vehicle brake control functional stability

2021 ◽  
Vol 12 (2) ◽  
pp. 33-44
Author(s):  
Volodymyr Volkov ◽  
◽  
Igor Gritsuk ◽  
Tetiana Volkova ◽  
Volodymyr Kuzhel ◽  
...  
Keyword(s):  
Energy Consumption ◽  
Control Method ◽  
Operating Conditions ◽  
National Standards ◽  
Passenger Vehicles ◽  
The Difference ◽  
Braking Control ◽  
The Stability ◽  
Friction Surfaces

The article is devoted to the study of the influence of the brake control elements of passenger vehicles on the stability of their braking properties. The analysis of the influence of uneven braking forces on the wheels of one axle of vehicles on the deviation of the distribution of braking forces between the axles from its calculated value is carried out. When assessing the error in regulating the distribution of braking forces between the axles of vehicles, three components were taken into account: the theoretical error due to the imperfection of the selected control method (the difference between the actual calculated control characteristic from the ideal), the error created due to the instability of the ratio of the braking forces on the front and rear wheels, an additional error caused by the unevenness of the braking forces on the wheels of individual axles, since the fulfillment of the most stringent requirements of international and national standards for the efficiency of braking of vehicles and is inextricably linked with the need to increase the energy consumption of brake mechanisms. The energy consumption of braking mechanisms is understood as the ability of the latter to dissipate the greatest amount of energy of the braking machine without reducing the braking efficiency indicators to the minimum permissible level. Excessive heating of the braking mechanisms leads to a decrease in the friction coefficient μ of the friction surfaces and increased wear of the friction linings, and the brakes are the most unstable element of the braking control, which ensures the absorption and dissipation of the vehicle's energy during braking. The instability of the braking torques on the front and rear wheels, caused by a change in the coefficients of friction of friction pairs, leads not only to a change in the distribution of braking forces between the axles and individual wheels, but also to a decrease in the braking efficiency of vehicles under operating conditions. A method is proposed that makes it possible to assess the quality of regulation of the distribution of braking forces between the axles of a car, taking into account the instability of the braking forces on the wheels.

scholarly journals A New Curcuma Extract (Flexofytol®) in Osteoarthritis: Results from a Belgian Real-Life Experience

2014 ◽  
Vol 8 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Thierry Appelboom ◽  
Nathalie Maes ◽  
Adelin Albert
Keyword(s):  
Quality Of Life ◽  
Patient Satisfaction ◽  
Observational Study ◽  
Life Experience ◽  
Real Life ◽  
Randomized Controlled ◽  
Randomized Controlled Studies ◽  
Patient Pain ◽  
Inflammatory Drugs

This retrospective observational study summarizes the experiences of 820 patients treated with a new Curcuma extract (Flexofytol®, 4-6 capsules per day), for more than 6 months for various forms of painful osteoarthritis. These experiences were reported by 110 Belgian general practitioners via a questionnaire that included quality-of-life parameters for assessing patient experience. Data were submitted to an independent statistician for analysis. Within the first 6 weeks, Flexofytol® improved patient pain, articular mobility, and quality of life. Excellent tolerance was reported, and more than half of these patients were able to discontinue analgaesic and anti-inflammatory drugs. Patient satisfaction was confirmed by their decision to maintain Flexofytol® therapy for more than 6 months. These data must be confirmed with randomized controlled studies. We currently conclude that Flexofytol® which is based on a new preparation of curcumin, is as a potential neutraceutical for the care of patients complaining of joint problems, with excellent tolerance and rapid benefits for articular mobility, pain, and quality of life.

NEPA as antiemetic prophylaxis after failure of 5HT3-RA plus dexamethasone in patients receiving carboplatin and gemcitabine chemotherapy: A monocentric real-life experience

2020 ◽  
pp. 107815522092940
Author(s):  
Maria Rosaria Valerio ◽  
Vittorio Gebbia ◽  
Nicolò Borsellino ◽  
Maria La Vecchia ◽  
Vincenzo Serretta ◽  
...  
Keyword(s):  
Combination Chemotherapy ◽  
Rescue Medication ◽  
Life Experience ◽  
Real Life ◽  
Complete Response ◽  
Antiemetic Prophylaxis ◽  
Phase 0 ◽  
Subsequent Cycle ◽  
Delayed Cinv

Introduction Chemotherapy-induced nausea and vomiting (CINV) may affect adherence to planned chemotherapy treatments and compromise patients’ quality of life during the therapy. NEPA is an oral fixed combination of netupitant, a highly-selective NK1-RA and palonosetron, a 5HT3-RA, approved for the prevention of acute and delayed CINV. The aim of this study was to evaluate the efficacy and safety of NEPA with dexamethasone for CINV prophylaxis in the challenging setting of carboplatin and gemcitabine combination chemotherapy, after failure of prophylaxis with 5HT3 receptor antagonist. Methods Eligible patients were undergoing carboplatin and gemcitabine combination chemotherapy for metastatic non-small cell lung cancer (NSCLC), ovarian cancer or urothelial cancer and experienced nausea and/or vomiting after the first cycle of chemotherapy, despite an antiemetic prophylaxis with a 5HT3-RA and dexamethasone. Primary efficacy endpoint was complete response (CR: no emesis, no rescue medication) obtained with NEPA, during the overall phase (0–120 h), after the start of chemotherapy. Results During the first cycle of chemotherapy, 15 out of 30 (50%) patients did not properly control CINV with a 5HT3-RA plus dexamethasone used as primary antiemetic prophylaxis and then were switched to NEPA from the subsequent cycle. During NEPA administration, 13 out of 15 patients (86.7%) achieved an overall CR (no emesis, no rescue medication). Antiemetic treatment with NEPA was very well tolerated with only two patients (13.3%) that experienced a grade 1 TEAE. Conclusions Our experience showed that NEPA has proven to be very effective and well tolerated in the prophylaxis of CINV induced by carboplatin-based chemotherapy.

scholarly journals Real-life experience of quality of life, treatment satisfaction, and adherence in patients receiving oral anticoagulants for atrial fibrillation

2018 ◽  
Vol Volume 12 ◽  
pp. 79-87 ◽  
Author(s):  
Michaël Benzimra ◽  
Béatrix Bonnamour ◽  
Martin Duracinsky ◽  
Christophe Lalanne ◽  
Jean-Pierre Aubert ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Treatment Satisfaction ◽  
Life Experience ◽  
Oral Anticoagulants ◽  
Real Life

scholarly journals To the problem of formation of sence-of-life orientations of mature personality

HUMANITARIUM ◽  
2021 ◽  
Vol 44 (1) ◽  
pp. 34-41
Author(s):  
Oksana Voytenko
Keyword(s):  
Life Experience ◽  
Real Life ◽  
Adult Personality ◽  
Social Determinism ◽  
New Meanings ◽  
Psychological Influences ◽  
Psychological Influence ◽  
Methodological Principles ◽  
The Individual

The article is devoted to the research of the problem of formation of sence-of-life orientations of a mature personality: the theoretical analysis of the concept of personal maturity, the essence of sence-of-life orientations in the life of an adult personality is presented; the relevance and motivation of research in the direction of humanistic-existential paradigm are substantiated; processes of understanding the life experience of the individual, his role in the formation of a mature personality, the activation of its internal resource are emphasized. An empirical study and analysis of its results on the formation of sence-of-life orientations of the individual in adulthood are presented; the principles of psychological influences in the process of psychological support are presented: social determinism, freedom of choice, personal congruence, responsibility, individual approach, empathy, invaluable attitude to the client. In the course of the research hypotheses were put: the deepening crisis of the existence of a mature personality is mediated by personal experience of living out difficult life situations and overcoming them. The main purpose of crisis counseling as a special help of the individual, is to promote an in-depth understanding that only person is able to make choices, to take responsibility for their life. In the course of research and implementation of psychological influence, the methodological principles of humanistic and existential orientation, which determined professional interaction, were reflected. The essence of psychological care, which we see in the integration of the experience of psychotherapeutic meetings in the real life of the client, is determined. In the perspective of research, the formation of a stable resistance of the individual to stress, adaptation to the situation of frustration and, in particular, the search for new meanings of existence, improving the quality of life.

scholarly journals Effectiveness of Benralizumab in Improving the Quality of Life of Severe Eosinophilic Asthmatic Patients: Our Real-Life Experience

2021 ◽  
Vol 12 ◽  
Author(s):  
Giulia Scioscia ◽  
Giovanna Elisiana Carpagnano ◽  
Carla Maria Irene Quarato ◽  
Donato Lacedonia ◽  
Sonia Santamaria ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Function ◽  
Asthma Control ◽  
Severe Asthma ◽  
Life Experience ◽  
Real Life ◽  
Eosinophilic Inflammation ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma

Background: Severe eosinophilic asthma decreases lung function and causes worsen symptoms, often forcing recurrent maintenance corticosteroid use. The aim of our real-life study was to evaluate the effectiveness of an add-on treatment with benralizumab in patients with severe eosinophilic asthma, paying particular attention to the impact on their quality of life (QoL).Materials and methods: In this prospective study, 10 outpatients with severe eosinophilic asthma were added-on with benralizumab and followed-up in our severe asthma clinic after 12 and 24 weeks. At each patient visit, pre-bronchodilator FEV1 and inflammatory markers were recorded. Variations in asthma symptoms control and QoL perception was assessed by validated questionnaires.Results: All the subjects experienced a marked reduction of nocturnal and diurnal symptoms over time and were able to stop using OCS, as documented by the improvement in Asthma control test (ACT) and Asthma Control Questionnaire score. Similarly, we recorded a statistically significant increase in patient’s QoL perception in EQ-VAS, EQ-5D-3L and Asthma Quality of Life Questionnaire (AQLQ) assessment (p < 0.05). Simultaneously we recorded a significant reduction in eosinophilic inflammation, an improvement in pre-bronchodilator FEV1. These results appear to be in line with those already obtained in the previous randomized controlled trials (RCTs).Conclusion: Our 24-weeks real life experience supports the effectiveness of an add-on treatment with benralizumab in reducing eosinophilic inflammation and OCS-use, increasing lung function and improving control of nocturnal and diurnal symptoms, as well as restoring severe asthma patients to a better QoL.

scholarly journals Profile of system and product certification as quality infrastructure in Indonesia

2021 ◽  
Vol 11 (1) ◽  
pp. 556-569
Author(s):  
Febrian Isharyadi ◽  
E. Kristiningrum
Keyword(s):  
Quality Assurance ◽  
Third Party ◽  
Product Certification ◽  
Certification Body ◽  
Quality Of Products ◽  
Quality Infrastructure ◽  
Universal Standard

Abstract Quality is a universal standard that is expected by consumers of a product or service used. Consumers in general cannot individually assess this quality, with the help of an independent third party it can be done. The certification body is one element in the quality infrastructure that plays a role in providing quality assurance of products and services according to applicable standards. There are various certification bodies in Indonesia both for system and product certification, the kinds additionally range in accordance to the scope of certification. However, it is not yet known generally the condition of the system and product certification in Indonesia. The aim of this study is to conduct profiling and analyse the condition of the system and product certification in Indonesia using a comprehensive tool in order to assess part of the quality of a country's infrastructure. The results showed that there were several elements that were fulfilled, especially in terms of legality and national recognition. However, some elements still need improvement so that the certification body can do its part to ensure the quality of products and services.

scholarly journals Quality assurance and control system for railway track tamping

2018 ◽  
Vol 216 ◽  
pp. 03004 ◽  
Author(s):  
Andrey Ilinykh ◽  
Alexey Manakov ◽  
Andrey Abramov ◽  
Sergey Kolarzh
Keyword(s):  
Quality Assurance ◽  
Quality Criteria ◽  
Railway Track ◽  
Rolling Stock ◽  
Theoretical Studies ◽  
The Stability ◽  
And Control ◽  
Control Methodology ◽  
Quality Assurance And Control

Ensuring stable parameters of a railway track after bringing it into a design position is a key measure of quality for evaluating completed repairs. Identifying quality criteria for sleeper tamping using a special rolling stock is a high-priority problem for a railway track infrastructure. This problem is complicated by a large choice of ballast compaction, leveling and finishing machines, totaling more than 30 types. The paper presents results of theoretical studies aimed at assuring and controlling the quality of tamping by multi-purpose track machines. The factors that determine the stability of railway track parameters in operation were identified. The track repair processes were analyzed. The operating factors that are essential for developing qualitative process parameters were identified for various types of track machines. Based on the findings of these studies, a quality assurance and control methodology was developed for railway track repair and maintenance operations.

Sign in / Sign up

Export Citation Format

Share Document